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A/PROF STEPHEN ROGERSON



Contact Details

Organization: Medicine - Royal Melbourne and Western Hospitals
Position: WELLCOME TRUST FELLOW
Email:
Homepage: http://www.medrmhwh.unimelb.edu.au/staff/academic/rogerson.html
Work: 8345 3259
Fax: 9318 1157
Level: 04
Building: Clinical Sciences
Campus: Royal Melbourne Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Malaria Pregnancy Malawi, Papua New Guinea, Indonesia

International Linkages

Country Establishment Collaboration
Malawi University of Malawi Exchange, Research, Technical Assistance/Training
United States University of North Carolina Research
Papua New Guinea Papua New Guinea's Institute of Medical Research Exchange, Research, Teaching, Technical Assistance/Training
Indonesia The Eijkman Institute for Molecular Biology Exchange, Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Diploma in Tropical Medicine and Hygiene Institution not known 31-Dec-1990
Bachelor of Medicine & Bachelor of Surgery Adelaide University 31-Dec-1981
Member of the Royal College of Physicians (UK) University of London 31-Dec-1989
Doctor of Philosophy University of Melbourne 31-Dec-1996
test National Taiwan University 19-Oct-2009

Memberships

Membership Type Membership Body Description Start Date End Date
Member Royal Australasian College of Physicians Fellow 01-Jan-1990
Member Royal Society of Tropical Medicine and Hygiene Fellow 01-Jan-1989
Member Australsian College of Tropcal Medicine Fellow 01-Jan-2002

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 31-Dec-1990

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Plasmodium falciparum erythrocyte membrane protein 1 and var gene expression, parasite sequestration and anti-adhesion antibody responses Chief Investigator WELLCOME TRUST Overseas Senior Research Fellowships in Biomedical Science 01/06/2001
Centre for Clinical Research Excellence in Infectious Diseases Chief Investigator NHMRC Centres of Clinical Research Excellence (CCRE) 01/01/2003
ATTENDANCE AT MULTILATERAL INITIATIVE ON MALARIA MEETING, YAOUNDE CAMEROON, NOVEMBER 2005 Chief Investigator THE IAN POTTER FOUNDATION Travel and Conference Grants 05/07/2005
Identifying the targets of protective immunity to malaria in pregnancy Chief Investigator WALTER & ELIZA HALL INST Project Grants (NHMRC) 01/01/2006
HIV and immunity to malaria Chief Investigator NHMRC Project Grants 01/01/2006
Malaria in Pregnancy: Project Major Activity 7 Chief Investigator LIVERPOOL SCHOOL OF TROPICAL MEDICINE Global Health Program (GATES FOUNDATION) 01/12/2007
How placental malaria causes fetal growth restriction Chief Investigator NHMRC Project Grants 01/01/2008
BIOMEDICAL - THE ROLE OF THE IMMUNE SYSTEM IN MALARIAL DISEASE Principal Supervisor NHMRC Scholarships 01/01/2008
DEFINING THE TARGETS AND FUNCTION OF ANTIBODIES THAT PROTECT AGAINST MALARIA IN PREGNANCY Chief Investigator NHMRC Project Grants 01/01/2009
How white blood cells clear malaria infection, and how this alters the immune response Chief Investigator NHMRC Project Grants 01/01/2010
PARTNERSHIP AGREEMENT - PREGVAX - PLASMODIUM VIVAX INFECTION IN PREGNANCY Chief Investigator FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA (FCRB) 7th Framework Programme (EUROPEAN COMMISSION)

Contracts

Title Role Funding Source Award Date
INVESTIGATOR-INITIATED RESEARCH ("IIR") AGREEMENT: INTERMITTENT PREVENTIVE TREATMENT WITH AZITHROMYCIN CONTAINING REGIMENS FOR THE PREVENTION OF MALARIAL INFECTIONS" Chief Investigator PFIZER INC 24/06/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Antibodies to Variant Surface Antigens of Plasmodium falciparum-Infected Erythrocytes Are Associated with Protection from Treatment Failure and the Development of Anemia in Pregnancy


    Year: 2009
    Journal: Journal of Infectious Diseases
    Volume: 200
    Page numbers: 299-306
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  • A review of the current state of malaria among pregnant women in Papua New Guinea.
    Year: 2009
    Journal: Papua New Guinea Medical Journal
    Volume: 51
    Page numbers: 12-16
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  • Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta
    Year: 2009
    Journal: PLoS Pathogens
    Volume: 5
    Issue: 8
    Page numbers: e100543
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  • Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malaria.
    Year: 2009
    Journal: Clinical and Vaccine Immunology
    Volume: 16
    Issue: 3
    Page numbers: 312-319
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Publications in 2008

