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PROF JEFFREY ZAJAC



Contact Details

Organization: Medicine - Austin Health and Northern Health
Position: CHAIR OF MEDICINE - ARMC
Email:
Work: 9496 5198
Fax: 9457 5485
Room: 7.10
Level: 07
Building: Lance Townsend Building
Campus: Austin Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Genetically modified animal models in endocrinology genetically modified animal models, transgenics, knockouts, androgen receptor, calcitonin receptor Australia
Physiological role of calcitonin calcitonin, calcitonin receptor, physiology, hypercalcaemia, calcium homeostasis Australia
adipose tissue biology fat, obesity, metabolic syndrome, type 2 diabetes, metabolism Australia, United States of America
steroid hormone biology androgens, testosterone, dihydrotestosterone, androgen receptor Australia, United States of America
molecular endocrinology androgen receptor, skeletal muscle, genetically modified mouse models, anabolic actions, androgens, testosterone Australia, United States of America
Androgen action in bone androgens testosterone, physiology, bone histomorphometry, osteoblasts, Australia
Calcitonin action in bone calcitonin receptor, calcitonin, calcitonin-related peptides, bone cell metabolism Australia
skeletal muscle biology physiology, skeletal muscle, hypertrophy, muscle wasting Australia, United States of America
Kennedy's Disease spinal and bulbar muscular atrophy Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne
Bachelor of Medicine-Bachelor of Surgery University of Melbourne 31-Dec-1977
Doctor of Philosophy University of Melbourne 31-Dec-1985

Memberships

Membership Type Membership Body Description Start Date End Date
Member RACP Royal Australasian College of Physicians 01-Jan-1984

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 01-Jan-1984

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Role of androgens and androgen related genes in skeletal muscle Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2004
The molecular mechanisms of anabolic androgen actions in skeletal muscle Chief Investigator NHMRC Project Grants 01/01/2005
THE ROLE OF ANDROGENS IN OSTEOBLAST DEVELOPMENT AND BONE METABOLISM Chief Investigator NHMRC Project Grants 01/01/2005
Prevalence and outcome for general medical inpatients with diabetes mellitis and new hperglycemia Chief Investigator NOVO NORDISK PHARMACEUTICALS Regional Diabetes Scheme 01/01/2005
Calcitonin receptor and bone function. Chief Investigator NHMRC Project Grants 01/01/2007
Control of fat mass by male sex hormones Chief Investigator NHMRC Project Grants 01/01/2007
The Relationship between Testosterone and the Architecture of Bone in normal and Hypogonadal males Principal Supervisor ROYAL AUSTRALASIAN COLLEGE OF PHYSICIANS Research Entry Scholarship in Arthritis Research 04/02/2008
Targeted delivery of hypoxia selective anticancer agents - A new approach for the treatment of glioblastoma multiforme Chief Investigator CURE FOR LIFE FOUNDATION Ad Hoc Grants for Research into Brain Tumors 03/04/2008
MOOD CHECK: Development of a short form depression scale for assessment of quality of life in cardiac patients and examination of screening and management in health care settings Chief Investigator BEYONDBLUE Victorian Centre of Excellence in Depression and Related Disorders Grants 04/04/2008
The role of the lysosomal protein SCARB2 in kidney disease Principal Supervisor ROYAL AUST COLLEGE OF PHYSICIANS Research Entry Scholarships 20/12/2008
Male hormone receptors in bone forming cells. Chief Investigator NHMRC Project Grants 01/01/2009
The Relationship between Testosterone and the Architecture of Bone Principal Supervisor ROYAL AUST COLLEGE OF PHYSICIANS Osteoporosis Australia RACP Research Entry Scholarship 01/01/2009
Regulation of renin secretion by the AMP-activated protein kinase Principal Supervisor ROYAL AUST COLLEGE OF PHYSICIANS Research Entry Scholarships 09/03/2009
Testoterone treatement in men with type 2 diabetes mellitus and borderline low total testosterone levels Chief Investigator PFIZER AUST PTY LTD Cardio Vascular Lipid Research Grants 30/10/2009
Testosterone treatment in men with type 2 diabetes mellitus and borderline low total testosterone levels Principal Supervisor ROYAL AUST COLLEGE OF PHYSICIANS Osteoporosis Australia RACP Research Entry Scholarship 30/11/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Low testosterone and anaemia in men with type 2 diabetes
    Year: 2009
    Journal: Clinical Endocrinology
    Volume: 70
    Page numbers: 547-553
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  • Mineralization and bone resorption are regulated by the androgen receptor in male mice.
    Year: 2009
    Journal: Journal of Bone & Mineral Research
    Volume: 24
    Issue: 4
    Page numbers: 621-631
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Publications in 2008

