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A/PROF LEA DELBRIDGE



Contact Details

Organization: Physiology
Position: ASSOCIATE PROFESSOR
Email:
Homepage: http://www.physiology.unimelb.edu.au/lab-cardiacphen/index.asp
Work: 83445853
Fax: 83445818
Room: N524
Level: 05
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Angiotensin and genetic cardiac hypertrophy Australia
Gene expression profiling in the heart Australia
Do membrane lipids modulate ischemic vulnerability in the heart? Australia
Sex hormones and heart health Australia
Growth factor regulation of cardiomyocyte growth signalling Australia, Switzerland
Dietary impacts on heart health Australia
Membrane structural abnormalities in heart muscle disease Australia, United States of America

International Linkages

Country Establishment Collaboration
Switzerland University of Lausanne Exchange, Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 24-Nov-1978
Graduate Diploma in Education University of Melbourne 10-Dec-1986
Doctor of Philosophy University of Melbourne 15-Apr-1993

Memberships

Membership Type Membership Body Description Start Date End Date
Member International Society for Heart Research [ISHR] ISHR member 07-Jul-1987
Member Australian Physiological Society [AuPS, formerly APPS] AuPS Member 19-Sep-1989
Member Biophysical Society (USA) Biophysical Society Member 22-Mar-1993
Member American Physiological Society [APS] APS Member 08-Feb-2000
Member High Blood Pressure Research Council High Blood Pressure Research Council Member 09-Apr-1999

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship Canadian Commonwealth 15-Feb-1972
Scholarship University of Melbourne 23-Jun-1992

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Can dietary omega-3 lipid supplementation 'rescue' contractile and electrical dysfunction in cardiac hypertrophy Principal Supervisor NATIONAL HEART FOUNDATION National Heart Foundation Postgraduate Biomedical Research Scholarship 23/12/2003
NEONATAL HORMONES AND HEART GROWTH Principal Supervisor WENKART FOUNDATION Postgraduate Medical Grants 01/10/2005
MYOCARDIAL EFFECTS OF ESTOGEN WITHDRAWAL AND REPLACEMENT: CARDIOMYOCYTE FUNCTIONAL INVESTIGATIONS Chief Investigator NATIONAL HEART FOUNDATION Grants-in-Aid 01/01/2006
Shaping the heart in early development - new insights into cellular modelling processes Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
Omega 3 dietary lipids & primary cardioprotection Chief Investigator NHMRC Project Grants 01/01/2006
DIETARY FRUCTOSE & DIABETES: DOUBLE JEOPARDY FOR THE HEART Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
DIETARY FRUCTOSE AND ANGIOTENSIN II: CO-CONSPIRATORS IN CARDIOMYOPATHY Chief Investigator NATIONAL HEART FOUNDATION Grants-in-Aid 01/01/2007
TO ATTEND THE GORDON RESEARCH CONFERENCE ON CARDIAC REGULATORY MECHANISMS HELD AT BOSTON, USA Principal Supervisor NATIONAL HEART FOUNDATION Travel Grants 01/01/2007
EXCESS DIETARY FRUCTOSE - DOUBLE JEOPARDY FOR THE HEART IN DIABETES? Chief Investigator REBECCA L COOPER MEDICAL RESEARCH FOUNDATION LTD Research Grants 01/12/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Benchmarking ventricular arrhythmias in the mouse - revisiting the 'Lambeth Conventions' 20 years on
    Year: 2008
    Journal: Heart, Lung and Circulation
    Volume: 17
    Issue: 6
    Page numbers: 445-450
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  • Early origins of cardiac hypertrophy: Does cardiomyocyte attrition programme for pathological 'catch-up' growth of the heart?
    Year: 2008
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 35
    Page numbers: 1358-1364
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  • Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention
    Year: 2008
    Journal: Journal of Molecular and Cellular Cardiology
    Volume: 44
    Issue: 2008
    Page numbers: 270-280
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  • Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension
    Year: 2008
    Journal: Hypertension Research
    Volume: 31
    Issue: 5
    Page numbers: 941-955
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  • Sex differences in cardiac muscle responsiveness to Ca2+ and L-type Ca2+ channel modulation
    Year: 2008
    Journal: European Journal of Pharmacology
    Volume: 586
    Page numbers: 288-292
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  • The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy
    Year: 2008
    Journal: American Journal of Physiology - Heart and Circulatory Physiology
    Volume: 294
    Page numbers: H1514-H1522
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Publications in 2007

