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DR DAMIAN MYERS



Contact Details

Organization: Medicine - Royal Melbourne and Western Hospitals
Position: SENIOR RESEARCH FELLOW
Email:

Biography

Awards/Appointments: John Storey Junior Memorial Scholarship (1983); Campion-Ma-Playoust Award from the ASMR (1986); PhD scholarship through the NHF (1991); Faculty of Medicine Fellowship (1997-99); Current interests: As the Senior Scientist in the Epilepsy and Neuropharmacology Laboratory (headed by Prof Terry O’Brien) in the Department of Medicine at the RMH, I am currently working on several projects: (1) investigation of the neurological changes associated with epileptogenesis in temporal lobe epilepsy; (2) a study of structural, functional, neurobehavioural, neurocognitive and epilepsy outcomes associated with post-traumatic brain injury (funded through the Victorian Neurotrauma Initiative, TAC); (3) investigation of GABAA/central benzodiazepine receptor expression during epileptogenesis using PET imaging with [18F]-Flumazenil (through the Centre for Molecular Imaging at the Peter MacCallum Cancer Centre; CRC for Biomedical Imaging Development); (4) a study of adverse drug reactions associated with long-term epilepsy therapies; and, (5) various collaborations involving advanced imaging and development of imaging agents (in association with the CSIRO). My skills in advanced imaging techniques, including microfocus X-ray imaging (MXI) and pQCT, confocal microscopy as well as combined PET/MRI imaging complement a range of research projects within the Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne. Specialist training: Advanced imaging through the University of British Columbia (UBC), Vancouver, Canada (3D-Microscopy of Living Cells - July 1997) and at the ‘Bone and Mineral Centre’, The Rayne Institute, University College London; Other contributions to field: Convenor of workshops for the ANZBMS (Adelaide 2002; Sydney2004); immediate past-president of the Fluorescence Imaging Group of Victoria 2002-2004 (www.FIGroup.org); Member of Victorian Government Committee, the Beamline Advisory Panel for the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron.

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Applied Science Royal Melbourne Institute of Technology 31-Dec-1980
Master of Applied Science Royal Melbourne Institute of Technology 31-Dec-1984
Doctor of Philosophy University of Melbourne 31-Dec-1993

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Neuroscience Society Ordinary member 02-Jan-2005 01-Jan-2010

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship Royal Melbourne Institute of Technology University 01-Mar-1983
Other (Award) Australian Society of Medical Research 02-Dec-1986
Other (Award) University of Melbourne 01-Jan-1997
Scholarship National Heart Foundation 01-Jan-1991

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Characterisation of human osteoclastogenesis Chief Investigator NHMRC Project Grants 01/01/2002
LONGITUNDINAL VIVO STUDY OF PROGRESSIVE CHANGES IN HIPPOCAMPAL STRUCTURE AND FUNCTION POST HEAD INJURY IN RATS Chief Investigator TRANSPORT ACCIDENT COMMISSION Victorian Neurotrauma Initiative 09/10/2006
OPTIMISING THE BONE RESPONSE TO DIETARY CALCIUM: A PHYSIOLOGICAL APPROACH Chief Investigator GEOFFREY GARDINER DAIRY FOUND Innovation Program Major Projects 16/02/2007
LIVE CELL IMAGING - INFLAMMATION, BRAINS, CANCER AND MALARIA MULTIFUNCTIONAL IMAGING FACILITY Chief Investigator THE IAN POTTER FOUNDATION Project Grants 04/04/2007
PARTIAL VOLUME CORRECTION IN PET IMAGING OF THE RAT BRAIN: TOWARDS AN ACCURATE QUANTIFICATION Chief Investigator AINSE Awards 01/03/2008
Anti-epileptic drug effects on bone health: Microimaging of bone changes using Microfocus X-ray Imaging Chief Investigator UNIVERSITY OF MELBOURNE CSIRO Collaborative Research Support

Contracts

Title Role Funding Source Award Date
LONGITUDINAL IN VIVO STUDY OF HIPPOCAMPAL STRUCTURE AND FUNCTION, AND RELATIONSHIP TO NEUROCOGNITIVE, NEUROBEHAVIOURAL AND EPILEPTIC OUTCOMES, IN A MODEL OF HUMAN TRAUMATIC BRAIN INJURY (TBI) Chief Investigator HOWARD FLOREY INST 09/10/2006
RESEARCH SERVICES TO CSIRO (COMPANY) DEVELOPMENT OF IMAGING TECHNOLOGIES Chief Investigator CSIRO 01/02/2008
RESEARCH SERVICES AGREEMENT (BETWEEN DAMIAN MYERS AND CSIRO) Chief Investigator CSIRO MATERIALS SCIENCE & ENGINEERING 15/12/2008

Additional Grant and Contract Information

Current Grants/Awards
VNI DP0023 Victorian Neurotrauma Initiative through the TAC, Victoria; $973,347 over 3 years: Start date 9th of October 2006; 2006 $251,000; 2007 $200,000; 2008 $283,326; 2009 $238,998.
Longitudinal in vivo study of hippocampal structure and function, and relationship to neurocognitive, neurobehavioral and epileptic outcomes, in a model of human traumatic brain injury
O'Brien TJ, Myers DE (CIB), Hicks RJ, Howells D, Williams J, Velakoulis D, Pantelis C, Egan G, Dedeurwaerdere S, Jones N, Hogan E, Batchelor P, Jupp B, Fang K.

