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A/PROF DAVID MCFADYEN



Contact Details

Organization: Science, Chemistry
Position: ASST. DEAN-M-MSCI (PROFESSIONAL DEVELOPMENT PROG.), Honorary (Principal Fellow)
Email:
Homepage: http://www.chemistry.unimelb.edu.au/people/mcfadyen.php
Work: 44222
Fax: 9347 5180
Room: 101A
Level: 01
Building: Chemistry-East Wing
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Metal Based Drugs DNA Binding, Metal Complexes, Antitumour Agents Australia

International Linkages

Country Establishment Collaboration
New Zealand The University of Auckland Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne
Graduate Diploma in Education University of Melbourne
Doctor of Philosophy University of Melbourne

Memberships

Membership Type Membership Body Description Start Date End Date
Chartered Royal Australian Chemical Institute Member,Chartered Chemist 01-Jan-1996

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize Melbourne University, Union Carbide Prize in Chemistry 01-Jan-1968
Other (Award) Anti-Cancer Council of Victoria Mrs J Morce Research Award 01-Jan-1986
Other (Award) Anti-Cancer Council of Victoria Vito de Petro Research Award 01-Jan-1988
Other (Award) University of Melbourne Dean's Award for Excellence in Teaching, Faculty of Science 01-Jan-2000

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Development of DNA targeted platinum agents as potential anticancer drugs Chief Investigator NHMRC Project Grants 01/01/2003
Gas phase reactivity of charged peptide & DNA radicals: fundamentals & applications Chief Investigator AUST RESEARCH COUNCIL Discovery Projects

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

  • Synthesis and structural characterisation of a series of cobalt complexes of N-appended anthracenyl cyclam
    Year: 2007
    Journal: Polyhedron
    Volume: 26
    Page numbers: 1669-1676
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Publications in 2006

Journal Articles

  • 9,9a-Diphenyl-1,3,4,6,7,9a-hexahydro-2H-pyrazino[1,2-a]pyrimidine at 130 K
    Year: 2006
    Journal: Acta Crystallographica Section E - Structure Reports Online
    Volume: E62
    Page numbers: 1846-1848
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  • Metal-Mediated Formation of Gas-Phase Amino Acid Radical Cations
    Year: 2006
    Journal: Journal of Physical Chemistry A
    Volume: 110
    Page numbers: 8304-8315
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  • Peptide derivatization as a strategy to form fixed-charge peptide radicals†
    Year: 2006
    Journal: Rapid Communications in Mass Spectrometry
    Volume: 20
    Page numbers: 2865-2870
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  • Syntheses and structural studies of platinum(II) complexes of
    O-methylselenomethionine and related ligands
    Year: 2006
    Journal: Inorganica Chimica Acta
    Volume: 359
    Page numbers: 3252-3256
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  • The role of the position of the basic residue in the generation and fragmentation of peptide radical cations
    Year: 2006
    Journal: International Journal of Mass Spectrometry
    Volume: 249-250
    Page numbers: 171-183
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  • Tuning the gas phase redox properties of copper(II) ternary complexes of terpyridines to control the formation of nucleobase radical cations
    Year: 2006
    Journal: Dalton Transactions
    Page numbers: 5051-5061
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Publications in 2005

Journal Articles

  • Can radical cations of the constituents of nucleic acids be formed in the gas phase using ternary transition metal complexes?
    Year: 2005
    Journal: Rapid Communications in Mass Spectrometry
    Volume: 19
    Issue: 13
    Page numbers: 1797-1805
    Publisher: John Wiley & Sons(West Sussex)
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  • Dipyridophenazine Complexes of Cobalt (III): DNA Phtocleavage and Photobiology
    Year: 2005
    Journal: Australian Journal of Chemistry
    Volume: 58
    Page numbers: 206-212
    Publisher: CSIRO Publications(Collingwood)
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  • Formation of cationic peptide radicals by gas-phase redox reactions with trivalet chromium, manganese, iron, and cobalt complexes
    Year: 2005
    Journal: Journal of the American Chemical Society
    Volume: 127
    Issue: 16
    Page numbers: 6109-6115
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  • Hydrogen-bonded networks from novel platinum(II) dimers
    Year: 2005
    Journal: Crystal Engineering Communications
    Volume: 7
    Page numbers: 701-705
    Publisher: Royal Society of Chemistry(Cambridge)
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  • Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol
    Year: 2005
    Journal: Journal of Inorganic Biochemistry
    Volume: 99
    Page numbers: 1738-1743
    Publisher: Elsevier Science(New York)
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Publications in 2004

