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PROF GEOFFREY MCFADDEN



Contact Details

Organization: Botany
Position: ARC FEDERATION FELLOW
Email:
Homepage: http://www.homepage.mac.com/fad1/McfaddenLab.html
Work: 9344 4272
Mobile: 0414 189 905
Fax: 9347 1071
Room: 210
Level: 02
Building: Botany
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Parasitology, Endosymbiosis, Molecular Evolution. Malaria, Chloroplasts,drugs United States of America, United Kingdom, Canada, France, Germany

International Linkages

Country Establishment Collaboration
Canada Canadian Institute for Advanced Research Exchange, Research, Technical Assistance/Training
United States Marine Biological Laboratory Exchange, Teaching, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne
Doctor of Philosophy University of Melbourne

Memberships

Membership Type Membership Body Description Start Date End Date
Member International Society of Evolutionary Protistology President 01-Jan-1995
Member ARC/NHMRC Network for Parasitology Management Committee 01-Jan-2005
Associate CIAR-Canadian Institute of Advanced Research International Associate 01-Jan-1997
Associate Molecular Biology & Evolution Associate Editor 01-Jan-1999
Associate HHMI International Associate 01-Jan-2000
Member BioMed Central Image Library Editorial Board Member 01-Jan-2005
Member European Journal of Phycology Editorial Board 01-Jan-1998

Fellowships

Fellowship Date Awarded
Fellow of the Australian Academy of Science (FAA) 01-Jan-2005

Other Awards

Award Type Awarding Body Comments Date Awarded
Medal UOM Woodward Medal 27-Aug-2003
Prize International Society for Endocytobiology Miescher-Ishida Prize 01-Jan-2001
Medal Australian Society for Plant Physiology Goldacre Medal 01-Jan-1990
Prize AAS Frederick White Prize 01-Jan-1997
Prize UOM David Syme Prize 01-Jan-2001
Medal Lorne Genome Society Julian Wells Medal 01-Jan-2006

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Function of the relict chloroplast of Plasmodium falciparum Chief Investigator HOWARD HUGHES MEDICAL INSTITUTE International Research Scholars Program, Infectious Diseases and Parasitology 01/09/2000
Post-genomic investigation of the relict plastid and mitochondrion of malaria parasites Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2002
THE MALARIA PARASITE APICOPLAST AS A DRUG TARGET Chief Investigator HOWARD HUGHES MEDICAL INSTITUTE International Research Scholars Program, Infectious Diseases and Parasitology 01/09/2005
HOST PARASITE INTERACTIONS Chief Investigator WALTER & ELIZA HALL INST Project Grants (NHMRC) 01/01/2006
Drug targets in malaria parasites Chief Investigator AUST RESEARCH COUNCIL Federation Fellowships 01/01/2006
Infrakingdom Alveolata: searching for a defining structural feature Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
APICOLIPID MARIE CURIE OUTGOING INTERNATIONAL FELLOWSHIP- CYRILLE BOTTE Chief Investigator CNRS Marie Curie International Research Staff Exchange Scheme (IRSES) (EUROPEAN COMMISSION) 09/09/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Publications in 2008

Journal Articles

  • Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the Mammalian host
    Year: 2008
    Journal: Eukaryotic Cell
    Volume: 7
    Issue: 8
    Page numbers: 1256-1267
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  • Plasmodium falciparum growth is arrested by monoterpenes from eucalyptus oil
    Year: 2008
    Journal: Flavour & Fragrance Journal
    Volume: 23
    Page numbers: 315-318
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  • The chloroplast protein translocation complexes of Chlamydomonas reinhardtii: A bioinformatic comparison of Toc and Tic components in plants, green algae and red algae


    Year: 2008
    Journal: Genetics
    Volume: 179
    Issue: 1
    Page numbers: 95-112
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  • The mother of all parasites


