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DR ELIZABETH ALGAR



Contact Details

Organization: Paediatrics Royal Children's Hospital
Position: SENIOR RESEARCH FELLOW
Email:
Work: 03-93456579
Fax: 03-93454993

Biography

Dr. Elizabeth Algar has had nearly 20 years experience working on the genetics of paediatric cancer and cancer prediposition syndromes. She has published 38 articles in the peer-reviewed international literature. Dr. Algar is the head of a NATA accredited molecular genetics diagnostic and research group located within the Children's Cancer Centre at the Royal Children's Hospital and is funded by the Children's Cancer Centre Foundation. She is a regular reviewer for international scientific journals including Clincal Cancer Research, Cancer Research and Haematologica.

Audio visual presentation - Application of methylation sensitve high resolution melting in the diagnosis of growth disorders. At www.rcpa.edu.au under members log-in

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Molecular genetic and epigenetics of paediatric cancer and cancer syndromes Australia
Molecular diagnostic testing for paediatric solid tumors and leukaemias Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 31-Dec-1976
Master of Science La Trobe University 31-Dec-1983
Doctor of Philosophy Griffith University 31-Dec-1989

Memberships

Membership Type Membership Body Description Start Date End Date
Member American Society for Human Genetics Overseas affiliate 01-Oct-1997
Member Human Genetics Society of Australasia ordinary membership 01-Mar-1998
Member Clinical Oncology Society of Australasia ordinary membership 11-Apr-2006
Member Molecular Genetics Society of Australasia ordinary membership 30-Mar-2007
Member Australian Sarcoma Study Group Invited member 01-Jan-2008
Member Clinical and Laboratory Standards Institute Subcomittee member molecular haematology 01-Jan-2008
Member Australian Childhood Cancer Clinical Trails Study Committee Member 01-Jan-2009

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize International Journal of Molecular Medicine 13-Oct-2007
Scholarship Commonwealth post-graduate research award 01-Jan-1980
Scholarship Griffith University post-graduate scholarship 01-Jan-1986

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Additional Grant and Contract Information

1991. Royal Children's Hospital Foundation ( Brisbane ) Fellowship
1992-1994. University of Queensland Post-doctoral Fellowship.
1995. Queensland Cancer Fund Travel Award ( $4,500 ).
1998. Lorne Cancer Conference Poster prize. Molecular analysis of genes on 11p15.5 in Beckwith Wiedemann syndrome.

2004. CASS Foundation Travel Award

2006 MCRI "Insights into the epigentics of rhabdoid tumor" ($13,000) 2009 MCRI "Investigating the genetics of Wilms tumor predisposition" ($14,400) 2008 commerical contract with Novartis ' Epigentic therapies for rhabdoid tumor" (D Ashley and E Algar), ($40,000)

2007.  Link and Learn grant from the Victorian Cancer Agency

Other research grants

1992-1994. E.M. Algar and P.J. Smith " Molecular Pathology of childhood Embryonal Tumours ". ( $40,000 pa.) Queensland Cancer Fund.
1994-1996. E.M.Algar. "Transcription factors in haemopoiesis and leukaemia ".( $54,000 pa. ) Queensland Cancer Fund.
1995-1996. E.M.Algar. " Molecular genetics of childhood leukaemia " ( $ 77,000 pa. ) Royal Children's Hospital Foundation ( Brisbane ).
1996-1997. M.Little and E.M.Algar. " Preliminary investigations into the involvement of chromosome 1q21-22 genes in Wilms' tumour and leukaemia". ($ 45,395 pa ) Queensland Cancer Fund
1997-1999. E.M.Algar. Studies on the WT1 gene in Wilms' tumour and leukaemia.( $46,795 pa ) Murdoch Children’s Research Institute, Royal Children's Hospital. Melbourne
1998-2000. E.M.Algar and P.J.Smith. Molecular mechanisms in Beckwith Wiedemann syndrome. ( $67,000 pa ) NHMRC.
2000. E.M.Algar. Isolation and characterization of genes expressed during differentiation in leukaemic cells. ( $40,000 ) Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne.
2001. E.M.Algar. Molecular mechanisms in Beckwith Wiedemann syndrome ( $ 87,000 ). Bluey Day Fellowship, Royal Children’s Hospital Melbourne.
2002. E.M. Algar. Serial Analysis of Gene Expression ( SAGE ) in anaplastic Wilms tumor. Identification of novel gene targets with therapeutic potential. ( $13,367 ) Australian Kidney Foundation.
2002. E.M. Algar, C.W.Chow and D.Ashley. Classification of atypical and rhabdoid tumors using molecular genetics. ($4230.60) Royal Children’s Hospital . 2002-2003. E.Algar. Molecular diagnostic testing of paediatric cancer. $104,000. Bluey Day Fund. Royal Children’s Hospital. 
2005. E. Algar. The application of SNP and CpG island arrays to the diagnosis of childhood cancer and cancer syndromes. MCRI small clinical research grant $5000.


Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

  • Rapid detection of methylation change at H19 in human imprinting disorders using methylation sensitive high resolution melting.


    Year: 2008
    Journal: Human Mutation
    Volume: 29
    Page numbers: 1255-1260
    Author(s):
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  • ALK+ Histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy.
    Year: 2008
    Journal: Blood
    Volume: 112
    Page numbers: 2965-2968
    Author(s):
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  • Differences in extracellular matrix and mycoyte homeostasis between the neonatal right ventricle in hypoplastic left heart syndrome and truncus arteriosus
    Year: 2008
    Journal: European Journal of Cardio-Thoracic Surgery
    Volume: 34
    Page numbers: 738-744
    Author(s):
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  • Rhabdoid tumour: a malignancy of early childhod with variable primary site, histology and clinical behaviour.
    Year: 2008
    Journal: Pathology
    Volume: 40
    Page numbers: 664-670
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/18985520
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  • The Clinical Phenotype of Mosaicism for Genome-wide Paternal Uniparental Disomy : Two new reports
    Year: 2008
    Journal: American Journal of Medical Genetics
    Volume: 146A
    Page numbers: 137--148
    Author(s):
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Conference Publications/Papers

  • High resolution melting allows sensitive high-throughput assessment of methylation in tumor samples.
    Year: 2008
    Event name: EJC
    Conference Publication: EJC Supplements
    Volume: 6
    Issue: 9
    Page numbers: 104-105
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
  • Insights into epigenetics of atypical rhabdoid tumors-the potential for treatment wiht histone deacetylase inhibitors
    Year: 2008
    Event name: Society of Neuro-oncology conference
    Conference Publication: Neuro-oncology
    Volume: 10
    Issue: 3
    Page numbers: 372
    Publisher: Duke University Press
    Author(s):

Publications in 2007

Journal Articles

  • Paternally inherited submicroscopic duplication at 11p15.5 implicates lGF2 in Wilms tumorigenesis
    Year: 2007
    Journal: Cancer
    Volume: 67
    Page numbers: 2360
    Author(s):
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Publications in 2004

Journal Articles

  • Beckwith-Wiedemann syndrome and IVF: a case-control study.
    Year: 2004
    Journal: American Journal of Human Genetics
    Volume: 75
    Issue: 3
    Page numbers: 526-528
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Publications in 2003

Journal Articles

  • Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome
    Year: 2003
    Journal: Journal of Medical Genetics
    Volume: 40
    Issue: 11
    Page numbers: 797-801
    Publisher: BMJ Publishing Group(London)
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Publications in 2002

Journal Articles

  • Expression and mutation analysis of the Wilms tumor 1 gene in human neural tumours
    Year: 2002
    Journal: International Journal of Cancer
    Volume: 97
    Page numbers: 713-715
    Publisher: Wiley-Liss(New York)
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  • The Wilms' tumour 1 gene in haematopoiesis and leukaemia
    Year: 2002
    Journal: Journal of Hematotherapy and Stem Cell Research
    Volume: 11
    Page numbers: 589-599
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  • Wilms tumour in a pediatric renal transplant recipient with unexpected Denys-Drash syndrome
    Year: 2002
    Journal: Transplantation Proceedings
    Volume: 34
    Page numbers: 3203-3204
    Author(s):
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Publications in 2001

Journal Articles

  • Clinical spectrum of Denys-Drash and Frasier syndrome
    Year: 2001
    Journal: Pediatric Nephrology
    Author(s):
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