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PROF JOSEPH PROIETTO



Contact Details

Organization: Medicine - Austin Health and Northern Health
Position: SIR EDWARD DUNLOP CHAIR OF MEDICINE
Email:
Work: 9496 2250
Fax: 9497 4554
Level: Ground
Building: No Building
Campus: Repatriation Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Diabetes insulin resistance, beta cell function, management strategies Australia
Obesity Hypothalamic function, spontaneous activity, management strategies Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medicine and Bachelor of Surgery University of Melbourne 31-Dec-1973
Doctor of Philosophy University of Melbourne 31-Dec-1985

Memberships

Membership Type Membership Body Description Start Date End Date
Member ADS Australian Diabetes Society 01-Jan-2006
Member ASSO Australasian Society for the Study of Obesity 01-Jan-2006
Member ESA Endocrine Society of Australia 01-Jan-2006
Member ADPS Australian Diabetes in Pregnancy Society 01-Jan-2006
Member AMA Australian Medical Association 01-Jan-2006
Member ADA American Diabetes Association 01-Jan-2006
Member EASD European Association for the Study of Diabetes 01-Jan-2006

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 01-Jan-1982

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
The use of a high protein diet in achieving long-term weight maintenance and improved cardiovascular risk factors in overweight and obese men & women Chief Investigator MEAT & LIVESTOCK AUSTRALIA LTD MLA Out of Session/Special Funding (MEAT & LIVESTOCK AUST LTD) 01/03/2003
Does insulin cause obesity by inducing leptin insensitivity? Chief Investigator SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION Medical Research Grants 01/01/2005
CELLULAR MECHANISMS AND PHYSIOLOGICAL ROLES OF GLUT12 MEDIATED GLUCOSE TRANSPORT IN GLUCOSE HOMEOSTASIS Chief Investigator NHMRC Project Grants 01/01/2005
INVESTIGATION OF THE FUNCTION OF SEL S A NOVEL SELENOPROTEIN Chief Investigator CHEMGENEX PHARMACEUTICALS LIMITED,
AUST RESEARCH COUNCIL
Linkage Projects (AUST RESEARCH COUNCIL) 01/01/2006
Study of the Mechanisms of Obesity, and insulin resistance in transgenic rats overexpressing PEPCK Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
IMPROVEMENT IN HEPATIC INSULIN SENSITIVITY IN LIVER SPECIFIC SOCS KNOCKOUT MICE Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
INVESTIGATION OF THE IMPORTANCE OF FIRST-PHASE INSULIN SECRETION ON GLUCOSE TOLERANCE AND INSULIN RESISTANCE Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
INVESTIGATION OF THE IMPACT OF MUSCLE GLUCOSE STORAGE DEFECT ON GLUCOSE METABOLISM Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2007
Investigating physiological adaptations leading to weight regain after weight loss Principal Supervisor THE ENDOCRINE SOCIETY OF AUSTRALIA Researcher Higher Degree Scholarship 01/01/2007
Why it's hard to lose weight and keep it off Chief Investigator NHMRC Project Grants 01/01/2008
INVESITGATION OF THE ROLE OF NEPRILYSIN IN INSULIN SECRETION AND PANCREATIC BETA-CELL DYSFUNCTION Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2008
Understanding how obesity and abnormal lipids are linked Chief Investigator NHMRC Project Grants 01/01/2009
Is there an optimal rate of weight loss for long term success? Chief Investigator NHMRC Project Grants 01/01/2010

Contracts

Title Role Funding Source Award Date
A double blind, randomised, placebo controlled, multicentre study to assess the safety,tolerability & efficacy of MK0557 in combination with sibutramine or orlistat in obese subjects Chief Investigator MERCK SHARP & DOHME 09/06/2004
INVESTIGATION OF THE MECHANISM OF ACTION ASF402 ON INSULIN SENSITIVITY Chief Investigator MONASH UNIVERSITY 09/03/2006
CONSULTANCY WITH HOFFMAN LA ROCHE - FBPASE SUPPRESSION Chief Investigator HOFFMAN-LA ROCHE INC 01/03/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • One-year weight maintenance after significant weight loss in health overweight and obese subjects:  does diet composition matter?


