Contact Details
| Organization: | Pathology |
| Position: | SENIOR RESEARCH OFFICER |
| Email: | |
| Work: | 41952 |
| Fax: | 44004 |
| Room: | 338 |
| Level: | 03 |
| Building: | Alan Gilbert Building |
| Campus: | Parkville |
Biography
PUBLICATIONS
Haigh, CL. Drew, SC. Boland, MP. Masters, CL. Barnham, KJ. Lawson, VA. Collins, SJ. (2009) Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response. Journal of Cell Science 122(10), 1518-1528. Journal impact factor 6.247; Number of citations 0.
Haigh, CL. Lewis, V. Vella, LJ. Masters, CL. Hill, AF. Lawson, VA. Collins, SJ. PrPC related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site. Cell Research 19, 1062-1078. Journal impact factor 4.535; Number of citations 1.
Lewis, V. Hill, AF. Haigh, CL. Klug, GM. Masters, CL. Lawson, VA. Collins, SJ. Increased proportions of C1 truncated prion protein protect against cellular prion infection. Journal of Neuropathology and Experimental Neurology 68(10), 1125-1135. Journal impact factor 5.14; Number of citations 0.
Haigh, CL. Brown, DR. Investigation of PrPC metabolism and function in live cells: methods for studying individual cells and cell populations. In “Prion Protein Protocols” Methods in Molecular Biology, 2008, vol. 459, (Ed. A.F. Hill), Humana Press, New Jersey, pp 21-34.
Haigh, CL. Wright, JA. Brown, DR. (2007) Regulation of Prion protein Expression by non coding regions of the Prnp gene. Journal of Molecular Biology, 368(4), 915-27. Journal impact factor 4.146; Number of citations 4.
Haigh, CL. Brown, DR. (2006) Prion protein reduces both oxidative and non-oxidative copper toxicity. Journal of Neurochemistry 98 (3), 677-89. Journal impact factor 4.5; Number of citations 7.
Haigh, C.L. Brown, D.R. (2006) Regulation of Prion Protein Expression: A Potential Site for Therapeutic Intervention in the Transmissible Spongiform Encephalopathies. International Journal of Biomedical Science 2 (4), 315-23.
Cheng, F. Lindqvist, J. Haigh, CL. Brown, DR. Mani, K. (2006) Copper-Dependent Co-Internalisation of the Prion Protein and Glypican-1. Journal of Neurochemistry 98 (5), 1445-57. Journal impact factor 4.5; Number of citations 9.
Haigh, CL. Edwards, KE, Brown, DR. (2005) Copper binding is the governing determinant of prion protein turnover. Molecular and Cellular Neuroscience 30, 186-96. Journal impact factor 3.934; Number of citations 17.
Research Expertise and International Linkages
Research Expertise
| Research Interest | Key Words | Country of Expertise |
|---|---|---|
| Prion Disease | Trafficking, Expression, Copper Metabolism | United Kingdom |
| Prion disease - Role of alpha and beta cleavage events | Cleavage, Signal Transduction, Copper, ROS | Australia |
| Prion disease - Oxidative stress response | ROS, Lipid peroxidation, Infection | Australia |
| Prion disease - Apoptosis | Caspase, Signal Transduction, Fluorescence | Australia |
Qualifications, Honours, Fellowships and Other Awards
Qualifications
| Title | Institution | Date Awarded | Abbreviation |
|---|---|---|---|
| BSc(hons) Biomedical Sciences | University of Wales | 31-Dec-2002 | |
| PhD in Biology/Biochemistry | University of Bath | 31-Mar-2006 |
Memberships
| Membership Type | Membership Body | Description | Start Date | End Date |
|---|---|---|---|---|
| Member | FABLS | Network Member: Academic | 01-Oct-2006 | |
| Associate | Mental Health Research Institute | Honorary Researcher | 01-Jan-2007 | |
| Member | Fluorescence Imaging Group (FIG) | Member | 01-Aug-2008 | |
| Member | British Neuroscience Association (BNA) | Member | 31-Oct-2002 | |
| Member | Society for Neuroscience (SfN) | Member | 01-Jul-2005 |
Other Awards
| Award Type | Awarding Body | Comments | Date Awarded |
|---|---|---|---|
| Prize | Institute of Biomedical Sciences | 16-Jul-2002 | |
| Prize | British Neuroscience Association (BNA) | 02-Sep-2005 |
Government Research Classifications
Research Fields, Courses and Discipline Classifications
- Cell Metabolism (BIOCHEMISTRY AND CELL BIOLOGY) (270102)
- Protein Targeting and Signal Transduction (BIOCHEMISTRY AND CELL BIOLOGY) (270103)
- Cell Neurochemistry (BIOCHEMISTRY AND CELL BIOLOGY) (270107)
- Biochemistry and Cell Biology not elsewhere classified (BIOCHEMISTRY AND CELL BIOLOGY) (270199)
- Gene Expression (GENETICS) (270201)
- Neurogenetics (GENETICS) (270210)
- Diagnostic Applications (BIOTECHNOLOGY) (270802)
- Medical Infection Agents (incl. Prions) (MEDICAL MICROBIOLOGY) (320403)
- Neurosciences not elsewhere classified (NEUROSCIENCES) (320799)
- Medical Biotechnology (OTHER MEDICAL AND HEALTH SCIENCES) (329902)
Socio-Economic Objective Classifications
- Infectious diseases (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730101)
- Nervous system and disorders (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730104)
- Health related to ageing (PUBLIC HEALTH) (730203)
- Mental health (PUBLIC HEALTH) (730211)
- Diagnostic methods (HEALTH AND SUPPORT SERVICES) (730305)
Grants and Contracts
Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.
Grants
| Title | Role | Funding Source | Scheme | Award Date |
|---|---|---|---|---|
| Early oxidative changes in live cells following infection with the neurodegenerative disease associated prion protein. | Chief Investigator | BRAIN FOUNDATION | Specific Research Grants | 30/09/2007 |
| Non-invasive monitoring of neurodegeneration in vivo using near infrared optical imaging | Chief Investigator | ANZ CHARITABLE TRUSTS | Medical Research and Technology Grants | 01/01/2009 |
Additional Grant and Contract Information
2006-2007 University of Melbourne Early Career Researcher Grant (Principle Investigator). Project Title: The role of PrP N-terminal cleavage products in intracellular signalling.
Publications
Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.