Journal Articles

  • Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line
    Year: 2008
    Volume: 7
    Issue: 1
    Page numbers: 51
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  • Differential antibody responses to Plasmodium falciparum merozoite proteins in Malawian children with severe malaria
    Year: 2008
    Journal: Journal of Infectious Diseases
    Volume: 197
    Page numbers: 766-774
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  • Impact of human immunodeficiency virus infection in pregnant women on variant-specific immunity to malaria
    Year: 2008
    Journal: Clinical and Vaccine Immunology
    Volume: 15
    Issue: 4
    Page numbers: 617-621
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  • Maternal-Fetal DNA Admixture Is Associated with Intrapartum Mother-to-Child Transmission of HIV-1 in Blantyre, Malawi
    Year: 2008
    Journal: Journal of Infectious Diseases
    Volume: 197
    Page numbers: 1378-1381
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  • Placental hypoxia during placental malaria
    Year: 2008
    Journal: Journal of Infectious Diseases
    Volume: 197
    Page numbers: 757-766
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  • Plasmodium vivax infection during pregnancy: an important problem in need of new solutions
    Year: 2008
    Journal: Clinical Infectious Diseases
    Volume: 46
    Page numbers: 1382-1384
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  • Severe malaria in children and pregnancy: an update and perspective
    Year: 2008
    Journal: Trends in Parasitology
    Volume: 24
    Page numbers: 590-595
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  • Severe vivax malaria: newly recognised or rediscovered
    Year: 2008
    Journal: PLoS Medicine
    Volume: 5
    Issue: 6
    Page numbers: e136
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  • Socio-demographic characteristics associated with HIV and syphilis seroreactivity among pregnant women in Blantyre, Malawi, 2000-2004.
    Year: 2008
    Journal: Malawi Medical Journal
    Volume: 20
    Issue: 3
    Page numbers: 80-85
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Publications in 2007

Journal Articles

  • Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1.


    Year: 2007
    Journal: Infection and Immunity
    Volume: 75
    Issue: 7
    Page numbers: 3621-3632
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  • Serum lipoproteins promote efficient presentation of the malaria virulence protein PfEMP1 at the erythrocyte surface


    Year: 2007
    Journal: Eukaryotic Cell
    Volume: 6
    Issue: 9
    Page numbers: 1584-1594
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  • A novel flow cytometric phagocytosis assay of malaria-infected erythrocytes
    Year: 2007
    Journal: Journal of Immunological Methods
    Volume: 325
    Page numbers: 42-50
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  • A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women
    Year: 2007
    Journal: PLoS One
    Volume: 2
    Issue: 11
    Page numbers: e1166
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  • Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
    Year: 2007
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 76
    Issue: 5
    Page numbers: 860-864
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  • CCR5 haplotypes and mother-to-child HIV transmission in Malawi
    Year: 2007
    Journal: PLoS One
    Volume: 2
    Issue: 9
    Page numbers: e838
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  • CD16+ monocyte subset preferentially harbors HIV-1 and is expanded in pregnant malawian women with plasmodium falciparum malaria and HIV-1 infection.
    Year: 2007
    Journal: Journal of Infectious Diseases
    Volume: 196
    Page numbers: 38-42
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  • Differential var gene expression in the organs of patients dying of falciparum malaria
    Year: 2007
    Journal: Molecular Microbiology
    Volume: 65
    Issue: 4
    Page numbers: 959-967
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  • Disruption of var2csa gene impairs placental malaria associated adhesion phenotype
    Year: 2007
    Journal: PLoS One
    Volume: 2
    Issue: 9
    Page numbers: e910
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  • Expression of merozoite surface protein markers by Plasmodium falciparum-infected erythrocytes in peripheral blood and tissues of children with fatal malaria.
    Year: 2007
    Journal: Infection and Immunity
    Volume: 75
    Issue: 2
    Page numbers: 643-652
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  • Identification of basic transcriptional elements required for rif gene transcription
    Year: 2007
    Journal: International Journal for Parasitology
    Volume: 37
    Issue: 6
    Page numbers: 605-615
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  • Malaria in pregnancy: linking immunity and pathogenesis to prevention
    Year: 2007
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 77
    Issue: 6
    Page numbers: 14-22
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  • Malaria in pregnancy: pathogenesis and immunity
    Year: 2007
    Journal: The Lancet Infectious Diseases
    Volume: 7
    Page numbers: 105-117
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  • New approaches to pathogenesis of malaria in pregnancy
    Year: 2007
    Journal: Parasitology
    Volume: 134
    Page numbers: 1883-1893
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Publications in 2006

