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PROF MAURO SANDRIN



Contact Details

Organization: Surgery - Austin Health and Northern Health
Position: NH&MRC SENIOR PRINCIPAL RESEARCH FELLOW
Email:
Work: 03 94963671
Fax: 03 92870604
Room: 8.4
Level: 01
Building: Lance Townsend Building
Campus: Austin Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Transplantation Immunobiology Transplantation, Immunology, Xenotransplantation Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctorate of Science University of Melbourne 31-Dec-1999
Bachelor of Science University of Melbourne 31-Dec-1976
Doctor of Philosophy University of Melbourne 31-Dec-1979

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Immunology ASI 01-Jan-1976 31-Dec-2006
Member Transplantation Society Transplantation Member 01-Jan-1980 31-Dec-2006
Member American Association of Immunologists AAI 01-Jan-1980 31-Dec-2006
Member Transplantation Society of Australian and New Zealand TSANZ 01-Jan-1990 31-Dec-2006
Member Australian Society for Biochemistry and Molecular Biology ASBMB 01-Jan-1990 31-Dec-2006
Member Immunology and Cell Biology Editorial Board Membership 01-Jan-1990 31-Dec-2006
Member Transplantation Editorial Board Membership 01-Jan-1992 31-Dec-2006
Member Transplantation Editorial Board Membership 01-Jan-1994 31-Dec-2006
Member Frontiers in Bioscience Editorial Board Membership 01-Jan-1995 31-Dec-2006
Member International Xenotransplantation Association IXA 01-Jan-1996 31-Dec-2006
Member American Society for Biochemistry and Molecular Biology ASBMB 01-Jan-2002 31-Dec-2006

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Glaxo Wellcome Australia Glaxo Wellcome Australia Medal 31-Dec-1997

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
INNATE CELLULAR LECTIN-MEDIATED BINDING OF XENOGENIC ANTIGENS Chief Investigator UNIVERSITY OF TOLEDO Research Project Grants (NATIONAL INSTITUTE OF HEALTH) 09/09/2005
TOLERANCE INDUCTION TO PORCINE ISLET XENOGRAFTS Chief Investigator NHMRC Project Grants 01/01/2006
NHMRC RESEARCH FELLOWSHIP TRANSFER IN - PROF MAURO SANDRIN Chief Investigator NHMRC Research Fellowship 01/01/2006
DOES GALALPHA(1,3)GAL STILL PLAY A ROLE IN XENOGRAFT DESTRUCTION AFTER THE PRODUCTION OF GAL KNOCKOUT PIGS? Chief Investigator NHMRC Project Grants 01/01/2006
INNATE CELLULAR LECTIN-MEDIATED BINDING OF XENOGENIC ANTIGENS Chief Investigator UNIVERSITY OF TOLEDO Research Project Grants (NATIONAL INSTITUTE OF HEALTH) 01/09/2006
FLOUSTAR OPTIMA Chief Investigator PERPETUAL TRUSTEES AUST LTD Clive & Vera Ramaciotti Equipment Grants 01/01/2007
A PRE-CLINICAL XENOTRANSPLANTATION MODEL OF INSULIN DEPENDENT DIABETES Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2007
Studies on mechanisms of atherosclerosis in chronic renal failure Chief Investigator SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION Medical Research Grants 27/06/2008
Purchase of Leica DM4000 B Research Microscope Chief Investigator PERPETUAL TRUSTEES AUST LTD MISCELLANEOUS TRUSTS 30/06/2008
The Role of Carbohydrates in Transplantation Chief Investigator NHMRC Project Grants 01/01/2009
NHMRC Research Fellowship 2009 - SANDRIN Chief Investigator NHMRC Research Fellowship 01/01/2009
Determining factors which could lead to survival of pig-to-human transplants Principal Supervisor NHMRC Scholarships 01/01/2009
TOLARENCE INDUCTION TO PORCINE ISLETS IN PRECLINICAL TRANSPLANT MODELS Principal Supervisor ROYAL AUSTRALASIAN COLLEGE OF SURGEONS John Loewenthal Research Fellowship