    Year: 2008
    Journal: Future Microbiology
    Volume: 3
    Issue: 4
    Page numbers: 391-395
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  • Alveolins, a New Family of Cortical Proteins that Define the Protist Infrakingdom Alveolata
    Year: 2008
    Journal: Molecular Biology and Evolution
    Volume: 25
    Page numbers: 1219-1230
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  • Evolution of malaria parasite plastid targeting sequences
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 12
    Page numbers: 4781-4785
    Author(s):
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  • Fatty acid synthesis in protozoan parasites: Unusual pathways and novel drug targets
    Year: 2008
    Journal: Current Pharmaceutical Design
    Volume: 14
    Issue: 9
    Page numbers: 901-916
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  • Gamete fusion: Key protein identified
    Year: 2008
    Journal: Current Biology
    Volume: 18
    Issue: 13
    Page numbers: 571-573
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  • Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5
    Year: 2008
    Journal: Infection and Immunity
    Volume: 76
    Issue: 9
    Page numbers: 4332-4344
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  • Plastid Evolution
    Year: 2008
    Journal: Annual Review of Plant Biology
    Volume: 59
    Page numbers: 491-517
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  • Protein targeting to the malaria parasite plastid
    Year: 2008
    Journal: Traffic
    Volume: 9
    Issue: 2
    Page numbers: 166-175
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Publications in 2007

Journal Articles

  • Differential parasite drive


    Year: 2007
    Journal: Nature
    Volume: 450
    Page numbers: 955
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  • Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1.


    Year: 2007
    Journal: Infection and Immunity
    Volume: 75
    Issue: 7
    Page numbers: 3621-3632
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  • Fatty acid biosynthesis as a drug target in apicomplexan parasites
    Year: 2007
    Journal: Current Drug Targets
    Volume: 8
    Page numbers: 15-30
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  • Illuminating Plasmodium falciparum-infected red blood cells
    Year: 2007
    Journal: Trends in Parasitology
    Volume: 23
    Issue: 6
    Page numbers: 268-277
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  • Protein targeting to the malaria plastid
    Year: 2007
    Journal: Traffic
    Volume: 8
    Page numbers: 1-10
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  • The complete chloroplast genome of the chlorarachniophyte Bigelowiella natans: evidence for independent origins of chlorarachniophyte and euglenid secondary endosymbionts
    Year: 2007
    Journal: Molecular Biology and Evolution
    Volume: 24
    Issue: 1
    Page numbers: 54-62
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  • The effects of anti-bacterials on the malaria parasite Plasmodium falciparum
    Year: 2007
    Journal: Molecular and Biochemical Parasitology
    Volume: 152
    Issue: 2
    Page numbers: 113-224
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Publications in 2006

Journal Articles

  • Evidence for Golgi-independent transport from the early secretory pathway to the plastid in malaria parasites


    Year: 2006
    Journal: Molecular Microbiology
    Volume: 61
    Issue: 3
    Page numbers: 614-631
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  • A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.
    Year: 2006
    Journal: International Journal for Parasitology
    Volume: 36
    Issue: 14
    Page numbers: 1499-1514
    Author(s):
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  • An Australian network to support the understanding and control of parasites
    Year: 2006
    Journal: Trends in Parasitology
    Volume: 22
    Issue: 3
    Page numbers: 97-99
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  • Complete nucleotide sequence of the chlorarachniophyte nucleomorph: Nature's smallest nucleus
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 25
    Page numbers: 9566-9571
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  • Differential gene transfers and gene duplications in primary and secondary endosymbioses
    Year: 2006
    Journal: BMC Evolutionary Biology
    Volume: 6
    Issue: 38
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  • Membrane transporters in the relict plastid of malaria parasites
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 25
    Page numbers: 9572-9577
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  • Metabolic maps and functions of the Plasmodium mitochondrion
    Year: 2006
    Journal: FEMS Microbiology Reviews
    Volume: 30
    Issue: 4
    Page numbers: 596-630
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  • N-terminal positively charged amino acids, but not their exact position, are important for apicoplast transit peptide fidelity in Toxoplasma gondii
    Year: 2006
    Journal: Molecular and Biochemical Parasitology
    Volume: 150
    Issue: 2
    Page numbers: 192-200
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  • Protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum
    Year: 2006
    Journal: Current Opinion in Microbiology
    Volume: 9
    Issue: 4
    Page numbers: 381-387
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  • Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite
    Year: 2006
    Journal: Nature
    Volume: 443
    Issue: `7111
    Page numbers: 582-585
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  • protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum
    Year: 2006
    Journal: Current Opinion in Microbiology
    Volume: 9
    Issue: 4
    Page numbers: 381-387
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Publications in 2005

