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PROF JOHN HAMILTON



Contact Details

Organization: Medicine - Royal Melbourne and Western Hospitals
Position: SENIOR PRINCIPAL RESEARCH FELLOW (NH&MRC
Email:
Homepage: http://www.medrmhwh.unimelb.edu.au/staff/academic/hamilton.html
Work: 8344 5480
Mobile: 0417 379 078
Fax: 9347 1863
Level: 04
Building: Clinical Sciences
Campus: Royal Melbourne Hospital

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Science University of Melbourne 08-Dec-1990
Doctor of Philosophy University of Melbourne 02-Sep-1967

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize Australian Rheumatology Association Parr Rheumatic Prize 01-May-1985
Other (Award) National Heart Foundation Tattersall�s Research Award 01-Nov-1996
Scholarship Prize National Heart Foundation Fraser Post-Graduate Medical Research Scholarship 01-Nov-1990
Other (Award) National Association of Research Fellows Travel Award 17-Nov-2008
Other (Award) American Thoracic Society Travel Award 19-May-2008

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Control of monocyte/macrophage function by CSF-1 Chief Investigator NHMRC Project Grants 01/01/2001
NHMRC01/05-FEL-HAMIL Chief Investigator NHMRC Research Fellowship 01/01/2001
The role of the plasminogen activators urokinase-PA and tissue-type PA in arthritis Chief Investigator NHMRC Project Grants 01/01/2004
DEVELOPMENT OF A HIGHLY POTENT, FULLY HUMAN ANTI-GM-CSF MONOCLONAL ANTIBODY Chief Investigator NHMRC Development Grants 01/01/2005
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2006
LIVE CELL IMAGING - INFLAMMATION, BRAINS, CANCER AND MALARIA MULTIFUNCTIONAL IMAGING FACILITY Chief Investigator THE IAN POTTER FOUNDATION Project Grants 04/04/2007
Macrophage populations Chief Investigator NHMRC Project Grants 01/01/2008
The discovery of critical early markers of arthritic disease Chief Investigator HELEN MACPHERSON SMITH TRUST Research Grants 01/01/2008
CLINICAL - GM-CSF, A KEY MEDIATOR OF ARTHRITIC DISEASE AND ITS EFFECT ON MACROPHAGES Principal Supervisor NHMRC Scholarships 01/01/2008
The role of scavenging cells in the spread of breast cancer tumours Principal Supervisor NHMRC Scholarships 01/01/2009

Contracts

Title Role Funding Source Award Date
CRC for Chronic Inflammatory Diseases Chief Investigator CRC ASSOCIATION INC 01/07/2001
PARTICIPATION BY DEPT IN CRC FOR ORAL HEALTH SCIENCE Chief Investigator 553-MEDICINE - RMH & WESTERN HOSPITAL 01/07/2004
CRC for Chronic Inflammatory Diseases Chief Investigator CRC ASSOCIATION INC 01/01/2005
CRC for Chronic Inflammatory Diseases Chief Investigator CRC ASSOCIATION INC 01/01/2005
CRC FOR CHRONIC INFLAMMATORY DISEASES - MACROPHAGE-LINEAGE CELLS AND THE INFLAMMATORY REACTION TO JOINT PROTHESES Chief Investigator CRC ASSOCIATION INC 01/01/2005
Computational Biology and Structural Functional Genomics Chief Investigator CRC ASSOCIATION INC 01/01/2005
CRC for Chronic Inflammatory diseases -Target validation Chief Investigator CRC ASSOCIATION INC 01/01/2005
CRC for Chronic Inflammatory Diseases Chief Investigator CRC ASSOCIATION INC 01/01/2005
CRC for Chronic Inflammatory Diseases Chief Investigator CRC ASSOCIATION INC 01/01/2005
CRC FOR CHRONIC INFLAMATORY DISEASE - SERVICE AGREEMENT CONSORTIUM 01/07/2006 TO 30/06/2009 AGREEMENT NO. 17415 Chief Investigator DEPT OF HUMAN SERVICES 06/02/2007
REQUEST FOR BLOOD OF BLOOD PRODUCTS FOR RESEARCH Chief Investigator AUST RED CROSS BLOOD SERVICE 26/02/2007
TNF INHIBITORS Chief Investigator PROTAGONIST THERAPEUTICS 16/05/2008
THE EFFECT OF VITAMIN D ANALOGUES ON MACROPHAGE FUNCTION IN VITRO Chief Investigator LEO PHARMA A/S 19/12/2008
TNF INHIBITORS Chief Investigator PROTAGONIST THERAPEUTICS 24/04/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • The proliferative human monocyte subpopulation contains osteoclast precursors