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Transplantation immunobiology: two important themes


    Year: 2009
    Journal: Immunology and Cell Biology
    Volume: 87
    Page numbers: 194
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  • Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth
    Year: 2009
    Journal: Biochimica et Biophysica Acta - Molecular Cell Research
    Volume: 1793
    Issue: 3
    Page numbers: 477-488
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Publications in 2008

Journal Articles

  • Differential cytokine expression and regulation of human anti-pig xenogeneic responses by modified porcine dendritic cells


    Year: 2008
    Journal: Xenotransplantation
    Volume: 15
    Issue: 4
    Page numbers: 257-267
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  • Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D


    Year: 2008
    Journal: Xenotransplantation
    Volume: 15
    Page numbers: 321-332
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  • Antibody-ligand docking: insights into peptide-carbohydrate mimicry
    Year: 2008
    Journal: Molecular Simulation
    Volume: 34
    Issue: 4
    Page numbers: 461-468
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  • Humans Lack iGb3 Due to the Absence of Functional iGb3-Synthase: Implications for NKT Cell Development and Transplantation
    Year: 2008
    Journal: PLoS Biology
    Volume: 6
    Issue: 7
    Page numbers: 1527-1538
    Author(s):
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  • Local expression of IDO, either alone or in combination with CD40Ig, IL10 or CTLA4Ig, inhibits indirect xenorejection responses
    Year: 2008
    Journal: Xenotransplantation
    Volume: 155
    Page numbers: 174-183
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  • Reply to "Response to Milland et al.: Carbohydrate residues downstream of the terminal galalpha(1,3)gal epitope modulate the specificity of xenoreactive antibodies
    Year: 2008
    Journal: Immunology and Cell Biology
    Volume: 86
    Page numbers: 633-634
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  • Suppression of cytotoxic and proliferative xenogeneic T-cell responses by transgenic expression of indoleamine 2,3-diaxygenase
    Year: 2008
    Journal: Immunology and Cell Biology
    Volume: 86
    Page numbers: 460-465
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Publications in 2007

Journal Articles

  • Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies
    Year: 2007
    Journal: Immunology and Cell Biology
    Volume: 1
    Page numbers: 1-10
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  • Development of an anti-porcine CD34 monoclonal antibody that identifies hematopoietic stem cells
    Year: 2007
    Journal: Experimental Hematology
    Volume: 35
    Page numbers: 171-178
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  • Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat
    Year: 2007
    Journal: Journal of Comparative Neurology
    Volume: 501
    Page numbers: 70-82
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  • Gal knockout pigs: any more carbohydrates
    Year: 2007
    Journal: Transplantation
    Volume: 84
    Issue: 1
    Page numbers: 8-9
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  • Response to valdes-gonzalez "clinical trial of islet xenotransplantation in mexico"
    Year: 2007
    Journal: Xenotransplantation
    Volume: 14
    Issue: 1
    Page numbers: 90-91
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  • Spectrum of the early xenograft response: from hyperacute rejection to delayed xenograft injury
    Year: 2007
    Journal: Critical Reviews in Immunology
    Volume: 27
    Issue: 2
    Page numbers: 153-166
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  • The biology of alpha-gal
    Year: 2007
    Journal: Xenotransplantation
    Volume: 14
    Issue: 2
    Page numbers: 176
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Publications in 2006

Journal Articles

  • ABO blood group and related antigens, natural antibodies and transplantation
    Year: 2006
    Journal: Tissue Antigens
    Volume: 68
    Page numbers: 459-466
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  • Clinical trial of islet xenotransplantation in Mexico
    Year: 2006
    Journal: Xenotransplantation
    Volume: 13
    Page numbers: 371-372
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  • Lentiviral expression of CTLA4Ig inhibits primed xenogeneic lymphocyte proliferation and cytokine responses
    Year: 2006
    Journal: Xenotransplantation
    Volume: 13
    Page numbers: 248-252
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  • Symposium on Ethical Aspects of Xenotransplantation
    Year: 2006
    Journal: Xenotransplantation
    Volume: 13
    Page numbers: 500-513
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  • The molecular basis for Galalpha(1,3)Gal expression in animals with a deletion of the alpha1,3 galactosyltransferase gene.
    Year: 2006
    Journal: Journal of Immunology
    Volume: 176
    Issue: 4
    Page numbers: 2448-2454
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Publications in 2004