Journal Articles

  • The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo


    Year: 2007
    Journal: Journal of Molecular and Cellular Cardiology
    Volume: 42
    Issue: 2007
    Page numbers: 1119-1128
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  • Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression
    Year: 2007
    Journal: Journal of the Renin-Angiotensin-Aldosterone System
    Volume: 8
    Issue: 4
    Page numbers: 153-159
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  • Cardiomycytes birefingence imaging: simultaneous phase and retardation 2D measurements
    Year: 2007
    Journal: G I T Imaging & Microscopy
    Volume: 9
    Issue: 3
    Page numbers: 62-64
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  • Pacemaker cell and atrial function: Unravelling how calcium initiates and regulates the heart beat and how ionic dysfunction, 'Channelopathies' and other membrane remodelling contribute to atrial fibrillation
    Year: 2007
    Journal: Heart, Lung and Circulation
    Volume: 16
    Page numbers: 331-334
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  • Quantitative polarized phase microscopy for birefringence imaging
    Year: 2007
    Journal: Optics Express
    Volume: 15
    Issue: 26
    Page numbers: 17690-17698
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Publications in 2006

Journal Articles

  • Cardiac hypertrophy, substrate utilisation and metabolic remodelling: cause or effect?
    Year: 2006
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 33
    Page numbers: 159-166
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  • Single cell volume measurement by Quantitative Phase Microscopy (QPM): A case study of Erythrocyte Morphology
    Year: 2006
    Journal: Cellular Physiology and Biochemistry
    Volume: 17
    Page numbers: 193-200
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Publications in 2005

Journal Articles

  • Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure
    Year: 2005
    Journal: Hypertension
    Volume: 46
    Issue: 2
    Page numbers: 426-432
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Refractive index measurement in viable cells using quantitative phase-amplitude microscopy and confocal microscopy
    Year: 2005
    Journal: Cytometry Part A
    Volume: 65a
    Page numbers: 88-92
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Publications in 2004

Journal Articles

  • Development of colorectal sensitization is associated with increased eosinophils and mast cells in dextran sulfate sodium-treated rats
    Year: 2004
    Journal: Digestive Diseases and Sciences
    Volume: 49
    Page numbers: 1302-1310
    Publisher: Kluwer Academic/Plenum Publishers(New York)
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  • Elevated dietary sodium intake exacerbates myocardial hypertrophy associated with cardiac-specific overproduction of angiotensin II
    Year: 2004
    Journal: Journal of the Renin-Angiotensin-Aldosterone System
    Volume: 5
    Issue: 4
    Page numbers: 169-175
    Publisher: Journal of the Renin-Angiotensin-Aldosterone System(Birmingham)
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  • Putting the heart through its paces - cellular insights from frequency phenomena
    Year: 2004
    Journal: Heart, Lung and Circulation
    Volume: 13
    Issue: 4
    Page numbers: 361-362
    Publisher: Blackwell Science Asia
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  • Quantitative phase amplitude microscopy IV: imaging thick specimens
    Year: 2004
    Journal: Journal of Microscopy - Oxford
    Volume: 214
    Issue: 1
    Page numbers: 62-69
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  • Quantitative phase microscopy: A new tool for investigating the structure and function of unstained live cells
    Year: 2004
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 31
    Page numbers: 896-901
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  • Quantitative phase microscopy: a new tool for measurement of cell culture growth and confluency in situ
    Year: 2004
    Journal: Pflugers Archiv - European Journal of Physiology
    Volume: 448
    Page numbers: 462-468
    Publisher: Springer Verlag(New York)
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  • Transitory reduction in angiotensin AT2 receptor expression levels in postinfarct remodelling in rat myocardium
    Year: 2004
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 31
    Page numbers: 512-517
    Publisher: Blackwell Science Asia(Carlton)
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  • Vascular and brain neuropeptide Y in banded and spontaneously hypertensive rats
    Year: 2004
    Journal: Peptides
    Volume: 25
    Page numbers: 1313-1319
    Publisher: Elsevier(New York)
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Publications in 2003

