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PROF MICHAEL HYNES



Contact Details

Organization: Genetics
Position: PROFESSOR
Email:
Homepage: http://www.genetics.unimelb.edu.au/research/hd/
Work: 8344 6239
Fax: 8344 5139
Room: 213
Level: 02
Building: Genetics Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Molecular Genetics of Fungi Gene Regulation, Metabolism, Transcription Factors Australia

International Linkages

Country Establishment Collaboration
Germany Hans-Knoll Institute of Natural Product Research Exchange, Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Agricultural Science Adelaide University
Doctor of Philosophy Flinders University of South Australia

Memberships

Membership Type Membership Body Description Start Date End Date
Member Genetics Society of Australia Member 01-Jan-1968
Member Genetics Society of America Member 01-Jan-1984
Member Australian Society Molecular Biology and Biochemistry Member 01-Jan-1968
Member American Society for Microbiology Member 01-Jan-1973

Fellowships

Fellowship Date Awarded
Fellow of the Australian Academy of Science (FAA) 01-Jan-2003

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Molecular genetic analysis of dimorphic switching in Penicillium marneffei Chief Investigator AUST RESEARCH COUNCIL Large Research Grants Scheme 01/01/2001
Molecular genetic analysis of genes regulating metabolism in the fungus aspergillus nidulans Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2003
Identifying and characterising the molecular determinants of fungal pathogenesis Chief Investigator NHMRC Project Grants 01/01/2003
MAJOR UPGRADE OF THE COMPUTING HARDWARE AND SOFTWARE FOR THE WIDELY USED BIOMANAGER BIOINFORMATICS SERVICE Chief Investigator UNIVERSITY OF SYDNEY Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2006
Global genetic regulation of carbon metabolism in filamentous fungi. Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Book Chapters

  • Advances in gene manipulations using Aspergillus nidulans
    Year: 2008
    Book: The Aspergilli-Genomics, Medical Aspects, Biotechnology and Research Methods
    Publisher: CRC Press(New York)
    Authors(s):
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  • Gluconeogenic carbon metabolism
    Year: 2008
    Book: The Aspergilli-Genomics, Medical Aspects, Biotechnology and Research Methods
    Publisher: CRC Press(New York)
    Authors(s):
    Editors(s):

Journal Articles

  • Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans
    Year: 2008
    Journal: Genetics
    Volume: 178
    Page numbers: 1355-1369
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  • Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster
    Year: 2008
    Journal: Molecular Microbiology
    Volume: 70
    Issue: 2
    Page numbers: 445-461
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  • Recent advances in nitrogen regulation: a comparison between Saccharomyces cerevisiae and filamentous fungi
    Year: 2008
    Journal: Eukaryotic Cell
    Volume: 7
    Issue: 6
    Page numbers: 917-925
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  • Sumoylation in Aspergillus nidulans: sumO inactivation, overexpression and live-cell imaging
    Year: 2008
    Journal: Fungal Genetics and Biology
    Volume: 45
    Page numbers: 728-737
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Publications in 2007

Journal Articles

  • Genetic manipulation of Asperfillus nidulans: meiotic progeny for genetic analysis and strain construction
    Year: 2007
    Journal: Nature Protocols
    Volume: 2
    Issue: 4
    Page numbers: 811-21
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  • Genetic manipulation of Aspergillus nidulans: heterokaryons and diploids for dominance, complementation and haploidization analyses
    Year: 2007
    Journal: Nature Protocols
    Volume: 2
    Issue: 4
    Page numbers: 822-830
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  • Transcriptional Control of Gluconeogenesis in Aspergillus nidulans
    Year: 2007
    Journal: Genetics
    Volume: 176
    Page numbers: 139-150
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  • Transcriptional control of nmrA by the bZIP transcription factor MeaB reveals a new level of nitrogen regulation in Aspergillus nidulans
    Year: 2007
    Journal: Molecular Microbiology
    Volume: 66
    Issue: 2
    Page numbers: 534-551
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Publications in 2006