    Year: 2009
    Journal: American Journal of Clinical Nutrition
    Volume: 90
    Issue: 5
    Page numbers: 1203-1214
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  • When does severe childhood obesity become a child protection issue?


    Year: 2009
    Journal: Medical Journal of Australia
    Volume: 190
    Issue: 11
    Page numbers: 653-654
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  • Effects and clinical potential of very-low-calorie diets (VLCDs) in type 2 diabetes
    Year: 2009
    Journal: Diabetes Research and Clinical Practice
    Volume: 85
    Issue: 3
    Page numbers: 235-242
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Publications in 2008

Journal Articles

  • Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion


    Year: 2008
    Journal: Diabetes
    Volume: 57
    Issue: 2007
    Page numbers: 1887-1895
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  • Identification of the Alzheimer’s disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth


    Year: 2008
    Journal: Journal of Pathology
    Volume: 215
    Issue: 2008
    Page numbers: 155-163
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  • Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver


     


     


    Year: 2008
    Volume: 295
    Page numbers: E1132-E1141
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  • Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes
    Year: 2008
    Journal: JAMA - Journal of the American Medical Association
    Volume: 299
    Issue: 3
    Page numbers: 316-323
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  • Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations1-3
    Year: 2008
    Journal: American Journal of Clinical Nutrition
    Volume: 87
    Issue: 5
    Page numbers: 1238-1246
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  • Evaluating the glucose tolerance test in mice
    Year: 2008
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 295
    Page numbers: E1323-E1332
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  • Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention
    Year: 2008
    Journal: Journal of Molecular and Cellular Cardiology
    Volume: 44
    Issue: 2008
    Page numbers: 270-280
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  • Insulin may have a role to play in protecting beta cells from deterioration in diabetes. Reply to Del Parigi A [letter]
    Year: 2008
    Journal: Diabetologia
    Volume: 51
    Issue: 2008
    Page numbers: 1341-1342
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  • Ketogenic diets for weight loss: A review of their principles, safety and efficacy

    Year: 2008
    Journal: Obesity Research & Clinical Practice
    Volume: 2
    Issue: 2008
    Page numbers: 1-13
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  • Reduction of proteinuria by rosiglitazone in non-diabetic renal disease
    Year: 2008
    Journal: Nephrology
    Volume: 13
    Issue: 2008
    Page numbers: 58-62
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  • Safe year-long use of a very-low-calorie diet for the treatment of severe obesity
    Year: 2008
    Journal: Medical Journal of Australia
    Volume: 188
    Issue: 6
    Page numbers: 366-368
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  • Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin
    Year: 2008
    Journal: Diabetologia
    Volume: 51
    Issue: 2008
    Page numbers: 540-545
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Publications in 2007

Journal Articles

  • Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity


    Year: 2007
    Journal: Diabetes Obesity & Metabolism
    Volume: 5
    Issue: 6
    Page numbers: 840-852
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  • The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo


    Year: 2007
    Journal: Journal of Molecular and Cellular Cardiology
    Volume: 42
    Issue: 2007
    Page numbers: 1119-1128
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  • In vivo quantification of fat content in mice using the Hologic QDR 4500A densitometer
    Year: 2007
    Journal: Obesity Research & Clinical Practice
    Volume: 1
    Page numbers: 69-77
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  • Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes
    Year: 2007
    Journal: Diabetologia
    Volume: 50
    Issue: 2007
    Page numbers: 2476-2485
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  • NPY5R Antagonism Does Not Augment the Weight Loss Efficacy of Orlistat or Sibutramine
    Year: 2007
    Journal: Obesity
    Volume: 15
    Issue: 2007
    Page numbers: 2027-2042
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Publications in 2006