Journal Articles

  • Combined renin-angiotensin system blockade and dietary sodium restriction impairs cardiomyocyte contractility
    Year: 2003
    Journal: Journal of the Renin-Angiotensin-Aldosterone System
    Volume: 4
    Issue: 4
    Page numbers: 213-219
    Publisher: Journal of the Renin-Angiotensin-Aldosterone System(Birmingham)
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  • Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice
    Year: 2003
    Journal: Journal of the Renin-Angiotensin-Aldosterone System
    Volume: 4
    Issue: 3
    Page numbers: 186-190
    Publisher: Journal of the Renin-Angiotensin-Aldosterone System(Birmingham)
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  • Endogenous cardiac opioids: Enkephalins in adaptation and protection of the heart
    Year: 2003
    Journal: Heart, Lung and Circulation
    Volume: 12
    Page numbers: 178-187
    Publisher: Blackwell Science Asia
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  • Threshold effects of glucose transporter-4 (GLUT-4) deficiency on cardiac glucose uptake and development of hypertrophy
    Year: 2003
    Journal: Journal of Molecular Endocrinology
    Volume: 31
    Page numbers: 449-459
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Publications in 2002

Journal Articles

  • Evolution of a Student Model-Building Program
    Year: 2002
    Journal: Advances in Physiology Education
    Volume: 26
    Issue: 4
    Page numbers: 288-298
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  • Interaction of ACE inhibitors and AT1-receptor blockers on maximum blood pressure response in spontaneous hypertensive rats
    Year: 2002
    Journal: Journal of the Renin-Angiotensin-Aldosterone System
    Volume: 3
    Issue: 1
    Page numbers: 16-18
    Publisher: Journal of the Renin-Angiotensin-Aldosterone System(Birmingham)
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  • Low doses of Angiotensin Converting Enzyme Inhibitors and Angiotensin Type 1 Blockers have a synergistic effect but high doses are less than additive
    Year: 2002
    Journal: American Journal of Hypertension
    Volume: 15
    Page numbers: 1003-1005
    Publisher: Elsevier Science(New York)
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  • Optical Phase Microscopy: Quantitative Imaging and Conventional Phase Analogs
    Year: 2002
    Journal: Microscopy and Analysis
    Volume: 52
    Page numbers: 13-15
    Publisher: Rolston Gordon Communications(Surrey)
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  • Quantitative Phase Imaging - a new way to 'see' cells
    Year: 2002
    Journal: Today's Life Science
    Volume: 14
    Issue: 2
    Page numbers: 28-32
    Publisher: Reed Business Information
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  • The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophy
    Year: 2002
    Journal: Physiological Genomics
    Volume: 9
    Page numbers: 43-48
    Publisher: American Physiological Society(Maryland)
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Publications in 2001

Book Chapters

  • Wall stress, Angiotensin II, and Left Ventricular Hypertrophy
    Year: 2001
    Book: Angiotensin II Receptor Antagonists
    Publisher: Hanley and Belfus(Pennsylvania)
    Authors(s):

Journal Articles

  • Angiotensin II: A proven therapeutic target with some mechanistic mysteries
    Year: 2001
    Journal: Heart, Lung and Circulation
    Publisher: Blackwell Science Asia
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  • Effects of combined administration of ACE inhibitor and angiotensin II receptor antagonist are prevented by a high NaCl intake
    Year: 2001
    Journal: Journal of Hypertension
    Volume: 19
    Issue: 11
    Page numbers: 2087-2095
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Regression of cardiac hypertrophy in the SHR by combined renin-angiotensin system blockade and dietary sodium restriction
    Year: 2001
    Journal: Journal of the Renin-Angiotensin-Aldosterone System
    Volume: 2
    Page numbers: S148-S153
    Publisher: Journal of the Renin-Angiotensin-Aldosterone System(Birmingham)
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Conference Publications/Papers

  • Evolution of a student model building program designed to assist understanding of Biological Control Systems
    Year: 2001
    Event name: Ed-Media 2001 World Conference on Educational Multimedia, Hypermedia & Telecommunications
    Conference Publication: Proceedings of Ed-Media 2001 World Conference on Educational Multimedia, Hypermedia & Telecommunications
    Page numbers: 2009-2010
    Publisher: Association for the Advancement of Computing in Education(Virginia)
    Author(s):
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