Biography
Marie A Bogoyevitch is an Associate Professor in Biochemistry and Molecular Biology at the University of Melbourne and the Bio21 Molecular Science and Biotechnology Institute. Marie?s current research explores molecular mechanisms in eukaryotic signal transduction with an emphasis on the discovery of new molecules to block protein kinase-substrate interactions and the exploration of how subtle differences in signal transduction proteins can have major effects on cellular events. A major challenge arising from this research area is to translate these interests in the area of rational drug design, thereby generating new approaches to therapeutic inhibition of these signaling interactions in disease. Her interests in these areas were initiated during postdoctoral work in London with Peter Sudgen (National Heart and Lung Institute) and Chris Marshall FRS (Institute for Cancer Research) and then were expanded upon during her appointments at the University of Western Australia (Lecturer, Senior Lecturer, Associate Professor; 1997-2006).
Marie is an Editorial Board Member of the Biochemical Journal and the International Journal for Biochemistry and Molecular Biology. She is an Executive member of the Australian Society for Biochemistry and Molecular Biology (ASBMB) in her role as national Secretary, having previously been on the Editorial Board of the Society?s magazine ?The Australian Biochemist? and has acted as the Western Australian state representative. She is an International Advisory Board Member for the International Workshops on Protein Kinase Inhibitors that are organized biannually in Warsaw, Poland. She is a Scientific Advisory Board Member of Phylogica Ltd.
Marie has also participated in the grant peer review process by reviewing grants for agencies including the Australian Research Council and Wellcome Trust (UK). She has acted on the Regional Grant Interview Committees for the National Heart Foundation (NHF) as well as the Grant Review Panels for the National Health and Medical Research Council (NHMRC) in Biochemistry and Cell Biology.
In her Bio21 Institute role, Marie leads a research team that aims to discover and commercialize candidate drugs that target key signal transduction events in stroke, cardiovascular disease, cancer and diabetes.
Profile of Specific Research Interests and Other Activities:
? Research experience in protein and gene technologies and the applications of these technologies in the investigation of mammalian signaling events and their regulation by hormones, cytokines and growth factors.
? Co-inventor on a patent exploring new approaches to the identification of key protein-protein interaction interfaces.
? Appointments at a number of leading research institutes and universities in the UK and Australia.
? Scientific Advisory Board Member of Phylogica Ltd.
? International Scientific Advisory Board Member of the International Workshops in Protein Kinase Inhibitors.
? Editorial Board member of Biochemical Journal and the International Journal for Biochemistry and Cell Biology.
Research Expertise and International Linkages
Research Expertise
| Research Interest |
Key Words |
Country of Expertise |
| Cardiac disease: changes to heart structure and function |
heart failure, cardiac hypertrophy, infarction |
Australia |
| Protein phosphorylation: post-translational regulatory mechanisms in intracellular control |
protein kinase substrate specificity, consensus motifs |
Australia |
| Signal transduction: the biochemical processes of intracellular communication |
protein kinases, transcription factors |
Australia |
| Cell death mechanisms: drivers of cardiac and neurodegenerative diseases |
apoptosis, necrosis, autophagy |
Australia |
| Signalling complexes: interacting partners controlling intracellular communication networks |
adaptors, scaffolds, enzymes |
Australia |
| Protein Kinase Inhibitors: peptides and small molecules as new drug leads |
ATP competitive, non-competitive or allosteric inhibitors |
Australia |
| c-Jun N-terminal kinases: therapeutic targets |
stroke, cardiovascular disease, diabetes, inflammatory disease |
Australia |
| Peptides: new tools for biological research and novel drug leads |
random sequence, protein-based, gene fragment libraries, inhibitors, probes |
Australia |
Qualifications, Honours, Fellowships and Other
Awards
Qualifications
| Title |
Institution |
Date Awarded |
Abbreviation |
| Doctor of Philosophy |
The University of Queensland |
31-Dec-1990 |
|
| Bachelor of Science |
The University of Queensland |
31-Dec-1987 |
|
| Bachelor of Science |
The University of Queensland |
31-Dec-1986 |
|
Memberships
| Membership Type |
Membership Body |
Description |
Start Date |
End Date |
| Council |
Australian Society for Biochemistry and Molecular Biology |
Honorary Secretary and Executive Member |
01-Mar-1996 |
|
| Member |
Australian and New Zealand Society for Cell and Developmental Biology |
Member, former WA representative |
01-Jan-1997 |
|
| Member |
British Biochemical Society |
Member and Editorial Board Member of Biochemical Journal |
01-Jan-1990 |
|
Other Awards
| Award Type |
Awarding Body |
Comments |
Date Awarded |
| Medal |
The University of Queensland |
University of Queensland Medal for Outstanding Academic Achievement |
19-Dec-1986 |
| Other (Award) |
The University of Western Australia |
Excellence in Teaching Award - Honours Supervision |
01-Jul-2000 |
Government Research Classifications
Research Fields, Courses and Discipline Classifications
Socio-Economic Objective Classifications
Grants and Contracts
Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.
Grants
| Title |
Role |
Funding Source |
Scheme |
Award Date |
| TRANSCRIPTIONAL AND FUNCTIONAL CONSEQUENCES OF STAT3 ACTIVATION IN THE HEART |
Chief Investigator |
NHMRC |
Project Grants |
01/01/2008 |
| New actions for cell stress responders - implications for health and disease |
Chief Investigator |
NHMRC |
Project Grants |
01/01/2009 |
| New peptides to probe protein kinase functions |
Chief Investigator |
AUST RESEARCH COUNCIL |
Discovery Projects |
01/01/2009 |
Publications
Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.
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