Journal Articles

  • Of mice and men : the evolving phenotype of aromatase deficiency


    Year: 2006
    Journal: Trends in Endocrinology and Metabolism
    Volume: 17
    Issue: 2006
    Page numbers: 55-64
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  • Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis
    Year: 2006
    Journal: Endocrinology
    Volume: 147
    Issue: 2006
    Page numbers: 2764-2772
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  • Insulin levels in insulin resistance: phantom of the metabolic opera?
    Year: 2006
    Journal: Medical Journal of Australia
    Volume: 185
    Issue: 2006
    Page numbers: 159-161
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  • Of mice and men: the evolving phenotype of aromatase deficiency.
    Year: 2006
    Journal: Trends in Endocrinology and Metabolism
    Volume: 17
    Issue: 2
    Page numbers: 55-64
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  • Safety of Drug Therapies Used for Weight Loss and Treatment of Obesity
    Year: 2006
    Journal: Expert Opinion on Drug Safety
    Volume: 29
    Issue: 2006
    Page numbers: 277-302
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  • State of the science: (Very Low Energy Diet) for obesity
    Year: 2006
    Journal: Asia Pacific Journal of Clinical Nutrition
    Volume: 15
    Issue: 2006
    Page numbers: 49-54
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  • The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets
    Year: 2006
    Journal: Diabetologia
    Volume: 49
    Issue: 2006
    Page numbers: 1254-1263
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  • Treatment of Mild to Moderate Obesity with Laparoscopic Adjustable Gastric Banding or an Intensive Medical Program
    Year: 2006
    Journal: Annals of Internal Medicine
    Volume: 144
    Issue: 2006
    Page numbers: 625-633
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  • Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Year: 2006
    Journal: Cell Metabolism
    Volume: 4
    Issue: 6
    Page numbers: 465-74
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Publications in 2005

Journal Articles

  • Socs 1 deficiency enhances hepatic insulin signaling
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 31516-31521
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Effect of orlistat on cardiovascular disease risk in obese adults


    Year: 2005
    Journal: Diabetes Obesity & Metabolism
    Volume: 7
    Issue: 2005
    Page numbers: 54-262
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  • Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet
    Year: 2005
    Journal: Journal of Endocrinology
    Volume: 187
    Page numbers: 45-53
    Publisher: Society of Endocrinology(Stokebristol)
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  • High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction
    Year: 2005
    Journal: Journal of Molecular Endocrinology
    Volume: 35
    Page numbers: 39-48
    Publisher: Society for Endocrinology(Stokebristol)
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  • Investigational agents that protect pancreatic islet Β-cells from failure
    Year: 2005
    Journal: Expert Opinion on Investigational Drugs
    Volume: 14
    Issue: 10
    Page numbers: 1241-1250
    Publisher: Ashley Publications(London)
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  • Obesity and the female sex, risk factors for knee osteoarthritis that may be attributable to systemic or local leptin biosynthesis and its cellular effects
    Year: 2005
    Journal: Medical Hypotheses
    Volume: 65
    Page numbers: 312-315
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
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  • Pharmacotherapy for Obesity
    Year: 2005
    Journal: Drugs
    Volume: 65
    Issue: 10
    Page numbers: 1391-1418
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Publications in 2004

