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PROF STEPHEN HARRAP



Contact Details

Organization: Physiology
Position: PROFESSOR
Email:
Homepage: http://www.physiology.unimelb.edu.au/lab-genetics/genetics.asp
Work: 83445837
Mobile: 0408509322
Fax: 83445818
Room: N421
Level: 04
Building: Medical Centre
Campus: Parkville

Biography

Since 1995 Stephen Harrap has been Professor and Head of the Department of Physiology at the University of Melbourne. He is also a visiting specialist physician at the Royal Melbourne Hospital. He has long-standing research interests in the genetics of common conditions, in particular cardiovascular disease. As Director of the Victorian Family Heart Study and the AMIGO Study he has been instrumental in important discoveries of the genetics of blood pressure, acute coronary syndrome, height and male pattern baldness. He was the Regional Principal Investigator and Member of the International Management Committee for the PROGRESS and ADVANCE Study of secondary stroke prevention and cardiovascular protection in diabetes respectively. He is on a range of professional committees, editorial boards and advisory groups. Currently he is the President of the High Blood Pressure Research Council of Australia and Secretary of the International Society of Hypertension.

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Genetics of common conditions Australia

International Linkages

Country Establishment Collaboration
France College de France Exchange, Research, Technical Assistance/Training
United Kingdom The University of Glasgow Research

Languages

Languages

Language Proficiency
French Speak, Read & Write

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medicine & Bachelor of Surgery University of Melbourne 31-Dec-1978
Doctor of Philosophy University of Melbourne 31-Dec-1986

Memberships

Membership Type Membership Body Description Start Date End Date
Senior Member Austin Hospital Medical Research Foundation Chairman of Board 11-Dec-2006
Member High Blood Pressure Research Council of Australia President 01-Jan-2005
Unspecified High Blood Pressure Research Foundation Trustee 01-Jan-2005
Member International Society of Hypertension Secretary 01-Jan-1983
Member Australian Physiological Society Member 26-Sep-2006
Member American Heart Association Fellow 01-Jan-1995

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 13-Dec-1984

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
ADVANCE 2000-2007: RCC CLINICAL TRIAL Chief Investigator INSTITUTE FOR INTERNATIONAL HEALTH Clinical Trial Agreement for Regional Coordinating Centre 29/11/2000
Linkage and association analyses of a locus on chromosome 4 that contributes to population variation in HDL cholesterol Chief Investigator NHMRC Project Grants 01/01/2003
A paradigm of genomic discovery - an investigation of the allelic architecture of height Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
Multiphoton microscope - neuroscience core facility Chief Investigator THE IAN POTTER FOUNDATION Project Grants 13/10/2004
Identificatin of DNA variation on chromosome 16p12 responsible for the control of blood pressure Chief Investigator NATIONAL HEART FOUNDATION Grants-in-Aid 01/01/2005
Angiotensin receptor gene polymorphism and human heart size Chief Investigator NATIONAL HEART FOUNDATION Grants-in-Aid 01/01/2005
Discovering cardiovascular predictors of hypertensive complications of pregnancy Principal Supervisor NHMRC Medical & Dental Postgraduate Scholarships 01/01/2005
FINDING THE GENES DRIVING ALCOHOL CONSUMPTION - AN EXPERIMENTAL APPROACH Chief Investigator AUST BREWERS FOUNDATION Alcohol-related Medical Research Grants 01/01/2006
Understanding enlargement of the heart Chief Investigator NHMRC Project Grants 01/01/2007
2007 NATIONAL HEART FOUNDATION TRAVEL GRANT - BUSST Principal Supervisor NATIONAL HEART FOUNDATION Travel Grants 01/01/2007
GENES DETERMINING POSTURAL BLOOD PRESSURE RESPONSES Chief Investigator NATIONAL HEART FOUNDATION Grants-in-Aid 01/01/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Gene-wide association study between aromatase gene (CYP19A1) and female pattern hair loss
    Year: 2009
    Journal: British Journal of Dermatology
    Volume: 161
    Page numbers: 289-294
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Publications in 2008

Journal Articles

  • APOE genotype, ethnicity, and the risk of cerebral hemorrhage
    Year: 2008
    Journal: Neurology
    Volume: 70
    Issue: 16
    Page numbers: 1322-1328
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  • Contribution of genes and environment to variation in postural changes in mean arterial and pulse pressure
    Year: 2008
    Journal: Journal of Hypertension
    Volume: 26
    Page numbers: 2319-2332
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  • Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes
    Year: 2008
    Journal: New England Journal of Medicine
    Volume: 358
    Page numbers: 2560-2572
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  • Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension
    Year: 2008
    Journal: Hypertension Research
    Volume: 31
    Issue: 5
    Page numbers: 941-955
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  • Searching for functional genetic variants in non-coding DNA
    Year: 2008
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 35
    Page numbers: 372-375
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  • The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy
    Year: 2008
    Journal: American Journal of Physiology - Heart and Circulatory Physiology
    Volume: 294
    Page numbers: H1514-H1522
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Publications in 2007

Journal Articles

  • Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia
    Year: 2007
    Journal: Human Genetics
    Volume: 121
    Page numbers: 451-457
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  • Comprehensive multi-stage linkage analyses identify a locus for adult height on chromosome 3p in a healthy Caucasian population
    Year: 2007
    Journal: Human Genetics
    Volume: 121
    Issue: 2
    Page numbers: 213-222
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  • Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
    Year: 2007
    Journal: The Lancet
    Volume: 370
    Page numbers: 829-840
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  • Selective genotyping reveals association between the epithelial sodium channel ϒ-subunit and systolic blood pressure
    Year: 2007
    Journal: Hypertension
    Volume: 50
    Page numbers: 672-678
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Publications in 2006