CSIRO-University of Melbourne Research Support Scheme
2006 $25,000; 2007 $25,000. Anti-epileptic drug effects on bone health: Microimaging of bone changes using Microfocus X-ray Imaging.
Myers DE (CIA) and Stevenson AW.

Collaborative project with the Peter MacCallum Cancer Institute: Funds from the Centre for Molecular Imaging. 2006 $75,000; 2007 $225,000; 2008 $225,000. [18F]-Flumazenil as a radiotracer for longitudinal measurements of GABAA/cBZR in the brain during epileptogenesis.
A/Prof TJ O'Brien, Dr DE Myers (CIB), Dr M-C Gregoire, Dr S Dedeurwaerdere, Dr A Katsifis, Prof RJ Hicks.

[18-F]-FMZ-PET IMAGING IN MEDICALLY REFRACTORY FOCAL EPILEPSY PATIENTS: DOES IT PROVIDE SUPERIOR LOCALIZATION OF THE EPILEPTOGENIC ZONE THAN FDG-PET?
Principal Researcher: Prof Terence J. O’Brien
Associate Researcher(s): Prof Rodney Hicks, Dr Viviane Bouilleret, Dr WF Eddie Lau, Dr Peter Roselt, Dr David Binns, Dr Andrew Katsifis, Dr Marie Claude Gregoire, Dr Damian Myers and Ms Annie Roten
On-going clinical study.

Geoffrey Gardiner Dairy Foundation. 2007 $25,000; 2008 $25,000; 2009 $25,000. Optimizing the bone response to dietary calcium: a physiological approach.
Wark JD, Wlodek MJ, Myers DE.

Series of grants for funding of the ‘Live-cell Imaging Facility’ in the Department of Medicine at the Royal Melbourne Hospital: University of Melbourne NHMRC Equipment grants: $140,000; Ian Potter Foundation 2007: $100,000; Neuroscience Foundation: $48,000; Ian Potter Foundation 2008: $95,000; negotiated for Genetics to join our facility with their Rowden White funding of $150,000; Facility now established with 80 users – Dr DE Myers prepared all the grants, organized the establishment of the facility and co-ordinates the running of the facility (administration and running facility).
The ‘Live-cell Imaging Laboratory’ has become a central facility for the department and several collaborators; the key benefit is to value-add to our current projects such as the VNI grant as well as advance novel areas of work. This facility has enabled the introduction of a range of students into the area of neurotrauma research (PhD, Honours Degree and AMS students) who have learned these advanced imaging techniques.

Australian Institute of Nuclear Science and Engineering (AINSE): through the Australian Nuclear Technology Organisation (ANSTO) $17,000 (2008-2009); Partial volume correction in PET imaging of the rat brain: towards an accurate quantification; Dr Damian Myers (CIA), Dr Marie-Claude Gregoire , Dr Andrew Katsifis, Prof Terence O’Brien, Prof Rod Hicks, Dr Stefanie Dedeurwaerdere;

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1
    Year: 2009
    Journal: Experimental Neurology
    Volume: 219
    Issue: 1
    Page numbers: 249-257
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  • In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat
    Year: 2009
    Journal: European Journal of Nuclear Medicine and Molecular Imaging
    Volume: 36
    Issue: 6
    Page numbers: 958-965
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  • Lamina-specific changes in hippocampal GABA(A)/cBZR and mossy fibre sprouting during and following amygdala kindling in the rat
    Year: 2009
    Journal: Neurobiology of Disease
    Volume: 35
    Issue: 3
    Page numbers: 337-347
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  • MRI-based large deformation high dimensional mapping of the hippocampus in rats: development and validation of the technique
    Year: 2009
    Journal: Journal of Magnetic Resonance Imaging
    Volume: 29
    Page numbers: 1027-1034
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Publications in 2008

Journal Articles

  • Experimental Traumatic Brain Injury Induces a Pervasive Hyperanxious Phenotype in Rats
    Year: 2008
    Journal: Journal of Neurotrauma
    Volume: 25
    Page numbers: 1367-1374
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  • Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures
    Year: 2008
    Journal: BMC Neuroscience
    Volume: 9
    Page numbers: 59
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Publications in 2005

Journal Articles

  • The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line
    Year: 2005
    Journal: Cancer Research
    Volume: 65
    Issue: 11
    Page numbers: 4929-4938
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Publications in 2004

Journal Articles

  • Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
    Year: 2004
    Journal: Journal of Bone & Mineral Research
    Volume: 19
    Page numbers: 89-99
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  • Osteoclastic Potential of Human CFU-GM: Biphasic Effect of GM-CSF
    Year: 2004
    Journal: Journal of Bone & Mineral Research
    Volume: 19
    Issue: 2
    Page numbers: 190-199
    Publisher: American Society for Bone and Mineral Research(Washington DC)
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Publications in 2003

Journal Articles

  • α-Melanocyte-stimulating hormong is a novel regulator of bone
    Year: 2003
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 284
    Page numbers: E1181-E1190
    Publisher: American Physiological Society(Maryland)
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Publications in 2002

Journal Articles

  • Leptin inhibitis osteoclast generation.
    Year: 2002
    Journal: Journal of Bone & Mineral Research
    Volume: 17
    Issue: 2
    Page numbers: 200-209
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