PROF MARK HARGREAVES

Contact Details

Organization:	Physiology
Position:	HEAD OF DEPARTMENT
Email:
Homepage:	http://www.physiology.unimelb.edu.au/MuscleExercise/muscleexercise.asp
Work:	83448007
Fax:	83445818
Room:	N603
Level:	06
Building:	Medical Centre
Campus:	Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest	Key Words	Country of Expertise
Exercise Physiology and Metabolism	skeletal muscle metabolism	Australia
Exercise Metabolism	GLUT4, muscle glycogen	Australia

International Linkages

Country	Establishment	Collaboration
United Kingdom	University of Dundee	Research, Technical Assistance/Training
Denmark	Copenhagen University	Research, Technical Assistance/Training
United States	University of Oklahoma	Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title	Institution	Date Awarded
Bachelor of Science	University of Melbourne	27-Mar-1982
Master of Arts	Ball State University	26-May-1984
Doctor of Philosophy	University of Melbourne	13-Sep-1989

Memberships

Membership Type	Membership Body	Description	Start Date
Member	Australian Physiological Society	Regular Member	01-Jan-1989
Member	American Physiological Society	Regular Member	01-Jan-2001
Member	American College of Sports Medicine	Fellow	01-Jan-1992
Member	Australian Association of Exercise and Sports Science	Regular Member	13-Oct-1996
Member	The Physiological Society	Regular Member	01-Jan-2005
Member	Sports Medicine Australia	Member	01-Jan-1996

Fellowships

Fellowship	Date Awarded
Fellow, Australian Association for Exercise and Sports Science (FAAESS)	08-Sep-2006
Fellow of the American College of Sports Medicine (FACSM)	31-May-1995

Other Awards

Award Type	Awarding Body	Comments	Date Awarded
Prize	Australian Physiological Society	AK McIntyre Prize	27-Sep-1994
Other (Award)	American College of Sports Medicine	New Investigator Award	03-Jun-1994

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Endocrine organs and diseases (incl. Diabetes) (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730105)
Skeletal system and disorders (incl. Arthritis) (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730114)
Organs, diseases & abnormal conditions not elsewhere classified (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730118)
Clin health not spec to partlar organs, diseases & condits (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730199)
Preventive medicine (PUBLIC HEALTH) (730213)
Biological sciences (NON-ORIENTED RESEARCH) (780105)

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title	Role	Funding Source	Scheme	Award Date
DOES AN ACUTE BOUT OF EXERCISE ACTIVATE SKELETAL MUSCLE MITOCHONDRIAL BIOGENESIS AND GLUT-4 EXPRESSION NORMALLY IN PEOPLE WITH TYPE 2 DIABETES?	Chief Investigator	DIABETES AUST RESEARCH TRUST	Research Grants	01/01/2006
INTRACELLULAR LOCALISATION OF INSULIN SIGNALLING PROTEINS IN HUMAN SKELETAL MUSCLE FOLLOWING EXERCISE	Chief Investigator	DEAKIN UNIVERSITY	Discovery Projects (AUST RESEARCH COUNCIL)	24/03/2006
EXERCISE TRAINING, ADIPOSE TISSUE GLUT4 AND ADIPOKINES IN TYPE 2 DIABETES	Chief Investigator	DIABETES AUST RESEARCH TRUST	Research Grants	01/01/2007
Exercise training in insulin resistance: role of HSP70 and HDAC5	Chief Investigator	DIABETES AUST RESEARCH TRUST	Research Grants	06/11/2008

Contracts

Title	Role	Funding Source	Award Date
AN EXAMINATION OF THE INFLUENCE OF INGESTED CARBOHYDRATE ON FLUID BIOAVAILABILITY DURING EXERCISE	Chief Investigator	THE QUAKER OATS COMPANY	01/02/2005
SKELETAL MUSCLE MODIFICATIONS WITH EXERCISE AND ERGOGENIC SUPPLEMENTS	Chief Investigator	DEFENCE SCIENCE & TECHNOLOGY ORGANISATION	15/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Book Chapters

Performance limitations due to substrate availability

Year:	2008
Book:	Physiological Bases of Human Performance During Work and Exercise
Publisher:	Churchill Livingstone Elsevier(London)
Authors(s):
Editors(s):

Journal Articles

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

Year:	2008
Journal:	Diabetes
Volume:	57
Issue:	4
Page numbers:	860-867
Author(s):
Super Search	locate this resource.

AMPK and transcriptional regulation

Year:	2008
Journal:	Frontiers in Bioscience
Volume:	13
Page numbers:	3022-3033
Author(s):
Super Search	locate this resource.

Effect of sex differences on human MEF2 regulation during endurance exercise

Year:	2008
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	294
Issue:	2
Page numbers:	E408-E415
Author(s):
Super Search	locate this resource.

Fatigue mechanisms determining exercise performance: integrative physiology is systems biology

Year:	2008
Journal:	Journal of Applied Physiology
Volume:	104
Page numbers:	1541-1542
Author(s):
Super Search	locate this resource.