Journal Articles

  • A versatile and efficient gene-targeting system for Aspergillus nidulans
    Year: 2006
    Journal: Genetics
    Volume: 172
    Page numbers: 1557-1566
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  • Differential expression of Aspergillus nidulans ammonium permease genes is regulated by GATA transcription factor AreA
    Year: 2006
    Journal: Eukaryotic Cell
    Volume: 5
    Issue: 2
    Page numbers: 226-237
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  • Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans
    Year: 2006
    Journal: Eukaryotic Cell
    Volume: 5
    Issue: 5
    Page numbers: 794-805
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  • The Aspergillus nidulans rcoA gene is required for veA-dependent sexual development
    Year: 2006
    Journal: Genetics
    Volume: 174
    Issue: 3
    Page numbers: 1685-1688
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Publications in 2005

Journal Articles

  • Amino acid catabolism by an areaA-regulated gene encoding an L-amino acid oxidase with broad substrate specificity in Aspergillus nidulans
    Year: 2005
    Journal: Applied and Environmental Microbiology
    Volume: 71
    Issue: 7
    Page numbers: 3551-3555
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  • Nuclear accummulation of the GATA factor areA in response to complete nitrogen starvation by regulation of nuclear export
    Year: 2005
    Journal: Eukaryotic Cell
    Volume: 4
    Issue: 10
    Page numbers: 1646-1653
    Publisher: American Society for Microbiology(Washington DC)
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  • Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
    Year: 2005
    Journal: Nature
    Volume: 438
    Issue: 22
    Page numbers: 1105-1115
    Publisher: Macmillan Publishers(London)
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  • The Ras and Rho GTPases genetically interact to co-ordinately regulate cell polarity during development in Penicillium marneffei
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 55
    Page numbers: 1487-1501
    Publisher: Blackwell Science(Oxford)
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Publications in 2004

Book Chapters

  • Regulation of the amdS Gene in Aspergillus nidulans
    Year: 2004
    Book: The Mycota III- Biochemistry and Molecular Biology
    Publisher: Springer Verlag(Berlin)
    Authors(s):

Journal Articles

  • TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans
    Year: 2004
    Journal: Molecular Genetics and Genomics
    Volume: 272
    Page numbers: 452-459
    Publisher: Springer Verlag(New York)
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Publications in 2003

Journal Articles

  • Control of morphogenesis and actin localization by the Penicillium marneffei RAC homolog
    Year: 2003
    Journal: Journal of Cell Science
    Volume: 116
    Issue: 7
    Page numbers: 1249-1260
    Publisher: Company of Biologists(Cambridge)
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  • Detection of unpaired DNA at meiosis results in RNA-mediated silencing
    Year: 2003
    Journal: Bioessays
    Volume: 25
    Page numbers: 99-103
    Publisher: Company of Biologists(Cambridge)
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  • The Neurospora crassa genome opens up the world of filamentous fungi
    Year: 2003
    Journal: Genome Biology
    Volume: 4
    Issue: 6
    Page numbers: 1-4
    Publisher: Biomed Central(London)
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  • The G-Protein α-subunit GasC Plays a Major Role in Germination in the Dimorphic Fungus Penicillium marneffei
    Year: 2003
    Journal: Genetics
    Volume: 164
    Page numbers: 487-499
    Publisher: Genetic Society of America(Maryland)
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  • TupA, the Penicillium marneffei Tup 1p homologue, represses both yeast and spore development
    Year: 2003
    Journal: Molecular Microbiology
    Volume: 48
    Issue: 1
    Page numbers: 85-94
    Publisher: Blackwell Science(Oxford)
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Publications in 2002