Journal Articles

  • Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase
    Year: 2005
    Journal: International Journal for Parasitology
    Volume: 35
    Page numbers: 861-873
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 57
    Issue: 2
    Page numbers: 405-419
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  • The apicoplast: a review of the derived plastid of apicomplexan parasites
    Year: 2005
    Journal: Current Issues in Molecular Biology
    Volume: 7
    Page numbers: 57-79
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  • The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 55
    Issue: 1
    Page numbers: 27-38
    Publisher: Blackwell Science(Oxford)
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  • The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 55
    Issue: 1
    Page numbers: 39-53
    Publisher: Blackwell Science(Oxford)
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Publications in 2004

Book Chapters

  • The Apicoplast


    Year: 2004
    Book: Genomes and The Molecular Cell Biology of Malaria Parasites
    Publisher: Horizon Bioscience(Norwich)
    Authors(s):
  • The apicoplast
    Year: 2004
    Book: Malaria parasites: genomes and molecular biology
    Publisher: Caister Academic Press(Norwich)
    Authors(s):

Journal Articles

  • Diatom genomics: Genetic acquisitions and mergers
    Year: 2004
    Journal: Current Biology
    Volume: 14
    Issue: 12
    Page numbers: 1048-1050
    Publisher: Cell Press(Massachusetts)
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  • Evolution: red algal genome affirms a common origin of all plastids
    Year: 2004
    Journal: Current Biology
    Volume: 14
    Issue: 13
    Page numbers: 514-516
    Publisher: Cell Press(Massachusetts)
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  • Evolutionary pressures on apicoplast transit peptides
    Year: 2004
    Journal: Molecular Biology and Evolution
    Volume: 21
    Issue: 12
    Page numbers: 2183-2194
    Publisher: Society for Molecular Biology and Evolution(Kansas)
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  • Localization of organellar proteins in Plasmodium falciparum
    Year: 2004
    Journal: Molecular and Biochemical Parasitology
    Volume: 137
    Page numbers: 13-21
    Publisher: Elsevier Science(Amsterdam)
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  • Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method
    Year: 2004
    Journal: Molecular and Biochemical Parasitology
    Volume: 137
    Issue: 1
    Page numbers: 13-21
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  • Metabolic maps and functions of the Plasmodium falciparum apicoplast
    Year: 2004
    Journal: Nature Reviews Microbiology
    Volume: 2
    Page numbers: 203-216
    Publisher: Nature Publishing Group(London)
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  • More plastids in human parasites?
    Year: 2004
    Journal: Trends in Parasitology
    Volume: 20
    Issue: 2
    Page numbers: 54-57
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  • SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania
    Year: 2004
    Journal: Molecular Biology of the Cell
    Volume: 15
    Page numbers: 4775-4786
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  • Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast.
    Year: 2004
    Journal: Nature Reviews Microbiology
    Volume: 2
    Page numbers: 203-216
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Publications in 2003

Book Chapters

  • Plastids, mitochondria, and hydrogenosomes
    Year: 2003
    Book: Molecular Medical Parasitology
    Publisher: Academic Press(London)
    Authors(s):

