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DR BRADFORD MOFFAT



Contact Details

Organization: Radiology
Position: SENIOR RESEARCH OFFICER
Email:
Homepage: http://www.melbourne-radiology.org/Brain_Imaging_Lab.html
Work: 9342 8342
Fax: 9342 8369
Room: 2324
Level: 02
Building: Main Block
Campus: Royal Melbourne Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Imaging of Brain Tumours MRI, PET, Glioblastoma, Brain Tumour Australia
Neuroimaging MRI, PET, Image Processing Australia
Magnetic Resonance Imaging (MRI), technology, safety and quality assurance MRI Medical physics Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) The University of Queensland 31-Dec-1994
Masters of Applied Science (Med. Phys) Queensland University of Technology 31-Dec-1996
Doctor of Philosophy Queensland University of Technology 31-Dec-2001

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
FUNCTIONAL DIFFUSION MAPPING OF BRAIN TUMOUR THERAPEUTIC EFFICACY Chief Investigator CANCER AUSTRALIA,
DEPT OF HEALTH & AGEING		 Priority-Driven Collaborative Cancer Research Scheme (CANCER AUSTRALIA) 16/05/2008
Molecular imaging of brain tumours Chief Investigator NHMRC Project Grants 01/01/2009
PRE-CLINICAL STUDY AND PHASE 1 TRIAL OF PI3-KINASE INHIBITORS IN THE TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA Chief Investigator VIC CANCER AGENCY Clinical Trials Pilot Study Grant 14/05/2009
Acute Stroke Imaging: Improving patient selection for treatment in ischemic stroke. Chief Investigator PFIZER AUST PTY LTD Cardio Vascular Lipid Research Grants 30/10/2009
Brain tumors and seizures Chief Investigator NHMRC Project Grants 01/01/2010

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Diffusion magnetic resonance imaging: an imaging treatment response biomaker to chemoradiotherapy in a mouse model of squamous cell cancer of the head and neck
    Year: 2008
    Journal: Translational Oncology
    Volume: 1
    Issue: 4
    Page numbers: 187-94
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  • Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
    Year: 2008
    Journal: Biomaterials
    Volume: 29
    Issue: 4
    Page numbers: 487-96
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Publications in 2007

Journal Articles

  • An imaging biomarker of early treatment response in prostate cancer that has metastasized to the bone.
    Year: 2007
    Journal: Cancer Research
    Volume: 67
    Issue: 8
    Page numbers: 3524-8
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  • Magnetization transfer effects on the efficiency of flow-driven adiabatic fast passage inversion of arterial blood
    Year: 2007
    Journal: NMR in Biomedicine
    Volume: 20
    Page numbers: 733-742
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  • Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy
    Year: 2007
    Journal: Clinical Cancer Research
    Volume: 13
    Issue: 2
    Page numbers: 443-450
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Publications in 2006

Journal Articles

  • A Methodology for Registration of a Histological Slide and In Vivo MRI Volume Based on Optimizing Mutual Information
    Year: 2006
    Journal: Molecular Imaging
    Volume: 5
    Issue: 1
    Page numbers: 16-23
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  • Dynamic Imaging of Emerging Resistance during Cancer Therapy
    Year: 2006
    Journal: Cancer Research
    Volume: 66
    Issue: 9
    Page numbers: 4687-92
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  • Fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit.
    Year: 2006
    Journal: Gene Therapy
    Volume: 13
    Page numbers: 127-137
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  • Inhibition of vascular Endothelial Growth Factor (VEGF)-A Causes a Paradoxical Increase in Tumour Blood Flow and Up-Regulation of VEGF-D
    Year: 2006
    Journal: Clinical Cancer Research
    Volume: 12
    Issue: 5
    Page numbers: 1525-32
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  • The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome.
    Year: 2006
    Journal: NeoPlasia
    Volume: 8
    Issue: 4
    Page numbers: 259-267
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  • Vascular targeted nanoparticles for imaging and treatment of brain tumors.
    Year: 2006
    Journal: Clinical Cancer Research
    Volume: 12
    Issue: 22
    Page numbers: 6677-6686
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Publications in 2005

Book Chapters

  • Diffusion MR imaging in adult neoplasia.


