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DR RICKY JOHNSTONE



Contact Details

Organization: Biochemistry and Molecular Biology, Pathology
Position: Honorary (Senior Fellow), Honorary (Principal Fellow)
Email:
Homepage: http://www.petermac.unimelb.edu.au
Work: 9656 1111
Building: No Building
Campus: Peter Maccallum Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
oncology chemotherapeutic drugs Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Hons) University of Melbourne 31-Dec-1988
Doctor of Philosophy University of Melbourne 31-Dec-1993

Memberships

Membership Type Membership Body Description Start Date End Date
Unspecified Australian Society for Immunology member 24-Aug-2006
Unspecified The Transplantation Society of Australia and New Zealand member 24-Aug-2006
Unspecified The American Society for Cell Biology member 24-Aug-2006
Unspecified Australian Society for Biochemistry and Molecular Biology member 24-Aug-2006
Unspecified Australian Society for Medical Research member 24-Aug-2006
Unspecified National Association of Research Fellows member 24-Aug-2006
Unspecified International Cell Death Society member 24-Aug-2006
Unspecified American Association for Cancer Research member 24-Aug-2006
Unspecified International Society for Interferon and Cytokine Research member 24-Aug-2006

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Australian Life Science Research Award 31-Dec-1999
Prize Amgen Prize for Excellence in Translational Medical Research 31-Dec-2003
Medal Australian Academy of Science Gottschalk Medal 31-Dec-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Immune regulation, effector function and therapy Chief Investigator NHMRC Program Grants 01/01/2003
Mechanism of action of histone deacetylase inhibitors: novel anti-cancer drugs Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2003
CHARACTERISATION OF THE ANTI-APOPTOTIC FUNCTION OF P-GLYCOPROTEIN AND TRANSCRIPTIONAL REGULATION OF THE MDR1 GENE Chief Investigator NHMRC Project Grants 01/01/2005
Research Chief Investigator NHMRC Research Fellowship 01/01/2005
Research Fellowship Chief Investigator PFIZER AUST PTY LTD Research Fellowships 01/07/2005
MECHANISMS OF ACTION OF HISTONE DEACETYLASE INHIBITORS: NOVEL ANTI-CANCER DRUGS Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2006
2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY) Chief Investigator NHMRC Program Grants 01/01/2007
IDENTIFICATION OF NOVEL TUMOR SUPPRESSOR GENES IN BREAST CANCER AND LYMPHOMA USING SH-RNA-MEDIATED FUNCTIONAL GENOMICS SCREENS Chief Investigator CANCER COUNCIL VICTORIA Venture Grants - EOI 31/03/2007
Anti-cancer activities of HDAC inhibitors Chief Investigator NHMRC Project Grants 01/01/2009
RESEARCH FELLOWSHIP- ASSOC PROF RICKY JOHNSTONE Chief Investigator NHMRC Research Fellowship 29/10/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

  • Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 32
    Page numbers: 11317-11322
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  • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
    Year: 2008
    Journal: Clinical Cancer Research
    Volume: 14
    Issue: 14
    Page numbers: 4500-10
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  • Histone deacetylase inhibitors in lymphoma and solid malignancies
    Year: 2008
    Journal: Expert Review of Anticancer Therapy
    Volume: 8
    Issue: 3
    Page numbers: 413-32
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  • The role of p202 in regulating hematopoietic cell proliferation and differentiation
    Year: 2008
    Journal: Journal of Interferon and Cytokine Research
    Volume: 30
    Issue: 2
    Page numbers: 245-257
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Publications in 2007

Journal Articles

  • Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

    Year: 2007
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 104
    Issue: 19
    Page numbers: 8071-8076
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Publications in 2004

Journal Articles

  • Histone-deacetylase inhibitors for the treatment of cancer
    Year: 2004
    Journal: Cell Cycle
    Volume: 3
    Page numbers: 779-788
    Publisher: Landes Bioscience
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  • Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux
    Year: 2004
    Journal: Cell Death & Differentiation
    Volume: 11
    Page numbers: 1028-1037
    Publisher: Nature Publishing Group(Basingstroke)
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Publications in 2003

