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A/PROF GEOFF HOWLETT



Contact Details

Organization: Biochemistry and Molecular Biology
Position: ASSOCIATE PROFESSOR
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_howlett.htm
Work: 8344 2271
Room: 122
Level: 01
Building: David Pennington Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Physical Biochemistry Protein chemistry Australia

International Linkages

Country Establishment Collaboration
United States Harvard University Research
United States National Institutes of Health Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) University of Melbourne 30-Jun-1969
Doctor of Philosophy University of Melbourne 22-Dec-1972

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Biochemistry and Molecular Biology Ordinary member 26-Apr-1976

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
The activation of lipoprotein lipase by apolipoprotein C-II Chief Investigator NHMRC Project Grants 01/01/2003
Protein-protein interactions in amyloid deposits Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION Chief Investigator NHMRC Equipment Grants 01/01/2005
HIGH-SPEED ULTRACENTRIFUGE FACILITY WITH SENSITIVE SCANNING OPTICS FOR THE ANALYSIS OF INTERACTING BIOMOLECULES Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2005
Apolipoproteins and Amyloid formation in Atheroma Chief Investigator NHMRC Project Grants 01/01/2005
Macromolecular Self-Assembly of Amyloid Fibrils Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
PROTEIN SELF-ASSEMBLY ON SURFACES, INTERFACES AND NANOPARTICLES Chief Investigator RMIT Discovery Projects (AUST RESEARCH COUNCIL) 01/01/2009

Contracts

Title Role Funding Source Award Date
AMYLOID FORMATION Chief Investigator CSIRO HEALTH SCIENCES & NUTRITION 01/07/2003

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Lipids enhance apolipoprotein C-II-derived amyloidogenic peptide oligomerization but inhibit fibril formation.
    Year: 2009
    Journal: Journal of Physical Chemistry B
    Volume: 113
    Issue: 28
    Page numbers: 9447-9453
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  • Lipids enhance apolipoprotein C-II-derived amyloidogenic peptide oligomerization but inhibit fibril formation.
    Year: 2009
    Journal: Journal of Physical Chemistry B
    Volume: 113
    Issue: 28
    Page numbers: 9447-9453
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  • Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils.
    Year: 2009
    Journal: Molecular and Biochemical Parasitology
    Volume: 166
    Issue: 2
    Page numbers: 159-71
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  • Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils.
    Year: 2009
    Journal: Molecular and Biochemical Parasitology
    Volume: 166
    Issue: 2
    Page numbers: 159-71
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

Publications in 2005

Journal Articles

  • Oxidation of Low-Density Lipoproteins Induces Amyloid-like Structures That Are Recognized by Macrophages
    Year: 2005
    Journal: Biochemistry
    Volume: 44
    Issue: 25
    Page numbers: 9108-9116
    Publisher: American Chemical Society(Washington DC)
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  • Conformation and orientation of penetration in phospholipid membranes
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 715
    Page numbers: 1-6
    Publisher: John Wiley & Sons(West Sussex)
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  • Shear Flow Induces Amyloid Fibril Formation
    Year: 2005
    Journal: Biomacromolecules
    Volume: 7
    Page numbers: 10-13
    Publisher: American Chemical Society(Washington)
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  • The molybdate binding protein Mop from Haemophilus influenzae - -biochemical and thermodynamic characterisation.
    Year: 2005
    Journal: Archives of Biochemistry and Biophysics
    Volume: 439
    Issue: 1
    Page numbers: 105-112
    Publisher: Academic Press(California)
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Publications in 2004

Journal Articles

  • C-Terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins invlolved in copper trafficking
    Year: 2004
    Journal: Journal of the American Chemical Society
    Volume: 124
    Page numbers: 3081-3090
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  • Fibrillar amyloid protein present in atheroma activates CD36 signal transduction
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 11
    Page numbers: 10643-10648
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Non-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 20
    Page numbers: 21038-21045
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  • The structure and interactions of human apolipoprotein C-II dodecyl phosphocholine
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Page numbers: 8084-8093
    Publisher: American Chemical Society(Washington DC)
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Publications in 2003

