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PROF ELEANOR JEAN MACKIE



Contact Details

Organization: Veterinary Science
Position: PROFESSOR
Email:
Homepage: http://research.vet.unimelb.edu.au/staff.php?staffID=169
Work: 8344 7360
Fax: 8344 7374
Room: 216
Level: 02
Building: Vet Preclinical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Development and pathology of the musculoskeletal system Australia
Development and pathology of the musculoskeletal system Australia
Development and pathology of the musculoskeletal system Australia

International Linkages

Country Establishment Collaboration
Japan Nihon University Research
Switzerland Friedrich Miescher Institute Research
Sweden Umea University Research
United Kingdom University of Cambridge Research
United States University of California - Davis Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Veterinary Science University of Sydney 31-Dec-1977
Doctorate of Veterinary Medicine University of Zurich 31-Dec-1986
Master of Science Iowa State University 31-Dec-1980

Memberships

Membership Type Membership Body Description Start Date End Date
Member The Royal College of Veterinary Surgeons (MRCVS) 31-Dec-1991

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
PROTEASES- THEIR INHIBITORS & RECEPTORS IN DEGENERATIVE DISEASE Chief Investigator MONASH UNIVERSITY Program Grants (NHMRC) 01/01/2004
Structural Basis of Femoral Neck Strength Chief Investigator NHMRC Project Grants 01/01/2006
PATHOPHYSIOLOGICAL MECHANISMS IN EQUINE OSTEOCHONDROSIS Chief Investigator UNIVERSITY OF MELBOURNE,
RURAL INDUSTRIES R & D CORPORATION
Project Grants (RURAL INDUSTRIES R & D CORPORATION) 01/05/2007
UTILISATION OF CELL LINES FOR FUNCTIONAL ANALYSIS OF CANDIDATE GENES AND REGULATORY MECHANISMS (SHEEP GENOMICS) Chief Investigator MEAT & LIVESTOCK AUST LTD MLA Out of Session/Special Funding 01/06/2007
In vitro optimisation of conditions for laryngeal reinnervation surgery Chief Investigator RURAL INDUSTRIES R & D CORPORATION Project Grants 01/06/2008
Contribution of Cortical Porosity to Bone Fragility Chief Investigator NHMRC Project Grants 01/01/2009
Pathophysiological mechanisms in Equine Dyschondroplasia Chief Investigator RACING VIC Linkage Projects (AUST RESEARCH COUNCIL)

Contracts

Title Role Funding Source Award Date
PROJECT NO. SFG.003 - DEVELOPMENT OF CELLULAR RESOURCES TO SUPPORT EXPRESSION PROFILING AND PROTEOMIC STUDIES IN DEFINED GENOTYPES IN MUSCLE AND ENERGY UTILISATION SUB PRGRAM (MEUSP) OF MLA/AWI SHEEP GENOMICS PROGRAM Chief Investigator MEAT & LIVESTOCK AUST LTD 01/11/2003
PROJECT NO. SFG.004A - MUSCLE AND ENERGY UTILISATION SUB-PROGRAM INTELLIGENCE UNIT- SHEEP GENOME Chief Investigator MEAT & LIVESTOCK AUST LTD 01/01/2005
PHENOTYPIC CHARACTERISATION OF SHEEP GENETIC VARIANTS- SHEEP GENOMICS Chief Investigator MEAT & LIVESTOCK AUST LTD 01/01/2005

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Journal Articles

  • Hypertrophy and physiological death of equine chondrocytes in vitro
    Year: 2007
    Journal: Equine Veterinary Journal
    Volume: 39
    Issue: 6
    Page numbers: 546-552
    Author(s):
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  • Mycoblasts isolated from hypertrophy-responsive callipyge muscles show altered growth rates and increased resistance to serum deprivation-induced apoptosis
    Year: 2007
    Journal: Cells Tissues Organs
    Volume: Epub
    Issue: Oct
    Page numbers: 1-11
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  • Physiological death of hypertrophic chondrocytes
    Year: 2007
    Journal: Osteoarthritis and Cartilage
    Volume: 15
    Page numbers: 575-586
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Publications in 2006

Journal Articles

  • Functional responses of bone cells to thrombin
    Year: 2006
    Journal: Biological Chemistry
    Volume: 387
    Page numbers: 1037-1041
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Publications in 2005

Journal Articles

  • Studies on the receptors mediating responses of osteoblasts to thrombin
    Year: 2005
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 37
    Page numbers: 206-213
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • The role of protease-activated receptor-1 in bone healing
    Year: 2005
    Journal: American Journal of Pathology
    Volume: 166
    Issue: 3
    Page numbers: 857-868
    Publisher: American Society of Investigative Pathology Inc(Maryland)
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  • Thrombin is a pro-fibrotic factor for rat renal fibroblasts in vitro
    Year: 2005
    Journal: Nephron Experimental Nephrology
    Volume: 1-1
    Page numbers: e42-e49
    Publisher: Karger(Basel)
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Publications in 2004

Journal Articles

  • Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation
    Year: 2004
    Journal: Journal of Bone & Mineral Research
    Volume: 19
    Issue: 3
    Page numbers: 507-516
    Publisher: American Society of Bone and Mineral Research(Washington DC)
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Publications in 2003

Journal Articles

  • Establishment of a model of cortical bone repair in mice
    Year: 2003
    Journal: Calcified Tissue International
    Volume: 73
    Issue: 1
    Page numbers: 49-55
    Publisher: Springer Verlag(New York)
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  • Inhibition of osteoblast apoptosis by thrombin
    Year: 2003
    Journal: Bone
    Volume: 33
    Page numbers: 733-743
    Publisher: Elsevier Science(New York)
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  • Osteoblasts: novel roles in orchestration of skeletal architecture
    Year: 2003
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 35
    Page numbers: 1301-1305
    Publisher: Pergamon-Elsevier Science(Oxford)
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Publications in 2002

Journal Articles

  • Dissection of Protease-Activated Receptor-1-Dependent and -Independent Responses to Thrombin in Skeletal Myoblasts
    Year: 2002
    Journal: Experimental Cell Research
    Volume: 274
    Page numbers: 149-156
    Publisher: Academic Press(California)
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  • Protease-Activated Receptors: A means of converting extracellular proteolysis into intracellular signals
    Year: 2002
    Journal: IUBMB Life
    Volume: 53
    Page numbers: 277-281
    Publisher: Taylor & Francis Ltd(Pennsylvania)
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Publications in 2001

Journal Articles

  • Arginine-Specific Protease from Porphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion
    Year: 2001
    Journal: Infection and Immunity
    Volume: 69
    Issue: 8
    Page numbers: 5121-5130
    Publisher: American Society for Microbiology(Washington DC)
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