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DR SIEW CHAI



Contact Details

Organization: Medicine, Dentistry and Health Sciences
Position: Honorary (Fellow)
Email:
Work: +61 3 8344 7782
Fax: +61 3 9348 1707
Level: 01
Building: Howard Florey
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Role of metallopeptidases in the brain memory, cognitive function, Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science with Honours Monash University
Doctor of Philosophy University of Melbourne

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Neuroscience Society contributing member 01-Jan-2009 31-Dec-2009
Member Society for Neuroscience, USA foreign member 01-Jan-2009 31-Dec-2009
Member International Society for Neurochemistry contributing member 01-Jan-2009 31-Dec-2009
Member International Proteolysis Society contributing member 01-Jan-2009 31-Dec-2009
Member National Association of Research Fellows contributing member 01-Jan-2009 31-Dec-2009
Member Women in Science Network (WISENET) contributing member 01-Jan-2009 31-Dec-2009

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Research fellowship Chief Investigator NHMRC Research Fellowship 01/01/2004
DEVELOPMENT OF DRUGS THAT BLOCK ACTIVITY AS ANTI-DEMENTIA AGENTS Chief Investigator NHMRC Development Grants 01/01/2007
Role of the enzyme IRAP in memory processing Chief Investigator NHMRC Project Grants 01/01/2008
THE USE OF SMALL MOLECULE IRAP INHIBITORS FOR TREATING DEMENTIA Principal Supervisor ALZHEIMER'S AUST RESEARCH LTD Sylvia and Charles Viertel Postgrad Scholarship in Dementia 01/01/2008
DEVELOPMENT OF SMALL MOLECULE IRAP INHIBITORS FOR TREATING MEMORY DEFICITS Chief Investigator NHMRC Development Grants 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Angiotensin IV-evoked vasoprotection is conserved in advanced atheroma


    Year: 2008
    Journal: Atherosclerosis
    Volume: 200
    Page numbers: 37-44
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  • Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion


    Year: 2008
    Journal: Journal of Peptide Science
    Volume: 14
    Issue: 7
    Page numbers: 883-887
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  • Identification and characterization of a new class of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase.


    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Page numbers: 4209-4217
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  • Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 86
    Page numbers: 251-261
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  • The insulin-regulated aminopeptidase IRAP is co-localised with GLUT4 inthe mouse hippocampus - potential role in modulation of glucose uptake in neurons?


    Year: 2008
    Journal: European Journal of Neuroscience
    Volume: 28
    Page numbers: 588�598
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Publications in 2007

Journal Articles

  • Effect of chronic angiotensin converting enzyme inhibition on spatial memory and anxiety-like behaviours in rats
    Year: 2007
    Journal: Neurobiology of Learning and Memory
    Volume: 87
    Page numbers: 218-224
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  • Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain
    Year: 2007
    Journal: Biological Chemistry
    Volume: 388
    Page numbers: 399-403
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  • Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons
    Year: 2007
    Journal: Journal of Neurochemistry
    Volume: 102
    Page numbers: 967-976
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  • Therapeutic targeting of insulin-regulated aminopeptidase: Heads and tails?
    Year: 2007
    Journal: Pharmacology and Therapeutics
    Volume: 116
    Page numbers: 417-427
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Publications in 2006

Journal Articles

  • Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase.
    Year: 2006
    Journal: Molecular Endocrinology
    Volume: 20
    Issue: 10
    Page numbers: 2576-2583
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Publications in 2005

Journal Articles

  • Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system
    Year: 2005
    Journal: Journal of Comparative Neurology
    Volume: 487
    Page numbers: 372-390
    Publisher: Wiley-Liss(New York)
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Publications in 2004

Book Chapters

  • Insulin-regulated aminopeptidase
    Year: 2004
    Book: Aminopeptidases in Biology and Disease
    Publisher: Kluwer Academic/Plenum Publishers(New York)
    Authors(s):

Journal Articles

  • Alzheimer's angiotensin IV and an aminopeptidase
    Year: 2004
    Journal: Biological & Pharmaceutical Bulletin
    Volume: 27
    Issue: 6
    Page numbers: 765-767
    Publisher: Pharmaceutical Society of Japan
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  • Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms
    Year: 2004
    Journal: Behavioural Brain Research
    Volume: 154
    Issue: 1
    Page numbers: 239-243
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  • Effect of I.C.V. injection of AT4 receptor ligands, NLE1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats
    Year: 2004
    Journal: Neuroscience
    Volume: 124
    Issue: 2
    Page numbers: 341-349
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  • In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain
    Year: 2004
    Journal: Journal of Chemical Neuroanatomy
    Volume: 27
    Page numbers: 217-236
    Publisher: Elsevier Science(Amsterdam)
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  • Membrane bound members of the M1 family: more than aminopeptidases
    Year: 2004
    Journal: Protein and Peptide Letters
    Volume: 11
    Issue: 5
    Page numbers: 491-500
    Publisher: Bentham Science Publishers(Philadelphia)
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  • Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus
    Year: 2004
    Journal: Regulatory Peptides
    Volume: 122
    Page numbers: 85-89
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  • The angiotensin IV/AT4 receptor
    Year: 2004
    Journal: Cellular and Molecular Life Sciences
    Volume: 61
    Page numbers: 1-10
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Publications in 2003

Journal Articles

  • AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement
    Year: 2003
    Journal: Trends in Endocrinology and Metabolism
    Volume: 14
    Issue: 2
    Page numbers: 72-77
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  • Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)
    Year: 2003
    Journal: Journal of Neurochemistry
    Volume: 86
    Page numbers: 344-350
    Publisher: Blackwell Science(Oxford)
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  • Effect of fimbria-fornix lesion on 125l-angiotensin IV (AngIV) bidning in the guinea pig hippocampus
    Year: 2003
    Journal: Brain Research
    Volume: 979
    Page numbers: 7-14
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  • Structure-activity study of LVV-hemorphin-7: Angiotensin At4 receptor ligand and inhibitor of insulin-regulated aminopeptidase
    Year: 2003
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 305
    Issue: 1
    Page numbers: 205-211
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  • The brain renin-angiotensin system: location and physiological roles
    Year: 2003
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 35
    Issue: 6
    Page numbers: 901-918
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