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DR NICHOLAS WILLIAMSON



Contact Details

Organization: Bio21 Institute
Position: MANAGER OF MASS SPECTROMETRY
Email:

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) University of Melbourne 31-Dec-1997
Doctor of Philosophy University of Melbourne 31-Dec-2001

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
DECIPHERING THE BIOCHEMICAL PROPERTIES OF PARKINSONS DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 Chief Investigator BRAIN FOUNDATION Specific Research Grants 01/09/2007
NIIPe - A new method for the Discovery of peptide epitopes Chief Investigator ANZ CHARITABLE TRUSTS Medical Research and Technology Grants 15/10/2007
MASS SPECTROMETRY FACILITY FOR THE QUANTITATION AND ANALYSIS OF POST-TRANSLATIONALLY MODIFIED PEPTIDES Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
The basis of immune-mediated drug reactions Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Mass Spectral Identification of Vc1.1 and Differential Distribution
    of Conopeptides in the Venom Duct of Conus victoriae. Effect
    of Post-Translational Modifications and Disulfide Isomerisation
    on Bioactivity
    Year: 2009
    Journal: International Journal of Peptide Research and Therapeutics
    Volume: 15
    Page numbers: 195-203
    Author(s):
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  • Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 8
    Page numbers: 2776-81
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  • Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 8
    Page numbers: 2776-81
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes


    Year: 2006
    Journal: Antiviral Therapy
    Volume: 11
    Issue: 8
    Page numbers: 1005-14
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  • A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition
    Year: 2006
    Journal: Journal of Experimental Medicine
    Volume: 203
    Issue: 3
    Page numbers: 661-673
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  • C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 44
    Page numbers: 32988-32999
    Author(s):
    URL - restricted access http://www.jbc.org/cgi/reprint/281/44/32988
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  • Tumors reveal their secrets to cytotoxic T cells
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 40
    Page numbers: 14649-14650
    Author(s):
    URL - restricted access http://www.pnas.org/cgi/content/full/103/40/14649
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Publications in 2005

Journal Articles

  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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  • T Cell Determinants Incorporating B-Amino Acid Residues Are Protease Resistant and Remain Immunogenic In Vivo
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 3810-3818
    Publisher: American Association of Immunologists(Maryland)
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  • The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 9
    Page numbers: 1249-1260
    Publisher: Rockefeller University Press(New York)
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  • The insulin A-chain epitope recognized by human T cells is posttranslationally modified
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 9
    Page numbers: 1191-1197
    Publisher: Rockefeller University Press(New York)
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  • Use of proteomics to define targets of T-cell immunity
    Year: 2005
    Journal: Expert Review in Proteomics
    Volume: 2
    Issue: 3
    Page numbers: 367-380
    Publisher: Future Drugs(London)
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Publications in 2004

Journal Articles

  • Characterization of presenilin complexes from mouse and human brain using Blue Native gel eletrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
    Year: 2004
    Journal: European Journal of Biochemistry
    Volume: 271
    Page numbers: 375-383
    Publisher: Blackwell Science(Oxford)
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  • Interaction of the molecular chaperone ΑB-crystallin with Α-synuclein: effects on amyloid fibril formation and chaperone activity
    Year: 2004
    Journal: Journal of Molecular Biology
    Volume: 340
    Page numbers: 1167-1183
    Publisher: Academic Press(London)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
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  • Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease β-amyloid protein precursor: effect of C-terminal truncation on production of β-amyloid protein
    Year: 2003
    Journal: Journal of Neuroscience Research
    Volume: 74
    Page numbers: 378-385
    Publisher: Wiley-Liss(New York)
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  • Structure of the Alzheimer's disease amyloid precursor protein copper binding domain
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 19
    Page numbers: 17401-17407
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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