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DR ANDREW JOBLING



Contact Details

Organization: Optometry and Vision Sciences
Position: NHMRC SENIOR RESEARCH OFFICER
Email:
Homepage: http://www.optometry.unimelb.edu.au/research/myopia.html
Work: 61 3 93497417
Fax: 61 3 93497498
Room: J307
Level: 02
Building: 374 Cardigan St.
Campus: Parkville

Biography

Andrew Jobling has worked in the field of ocular growth and scleral biochemistry since 2002. Prior to that he worked on retinal and lens systems, investigating the role of growth factors and transcription factors in several pathological ocular conditions. Since completing his PhD in 1999, he has published 17 journal articles in vision science (11) and more general (6) journals. His work in Vision Science was rewarded with the Lions Vision Research Fellowship in 2001.

In the field of ocular growth and scleral biochemistry, his most significant contribution relates to the 2004 and 2009 papers (J. Biol. Chem.) showing TGF-beta isoform regulation could mediate a number of the key remodeling steps during eye growth. This work was the basis for a National Health and Medical Research Council application which was successfully funded (2007-2009). He has extensive experience in cell culture systems, with particular experience in mammalian cell cuture and 3-D cell culture systems which investigate matrix stresses (Flexcell TissueTrain system). He has also developed a sensitive quantitative real-time PCR technique is used to investigate alterations in ocular gene expression.

Andrew Jobling has presented at National and International Vision Science meetings and was an invited speaker at the 16th International Congress of Eye Research in 2004 as well as presenting at the International Myopia Conference in 2008. Due to his expertise in growth factors and various molecular techniques he was invited to chair the gene expression session at the 2005 Australasian Ophthalmic and Visual Sciences Meeting. He is also a reviewer for several Vision Science journals, such as Investigative Ophthalmology and Visual Science (highest ranking journal for research articles in Ophthalmology and Vision Science field) and Experimental Eye Research.

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
ocular growth and myopia myopia, sclera, growth factors, cell culture, molecular biology, real-time PCR, cell stress Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) University of Melbourne 31-Dec-1992
Doctor of Philosophy University of Melbourne 12-Aug-1999

Memberships

Membership Type Membership Body Description Start Date End Date
Member The Association for Research in Vision and Ophthalmology Postdoctoral student 31-Dec-2003 31-Dec-2009

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship Nation Vision Research Institute of Australia Jean S Colledge Bursary 14-Sep-1996
Scholarship Commonwealth of Australia Australian Post Graduate Research Award 01-Mar-1993

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Additional Grant and Contract Information

2001. Australian Companion Animal Health Foundation. Distribution of the CLAD mutation in the Irish Setter population in Australia.In conjunction with Prof. AC Augusteyn.

2004. KM Brutton Bequest. The role of scleral cells in the control of eye growth.

2008 KM Brutton Bequest. Age-related consequences for pathological myopia and glaucoma. In conjunction with Dr BV Bui.

2001 Lions Vision Research Fellow, funded by the National Vision Research Institute.

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Biomechanics of the sclera in myopia:  Extracellular and cellular factors.
    Year: 2009
    Journal: Optometry and Vision Science
    Volume: 86
    Issue: 1
    Page numbers: 23-30
    Author(s):
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  • Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia.
    Year: 2009
    Journal: Molecular Vision
    Volume: 15
    Page numbers: 464-475
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  • Regulation of scleral cell contraction by transforming growth factor-beta and stress.
    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 4
    Page numbers: 2072-2079
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  • Retinal and choroidal TGF-ß in the tree shrew model of myopia:  Isoform expression, activation and effects on function.
    Year: 2009
    Journal: Experimental Eye Research
    Volume: 88
    Issue: 3
    Page numbers: 458-466
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Publications in 2006

Journal Articles

  • Characterization of the integrin receptor subunit profile in the mammalian sclera
    Year: 2006
    Journal: Molecular Vision
    Volume: 12
    Page numbers: 725-734
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  • Expression of Collagen-Binding Integrin Receptors in the Mammalian Sclera and Their Regulation during the Development of Myopia
    Year: 2006
    Journal: Investigative Ophthalmology and Visual Science
    Volume: 47
    Issue: 11
    Page numbers: 4674-4682
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Publications in 2005

Journal Articles

  • Glutamate uptake in retinal glial cells during diabetes
    Year: 2005
    Journal: Diabetologia
    Volume: 48
    Issue: 2
    Page numbers: 351-360
    Publisher: Springer Verlag(New York)
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Publications in 2004

Journal Articles

  • Isoform-specific Changes in Scleral Transforming Growth Factor-β Expression and the Regulation of Collagen Synthesis during Myopia Progression
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 18
    Page numbers: 18121-18126
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Localization and expression of the glutamate transporter, excitatory amino acid transporter 4, within atrocytes of the rat retina
    Year: 2004
    Journal: Cell and Tissue Research
    Volume: 315
    Page numbers: 305-310
    Publisher: Springer Verlag(New York)
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Publications in 2003

Journal Articles

  • The frequency of the canine leukocyte adhesion deficiency (CLAD) allele within the Irish Setter population in Australia
    Year: 2003
    Journal: Australian Veterinary Journal
    Volume: 81
    Issue: 12
    Page numbers: 763-765
    Publisher: Australian Veterinary Association(Brunswick)
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Publications in 2002

Journal Articles

  • Expression of the ETS Transcription Factor ELF3 in the Retinal Pigment Epithelium
    Year: 2002
    Journal: Investigative Ophthalmology and Visual Science
    Volume: 43
    Issue: 11
    Page numbers: 3530-3537
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  • What causes steroid cataracts? A review of steroid-induced posterior subcapsular cataracts
    Year: 2002
    Journal: Clinical and Experimental Optometry
    Volume: 85
    Issue: 2
    Page numbers: 61-75
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Publications in 2001

Journal Articles

  • Binding of Dexamethasone by α-Crystallin
    Year: 2001
    Journal: Investigative Ophthalmology and Visual Science
    Volume: 42
    Issue: 8
    Page numbers: 1829-32
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  • Is there a Glucocorticoid Receptor in the Bovine Lens?
    Year: 2001
    Journal: Experimental Eye Research
    Volume: 72
    Issue: 6
    Page numbers: 687-94
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