Journal Articles

  • Antigenic differences and conservation among placental Plasmodium falciparum-infected erythrocytes and acquisition of variant-specific and cross-reactive antibodies.
    Year: 2006
    Journal: Journal of Infectious Diseases
    Volume: 193
    Issue: 5
    Page numbers: 721-730
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  • Are Plasmodium falciparum parasites present in peripheral blood genetically the same as those sequestered in the tissues?
    Year: 2006
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 74
    Issue: 5
    Page numbers: 730-732
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  • Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains.
    Year: 2006
    Journal: Eukaryotic Cell
    Volume: 5
    Issue: 5
    Page numbers: 849-860
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  • Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria.
    Year: 2006
    Journal: Journal of Infectious Diseases
    Volume: 194
    Page numbers: 122
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  • Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi.
    Year: 2006
    Journal: AIDS
    Volume: 20
    Page numbers: 1869-1877
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  • Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi.
    Year: 2006
    Journal: PLoS Medicine
    Volume: 3
    Issue: 1
    Page numbers: 70-75
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  • Placental malaria in women with South-East Asian ovalocytosis.
    Year: 2006
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 75
    Issue: 4
    Page numbers: 597-604
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  • Protecting Pregnant Women from Malaria in Areas of High HIV Infection Prevalence.
    Year: 2006
    Journal: Journal of Infectious Diseases
    Volume: 194
    Page numbers: 273-275
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  • Transcribed var genes associated with placental malaria in Malawian women.
    Year: 2006
    Journal: Infection and Immunity
    Volume: 74
    Issue: 8
    Page numbers: 4875-4883
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  • Treatment and prevention of malaria in pregnancy: opportunities and challenges.
    Year: 2006
    Journal: Expert Review of Anti-infective Therapy
    Volume: 4
    Issue: 4
    Page numbers: 687-702
    Author(s):
    URL - restricted access http://www.future-drugs.com/doi/abs/10.1586/14787210.4.4.687
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  • VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum.
    Year: 2006
    Journal: Molecular and Biochemical Parasitology
    Volume: 148
    Issue: 2
    Page numbers: 117-124
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Publications in 2005

Journal Articles

  • Broad analysis reveals a consistent pattern of var gene transcription in Plasmoidum falciparum repeatedly selected for a defined adhesion phenotype
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 56
    Page numbers: 774-788
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  • Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa
    Year: 2005
    Journal: Infection and Immunity
    Volume: 73
    Page numbers: 2848-2856
    Publisher: American Society for Microbiology(Washington DC)
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  • Malaria during pregnancy and foetal haematological status in Blantyre, Malawi
    Year: 2005
    Journal: Malaria Journal
    Volume: 4
    Page numbers: 39
    Publisher: Biomed Central(London)
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  • Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi
    Year: 2005
    Journal: Antimicrobial Agents and Chemotherapy
    Volume: 49
    Page numbers: 3919-3921
    Publisher: American Society for Microbiology(Washington DC)
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  • Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity
    Year: 2005
    Journal: Infection and Immunity
    Volume: 73
    Page numbers: 5903-5907
    Publisher: American Society for Microbiology(Washington DC)
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  • Targets ofprotective antibodies to malaria during pregnancy
    Year: 2005
    Journal: Journal of Infectious Diseases
    Volume: 192
    Page numbers: 1647-1650
    Publisher: University of Chicago Press(Illinois)
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Publications in 2004

Journal Articles

  • Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and having overlapping and distinct targets
    Year: 2004
    Journal: Journal of Infectious Diseases
    Volume: 189
    Page numbers: 540-551
    Publisher: University of Chicago Press(Illinois)
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  • HIV infection among paediatric in-patients in Blantyre, Malawi
    Year: 2004
    Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
    Volume: 98
    Page numbers: 544-552
    Publisher: Royal Society of Tropical Medicine & Hygiene(London)
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  • Impairment of humoral immunity to Plasmodium falciparum malaria in pregnancy by HIV infection
    Year: 2004
    Journal: The Lancet
    Volume: 363
    Page numbers: 1860-1867
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  • Malaria in pregnancy and the endemicity spectrum: what can we learn?
    Year: 2004
    Journal: Trends in Parasitology
    Volume: 20
    Page numbers: 425-432
    Publisher: Elsevier Science(Oxford)
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  • Molecular approaches to malaria
    Year: 2004
    Journal: Molecular Microbiology
    Volume: 54
    Page numbers: 575-587
    Publisher: Blackwell Science(Oxford)
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  • Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions
    Year: 2004
    Journal: International Journal for Parasitology
    Volume: 34
    Page numbers: 163-189
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Phenotypes of Plasmodium falciparum from the peripheral blood of pregnant women
    Year: 2004
    Journal: Infection and Immunity
    Volume: 72
    Page numbers: 1841
    Publisher: American Society for Microbiology(Washington DC)
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  • Risk factors and mechanisms of preterm delivery in Malawi
    Year: 2004
    Journal: American Journal of Reproductive Immunology
    Volume: 52
    Page numbers: 174-183
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in Sub-Saharan Africa
    Year: 2004
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 71
    Page numbers: 41-54
    Publisher: American Society of Tropical Medicine and Hygiene
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  • The effect of Plasmodium falicparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women
    Year: 2004
    Journal: AIDS
    Volume: 18
    Page numbers: 1051-1059
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • The microcirculation in severe malaria
    Year: 2004
    Journal: Microcirculation
    Volume: 11
    Page numbers: 559-576
    Publisher: Taylor & Francis Ltd(Philadelphia)
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Publications in 2003

