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DR MICHAEL DUFFY



Contact Details

Organization: Medicine - Royal Melbourne and Western Hospitals
Position: RESEARCH OFFICER (NH&MRC)
Email:

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
How malaria parasites evade immunity by changing their appearance to the immune system through antigenic variation. malaria, transcription, gene expression, epigenetics, antigenic variation Australia, Indonesia

International Linkages

Country Establishment Collaboration
UK Wellcome Trust Sanger Institute, Cambridgeshire Research
Singapore Nanyang Technological University Research
Papua New Guinea Papua New Guinea's Institute of Medical Research Research
Indonesia The Eijkman Institute for Molecular Biology Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 01-Jan-1993
Doctor of Philosophy University of Melbourne 01-Sep-1997

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Medical Research member 01-Jan-2007 01-Dec-2009

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) University of Melbourne Early Career Researcher Award 01-Jun-2006
Other (Award) University of Melbourne Melbourne Research Grant Scheme 01-Jan-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Transcriptional control of antigenic variation in the malaria parasite Plasmodium falciparum Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
IDENTIFYING THE PARASITE PROTEIN RESPONSIBLE FOR PLACENTAL MALARIA - MELBOURNE EARLY CAREER RESEARCHER GRANT SCHEME 2006 Chief Investigator UNIVERSITY OF MELBOURNE Early Career Researcher Grants Scheme

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rate
    Year: 2009
    Journal: Journal of Molecular Biology
    Volume: 389
    Page numbers: 453-469
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  • Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    Year: 2009
    Journal: PLoS Biology
    Volume: 7
    Issue: 4
    Page numbers: e84
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Publications in 2008

Journal Articles

  • Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line
    Year: 2008
    Volume: 7
    Issue: 1
    Page numbers: 51
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Publications in 2007

Journal Articles

  • Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
    Year: 2007
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 76
    Issue: 5
    Page numbers: 860-864
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  • Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity.
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 31
    Page numbers: 22426
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  • Transcription and coregulation of multigene families in Plasmodium falciparum.
    Year: 2007
    Journal: Trends in Parasitology
    Volume: 23
    Issue: 5
    Page numbers: 183-186
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Publications in 2006

Journal Articles

  • A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria.
    Year: 2006
    Journal: Nature
    Volume: 439
    Issue: 7079
    Page numbers: 1004-1008
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  • Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation.
    Year: 2006
    Journal: Molecular Microbiology
    Volume: 62
    Issue: 1
    Page numbers: 72
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  • Transcribed var genes associated with placental malaria in Malawian women.
    Year: 2006
    Journal: Infection and Immunity
    Volume: 74
    Issue: 8
    Page numbers: 4875-4883
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  • VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum.
    Year: 2006
    Journal: Molecular and Biochemical Parasitology
    Volume: 148
    Issue: 2
    Page numbers: 117-124
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Publications in 2005

Journal Articles

  • Broad analysis reveals a consistent pattern of var gene transcription in Plasmoidum falciparum repeatedly selected for a defined adhesion phenotype
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 56
    Page numbers: 774-788
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  • Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa
    Year: 2005
    Journal: Infection and Immunity
    Volume: 73
    Page numbers: 2848-2856
    Publisher: American Society for Microbiology(Washington DC)
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  • Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum
    Year: 2005
    Journal: Cell
    Volume: 121
    Page numbers: 13-24
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  • Targets ofprotective antibodies to malaria during pregnancy
    Year: 2005
    Journal: Journal of Infectious Diseases
    Volume: 192
    Page numbers: 1647-1650
    Publisher: University of Chicago Press(Illinois)
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Publications in 2003

Journal Articles

  • Regulation of antigenic variation in Plasmodium falciparum: censoring freedom of expression?
    Year: 2003
    Journal: Trends in Parasitology
    Volume: 19
    Page numbers: 121-124
    Publisher: Elsevier Science(Oxford)
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Publications in 2002

Journal Articles

  • Transcription of multiple var genes by individual, trophozoite-stage Plasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype
    Year: 2002
    Journal: Molecular Microbiology
    Volume: 43
    Page numbers: 1285-1293
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Publications in 2001

Journal Articles

  • Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion
    Year: 2001
    Journal: Molecular and Biochemical Parasitology
    Volume: 114
    Page numbers: 227-237
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