Journal Articles

  • Comparing the gas-phase fragmentation reactions of protonated and radical cations of the tripeptides GXR
    Year: 2004
    Journal: International Journal of Mass Spectrometry
    Volume: 234
    Page numbers: 101-122
    Publisher: Elsevier Science(Amsterdam)
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  • Designing copper(II) ternary complexes to generate radical cations of peptides in the gas phase: Role of the auxiliary ligand
    Year: 2004
    Journal: Journal of the Chemical Society - Dalton Transactions
    Volume: 18
    Page numbers: 3199-3204
    Publisher: Royal Society of Chemistry(Cambridge)
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  • Gas-phase ligand loss and ligand substitution reactions of platinum(II) complexes of tridentate nitrogen donor ligands
    Year: 2004
    Journal: Rapid Communications in Mass Spectrometry
    Volume: 18
    Page numbers: 1221-1226
    Publisher: John Wiley & Sons(West Sussex)
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Publications in 2003

Journal Articles

  • Gas-phase studies on the reactivity of the azido(diethylenetriamine)platinum(II) cation and derived species
    Year: 2003
    Journal: Australian Journal of Chemistry
    Volume: 56
    Page numbers: 1201-1207
    Publisher: CSIRO Publications(Collingwood)
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  • Synthesis, structural studies and photochemistry of cobalt(III) complexes of anthracenylcyclam macrocycles
    Year: 2003
    Journal: Journal of the Chemical Society - Dalton Transactions
    Volume: 2003
    Issue: 19
    Page numbers: 3704-3712
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Publications in 2002

Journal Articles

  • A pulse radiolysis study of the rate of ligand dissociation from mixed ligand cobalt(II) complexes
    Year: 2002
    Journal: Journal of the Chemical Society - Dalton Transactions
    Page numbers: 2053-2060
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  • Side-chain radical losses from radical cations allows distinction of leucine and isoleucine residues in the isomeric peptides Gly-XXX-Arg
    Year: 2002
    Journal: Rapid Communications in Mass Spectrometry
    Volume: 16
    Page numbers: 884-890
    Publisher: John Wiley & Sons(West Sussex)
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  • The synthesis and crystal structures of two cobalt(III) complexes containing the ligand 1,4,8,11-Tetraazacyclotetradecane
    Year: 2002
    Journal: Australian Journal of Chemistry
    Volume: 55
    Page numbers: 535-538
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Conference Publications/Papers

  • ChemCAL Prelabs Online


    Year: 2002
    Event name: Uniserve Science Scholarly Inquiry in Flexible Science Teaching and Learning Symposium
    Conference Publication: Uniserve Science Scholarly Inquiry Symposium Proceedings
    Page numbers: 25-30
    Publisher: University of New South Wales
    Author(s):
    Editor(s):

Publications in 2001

Journal Articles

  • cis-Dichloroplatinum(II) complexes tethered to 9-aminoacridine-4-carboxamides: synthesis and action in resistant cell lines in vitro
    Year: 2001
    Journal: Journal of Inorganic Biochemistry
    Volume: 85
    Issue: 2-3
    Page numbers: 209-217
    Publisher: Elsevier Science(New York)
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  • Cobalt(III) complexes of monobenzyl-cyclam macrocycle derivatives
    Year: 2001
    Journal: Australian Journal of Chemistry
    Volume: 54
    Issue: 2
    Page numbers: 101-104
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  • Evaluating the role of the ligand in the fragmentation reactions of platinum(II) complexes of aliphatic dipeptides. Electrospray ionization tandem mass spectrometry of [Pt(L3)M]2+ and [Pt(L3)M - H]+ ions [L3 = (H3N)3, diethylenetriamine and terpyridine; M = gly-gly, ala-gly and gly-ala]
    Year: 2001
    Journal: European Journal of Mass Spectrometry
    Volume: 7
    Issue: 1
    Page numbers: 69-78
    Publisher: IM Publications(Chichester)
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  • Gas-phase and condensed-phase studies on the reactivity of the azido(2,2':6',2"-terpyridine)platinum(II) cation
    Year: 2001
    Journal: Australian Journal of Chemistry
    Volume: 2001
    Issue: 54
    Page numbers: 245-251
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