    Year: 2009
    Journal: Arthritis Research & Therapy
    Volume: 11
    Page numbers: R23
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  • Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages
    Year: 2009
    Journal: Cellular Signaling
    Volume: 21
    Issue: 2
    Page numbers: 246-252
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  • GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling
    Year: 2009
    Journal: Journal of Leukocyte Biology
    Volume: 86
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  • Glucose Metabolism Is Required for Oxidized LDL-Induced Macrophage Survival. Role of PI3K and Bcl-2 Family Proteins
    Year: 2009
    Journal: Arteriosclerosis Thrombosis and Vascular Biology
    Volume: 29
    Page numbers: 1283-1289
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  • Glycolytic control of adjuvant-induced macrophage survival: role of PI3K, MEK1/2, and Bcl-2
    Year: 2009
    Journal: Journal of Leukocyte Biology
    Volume: 85
    Page numbers: 947-956
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  • Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions
    Year: 2009
    Journal: Journal of Immunology
    Volume: 182
    Issue: 12
    Page numbers: 7974
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  • Low dose metal particles can induce monocyte/macrophage survival
    Year: 2009
    Journal: Journal of Orthopaedic Research
    Volume: 27
    Issue: 11
    Page numbers: 1481-6
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  • Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake
    Year: 2009
    Journal: Cellular Signaling
    Volume: 21
    Issue: 9
    Page numbers: 1361-1369
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  • Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation
    Year: 2009
    Journal: Osteoarthritis and Cartilage
    Volume: 17
    Issue: 6
    Page numbers: 735-742
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  • Regulation of IRAK-1 activation by its C-terminal domain
    Year: 2009
    Journal: Cellular Signaling
    Volume: 21
    Page numbers: 719-726
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  • The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases
    Year: 2009
    Journal: Arthritis and Rheumatism
    Volume: 60
    Issue: 5
    Page numbers: 1210-1221
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  • The generation and properties of human macrophage populations from hemopoietic stem cells
    Year: 2009
    Journal: Journal of Leukocyte Biology
    Volume: 85
    Issue: 5
    Page numbers: 766-78
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Publications in 2008

Journal Articles

  • Regulation of WAVE1 expression in macrophages at multiple levels


    Year: 2008
    Journal: Journal of Leukocyte Biology
    Volume: 84
    Page numbers: 1483-1491
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  • Regulation of the Endosomal SNARE Protein Syntaxin 7 by Colony Stimulating Factor-1 in Macrophages


    Year: 2008
    Journal: Molecular and Cellular Biology
    Volume: 28
    Issue: 20
    Page numbers: 6149-6159
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  • Colony-stimulating factors in inflammation and autoimmunity
    Year: 2008
    Journal: Nature Reviews Immunology
    Volume: 8
    Page numbers: 533-544
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  • Plasminogen activator/plasmin system in arthritis and inflammation: friend or foe?
    Year: 2008
    Journal: Arthritis and Rheumatism
    Volume: 58
    Issue: 3
    Page numbers: 645-648
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  • The critical role of the colony-stimulating factor-1 receptor in the differentiation of myeloblastic leukemia cells
    Year: 2008
    Journal: Molecular Cancer Research
    Volume: 6
    Issue: 3
    Page numbers: 458-467
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  • The role of the RgpA-Kgp proteinase-adhesin complexes in the adherence of Porphyromonas gingivalis to fibroblasts
    Year: 2008
    Journal: Microbiology
    Volume: 154
    Page numbers: 2904-2911
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Publications in 2007