Journal Articles

  • A Gene from Aspergillus nidulans with Similarity to URE2 of Saccharomyces cerevisiae Encodes a Glutathione S-Transferase Which Contributes to Heavy Metal and Xenobiotic Resistance
    Year: 2002
    Journal: Applied and Environmental Microbiology
    Volume: 68
    Issue: 6
    Page numbers: 2802-2808
    Publisher: American Society for Microbiology(Washington DC)
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  • A basic helix-loop-helix protein with similarity to the fungal morphological regulators, Phd1p, Efg1p and StuA, controls conidiation but not dimorphic growth in Penicillium marneffei
    Year: 2002
    Journal: Molecular Microbiology
    Volume: 44
    Issue: 3
    Page numbers: 621-631
    Publisher: Blackwell Science(Oxford)
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  • G-Protein Signaling Mediates Asexual Development at 25 degrees but Has No Effect on Yeast-Like Growth at 37 degrees in the Dimorphic Fungus Penicillium marneffei
    Year: 2002
    Journal: Eukaryotic Cell
    Volume: 1
    Issue: 3
    Page numbers: 440-447
    Publisher: American Society for Microbiology(Washington DC)
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  • Isolation and Characterization of Two Ammonium Permease Genes, meaA and mepA, from Aspergillus nidulans
    Year: 2002
    Journal: Eukaryotic Cell
    Volume: 1
    Issue: 1
    Page numbers: 85-94
    Publisher: American Society for Microbiology(Washington DC)
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  • Mutation and functional analysis of the Aspergillus nidulans ammonium permase MeaA and evidence for interaction with itself and MepA
    Year: 2002
    Journal: Fungal Genetics and Biology
    Volume: 36
    Issue: 1
    Page numbers: 35-46
    Publisher: Academic Press(San Diego)
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  • Regulation of the acuF Gene, Encoding Phosphoenolpyruvate Carboxykinase in the Filamentous Fungus Aspergillus nidulans
    Year: 2002
    Journal: Journal of Bacteriology
    Volume: 184
    Issue: 1
    Page numbers: 183-190
    Publisher: American Society for Microbiology(Washington DC)
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  • The Genes gmdA, Encoding an Amidase, and bzuA, Encoding a Cytochrome P450, Are Required for Benzamide Utilization in Aspergillus nidulans
    Year: 2002
    Journal: Fungal Genetics and Biology
    Volume: 35
    Issue: 2
    Page numbers: 135-146
    Publisher: Academic Press(San Diego)
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Publications in 2001

Journal Articles

  • A Single Gene Produces Mitochondrial, Cytoplasmic, and Peroxisomal NADP-dependent Isocitrate Dehydrogenase in Aspergillus nidulans
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 40
    Page numbers: 37722-37729
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • An STE12 Homolog From the Asexual, Dimorphic Fungus Penicillium marneffei Complements the Defect in Sexual Development of an Aspergillus nidulans steA Mutant
    Year: 2001
    Journal: Genetics
    Volume: 157
    Issue: 3
    Page numbers: 1003-1014
    Publisher: Genetic Society of America(Maryland)
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  • AoHapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the corresponding subunits in Aspergillus nidulans
    Year: 2001
    Journal: Current Genetics
    Volume: 39
    Issue: 3
    Page numbers: 175-182
    Publisher: Springer Verlag(New York)
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  • Functional analysis of TamA, a coactivator of nitrogen-regulated gene expression in Aspergillus nidulans
    Year: 2001
    Journal: Molecular Genetics and Genomics
    Volume: 265
    Issue: 4
    Page numbers: 636-646
    Publisher: Springer Verlag(New York)
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  • Role of Glutamine Synthetase in Nitrogen Metabolite repression in Aspergillus nidulans
    Year: 2001
    Journal: Journal of Bacteriology
    Volume: 183
    Issue: 20
    Page numbers: 5826-5833
    Publisher: American Society for Microbiology(Washington DC)
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  • The Aspergillus nidulans Multimeric CCAAT Binding Complex AnCF is Negatively Autoregulated via its hapB Subunit Gene
    Year: 2001
    Journal: Journal of Molecular Biology
    Volume: 306
    Issue: 4
    Page numbers: 643-653
    Publisher: Academic Press(London)
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  • The CDC42 Homolog of the Dimorphic Fungus Penicillium marneffei Is Required for Correct Cell Polarization during Growth but Not Development
    Year: 2001
    Journal: Journal of Bacteriology
    Volume: 183
    Issue: 11
    Page numbers: 3447-3457
    Publisher: American Society for Microbiology(Washington DC)
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  • The Formamidase Gene of Aspergillus nidulans: Regulation by Nitrogen Metabolite Repression and Transcriptional Interference by an Overlapping Upstream Gene
    Year: 2001
    Journal: Genetics
    Volume: 157
    Issue: 1
    Page numbers: 119-131
    Publisher: Genetic Society of America(Maryland)
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