Journal Articles

  • Diagnosis of Plasmodium falciparum malaria at delivery: Comparison of blood film preparation methods and of blood films with histology
    Year: 2003
    Journal: Journal of Clinical Microbiology
    Volume: 41
    Page numbers: 1370-1374
    Publisher: American Society for Microbiology(Washington DC)
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  • Drugs and the placenta - a workshop report
    Year: 2003
    Journal: Placenta
    Volume: 24
    Page numbers: 55-59
    Publisher: WB Saunders Co(London)
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  • HIV-1, antiretroviral therapy, and malaria
    Year: 2003
    Journal: The Lancet
    Volume: 362
    Page numbers: 1008-1009
    Publisher: Lancet(London)
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  • Host response to malaria during pregnancy: Placental monocyte recruitment is associated with elevated beta chemokine expression
    Year: 2003
    Journal: Journal of Immunology
    Volume: 170
    Page numbers: 2759-2764
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  • Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes
    Year: 2003
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 68
    Page numbers: 115-119
    Publisher: American Society of Tropical Medicine and Hygiene
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  • Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women
    Year: 2003
    Journal: Infection and Immunity
    Volume: 71
    Page numbers: 267-270
    Publisher: American Society for Microbiology(Washington DC)
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Publications in 2002

Journal Articles

  • Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria


    Year: 2002
    Journal: Journal of Infectious Diseases
    Volume: 185
    Issue: 3
    Page numbers: 380-388
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  • Evaluating specific adhesion of Plasmodium falciparum-infected erythrocytes to immobilised hyaluronic acid with comparison to binding of mammalian cells
    Year: 2002
    Journal: International Journal for Parasitology
    Volume: 32
    Page numbers: 1245-1252
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Evaluation of the OptiMAL rapid antigen test and species-specific PCR to detect placental Plasmodium falciparum infection at delivery
    Year: 2002
    Journal: Journal of Clinical Microbiology
    Volume: 40
    Page numbers: 155-158
    Publisher: American Society for Microbiology(Washington DC)
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  • Expanding the paradigms of placental malaria
    Year: 2002
    Journal: Trends in Parasitology
    Volume: 18
    Page numbers: 145-147
    Publisher: Elsevier Science(Oxford)
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  • Identification of conserved Plasmodium falciparum var gene implicated in malaria in pregnancy.
    Year: 2002
    Journal: Journal of Infectious Diseases
    Volume: 185
    Issue: 8
    Page numbers: 1207-1211
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  • Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants
    Year: 2002
    Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
    Volume: 96
    Page numbers: 145-149
    Publisher: Royal Society of Tropical Medicine & Hygiene(London)
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  • Selective accumulation of mature asexual stages of Plasmodium falciparum-infected erythrocytes in the placenta
    Year: 2002
    Journal: Infection and Immunity
    Volume: 70
    Page numbers: 5412-5415
    Publisher: American Society for Microbiology(Washington DC)
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Publications in 2001

Book Chapters

  • The epidemiology and outcomes of maternal malaria.
    Year: 2001
    Book: Malaria in pregnancy: deadly parasite, susceptible host.
    Publisher: Taylor & Francis
    Authors(s):

Journal Articles

  • Blood-brain barrier function in cerebral malaria in Malawian children.


    Year: 2001
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 64
    Issue: 3,4
    Page numbers: 207-213
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  • Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo
    Year: 2001
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 98
    Page numbers: 10829-10832
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  • Parasite adhesion and immune evasion in placental malaria
    Year: 2001
    Journal: Trends in Parasitology
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  • Sticky rings: challenging the cytoadherence dogma
    Year: 2001
    Journal: Trends in Parasitology
    Volume: 17
    Page numbers: 61
    Publisher: Elsevier Science(Oxford)
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