Journal Articles

  • Androgen Receptor Expression and Function in Osteoclasts


    Year: 2008
    Journal: The Open Physiology Journal
    Volume: 1
    Page numbers: 28-33
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  • Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats


    Year: 2008
    Journal: Bone
    Volume: 42
    Issue: 2008
    Page numbers: 1164-1174
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  • Outcomes for general medical inpatients with diabetes mellitus and new hyperglycaemia


    Year: 2008
    Journal: Medical Journal of Australia
    Volume: 188
    Issue: 6
    Page numbers: 340-343
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  • The development of the parathyroid gland: from fish to human


    Year: 2008
    Journal: Current Opinion in Nephrology and Hypertension
    Volume: 17
    Page numbers: 353-356
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  • A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice
    Year: 2008
    Journal: Physiological Genomics
    Volume: 33
    Issue: 2008
    Page numbers: 133-137
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  • Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia inMice
    Year: 2008
    Journal: Journal of Bone & Mineral Research
    Volume: 23
    Issue: 8
    Page numbers: 1182-1193
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  • Generation and analysis of an androgen-responsive myoblast cell line indicates that androgens regulate myotube protein accretion
    Year: 2008
    Journal: Journal of Endocrinological Investigation
    Volume: 31
    Page numbers: 910-918
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  • Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice
    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Page numbers: 2676-89
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  • Intermittent Fugu parathyroid hormone 1 (1-34) is an ababolic bone agent in young male rats and osteopenic ovariectomized rats
    Year: 2008
    Journal: Bone
    Volume: 42
    Issue: 6
    Page numbers: 1164-74
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  • Low Testosterone Levels are Common and Associated with Insulin Resistance in Men with Diabetes
    Year: 2008
    Journal: Journal of Clinical Endocrinology & Metabolism
    Volume: 93
    Issue: 2008
    Page numbers: 1834-1840
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  • Lrp5 controls bone formationby inhibiting serotonin synthesis in the duodenum
    Year: 2008
    Journal: Cell
    Volume: 135
    Page numbers: 825-837
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  • Oestradiol-induced spermatogenesis requires a functional androgen receptor
    Year: 2008
    Journal: Reproduction, Fertility and Development
    Volume: 20
    Page numbers: 861-870
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  • Severe subfertility in mice with AR inactivation in sex accessory organs, but not in testis

    Year: 2008
    Journal: Endocrinology
    Volume: 149
    Issue: 7
    Page numbers: 3330-3338
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Publications in 2007

Journal Articles

  • Disruption of Prostate Epithelial Androgen Receptor Impedes Prostate Lobe-Specific Growth and Function
    Year: 2007
    Journal: Endocrinology
    Volume: 148
    Issue: 5
    Page numbers: 2264-2272
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  • Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility
    Year: 2007
    Journal: Endocrinology
    Volume: 148
    Issue: 8
    Page numbers: 3674-3684
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  • Men with Kennedy's disease have a reduced risk of androgenetic alopecia
    Year: 2007
    Journal: Australasian Journal of Dermatology
    Volume: 157
    Issue: 2
    Page numbers: 290-294
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  • Osteoblast Deletion of Exon 3 of the Androgen Receptor Gene Results in Trabecular Bone Loss in Adult MaleMice
    Year: 2007
    Journal: Journal of Bone & Mineral Research
    Volume: 22
    Issue: 3
    Page numbers: 347-356
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Publications in 2006