Journal Articles

  • Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock


    Year: 2007
    Journal: Biochemistry
    Volume: 45
    Issue: 51
    Page numbers: 15144-52
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  • Macrophage lineage phenotypes and osteoclastogenesis—Complexity in the control by GM-CSF and TGF-β


    Year: 2007
    Journal: Bone
    Volume: 40
    Page numbers: 323-336
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  • Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells.
    Year: 2007
    Journal: Infection and Immunity
    Volume: 75
    Issue: 5
    Page numbers: 2484-2492
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  • Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
    Year: 2007
    Journal: Journal of Immunology
    Volume: 178
    Page numbers: 5245-5252
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  • Macrophage lineage phenotypes and osteoclastogenesis-Complexity in the control by GM-CSF and TGF-beta.
    Year: 2007
    Journal: Bone
    Volume: 40
    Page numbers: 323-336
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  • Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
    Year: 2007
    Journal: Journal of Leukocyte Biology
    Volume: 82
    Page numbers: 1-13
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Publications in 2006

Journal Articles

  • A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor.
    Year: 2006
    Journal: FEBS Journal
    Volume: 273
    Issue: 8
    Page numbers: 1791-1804
    Author(s):
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  • CpG DNA enhances macrophage cell spreading by promoting the Src-family kinase-mediated phosphorylation of paxillin.
    Year: 2006
    Journal: Cellular Signaling
    Volume: 18
    Issue: 12
    Page numbers: 2252-2261
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  • Detection and properties of the human proliferative monocyte subpopulation.
    Year: 2006
    Journal: Journal of Leukocyte Biology
    Volume: 79
    Issue: 4
    Page numbers: 757-766
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  • M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts.
    Year: 2006
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 38
    Issue: 9
    Page numbers: 1518-1529
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  • The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation.
    Year: 2006
    Journal: Thrombosis and Haemostasis
    Volume: 95
    Issue: 4
    Page numbers: 659-667
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  • Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF).
    Year: 2006
    Journal: Pharmacology and Therapeutics
    Volume: 112
    Issue: 1
    Page numbers: 106-115
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Publications in 2005

Journal Articles

  • A central role for the Hsp90-Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 9813-9822
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • A proteomics stretegy for the enrichment of receptor-associated complexes
    Year: 2005
    Journal: Proteomics
    Volume: 5
    Page numbers: 4754-4763
    Publisher: Wiley-VCH(Berlin)
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  • Functions of granulocyte-macrophage colony-stimulating factor
    Year: 2005
    Journal: Critical Reviews in Immunology
    Volume: 25
    Page numbers: 405-428
    Publisher: Begell House(New York)
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  • Regulation of Toll-like receptor (TRL)2 and TLR4 on CD14dimCD16+ monocytes in response to sepsis-related antigens
    Year: 2005
    Journal: Clinical and Experimental Immunology
    Volume: 141
    Page numbers: 270-278
    Publisher: Blackwell Science(Oxford)
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  • S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo
    Year: 2005
    Journal: Journal of Proteome Research
    Volume: 4
    Issue: 1
    Page numbers: 136-145
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  • cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation
    Year: 2005
    Journal: The FEBS Journal
    Volume: 272
    Page numbers: 4141-4152
    Publisher: Blackwell Publishers
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Publications in 2004

Journal Articles

  • A novel 110kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling
    Year: 2004
    Journal: Biochemical Journal
    Volume: 380
    Page numbers: 243-253
    Publisher: Portland Press(London)
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  • GM-CSF biology
    Year: 2004
    Journal: Growth Factors
    Volume: 22
    Page numbers: 225-231
    Publisher: Harwood Academic Publishing GMBH(Reading)
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  • Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4
    Year: 2004
    Journal: American Journal of Physiology - Lung Cellular and Molecular Physiology
    Volume: 286
    Page numbers: L877-L885
    Publisher: American Physiological Society(Maryland)
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  • Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation
    Year: 2004
    Journal: Journal of Immunology
    Volume: 173
    Page numbers: 4643-4651
    Publisher: American Association of Immunologists(Maryland)
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Publications in 2003