Journal Articles

  • Diabetes and antipsychotic drugs
    Year: 2004
    Journal: Australian Prescriber
    Volume: 27
    Issue: 5
    Page numbers: 118-119
    Publisher: Australian Prescriber
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  • Effectiveness and side effects of thiazolidinediones for type 2 diabetes: real-life experience from a tertiary hospital
    Year: 2004
    Journal: Medical Journal of Australia
    Volume: 181
    Page numbers: 536-539
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Elevated SNAP-25 is associated with fatty acid-induced impairment of mouse islet function
    Year: 2004
    Journal: Biochemical and Biophysical Research Communications
    Volume: 317
    Page numbers: 472-477
    Publisher: Academic Press(California)
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  • Managment of obesity
    Year: 2004
    Journal: Medical Journal of Australia
    Volume: 180
    Page numbers: 474-480
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2, and 129T2) in response to a high-fat diet
    Year: 2004
    Journal: Journal of Nutrition
    Volume: 134
    Page numbers: 3264-3269
    Publisher: American Institute of Nutrition(Maryland)
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  • Molecular mechanisms of increased glucose production: Identifying potential therapeutic targets
    Year: 2004
    Journal: Journal of Investigative Medicine
    Volume: 52
    Page numbers: 389-393
    Publisher: BC Decker Inc(Ontario)
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Publications in 2003

Journal Articles

  • A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models
    Year: 2003
    Journal: Computer Methods and Programs in Biomedicine
    Volume: 71
    Page numbers: 269-281
    Publisher: Elsevier Ireland
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  • Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation
    Year: 2003
    Journal: Biochemical and Biophysical Research Communications
    Volume: 302
    Page numbers: 837-840
    Publisher: Academic Press(California)
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  • Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney
    Year: 2003
    Journal: Diabetologia
    Volume: 123
    Page numbers: 456-789
    Publisher: Springer Verlag(New York)
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  • The therapeutic potential of leptin
    Year: 2003
    Journal: Expert Opinion on Investigational Drugs
    Volume: 12
    Page numbers: 373-378
    Publisher: Ashley Publications(London)
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  • Threshold effects of glucose transporter-4 (GLUT-4) deficiency on cardiac glucose uptake and development of hypertrophy
    Year: 2003
    Journal: Journal of Molecular Endocrinology
    Volume: 31
    Page numbers: 449-459
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Publications in 2002

Journal Articles

  • Activation of PI 3-kinase by the hexosamine biosynthesis pathway
    Year: 2002
    Journal: Molecular and Cellular Endocrinology
    Volume: 194
    Issue: 2002
    Page numbers: 29-37
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  • Comparison of insulin secretory function in two mouse models with different susceptibility to beta cell failure
    Year: 2002
    Journal: Endocrinology
    Volume: 143
    Page numbers: 2085-2092
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  • Effects of free fatty acids on insulin secretion in obesity
    Year: 2002
    Journal: Obesity Reviews
    Volume: 3
    Page numbers: 103-112
    Publisher: Blackwell Science
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  • The hexosamine biosynthesis pathway regulates insulin secretion via protein glycoylation in mouse islets
    Year: 2002
    Journal: Archives of Biochemistry and Biophysics
    Volume: 405
    Page numbers: 275-279
    Publisher: Academic Press(California)
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Publications in 2001

Book Chapters

  • The New Zealand obese mouse: A polygenic model of type 2 diabetes
    Year: 2001
    Book: Animal Models of Diabetes A Primer
    Publisher: Harwood Academic Publishers(Amsterdam)
    Authors(s):

Journal Articles

  • Aromatase-deficient (ArKO) mice accumulate excess adipose tissue
    Year: 2001
    Journal: Journal of Steroid Biochemistry and Molecular Biology
    Volume: 79
    Page numbers: 3-9
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y
    Year: 2001
    Journal: International Journal of Obesity
    Volume: 25
    Page numbers: 1680-1688
    Publisher: Nature Publishing Group(Basingstroke)
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  • Mechanism of fat-induced hepatic glucoeogenesis: effect of metformin
    Year: 2001
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 281
    Page numbers: E275-E282
    Publisher: American Physiological Society(Maryland)
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  • The role of low birthweight in the aetiology of type 2 diabetes
    Year: 2001
    Journal: Papua New Guinea Medical Journal
    Volume: 44
    Issue: 2001
    Page numbers: 111-123
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