Journal Articles

  • Alkaline phosphatase: when to measure it and what to do next
    Year: 2006
    Journal: Medicine Today
    Volume: 3
    Issue: 2006
    Page numbers: 32-38
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  • Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice
    Year: 2006
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 291
    Issue: 2006
    Page numbers: E506-E516
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  • Double-Strand DNA Break Repair With Repllication Slippage on Two Strands: A Novel Mechanism of Deletion Formation
    Year: 2006
    Journal: Human Mutation
    Volume: 27
    Issue: 2006
    Page numbers: 483-489
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  • Effects of Amylin Deficiency on Trabecular Bone in Young Mice Are Sex-Dependent
    Year: 2006
    Journal: Calcified Tissue International
    Volume: 78
    Issue: 2006
    Page numbers: 398-403
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  • Severe combined hyperlipidaemia and retinal lipid infiltration in a patient with Type 2 diabetes mellitus.
    Year: 2006
    Journal: Lipids in Health and Disease
    Volume: 5
    Issue: 29
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Publications in 2005

Journal Articles

  • A controlled, prospective study of neuropsychological outcomes post parathyroidectomy in primary hyperparathyroid patients
    Year: 2005
    Journal: Clinical Endocrinology
    Volume: 62
    Page numbers: 99-104
    Publisher: Blackwell Science(Oxford)
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  • A long-term outcome study of intersex conditions.
    Year: 2005
    Journal: Journal of Pediatric Endocrinology and Metabolism
    Volume: 18
    Issue: 6
    Page numbers: 555-567
    Publisher: Freund Publishing House
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  • Age-dependent differences in androgen binding affinity in a family with spinal and bulbar muscular atrophy
    Year: 2005
    Journal: Neurological Research
    Volume: 27
    Issue: 5
    Page numbers: 548-551
    Publisher: Maney Publishing(Leeds)
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  • Androgen regulation of satellite cell function
    Year: 2005
    Journal: Journal of Endocrinology
    Volume: 186
    Page numbers: 21-31
    Publisher: Society of Endocrinology(Stokebristol)
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  • Can't cope with 'acopoa' - letters to the editor
    Year: 2005
    Journal: Internal Medicine Journal
    Volume: 35
    Page numbers: 1-1
    Publisher: Blackwell Science Asia(Carlton)
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  • Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model
    Year: 2005
    Journal: Journal of Molecular Endocrinology
    Volume: 35
    Page numbers: 547-555
    Publisher: Society for Endocrinology(Stokebristol)
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  • Hormonal therapies for individuals with intersex conditions
    Year: 2005
    Journal: Treatments in Endocrinology
    Volume: 4
    Issue: 1
    Page numbers: 19-29
    Publisher: Adis International(Bayauckland)
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Publications in 2004