Journal Articles

  • Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex
    Year: 2003
    Journal: Blood
    Volume: 101
    Issue: 4
    Page numbers: 1308-1315
    Publisher: American Society of Hematology(Washington DC)
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  • Phospholipid complexation and association with apolipoprotein C-II: insights from mass spectrometry
    Year: 2003
    Journal: Biophysical Journal
    Volume: 6
    Page numbers: 3802-3812
    Publisher: Biophysical Society(Maryland)
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  • Sedimentation Velocity Analysis of Flexible Macromolecules: Self-Association and Tangling of Amyloid Fibrils
    Year: 2003
    Journal: Biophysical Journal
    Volume: 84
    Page numbers: 2562-2569
    Publisher: Biophysical Society(Maryland)
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  • The circularization of amyloid fibrils formed by apolipoprotein C-II
    Year: 2003
    Journal: Biophysical Journal
    Volume: 85
    Issue: 6
    Page numbers: 3979-3990
    Publisher: Biophysical Society(Maryland)
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Publications in 2002

Journal Articles

  • Acid Denaturation of a1-Antitrypsin: Characterization of a Novel Mechanism of Serpin Polymerisation
    Year: 2002
    Journal: Journal of Molecular Biology
    Volume: 324
    Issue: 4
    Page numbers: 859-870
    Publisher: Academic Press(London)
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  • Cross-Linking and Amyloid Formation by N- and C-Terminal Cysteine Derivatives of Human Apolipoprotein C-II
    Year: 2002
    Journal: Biochemistry
    Volume: 41
    Page numbers: 14313-14322
    Publisher: American Chemical Society(Washington DC)
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  • Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractional lipid emulsions
    Year: 2002
    Journal: European Journal of Biochemistry
    Volume: 369
    Page numbers: 1-11
    Publisher: Blackwell Science(Oxford)
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  • Macromolecular Crowding Accelerates Amyloid Formation by Human Apolipoprotein C-II
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 10
    Page numbers: 7824-7830
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Size-Distribution Analysis of Proteins by Analytical Ultracentrifugation: Strategies and Application to Model Systems
    Year: 2002
    Journal: Biophysical Journal
    Volume: 82(2)
    Page numbers: 1096-1111
    Publisher: Biophysical Society(Maryland)
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  • Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin
    Year: 2002
    Journal: European Journal of Biochemistry
    Volume: 269
    Issue: 11
    Page numbers: 2789-2794
    Publisher: Blackwell Science(Oxford)
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  • The central domain of Escherichia coli TyrR is responsible for hexamerization associated with tyrosine-mediated repression of gene expression
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 26
    Page numbers: 23186-23192
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The structural basis for amyloid formation by plasma apolipoproteins: a review
    Year: 2002
    Journal: European Biophysics Journal with Biophysics Letters
    Volume: 31
    Page numbers: 2-8
    Publisher: Springer Verlag(New York)
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Publications in 2001

Journal Articles

  • Biophysical Characterization of Interactions Involving Importin-a during Nuclear Import
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 36
    Page numbers: 34189-34198
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Identification of a Determinant of Epidermal Growth Factor Receptor Ligand-Binding Specificity Using a Truncated, High-Affinity Form of the Ectodomain
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8930-8939
    Publisher: American Chemical Society(Washington DC)
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  • NMR Structure of Human Apolipoprotein C-11 in the Presence of Sodium Dodecyl Sulfate
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Issue: 18
    Page numbers: 5414-5421
    Publisher: American Chemical Society(Washington DC)
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  • Sedimentation Analysis of Novel DNA Structures Formed by Homo-Oligonucleotides
    Year: 2001
    Journal: Biophysical Journal
    Volume: 81
    Page numbers: 371-381
    Publisher: Biophysical Society(Maryland)
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  • Sub-micellar phospholipid accelerates amyloid formation by apolipoprotein C-11
    Year: 2001
    Journal: FEBS Letters
    Volume: 494
    Page numbers: 220-224
    Publisher: Elsevier Science(Amsterdam)
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  • The Molecular Chaperone, a-Crystallin, Inhibits Amyloid Formation by Apolipoprotein C-11
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 36
    Page numbers: 33755-33761
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The interaction of human apolipoprotein C-1 with sub-micellar phospholipid
    Year: 2001
    Journal: European Journal of Biochemistry
    Volume: 268
    Page numbers: 2838-2846
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