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PROF ALASTAIR STEWART



Contact Details

Organization: Pharmacology
Position: DEPUTY HEAD
Email:
Work: 613-83445675
Fax: 613-83440241
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
anti-inflammatory drugs glucocorticoids Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 31-Dec-1980
Doctor of Philosophy University of Melbourne 31-Dec-1984

Memberships

Membership Type Membership Body Description Start Date End Date
Member Research Australia Director 10-Nov-2008 09-Nov-2011
Member Australian Society of Clinical and Experimental Pharmacologists and Toxicologists ordinary 01-Dec-1980
Member Australian Society for Medical Research ordinary 06-Nov-1989
Member Thoracic Society of Australia and New Zealand ordinary 04-Nov-1996
Member American Thoracic Society ordinary 01-May-1996

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Australian Society for Clinical and Experimental Pharmacology and Toxicology ASCEPT visiting lecturer to the British Pharmacological Society 2009. 28-Nov-2008

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Impact of airway wall fibrosis on the efficacy of anti-asthma drugs Chief Investigator NHMRC Project Grants 01/01/2004
New treatments for lung scarring Chief Investigator NHMRC Project Grants 01/01/2008
New treatments for cancer Chief Investigator NHMRC Project Grants 01/01/2009
Fibrinolysis in acute lung injury: validation of annexin 2 as a novel drug target Chief Investigator THE CASS FOUNDATION LTD Science & Medicine Grants 21/01/2009
New treatments for chronic inflammation Chief Investigator NHMRC Project Grants 01/01/2010

Contracts

Title Role Funding Source Award Date
CRYPTOPHARMA RESEARCH AND DEVELOPMENT Chief Investigator CRYPTOPHARMA PTY LTD 02/12/2004
CRYPTOPHARMA RESEARCH AND DEVELOPMENT Chief Investigator CRYPTOPHARMA PTY LTD 01/04/2006

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Book Chapters

  • Pharmacology of inflammation
    Year: 2008
    Book: Pharmacology
    Publisher: Eolss Publishers Co(Oxford)
    Authors(s):

Journal Articles

  • Proliferation is not increased in airway myofibroblasts isolated from asthmatics,
    Year: 2008
    Journal: European Respiratory Journal
    Volume: 32
    Page numbers: 362-371
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Publications in 2007

Journal Articles

  • 2-Methoxyestradiol - a unique blend of activities generating a new class of anti-tumor/anti-inflammatory agents
    Year: 2007
    Journal: Drug Discovery Today
    Volume: 12
    Issue: 13
    Page numbers: 577-584
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  • KCa3.1 Ca2+-Activated K+ channels regulate human airway smooth muscle proliferation
    Year: 2007
    Journal: American Journal of Respiratory Cell and Molecular Biology
    Volume: 37
    Page numbers: 525-531
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  • Resistance of fibrogenic response to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice
    Year: 2007
    Journal: Canadian Journal of Physiology and Pharmacology
    Volume: 85
    Page numbers: 727-738
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Publications in 2006

Journal Articles

  • Airway remodelling in asthma: Current understanding and implications for future therapies
    Year: 2006
    Journal: Pharmacology and Therapeutics
    Volume: 112
    Page numbers: 474-88
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  • Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling
    Year: 2006
    Journal: British Journal of Pharmacology
    Volume: 149
    Page numbers: 365-73
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  • Molecular and cellular targets in tissue remodelling
    Year: 2006
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 19
    Issue: 1
    Page numbers: 1-2
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  • Regulation of human airway mesenchymal cell proliferation by glucocorticoids and β2-adrenoceptor agonists
    Year: 2006
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 19
    Page numbers: 32-38
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  • The PPARγ ligand, rosiglitazone, reduces airways hyperresponsiveness in a murine model of allergen-induced inflammation
    Year: 2006
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 19
    Page numbers: 39-46
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Publications in 2005

Journal Articles

  • 2-Methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Page numbers: 1722-1732
    Publisher: American Association for Cancer Research(Alabama)
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  • Refractive index measurement in viable cells using quantitative phase-amplitude microscopy and confocal microscopy
    Year: 2005
    Journal: Cytometry Part A
    Volume: 65a
    Page numbers: 88-92
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  • Stimulus-dependent glucocorticoid-resistance of GM-CSF production in human cultured airway smooth muscle
    Year: 2005
    Journal: British Journal of Pharmacology
    Volume: 145
    Page numbers: 123-131
    Publisher: Nature Publishing Group(Basingstroke)
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Publications in 2004

Journal Articles

  • Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific
    Year: 2004
    Journal: British Journal of Pharmacology
    Volume: 142
    Page numbers: 1182-1190
    Publisher: Nature Publishing Group(Basingstroke)
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  • Early inducible nitric oxide synthase 2 (NOS 2) activity enhances ischaemic skin flap survival
    Year: 2004
    Journal: Angiogenesis
    Volume: 7
    Page numbers: 33-43
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Emigration and immigration of mesenchymal cells: a multicultural airway wall
    Year: 2004
    Journal: European Respiratory Journal
    Volume: 24
    Page numbers: 1-3
    Publisher: European Respiratory Society Journals(Sheffield)
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  • Factors controlling airway smooth muscle proliferation in asthma
    Year: 2004
    Journal: Current Allergy and Asthma Reports
    Volume: 4
    Page numbers: 109-115
    Publisher: Current Science(Philadelphia)
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  • On the terminology for describing the length-force relationship and its changes in airway smooth muscle
    Year: 2004
    Journal: Journal of Applied Physiology
    Volume: 97
    Page numbers: 2029-2034
    Publisher: American Physiological Society(Maryland)
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  • PPARγ ligands, 15-deoxy-Δ12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms
    Year: 2004
    Journal: British Journal of Pharmacology
    Volume: 141
    Page numbers: 517-525
    Publisher: Nature Publishing Group(Basingstroke)
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  • Proliferative aspects of airway smooth muscle
    Year: 2004
    Journal: Journal of Allergy and Clinical Immunology
    Volume: 114
    Issue: 2 (Supplement)
    Page numbers: S2-S17
    Publisher: Mosby(Missouri)
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  • Quantitative phase microscopy: a new tool for measurement of cell culture growth and confluency in situ
    Year: 2004
    Journal: Pflugers Archiv - European Journal of Physiology
    Volume: 448
    Page numbers: 462-468
    Publisher: Springer Verlag(New York)
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Conference Publications/Papers