Journal Articles

  • Alkaline phosphatase when to measure it and what to do next
    Year: 2004
    Journal: Medicine Today
    Volume: 5
    Issue: 12
    Page numbers: 43-46
    Publisher: Medicine Today
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  • Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
    Year: 2004
    Journal: Journal of Cell Biology
    Volume: 164
    Issue: 4
    Page numbers: 509-514
    Publisher: Rockefeller University Press(New York)
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  • Androgen deficiency and replacement therapy in men
    Year: 2004
    Journal: Medical Journal of Australia
    Volume: 180
    Page numbers: 529-535
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Application of differential display in the identification of androgen-regulated genes
    Year: 2004
    Journal: Endocrine Research
    Volume: 30
    Issue: 1
    Page numbers: 69-82
    Publisher: Marcel Dekker(New York)
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  • Genetically modified animal models as tools for studying bone and mineral metabolism
    Year: 2004
    Journal: Journal of Bone & Mineral Research
    Volume: 19
    Issue: 6
    Page numbers: 882-892
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  • Increased frequency of long androgen receptor CAG repeats in male breast cancers
    Year: 2004
    Journal: Breast Cancer Research and Treatment
    Volume: 88
    Page numbers: 239-246
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Kennedy's disease: pathogenesis and clinical approaches
    Year: 2004
    Journal: Internal Medicine Journal
    Volume: 34
    Page numbers: 279-286
    Publisher: Blackwell Science Asia(Carlton)
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  • Novel androgen receptor gene mutations in Australian patients with complete androgen insensitivity syndrome
    Year: 2004
    Journal: Human Mutation
    Volume: 23
    Issue: 3
    Page numbers: 287-292
    Publisher: Wiley-Liss(New York)
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  • Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease
    Year: 2004
    Journal: Journal of Neurology
    Volume: 251
    Page numbers: 35-41
    Publisher: DR Dietrich Steinkopff(Darmstadt)
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  • Transgenic mice that express cre recombinase in Osteoclasts
    Year: 2004
    Journal: Genesis
    Volume: 39
    Page numbers: 178-185
    Publisher: Wiley-Liss(New York)
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Publications in 2003

Journal Articles

  • Aberrant cryptic responsiveness of the pCAT 3- and pGL3-promoter reporter vectors
    Year: 2003
    Journal: Biotechniques
    Volume: 35
    Issue: 2
    Page numbers: 2-7
    Publisher: Eaton Publishing Group(Massachusetts)
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  • Biochemical measurements in osteoporosis
    Year: 2003
    Journal: Australian Doctor
    Issue: April
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  • Endocrinology in the 21st century
    Year: 2003
    Journal: Medical Journal of Australia
    Volume: 179
    Issue: 6 October 2003
    Page numbers: 378
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Identification of a Parathyroid Hormone in the fish Fugu rubripes
    Year: 2003
    Journal: Journal of Bone & Mineral Research
    Volume: 18
    Issue: 7
    Page numbers: 1326-1331
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  • Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney
    Year: 2003
    Journal: Diabetologia
    Volume: 123
    Page numbers: 456-789
    Publisher: Springer Verlag(New York)
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  • The public hospital of the future
    Year: 2003
    Journal: Medical Journal of Australia
    Volume: 179
    Issue: 5
    Page numbers: 250 - 252
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Threshold effects of glucose transporter-4 (GLUT-4) deficiency on cardiac glucose uptake and development of hypertrophy
    Year: 2003
    Journal: Journal of Molecular Endocrinology
    Volume: 31
    Page numbers: 449-459
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Publications in 2002

Journal Articles

  • Local secretion of parathyroid hormone-related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition
    Year: 2002
    Journal: Bone
    Volume: 31
    Issue: 5
    Page numbers: 598-605
    Publisher: Elsevier Science(New York)
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  • Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase
    Year: 2002
    Journal: Endocrine
    Volume: 18
    Page numbers: 47-56
    Publisher: Humana Press(New Jersey)
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Publications in 2001

Book Chapters

  • Evaluation of a child with ambiguous genitalia: A practical guide to diagnosis and management
    Year: 2001
    Book: Paediatric Endocrine Disorders
    Publisher: Orient Longman(New Delhi)
    Authors(s):

Journal Articles

  • A case-control study of the androgen receptor gene CAG repeat polymorphism in Australian prostate carcinoma subjects
    Year: 2001
    Journal: Cancer
    Volume: 92
    Page numbers: 941-949
    Publisher: John Wiley & Sons(New York)
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  • Low-intensity pulsed ultrasound stimulates a bone-forming response in UMR-106 cells
    Year: 2001
    Journal: Biochemical and Biophysical Research Communications
    Volume: 286
    Issue: 3
    Page numbers: 443-450
    Publisher: Academic Press(California)
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  • Relationships with serum parathyroid hormone in old institutionalized subjects
    Year: 2001
    Journal: Clinical Endocrinology
    Volume: 54
    Page numbers: 583-592
    Publisher: Blackwell Science(Oxford)
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