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Find an ExpertProfiling the University of Melbourne's Researchers

PROF LORENA BROWN



Contact Details

Organization: Microbiology and Immunology
Position: PROFESSOR
Email:
Homepage: http://www.microbiol.unimelb.edu.au/research/groups/brown
Work: 8344-3865/3867
Fax: 8344-3866
Room: 319
Level: 03
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Influenza virus virology, immunology and vaccinology Australia

International Linkages

Country Establishment Collaboration
United States St Judes Children's Research Hospital Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Honours) University of Melbourne 31-Dec-1975
Doctor of Philosophy University of Melbourne 01-Jan-1981

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australasian Society for Immunology Member 01-Jan-1994

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Potential of intranasally-delivered ISCOMsTM to elicit CTL-mediated clearance of influenza virus Chief Investigator AUST RESEARCH COUNCIL Strategic Partnerships with Industry - Research & Training Scheme 01/01/2000
Development of vaccines to immunise against new subtypes of influenza before they emerge Chief Investigator NHMRC Project Grants 01/01/2005
ASSESSMENT OF DEVELOPMENT OF RESISTANCE TO NEURAMINIDASE INHIBITORS IN A(H5N1) INFLUENZA VIRUSES USING A FERRET MODEL Chief Investigator NHMRC Potential Avian Influenza-Induced Pandemic Research Grants 01/01/2006
Establishing the capacity for H5N1 challenge of ferrets within Australia & optimising pandemic vaccines in this model Chief Investigator NHMRC Potential Avian Influenza-Induced Pandemic Research Grants 01/01/2006
Enhancing Australia's pandemic influenza vaccine output by increasing the yield of vaccine virus from eggs Chief Investigator NHMRC Potential Avian Influenza-Induced Pandemic Research Grants 01/01/2006
SELF ADJUVANTING CTL-BASED INFLUENZA VACCINES FOR HUMAN USE Chief Investigator NHMRC Potential Avian Influenza-Induced Pandemic Research Grants 01/01/2006
Using transgenic plant-based production and delivery systems to develop an avian influenza vaccine Chief Investigator AUST RESEARCH COUNCIL,
DOW AGROSCIENCES LLC
Linkage Projects (AUST RESEARCH COUNCIL) 01/01/2006
A New Method for Vaccine Design Chief Investigator NHMRC Project Grants 01/01/2007
Vaccines for protection against all influenza A virus strains Chief Investigator NHMRC Project Grants 01/01/2008
How influenza spreads within the body Chief Investigator NHMRC Project Grants 01/01/2008
UNDERSTANDING AND CONTROLLING INFLUENZA Chief Investigator NHMRC Program Grants 01/01/2010
Ability of H1N1/09 and seasonal influenza vaccines to reduce symptoms and halt spread of H1N1/09 infection in ferrets Chief Investigator NHMRC H1N1 Influenza

Contracts

Title Role Funding Source Award Date
EVALUATION OF AN IMMUNE STIMULANT ON PROTECTIVE IMMUNITY TO INFLUENZA VIRUS Chief Investigator IMPLICIT BIOSCIENCE 04/01/2006
ANTIBODY THERAPY FOR INFLUENZA Chief Investigator ANADIS LTD 01/05/2007
IMMUNOGENICITY AND EFFICACY TESTING OF NOVEL INFLUENZA VACCINES Chief Investigator CSL LIMITED 08/05/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

Conference Publications/Papers

  • Lipopeptide Vaccines Illustrate the Potential Role of Subtype-Crossreactive T Cell Responses in the Control of Seasonal and Pandemic Influenza
    Year: 2008
    Event name: Options for the Control of Influenza VI
    Conference Publication: Options for the Control of Influenza VI
    Page numbers: 199-201
    Publisher: International Medical Press(London)
    Author(s):