Journal Articles

  • A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum
    Year: 2003
    Journal: Antimicrobial Agents and Chemotherapy
    Volume: 47
    Page numbers: 297-301
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  • Comment on "A Green Algal Apicoplast Ancestor"
    Year: 2003
    Journal: Science
    Volume: 301
    Page numbers: 49
    Publisher: American Society for the Advancement of Science(Washington DC)
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  • Dissecting the apicoplast targeting in the malaria parasite Plasmodium falciparum
    Year: 2003
    Journal: Science
    Volume: 299
    Page numbers: 705-708
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  • Dynamin: the endosymbiosis ring of power?
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 7
    Page numbers: 3557-3559
    Publisher: National Academy of Sciences(Washington DC)
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  • Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targetingfor invasion of human erythrocytes
    Year: 2003
    Journal: EMBO Journal
    Volume: 22
    Issue: 5
    Page numbers: 1-11
    Publisher: Oxford University Press(Oxford)
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  • Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum
    Year: 2003
    Journal: Molecular and Biochemical Parasitology
    Volume: 132
    Page numbers: 59-66
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  • The apicoplast: a plastid in Plasmodium falciparum and other apicomplexan parasites
    Year: 2003
    Journal: International Review of Cytology
    Volume: 224
    Page numbers: 57-110
    Publisher: Academic Press
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Publications in 2002

Journal Articles

  • Cryptomonad evolution: nuclear 18S rDNA Phylogeny versus cell morphology and pigmentation
    Year: 2002
    Journal: Journal of Phycology
    Volume: 38
    Page numbers: 1236-1244
    Publisher: Blackwell Science(Massachusetts)
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  • Genome sequence of the human malaria parasite Plasmodium falciparum
    Year: 2002
    Journal: Nature
    Volume: 419
    Page numbers: 498-511
    Publisher: Macmillan Publishers(London)
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  • Independent Translocation of Two Micronemal Proteins in Developing Plasmodium falciparum Merozoites
    Year: 2002
    Journal: Infection and Immunity
    Volume: 70
    Issue: 10
    Page numbers: 5751-5758
    Publisher: American Society for Microbiology(Washington DC)
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  • Jam packed genomes - a preliminary, comparative analysis of nucleomorphs
    Year: 2002
    Journal: Genetica
    Volume: 115
    Page numbers: 13-28
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Processing of an Apicoplast Leader Sequence in Plasmodium falciparum and the Identification of a Putative Leader Cleavage Enzyme
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 26
    Page numbers: 23612-23619
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Publications in 2001

Book Chapters

  • In situ hybridization
    Year: 2001
    Book: Plant Cell Biology
    Publisher: Oxford University Press(Oxford)
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  • The Protists
    Year: 2001
    Book: Biology
    Publisher: McGraw Hill Australia(Roseville)
    Authors(s):
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Journal Articles

  • A grin without a cat
    Year: 2001
    Journal: Nature
    Volume: 410
    Page numbers: 1040-1041
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  • Chloroplast origin and integration
    Year: 2001
    Journal: Plant Physiology
    Volume: 125
    Page numbers: 50-53
    Publisher: American Society of Plant Physiologists(Maryland)
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  • Deciphering apicoplast targeting signals - feature extraction from nuclear-encoded precursors of Plasmondium falciparum apicoplast proteins
    Year: 2001
    Journal: Gene
    Volume: 280
    Page numbers: 19-26
    Publisher: Elsevier Science(Amsterdam)
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  • New agents to combat malaria
    Year: 2001
    Journal: Nature Medicine
    Volume: 7
    Issue: 2
    Page numbers: 149-150
    Publisher: Nature America(New York)
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  • Primary and secondary endosymbiosis and the origin of plastids
    Year: 2001
    Journal: Journal of Phycology
    Volume: 37
    Page numbers: 951-959
    Publisher: Blackwell Science(Massachusetts)
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  • Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana
    Year: 2001
    Journal: Molecular Biology of the Cell
    Volume: 12
    Page numbers: 2364-2377
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  • The apicoplast as an antimalarial drug target
    Year: 2001
    Journal: Drug Resistance Update
    Volume: 4
    Page numbers: 145-151
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
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  • Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes
    Year: 2001
    Journal: EMBO Journal
    Volume: 20
    Issue: 20
    Page numbers: 5636-5649
    Publisher: Oxford University Press(Oxford)
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  • Translocation of proteins across the multiple membranes of complex plastids
    Year: 2001
    Journal: Biochimica et Biophysica Acta - Molecular Cell Research
    Volume: 1541
    Page numbers: 34-53
    Publisher: Elsevier Science(Amsterdam)
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