    Year: 2005
    Book: Clinical MR Neuroimaging Diffusion, Perfusion and Spectroscopy
    Publisher: Press Syndicate of the University of Cambridge(Cambridge)
    Authors(s):

Journal Articles

  • Continuous Arterial Spin Labeling Using a Train of Adiabatic Inversion Pulses
    Year: 2005
    Journal: Journal of Magnetic Resonance Imaging
    Volume: 21
    Page numbers: 290-6
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  • Development of a syngeneic rat brian tumor model expressing EGFRvIII and Its use for molecular targeting studies with monoclonal antibody L8A4.
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Page numbers: 341-350
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  • Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 46
    Page numbers: 16759-16764
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  • Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 15
    Page numbers: 5524-5529
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  • High-throughput magnetic resonance imaging in mice for phenotyping and therapeutic evaluation
    Year: 2005
    Journal: Current Opinion in Chemical Biology
    Volume: 9
    Page numbers: 413-420
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  • Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor - a pharmacokinetic study
    Year: 2005
    Journal: Journal of Neuro-Oncology
    Volume: 73
    Page numbers: 225-238
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  • Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer.
    Year: 2005
    Journal: Journal of Magnetism and Magnetic Materials
    Volume: 293
    Page numbers: 404-410
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Publications in 2004

Book Chapters

  • Use of Magnetic Resonance Imaging (MRI) for evaluation treatment response.
    Year: 2004
    Book: Mouse models of human cancer
    Publisher: Wiley-Liss(New York)
    Authors(s):
    Editors(s):

Journal Articles

  • Diffusion imaging for evaluation of tumor therapies in preclinical animal models.


    Year: 2004
    Journal: Magnetic Resonance Materials in Physics, Biology and Medicine
    Volume: 3
    Page numbers: 1-13
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  • The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies
    Year: 2004
    Journal: Molecular Therapy
    Volume: 10
    Issue: 5
    Page numbers: 916-928
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  • Therapeutic Efficacy of DTI-015 using Diffusion Magnetic Resonance Imaging as an Early Surrogate Marker
    Year: 2004
    Journal: Clinical Cancer Research
    Volume: 10
    Page numbers: 7852-59
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Publications in 2003

Journal Articles

  • Evaluation of cancer therapy using diffusion magnetic resonance imaging


    Year: 2003
    Journal: Molecular Cancer Therapeutics
    Volume: 2
    Page numbers: 581-587
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  • A Novel Polyarcrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI
    Year: 2003
    Journal: Molecular Imaging
    Volume: 2
    Issue: 4
    Page numbers: 324-32
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Publications in 2002

Journal Articles

  • Anisotropic water transport in the human eye lens studied by diffusion tensor NMR Micro-imaging


    Year: 2002
    Journal: Experimental Eye Research
    Volume: 74
    Page numbers: 677-687
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  • Age-related changes in refractive index distribution and power of the human lens as measured by magnetic resonance micro-imaging in vitro
    Year: 2002
    Journal: Vision Research
    Volume: 42
    Page numbers: 1683-93
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  • Diffusion MRI: A new strategy for assessment of cancer therapeutic efficacy.
    Year: 2002
    Journal: Molecular Imaging
    Volume: 1
    Issue: 4
    Page numbers: 336-343
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  • Explanation of the lens paradox.
    Year: 2002
    Journal: Optometry and Vision Science
    Volume: 79
    Issue: 3
    Page numbers: 148-150
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  • The interpretation of multi-exponential water proton transverse relaxation of the human and porcine eye lens
    Year: 2002
    Journal: Magnetic Resonance Imaging
    Volume: 20
    Page numbers: 83-93
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