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

Year:	2008
Journal:	Diabetologia
Volume:	51
Page numbers:	1893-1900
Author(s):
Super Search	locate this resource.

Physiological limits to exercise performance in the heat

Year:	2008
Journal:	Journal of Science and Medicine in Sport
Volume:	11
Page numbers:	66-71
Author(s):
Super Search	locate this resource.

Resolving fatigue mechanisms determining exercise performance: integrative physiology at its finest!

Year:	2008
Journal:	Journal of Applied Physiology
Volume:	104
Issue:	1
Page numbers:	286-287
Author(s):
Super Search	locate this resource.

Publications in 2007

Journal Articles

Increased insulin-stimulated Akt pSer⁴⁷³ and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training

Year:	2007
Journal:	Journal of Applied Physiology
Volume:	102
Issue:	6
Page numbers:	1624-1631
Author(s):
Super Search	locate this resource.

Reduced plasma free fatty acid availability during exercise: effect on gene expression

Year:	2007
Journal:	European Journal of Applied Physiology
Volume:	99
Page numbers:	485-493
Author(s):
Super Search	locate this resource.

Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

Year:	2007
Journal:	Diabetes
Volume:	56
Page numbers:	1608-1614
Author(s):
Super Search	locate this resource.

Publications in 2006

Book Chapters

Skeletal muscle carbohydrate metabolism during exercise

Year:	2006
Book:	Exercise Metabolism
Publisher:	Human Kinetics(Illinois)
Authors(s):
Editors(s):

Overview of Exercise Metabolism

Year:	2006
Book:	Exercise Metabolism
Publisher:	Human Kinetics(Illinois)
Authors(s):
Editors(s):

Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation

Year:	2006
Book:	Essays in Biochemistry: The Biochemical Basis of the Health Effects of Exercise
Publisher:	Portland Press
Authors(s):
Editors(s):

The Metabolic Systems: Carbohydrate Metabolism

Year:	2006
Book:	ACSM's Advanced Exercise Physiology
Publisher:	Lippincott Williams & Wilkins(Baltimore)
Authors(s):
Editors(s):

The Metabolic Systems: Interaction of Lipid and Carbohydrate Metabolism

Year:	2006
Book:	ACSM's Advanced Exercise Physiology
Publisher:	Lippincott Williams & Wilkins(Baltimore)
Authors(s):
Editors(s):

Journal Articles

Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity

Year:	2006
Journal:	Journal of Applied Physiology
Volume:	101
Page numbers:	934-937
Author(s):
Super Search	locate this resource.

Carbohydrate ingestion does not alter skeletal muscle AMPK signaling during exercise in humans

Year:	2006
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	291
Page numbers:	E566-E573
Author(s):
Super Search	locate this resource.

Decreased PDH activation and glycogenolysis during exercise following fat adptation with carbohydrate restoration

Year:	2006
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	290
Page numbers:	E380-E388
Author(s):
Super Search	locate this resource.

Effect of exercise intensity and hypoxia on skeletal muscle AMPH signaling and substrate metabolism in humans

Year:	2006
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	290
Page numbers:	E694-E702
Author(s):
Super Search	locate this resource.

Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms

Year:	2006
Journal:	Clinical and Experimental Pharmacology and Physiology
Volume:	33
Page numbers:	395-399
Author(s):
Super Search	locate this resource.

Exercise does not alter subcellular localization, but increases phosphorylation of insulin-signalling proteins in human skeletal muscle

Year:	2006
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	290
Page numbers:	E341-E346
Author(s):
Super Search	locate this resource.

Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle

Year:	2006
Journal:	FASEB Journal
Volume:	20
Page numbers:	348-349
Author(s):
Super Search	locate this resource.

Insulin-stimulated insulin receptor substrate-2 -associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise

Year:	2006
Journal:	Metabolism: Clinical and Experimental
Volume:	55
Page numbers:	1046-1052
Author(s):
Super Search	locate this resource.

Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

Year:	2006
Journal:	Applied Physiology, Nutrition and Metabolism
Volume:	31
Issue:	3
Page numbers:	302-312
Author(s):
Super Search	locate this resource.

Publications in 2005

Journal Articles

Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression

Year:	2005
Journal:	Journal of Applied Physiology
Volume:	99
Issue:	4
Page numbers:	1359-1363
Author(s):
Super Search	locate this resource.

Heat stress, cytokines, and the immune response to exercise

Year:	2005
Journal:	Brain, Behavior and Immunity
Volume:	19
Issue:	5
Page numbers:	404-412
Publisher:	Academic Press
Author(s):
Super Search	locate this resource.

Publications in 2004

Journal Articles

Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction

Year:	2004
Journal:	FASEB Journal
Volume:	18
Page numbers:	1785-1787
Author(s):
Super Search	locate this resource.

Effect of exercise on protein kinase C activity and localization in human skeletal muscle

Year:	2004
Journal:	The Journal of Physiology
Volume:	561
Page numbers:	861-870
Author(s):
Super Search	locate this resource.

Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle

Year:	2004
Journal:	Experimental Physiology
Volume:	89
Page numbers:	559-563
Author(s):
Super Search	locate this resource.

Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle

Year:	2004
Journal:	Diabetes
Volume:	53
Page numbers:	1208-1214
Author(s):
Super Search	locate this resource.

Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting

Year:	2004
Journal:	Journal of Applied Physiology
Volume:	96
Page numbers:	2082-2087
Author(s):
Super Search	locate this resource.

Publications in 2003

Journal Articles

A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle^1-3

Year:	2003
Journal:	American Journal of Clinical Nutrition
Volume:	77
Page numbers:	313-318
Author(s):
Super Search	locate this resource.

Effect of alcohol intake on muscle glycogen storage after prolonged exercise

Year:	2003
Journal:	Journal of Applied Physiology
Volume:	95
Page numbers:	983-990
Author(s):
Super Search	locate this resource.

Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men

Year:	2003
Journal:	Medicine and Science in Sports and Exercise
Volume:	35
Page numbers:	69-74
Author(s):
Super Search	locate this resource.

Effect of exercise intensity on skeletal muscle AMPK signaling in humans

Year:	2003
Journal:	Diabetes
Volume:	52
Page numbers:	2205-2212
Author(s):
Super Search	locate this resource.

Exercise increases Ca²⁺-calmodulin-dependent protein kinase II activity in human skeletal muscle

Year:	2003
Journal:	The Journal of Physiology
Volume:	553
Issue:	1
Page numbers:	303-309
Author(s):
Super Search	locate this resource.

Exercise increases nuclear AMPK α₂ in human skeletal muscle

Year:	2003
Journal:	Diabetes
Volume:	52
Page numbers:	926-928
Author(s):
Super Search	locate this resource.

Publications in 2002

Journal Articles

Adaptations to short-term high-fat diet persist during exercise despite high carbohydrate availability

Year:	2002
Journal:	Medicine and Science in Sports and Exercise
Volume:	34
Page numbers:	83-91
Author(s):
Super Search	locate this resource.

Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man

Year:	2002
Journal:	The Journal of Physiology
Volume:	544
Issue:	3
Page numbers:	949-956
Author(s):
Super Search	locate this resource.

Effect of epinephrine on glucose disposal during exercise in humans: role of muscle glycogen

Year:	2002
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	283
Page numbers:	E578-E583
Author(s):
Super Search	locate this resource.

Exercise training increases lipid metabolism gene expression in human skeletal muscle

Year:	2002
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	283
Page numbers:	E66-E72
Author(s):
Super Search	locate this resource.

Exercise, diet, and skeletal muscle gene expression

Year:	2002
Journal:	Medicine and Science in Sports and Exercise
Volume:	34
Page numbers:	1505-1508
Author(s):
Super Search	locate this resource.

Plasma glucose kinetics during prolonged exercise in trained humans when fed carbohydrate

Year:	2002
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	283
Page numbers:	E573-E577
Author(s):
Super Search	locate this resource.

Publications in 2001

Journal Articles

Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans

Year:	2001
Journal:	The Journal of Physiology
Volume:	534
Issue:	1
Page numbers:	269-278
Author(s):
Super Search	locate this resource.

Carbohydrate metabolism during exercise in females: Effect of reduced fat availability

Year:	2001
Journal:	Metabolism: Clinical and Experimental
Volume:	50
Issue:	4
Page numbers:	481-487
Author(s):
Super Search	locate this resource.

Differential effects of exercise on insulin-signaling gene expression in human skeletal muscle

Year:	2001
Journal:	Journal of Applied Physiology
Volume:	90
Page numbers:	436-440
Author(s):
Super Search	locate this resource.

Effect of carbohydrate ingestion on glucose kinetics during exercise in the heat

Year:	2001
Journal:	Journal of Applied Physiology
Volume:	90
Issue:	2
Page numbers:	601-605
Author(s):
Super Search	locate this resource.

Effect of prior exercise on glucose metabolism in trained men

Year:	2001
Journal:	American Journal of Physiology - Endocrinology and Metabolism
Volume:	281
Page numbers:	E766-E771
Author(s):
Super Search	locate this resource.

No effect of mild heat stress on the regulation of carbohydrate metabolism at the onset of exercise

Year:	2001
Journal:	Journal of Applied Physiology
Volume:	91
Issue:	5
Page numbers:	2282-2288
Author(s):
Super Search	locate this resource.

Find an ExpertProfiling the University of Melbourne's Researchers

Find an Expert

PROF MARK HARGREAVES

Contact Details

Research Expertise and International Linkages

Research Expertise

International Linkages

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Memberships

Fellowships

Other Awards

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Grants

Contracts

Publications

Publications in 2008

Book Chapters

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Book Chapters

Journal Articles

Publications in 2005

Journal Articles

Publications in 2004

Journal Articles

Publications in 2003

Journal Articles

Publications in 2002

Journal Articles

Publications in 2001

Journal Articles