Journal Articles

  • Sex differences in genetic and environmental determinants of pulse pressure


    Year: 2006
    Journal: Genetic Epidemiology
    Volume: 30
    Page numbers: 397-408
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  • Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure
    Year: 2006
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 19
    Issue: 1
    Page numbers: 70-73
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  • Genome-wide linkage analysis of population variation in high-density lipoprotein cholesterol
    Year: 2006
    Journal: Human Genetics
    Volume: 119
    Page numbers: 541-546
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Publications in 2005

Journal Articles

  • Androgenic correlates of genetic variation in the gene encoding 5α-reductase type 1
    Year: 2005
    Journal: Journal of Human Genetics
    Volume: 50
    Page numbers: 534-537
    Publisher: Springer-Verlag Tokyo(Tokyo)
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Publications in 2004

Journal Articles

  • Familial and genomic analyses of postural changes in systolic and diastolic blood pressure
    Year: 2004
    Journal: Hypertension
    Volume: 43
    Page numbers: 586-591
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Sequence analysis of the fibroblast growth factor 2 gene from the spontaneously hypertensive and hypertrophic heart rats
    Year: 2004
    Journal: Clinical and Experimental Hypertension
    Volume: 26
    Issue: 3
    Page numbers: 209-218
    Publisher: Marcel Dekker(New York)
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  • Sex-dependent association of blood pressure with oestrogen receptor genes ERα and ERβ
    Year: 2004
    Journal: Journal of Hypertension
    Volume: 22
    Issue: 6
    Page numbers: 1127-1131
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Publications in 2003

Journal Articles

  • Antihypertensive treatments obscure familial contributions to blood pressure variation
    Year: 2003
    Journal: Hypertension
    Volume: 41
    Page numbers: 207-210
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Tall stories: the devilish detail of genetic association studies
    Year: 2003
    Journal: Clinical Endocrinology
    Volume: 59
    Issue: 3
    Page numbers: 278-279
    Publisher: Blackwell Science(Oxford)
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  • The ACE Gene I/D Polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition
    Year: 2003
    Journal: Hypertension
    Volume: 42
    Page numbers: 297-303
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Where are all the blood-pressure genes?
    Year: 2003
    Journal: The Lancet
    Volume: 361
    Page numbers: 2149-2151
    Publisher: Lancet(London)
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Publications in 2002

Journal Articles

  • Androgenetic alopecia: pathogenesis and potential for therapy
    Year: 2002
    Journal: Expert Reviews in Molecular Medicine
    Volume: N/A
    Page numbers: 1-11
    Publisher: Cambridge University Press(Cambridge)
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  • Blood pressure QTLs identified by genome-wide linkage analysis and dependence on associated phenotypes
    Year: 2002
    Journal: Physiological Genomics
    Volume: 8
    Page numbers: 99-105
    Publisher: American Physiological Society(Maryland)
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  • Genes and Family Environment Explain Correlations Between Blood Pressure and Body Mass Index
    Year: 2002
    Journal: Hypertension
    Volume: 40
    Issue: July
    Page numbers: 7-12
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Genome-Wide linkage Analysis of the Acute Coronary Syndrome suggests a Locus on Chromosome 2
    Year: 2002
    Journal: Arteriosclerosis Thrombosis and Vascular Biology
    Volume: 22
    Page numbers: 874-878
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophy
    Year: 2002
    Journal: Physiological Genomics
    Volume: 9
    Page numbers: 43-48
    Publisher: American Physiological Society(Maryland)
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Publications in 2001

Journal Articles

  • Genetics of Haemostasis
    Year: 2001
    Journal: The Lancet
    Publisher: Lancet(London)
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  • Male pattern bladness is not associated with established cardiovascular risk factors in the general population
    Year: 2001
    Journal: Clinical Science
    Volume: 100
    Page numbers: 401-404
    Publisher: Portland Press(London)
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  • Physiological relationships between central vascular haemodynamics and left ventricular structure
    Year: 2001
    Journal: Clinical Science
    Volume: 101
    Page numbers: 79-85
    Publisher: Portland Press(London)
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  • Polymorphism of the Androgen Receptor Gene is associated with Male Pattern Baldness
    Year: 2001
    Journal: Journal of Investigative Dermatology
    Volume: 116
    Issue: 3
    Page numbers: 452-455
    Publisher: Blackwell Science(Massachusetts)
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  • Sex, Genes and blood pressure
    Year: 2001
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 28
    Page numbers: 1053-1055
    Publisher: Blackwell Science Asia(Carlton)
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  • Significant population variation in adult male height associated with the Y Chromosome and the Aromatase Gene
    Year: 2001
    Journal: Journal of Clinical Endocrinology & Metabolism
    Volume: 86
    Issue: 9
    Page numbers: 4147-4150
    Publisher: Endocrine Society(Maryland)
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  • The Genetics of Androgenetic Alopecia
    Year: 2001
    Journal: Clinics in Dermatology
    Volume: 19
    Page numbers: 149-154
    Publisher: Elsevier Science(New York)
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  • Utility of genetic approaches to common cardiovascular diseases
    Year: 2001
    Journal: American Journal of Physiology - Heart and Circulatory Physiology
    Volume: 281
    Page numbers: H1-H6
    Publisher: American Physiological Society(Maryland)
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