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PROF JAMES CAMAKARIS



Contact Details

Organization: Genetics
Position: PROFESSOR
Email:
Homepage: http://www.genetics.unimelb.edu.au/research/camakaris/index.html
Work: 8344 5138
Fax: 8344 5139
Room: 1-06
Level: 01
Building: Genetics Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Copper homeostasis, Inherited diseases of copper homeostasis, Cell biology of copper transporters, Menkes disease, Alzheimers disease Copper, Menkes disease, Alzheimers disease, Protein trafficking, confocal microscopy Australia

International Linkages

Country Establishment Collaboration
United States Rutgers, The State University of New Jersey Research
United States Weill Medical College of Cornell University Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 01-Dec-1968
Doctor of Philosophy University of Melbourne 01-Dec-1973

Memberships

Membership Type Membership Body Description Start Date End Date
Member American Society for Cell Biology Member 01-Jan-2000
Member Australian Society of Biochemistry and Molecular Biology Member 01-Jan-1976
Member Human Genetics Society of Australasia Member 01-Jan-1996

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) IGOR STOJILJKOVIC MEMORIAL AWARD In recognition of outstanding contributions at the international level to the field of biometals research 18-Jul-2008
Medal AINSE AINSE gold medal awarded for excellence in research 26-May-2000

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Characterisation of heavy metal transport genes in the plant Arabidopsis: potential roles in metal detoxification & accumulation Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2003
Application of radiocopper for investigation of copper homeostasis and Alzheimer's disease Chief Investigator AINSE Awards 01/01/2005
Mechanisms of zinc transport and homeostasis in the plant, arabidopsis Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
Identification & characterisation of genes involved in the copper regulation of the human Alzheimer's disease Amyloid-beta Precursor Protein(APP) gene Chief Investigator AUST RESEARCH COUNCIL Discovery Indigenous Researchers Development Scheme 01/01/2005
Gene discovery and functional analysis of copper homeostasis genes in drosophila Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
Elucidation of trafficking of the Menkes (MNK;ATP7A) copper-transporting ATPase in epthelial cells Chief Investigator NHMRC Project Grants 01/01/2006
Use of radiocopper to investigate normal copper homeostasis and role of copper in early development and Alzheimer's disease Chief Investigator AINSE Awards 01/01/2006
Copper deficiency in Alzheimer's disease Chief Investigator NHMRC Project Grants 01/01/2007
APPLICATION OF COPPER-64 TO STUDIES ON ALZHEIMER'S DISEASE AND CHARACTERISATION OF NOVEL GENES AND PROTEINS INVOLVED IN COPPER HOMEOSTASIS Chief Investigator AINSE Awards 01/01/2007
COPPER HOMEOSTASIS AND ADD-INDUCED NEURODEGENERATION IN DROSOPHILA Chief Investigator MONASH UNIVERSITY Project Grants (NHMRC) 01/01/2007
UTILISATION OF COPPER-64 IN INVESTIGATIONS OF INVOLVEMENT OF COPPER IN ALZHEIMER'S DISEASE Chief Investigator AINSE Awards 01/01/2008
BIOMEDICAL - CHARACTERISATION OF NOVEL COPPER HOMEOSTASIS PROTEINS Principal Supervisor NHMRC Scholarships 01/01/2008
APPLICATION OF COPPER-64 IN STUDIES OF THE ROLE OF COPPER IN ALZHEIMER'S DISEASE Chief Investigator AINSE Awards 01/01/2009
PROTEIN NETWORKS MEDIATING COPPER BALANCE AND THEIR BREAK-DOWN IN DISEASE Chief Investigator DEAKIN UNIVERSITY Project Grants (NHMRC)

Contracts

Title Role Funding Source Award Date
COPPER HOMEOSTASIS: GENE DISCOVERY AND ANALYSING USING DROSOPHOLI Chief Investigator INTERNATIONAL COPPER ASSOC LTD 01/01/2003

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

  • ATP7B expression in human breast epithelial cells is mediated by lactational hormones
    Year: 2008
    Journal: Journal of Histochemistry and Cytochemistry
    Volume: 56
    Issue: 4
    Page numbers: 389-399
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  • Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Page numbers: 1850-1860
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  • Malvolio is a copper transporter in Drosophila melanogaster
    Year: 2008
    Journal: Journal of Experimental Biology
    Volume: 211
    Issue: 5
    Page numbers: 709-716
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  • Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Page numbers: 181-198
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  • Mechanisms of aβ mediated neurodegeneration in Alzheimer's disease
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 2
    Page numbers: 181-198
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Publications in 2007

Journal Articles

  • Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in human placental cells
    Year: 2007
    Journal: Cellular Physiology and Biochemistry
    Volume: 20
    Page numbers: 1073-1084
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  • Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells
    Year: 2007
    Journal: Biochemical Journal
    Volume: 402
    Page numbers: 241-50
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  • Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A)
    Year: 2007
    Journal: Biochemical Journal
    Volume: 401
    Page numbers: 569-79
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  • The use of the zinc-fluorophore, Zinpyr-1, in the study of zinc homeostasis in Arabidopsis roots
    Year: 2007
    Journal: New Phytologist
    Volume: 174
    Page numbers: 39-45
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Publications in 2006