Journal Articles

  • Nondisposable materials, chronic inflammation, and adjuvant action
    Year: 2003
    Journal: Journal of Leukocyte Biology
    Volume: 73
    Page numbers: 702-712
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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  • Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis
    Year: 2003
    Journal: Hepatology
    Volume: 37
    Page numbers: 1154-1164
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  • The interferon in TLR signaling: more than just antiviral
    Year: 2003
    Journal: Trends in Immunology (formerly Immunology Today)
    Volume: 24
    Page numbers: 534-539
    Publisher: Elsevier Science(Oxford)
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  • The phenotype of inflammatory macrophages is stimulus dependent: implications for the nature of the inflammatory response
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 4816-4823
    Publisher: American Association of Immunologists(Maryland)
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Publications in 2002

Journal Articles

  • GM-CSF in inflammation and autoimmunity


    Year: 2002
    Journal: Trends in Immunology (formerly Immunology Today)
    Volume: 23
    Issue: 8
    Page numbers: 403-408
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  • Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced prliferative response to CSF-1 (M-CSF)
    Year: 2002
    Journal: Brain Research
    Volume: 940
    Page numbers: 49-54
    Publisher: Elsevier Science(Amsterdam)
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  • Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis
    Year: 2002
    Journal: American Journal of Pathology
    Volume: 160
    Page numbers: 917-926
    Publisher: American Society of Investigative Pathology Inc(Maryland)
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  • Extravascular coagulation and the plasminogen activator/plasmin system in rheumatoid arthritis
    Year: 2002
    Journal: Arthritis and Rheumatism
    Volume: 46
    Page numbers: 2268-2279
    Publisher: Wiley-Liss(New York)
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  • Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkB and AP-1 in vivo
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 42808-42814
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The generation of highly enriched osteoclast-lineage cell populations
    Year: 2002
    Journal: Bone
    Volume: 30
    Page numbers: 164-170
    Publisher: Elsevier Science(New York)
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Publications in 2001

Journal Articles

  • Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF
    Year: 2001
    Journal: Arthritis Research
    Volume: 3
    Page numbers: 293-298
    Publisher: Biomed Central(London)
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  • Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity
    Year: 2001
    Journal: Biochemical Journal
    Volume: 358
    Page numbers: 431-436
    Publisher: Portland Press(London)
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  • Comparison of macrophage responses to oxidized low-density lipoprotein and macrophage colony-stimulating factor (M-CSF or CSF-1)
    Year: 2001
    Journal: Biochemical Journal
    Volume: 354
    Page numbers: 179-187
    Publisher: Portland Press(London)
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  • Copper/zinc superoxide dismutase is phosphorylated and modulated specifically by granulocyte-colony stimulating factor in myeloid cells
    Year: 2001
    Journal: Proteomics
    Volume: 1
    Page numbers: 435-443
    Publisher: Wiley-VCH(Berlin)
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  • Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor
    Year: 2001
    Journal: Arthritis and Rheumatism
    Volume: 44
    Page numbers: 111-119
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  • Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL
    Year: 2001
    Journal: Biochemical Journal
    Volume: 355
    Page numbers: 207-214
    Publisher: Portland Press(London)
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  • Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis
    Year: 2001
    Journal: Journal of Experimental Medicine
    Volume: 194
    Page numbers: 873-881
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  • Inflammatory microcrystals induce muring macrophage survival and DNA synthesis
    Year: 2001
    Journal: Arthritis Research
    Volume: 3
    Page numbers: 242-246
    Publisher: Biomed Central(London)
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  • Proteomic analysis of macrophage differentiation
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 26211-26217
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Tissue-type plasminogen activator deficiency exacerbates arthritis
    Year: 2001
    Journal: Journal of Immunology
    Volume: 167
    Page numbers: 1047-1052
    Publisher: American Association of Immunologists(Maryland)
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