  • Can we differentiate between airway and vascular smooth muscle?
    Year: 2004
    Event name: Australian society of clinical and experimental pharmacologists and toxicologists
    Conference Publication: Clinical and experimental pharmacology and physiology
    Volume: 31
    Page numbers: 1-6
    Publisher: Blackwell Science Asia(Carlton)
    Author(s):

Publications in 2003

Journal Articles

  • Airway Hyperresponsiveness: From Molecules to Bedside Invited Review: Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
    Year: 2003
    Journal: Journal of Applied Physiology
    Volume: 95
    Page numbers: 844-853
    Publisher: American Physiological Society(Maryland)
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  • Collagen-induced resistance to glucocorticoid anti-mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airway
    Year: 2003
    Journal: British Journal of Pharmacology
    Volume: 138
    Page numbers: 1203-1206
    Publisher: Nature Publishing Group(Basingstroke)
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  • Differential inhibition of thrombin- and EGF-stimulated human cultured airway smooth muscle proliferation by glucocorticoids
    Year: 2003
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 16
    Page numbers: 171-180
    Publisher: Academic Press(London)
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  • Impact of extracellular matrix and strain on proliferation of bovine airway smooth muscle
    Year: 2003
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 30
    Page numbers: 324-328
    Publisher: Blackwell Science Asia(Carlton)
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  • Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle
    Year: 2003
    Journal: British Journal of Pharmacology
    Volume: 138
    Page numbers: 865-875
    Publisher: Nature Publishing Group(Basingstroke)
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Publications in 2002

Book Chapters

  • Angiogenesis in wound healing and surgery
    Year: 2002
    Book: The new angiotherapy
    Publisher: Humana Press(New Jersey)
    Authors(s):

Journal Articles

  • 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding
    Year: 2002
    Journal: Molecular Pharmacology
    Volume: 61
    Issue: 5
    Page numbers: 1053-1069
    Publisher: American Society for Pharmacology and Experimental Therapeutics(Maryland)
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  • A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction
    Year: 2002
    Journal: American Journal of Respiratory and Critical Care Medicine
    Volume: 166
    Page numbers: 138-143
    Publisher: American Thoracic Society(New York)
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  • Antigen-induced airway inflammation in the Brown Norway rat results in airway smooth muscle hyperplasia
    Year: 2002
    Journal: Journal of Applied Physiology
    Volume: 93
    Page numbers: 1833-1840
    Publisher: American Physiological Society(Maryland)
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  • Growing up and advancing in airway smooth muscle research
    Year: 2002
    Journal: Trends in Pharmacological Sciences
    Volume: 23
    Issue: 450-451
    Page numbers: 10
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Publications in 2001

Book Chapters

  • Airway smooth muscle as a target for novel antiasthma drugs acting on airway wall remodeling
    Year: 2001
    Book: Airway Remodeling
    Publisher: Dekker - Marcel Dekker(New York)
    Authors(s):
  • Oestradiol Metabolites. Effects on Airway Remodelling
    Year: 2001
    Book: New Drugs for Asthma, Allergy and COPD
    Publisher: Karger AG(Basel)
    Authors(s):

Journal Articles

  • Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production
    Year: 2001
    Journal: Cancer Research
    Volume: 61
    Page numbers: 3182-3187
    Publisher: American Association for Cancer Research(Alabama)
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  • Airway wall remodelling and hyperresponsiveness: Modelling remodelling in vitro and in vivo
    Year: 2001
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 14
    Issue: 3
    Page numbers: 255-265
    Publisher: Academic Press(London)
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  • Anti-remodelling drugs for the treatment of asthma: requirement for animal models of airway wall remodelling
    Year: 2001
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 28
    Page numbers: 619-629
    Publisher: Blackwell Science Asia(Carlton)
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  • Determinants and Targets in Progressive Airways Disease
    Year: 2001
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 14
    Page numbers: 167
    Publisher: Academic Press(London)
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  • Effects of the endothelin receptor antagonist Bosentan on ischaemia/reperfusion injury in rat skeletal muscle
    Year: 2001
    Journal: European Journal of Pharmacology
    Volume: 424
    Issue: 1
    Page numbers: 59-67
    Publisher: Elsevier Science(Amsterdam)
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  • Inducible nitric oxide synthase (iNOS) activity promotes ischaemic skin flap survival
    Year: 2001
    Journal: British Journal of Pharmacology
    Volume: 132
    Page numbers: 1631-1638
    Publisher: Nature Publishing Group(Basingstroke)
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  • Lipopolysaccharide-induced cell cycle arrest in macrophages occurs independently of nitric oxide synthase II induction
    Year: 2001
    Journal: Biochimica et Biophysica Acta - Molecular Cell Research
    Volume: 1539
    Page numbers: 140-146
    Publisher: Elsevier Science(Amsterdam)
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  • Targeted disruption of the nitric oxide synthase 2 gene protects against ischaemia/reperfusion injury to skeletal muscle
    Year: 2001
    Journal: Journal of Pathology
    Volume: 194
    Issue: February 2001
    Page numbers: 109-115
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