Journal Articles

  • Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7
    Year: 2006
    Journal: Molecular Biology of the Cell
    Volume: 17
    Issue: 1
    Page numbers: 475-484
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Publications in 2005

Journal Articles

  • Menkes protein localization in rat parotid acinar cells
    Year: 2005
    Journal: Acta Histochemica
    Volume: 107
    Page numbers: 373-378
    Publisher: Elsevier GmbH, Urban & Fischer Verlag
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Publications in 2004

Book Chapters

  • P-type pumps:copper pump
    Year: 2004
    Book: Encyclopedia of Biological Chemistry, Volume 3
    Publisher: Elsevier(Oxford)
    Authors(s):

Journal Articles

  • Copper depletion down-regulates expression of the Alzheimer's disease amyloid-β precursor protein gene
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 20378-20386
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  • Copper depletion down-regulates expression of the Alzheimer's disease amyloid-β precursor protein gene
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 20378-20386
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  • Copper homeostasis in Drosophila melanogaster S2 cells
    Year: 2004
    Journal: Biochemical Journal
    Volume: 383
    Page numbers: 303-309
    Publisher: Portland Press(London)
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  • Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool
    Year: 2004
    Journal: Biochemical Journal
    Volume: 378
    Page numbers: 1031-1037
    Publisher: Portland Press(London)
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  • Copper:the Jekyll and Hyde element
    Year: 2004
    Journal: Australian Biochemist
    Volume: 35
    Issue: 3
    Page numbers: 5-8
    Publisher: Australian Society for Biochemistry and Molecular Biology(Melbourne)
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  • Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cullular copper levels in primary mouse cortical neurons and embryonic fibroblasts
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Page numbers: 423-428
    Publisher: Blackwell Science(Oxford)
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  • P-Type ATPase Heavy Metal Transporters with Roles in Essential Zinc Homeostasis in Arabidopsis
    Year: 2004
    Journal: The Plant Cell
    Volume: 16
    Page numbers: 1327-1339
    Publisher: American Society of Plant Biologists(Maryland)
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  • Signals regulating trafficking of Menkes (MNK;ATP7A) copper-translocating P-type ATPase in polarised MDCK cells
    Year: 2004
    Journal: American Journal of Physiology - Cell Physiology
    Volume: 287
    Page numbers: C1463-C1471
    Publisher: American Physiological Society(Maryland)
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  • Studies on endocytic mechanisms of the Menkes copper-translocating P-type ATPase (TP7A;MNK)
    Year: 2004
    Journal: Biometals
    Volume: 17
    Page numbers: 87-98
    Publisher: Kluwer Academic Publishers(Dordrecht)
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Publications in 2003

Journal Articles

  • Mutational analysis of the Menkes copper P-type ATPase (ATP7A)
    Year: 2003
    Journal: Biochemical and Biophysical Research Communications
    Volume: 301
    Page numbers: 488-494
    Publisher: Academic Press(California)
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  • Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase
    Year: 2003
    Journal: Biochemical and Biophysical Research Communications
    Volume: 303
    Page numbers: 337-342
    Publisher: Academic Press(California)
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Publications in 2002

Book Chapters

  • Molecular Basis of Diseases of Copper Homeostasis
    Year: 2002
    Book: Handbook of Copper Phamacology and Toxixology
    Publisher: Humana Press(New Jersey)
    Authors(s):
  • UNDERSTANDING THE MECHANISM AND FUNCTION OF COPPER P-TYPE ATPases
    Year: 2002
    Book: ADVANCES IN PROTEIN CHEMISTRY
    Publisher: Academic Press(San Diego)
    Authors(s):

Journal Articles

  • Copper-regulated Trafficking of the Menkes Disease Copper ATPase Is Associated with Formation of a Phosphorylated Catalytic Intermediate
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 48
    Page numbers: 46736-46742
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Correction of the copper transport defect of Menkes patient fibroblasts by expression of two forms of the sheep Wilson ATPase
    Year: 2002
    Journal: Biochimica et Biophysica Acta-Molecular Basis of Disease
    Volume: 1588
    Issue: 2
    Page numbers: 189-194
    Publisher: Elsevier Science(Amsterdam)
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  • Menkes Copper-Translocating P-type ATPase (ATP7A): Biochemical and Cell Biology Properties, and Role in Menkes Disease
    Year: 2002
    Journal: Journal of Bioenergetics and Biomembranes
    Volume: 34
    Issue: 5
    Page numbers: 363-371
    Publisher: Kluwer Academic/Plenum Publishers(New York)
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  • Occurrence of Cu-ATPase in Dictyostelium: Possible Role in Resistance to Copper
    Year: 2002
    Journal: Biochemical and Biophysical Research Communications
    Volume: 291
    Issue: 3
    Page numbers: 476-483
    Publisher: Academic Press(California)
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Publications in 2001

Journal Articles

  • Functional Studies on the Wilson Copper P-Type ATPase and Toxic Milk Mouse Mutant
    Year: 2001
    Journal: Biochemical and Biophysical Research Communications
    Volume: 281
    Issue: 4
    Page numbers: 966-970
    Publisher: Academic Press(California)
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  • The Regulation of Catalytic Activity of the Menkes Copper-translocating P-type ATPase
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 30
    Page numbers: 28620-28627
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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