Journal Articles

  • International cooperation on xenotransplantation
    Year: 2004
    Journal: Nature Medicine
    Volume: 10
    Page numbers: 119
    Publisher: Nature America(New York)
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  • World Health Organization resolution on xenotransplantation
    Year: 2004
    Journal: Xenotransplantation
    Volume: 11
    Page numbers: 224-225
    Publisher: Munksgaard International Publishers(Oxford)
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Publications in 2003

Journal Articles

  • A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death
    Year: 2003
    Journal: Journal of Cell Biology
    Volume: 160
    Issue: 2
    Page numbers: 223-233
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  • CD46 protects pig islets from antibody but not cell-mediated destruction in the mouse
    Year: 2003
    Journal: Xenotransplantation
    Volume: 10
    Page numbers: 615-621
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  • Characterization of the rat α(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galα(1,3)Gal by two separate glycosylation pathways
    Year: 2003
    Journal: Glycobiology
    Volume: 13
    Issue: 5
    Page numbers: 327-337
    Publisher: Oxford University Press(North Carolina)
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  • Evidence for structurally conserved recognition of the major carbohydrate xenoantigen by natural antibodies
    Year: 2003
    Journal: Cellular and Molecular Biology
    Volume: 49
    Issue: 2
    Page numbers: 307-317
    Publisher: RJ Wegmann
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  • Guidelines to xenotransplantation
    Year: 2003
    Journal: New England Journal of Medicine
    Volume: 349
    Issue: 13
    Page numbers: 1294-1295
    Publisher: Massachusetts Medical Society(Massachusetts)
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  • The ethics of xenotransplantation: position paper of the Ethics Committee of the International Xenotransplantation Association
    Year: 2003
    Journal: Xenotransplantation
    Volume: 10
    Page numbers: 194-203
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Publications in 2002

Journal Articles

  • Histidine 271 has a functional role in pig alpha-1,3galactosyltransferase enzyme activity
    Year: 2002
    Journal: Glycobiology
    Volume: 12
    Issue: 12
    Page numbers: 793-802
    Publisher: Oxford University Press(North Carolina)
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  • Reduction of alpha-Gal expression by relocalizing alpha-galactosidase to the trans-Golgi network and cell surface
    Year: 2002
    Journal: Glycobiology
    Volume: 12
    Page numbers: 729-739
    Publisher: Oxford University Press(North Carolina)
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  • The cytoplasmic tail of α1,3-galactosyltransferase inhibits golgi localization of the full-length enzyme
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 10374-10378
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Publications in 2001

Journal Articles

  • Characteristics of immunoglobulin gene usage of the xenoantibody binding to gal-alpha (1,3)gal target antigens in the gal knockout mouse
    Year: 2001
    Journal: Transplantation
    Volume: 72
    Issue: 1
    Page numbers: 147-155
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • LFA-1 and ICAM-1 antibody-idarubicin conjugates separately prolong murine cardiac allograft survival
    Year: 2001
    Journal: Transplant Immunology
    Volume: 9
    Issue: 1
    Page numbers: 7-11
    Publisher: Elsevier Science
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  • The cytoplasmic tail of alpha 1,2-fucosyltransferase contains a sequence for golgi localization
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 15
    Page numbers: 12012-12018
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  • Tolerance in baboon kidney transplantation with total lymphoid irradiation (TLI) and anti-CD3/CD4-idarubicin conjugates
    Year: 2001
    Journal: Transplantation
    Volume: 72
    Issue: 6
    Page numbers: 1150-1152
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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