Journal Articles

  • A member of the Pyrin family, IFI16, is a novel BRCA-1 associated protein involved in the p53-mediated apoptosis pathway
    Year: 2003
    Journal: Oncogene
    Volume: 22
    Page numbers: 8931-8938
    Publisher: Nature Publishing Group(Basingstroke)
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  • Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16
    Year: 2003
    Journal: Journal of Cellular Biochemistry
    Volume: 89
    Page numbers: 80-93
    Publisher: Wiley-Liss(New York)
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  • Expression of IFI 16 in epithelial cells and lymphoid tissues
    Year: 2003
    Journal: Histochemistry and Cell Biology
    Volume: 119
    Page numbers: 45-54
    Publisher: Springer Verlag(New York)
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  • Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?
    Year: 2003
    Journal: Cancer Cell
    Volume: 4
    Page numbers: 13-18
    Publisher: Cell Press(Philadelphia)
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  • Inhibition of retinoblastoma protein degradation by interaction with the serpin plaminogen activator inhibitor 2 via a novel consensus motif
    Year: 2003
    Journal: Molecular and Cellular Biology
    Volume: 23
    Issue: 18
    Page numbers: 6520-6532
    Publisher: American Society for Microbiology(Washington DC)
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  • Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
    Year: 2003
    Journal: Cancer Research
    Volume: 63
    Page numbers: 4460-4471
    Publisher: American Association for Cancer Research(Alabama)
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  • Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence
    Year: 2003
    Journal: Oncogene
    Volume: 22
    Issue: 31
    Page numbers: 4831-4840
    Publisher: Nature Publishing Group(Basingstroke)
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Publications in 2002

Book Chapters

  • P-glycoprotein as a general antiapoptotic protein
    Year: 2002
    Book: Encyclopedia of cancer: volume III
    Publisher: Academic Press(California)
    Authors(s):

Journal Articles

  • Apoptosis: a link between cancer genetics and chemotherapy
    Year: 2002
    Journal: Cell
    Volume: 108
    Page numbers: 153-164
    Publisher: Cell Press(Massachusetts)
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  • Deamidation of Bcl-XL: a new twist in a genotoxic murder mystery
    Year: 2002
    Journal: Molecular Cell
    Volume: 10
    Page numbers: 695-697
    Publisher: Cell Press(Philadelphia)
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  • Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia
    Year: 2002
    Journal: British Journal of Haematology
    Volume: 119
    Page numbers: 965-969
    Publisher: Blackwell Science(Oxford)
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  • Human Immunodeficiency Virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis
    Year: 2002
    Journal: Journal of Virology
    Volume: 76
    Page numbers: 2692-2702
    Publisher: American Society for Microbiology(Washington DC)
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  • Identifying molecular targets mediating the anticancer activity of histone deacetylase inhibitors: a work in progress
    Year: 2002
    Journal: Current Cancer Drug Targets
    Volume: 2
    Issue: 4
    Page numbers: 337-353
    Publisher: Bentham Science Publishers
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  • P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation
    Year: 2002
    Journal: Cell Death & Differentiation
    Volume: 9
    Page numbers: 1266-1272
    Publisher: Nature Publishing Group(Basingstroke)
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  • Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells
    Year: 2002
    Journal: International Journal of Cancer
    Volume: 99
    Page numbers: 292-298
    Publisher: Wiley-Liss(New York)
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Publications in 2001

Journal Articles

  • Novel properties of the protein kinase CK2-site-regulated nuclear-localization sequence of the interferon-induced nuclear factor IFI 16
    Year: 2001
    Journal: Biochemical Journal
    Volume: 353
    Page numbers: 69-77
    Publisher: Portland Press(London)
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  • P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 16667-16673
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
    Year: 2001
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 98
    Page numbers: 10833-10838
    Publisher: National Academy of Sciences(Washington DC)
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