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • Determinants of immunity to influenza
    Year: 2006
    Journal: Microbiology Australia
    Volume: 27
    Issue: 4
    Page numbers: 166-168
    Author(s):
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  • Intranasal Lipopeptide Primes Lung-Resident Memory CD8+ T cells for Long-term Pulmonary Protection against Influenza
    Year: 2006
    Journal: European Journal of Immunology
    Volume: 36
    Issue: 3
    Page numbers: 770-778
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  • Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines
    Year: 2006
    Journal: International Immunology
    Volume: 18
    Issue: 12
    Page numbers: 1801-1813
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  • Pandemic vaccines: promises and pitfalls
    Year: 2006
    Journal: Microbiology Australia
    Volume: 185
    Issue: 10
    Page numbers: 62-65
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  • Targetting CD45RB alters T cell migration and delays viral clearance
    Year: 2006
    Journal: International Immunology
    Volume: 18
    Issue: 2
    Page numbers: 291-300
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Publications in 2005

Journal Articles

  • Enumeration and characterization of virus-specific B cells by multicolor flow cytometry
    Year: 2005
    Journal: Journal of Immunological Methods
    Volume: 303
    Issue: 1-2
    Page numbers: 40-52
    Publisher: Elsevier Science(Amsterdam)
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  • ISCOMTM-based vaccines: The second decade
    Year: 2005
    Journal: Immunology and Cell Biology
    Volume: 83
    Issue: 2
    Page numbers: 119-128
    Publisher: Blackwell Science Asia(Carlton)
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  • Lipid-based self-adjuvanting vaccines
    Year: 2005
    Journal: Current Drug Delivery
    Volume: 2
    Issue: 4
    Page numbers: 383-393
    Publisher: Bentham Science Publishers(Hilversum)
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Publications in 2004

Journal Articles

  • A totally synthetic vaccine of generic structure that targets TLR2+ dendritic cells and promotes either antibody or CTL responses
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Page numbers: 15440-15445
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  • A totally synthetic vaccine of generic structure that targets TLR2+ dendritic cells and promotes either antibody or CTL responses.
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 43
    Page numbers: 15440-15445
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  • Responses Against Complex Antigens in Various Models of CD4 T-Cell Deficiency
    Year: 2004
    Journal: Immunologic Research
    Volume: 30
    Issue: 1
    Page numbers: 001-0014
    Publisher: Humana Press
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Publications in 2003

Journal Articles

  • Immune responses in hepatitis C virus infection: The role of dendritic cells
    Year: 2003
    Journal: Immunology and Cell Biology
    Volume: 81
    Page numbers: 63-66
    Publisher: Blackwell Science Asia(Carlton)
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  • Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus
    Year: 2003
    Journal: Immunology and Cell Biology
    Volume: 81
    Page numbers: 67-72
    Publisher: Blackwell Science Asia(Carlton)
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  • Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 5
    Page numbers: 2657-2662
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Publications in 2002

Journal Articles

  • A 320-Kilobase Artificial Chromosome Encoding the Human HLA DR3-DQ2 MHC Haplotype Confers HLA Restriction in Transgenic Mice1
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 3050-3056
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  • Highly Immunogenic and Totally Synthetic Lipopeptides as Self-Adjuvanting Immunocontraceptive
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Issue: 9
    Page numbers: 4905-4912
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  • Identification of antigenically active tryptic fragments of apical membrane antigen-1 (AMA1) of Plasmodium chabaudi malaria: strategies for assembly of immunologically active peptides
    Year: 2002
    Journal: Vaccine
    Volume: 20
    Page numbers: 3477-3484
    Publisher: Elsevier Science(Oxford)
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  • Induction of Long-Term Memory CD8+ T Cells for Recall of Viral Clearing Responses against Influenza Virus
    Year: 2002
    Journal: Journal of Virology
    Volume: 76
    Issue: 9
    Page numbers: 4212-4221
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Publications in 2001

Journal Articles

  • Antibodies to MMP-cleaved aggrecan
    Year: 2001
    Journal: Methods in Molecular Biology
    Volume: 151
    Page numbers: 425-449
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  • Differential effect of CD8+ and CD8- dendritic cells in the stimulation of secondary CD4+ T cells
    Year: 2001
    Journal: International Immunology
    Volume: 13
    Page numbers: 465-473
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  • Differential effect of CD8+ and CD8- dendritic cells in the stimulation of secondary CD4+ T cells
    Year: 2001
    Journal: International Immunology
    Volume: 13
    Issue: 4
    Page numbers: 465-473
    Publisher: Oxford University Press(Oxford)
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Major Reference Works

  • :Antigenic Competition
    Year: 2001
    Publisher: Macmillan Publishers(Basingstroke)
    Author(s):
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