University home page

Find an ExpertProfiling the University of Melbourne's Researchers

PROF ASHLEY BUSH



Contact Details

Organization: Pathology
Position: Honorary (Professorial Fellow)
Email:
Homepage: www.mhri.edu.au/
Work: 9389 2914
Fax: 9380 6182
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Alzheimer's disease copper, metals, oxidative stress Australia

International Linkages

Country Establishment Collaboration
Chile Universidad de Concepcion Research, Technical Assistance/Training
United States Massachusetts General Hospital Research, Teaching, Technical Assistance/Training

Languages

Languages

Language Proficiency
English Speak, Read & Write

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Diploma in Psychological Medicine University of Melbourne 01-Jan-1988
Bachelor of Medicine University of Melbourne 01-Jan-1982
Ph.D. (Pathology) University of Melbourne 01-Jan-1993

Memberships

Membership Type Membership Body Description Start Date End Date
Member Royal Australian and New Zealand College of Psychiatrists Fellow 01-Jan-1989
Member American Academy for the Advancement of Science Member 01-Jan-1993
Member Society for Neuroscience Member 01-Jan-1993
Member American Medical Association Member 01-Jan-1995
Member The American Society for Biochemistry and Molecular Biology Member 01-Jan-2003

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australian and New Zealand College of Psychiatrists (FRANZCP)

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Commonwealth Fund of New York 01-Jan-1992
Other (Award) The Royal Australian and New Zealand College of Psychiatry 01-Jan-1994
Other (Award) National Down Syndrome Society 01-Jan-1994
Scholarship Massachusetts General Hospital 01-Jan-1995
Other (Award) Paul B. Beeson 01-Jan-1998
Other (Award) Alzheimer's Association 01-Jan-2000
Prize American Academy of Neurology 01-Jan-2003
Other (Award) Australian Research Council 01-Jan-2004
Other (Award) Alzheimer's Association 01-Jan-2004
Medal Bethlehem Griffiths Research Foundation 01-Jan-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Novel therapies for Alzheimer's disease based on A-beta - metal interactions Chief Investigator NHMRC Project Grants 01/01/2001
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
THE ROLE OF AMYLOID PROTEIN PRECURSOR IN MAMMALIAN COPPER TRANSPORT Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
APPLICATION OF COPPER-64 TO STUDIES ON ALZHEIMER'S DISEASE AND CHARACTERISATION OF NOVEL GENES AND PROTEINS INVOLVED IN COPPER HOMEOSTASIS Chief Investigator AINSE Awards 01/01/2007
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
PETER DOHERTY AUSTRALIAN BIOMEDICAL FELLOWSHIP - EXAMINATION OF THE INVOLVEMENT OF COPPER IN THE DEVELOPMENT AND PROGRESSION OF ALZHEIMER'S DISEASE Principal Supervisor NHMRC Training (Postdoctoral) Fellowships 01/01/2008
Amyloid precursor protein aids iron efflux from neurons Chief Investigator NHMRC Project Grants 01/01/2009
Neural Copper Homeostasis: the role of the Alzheimer Amyloid-beta Precursor Protein Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2009
APPLICATION OF COPPER-64 IN STUDIES OF THE ROLE OF COPPER IN ALZHEIMER'S DISEASE Chief Investigator AINSE Awards 01/01/2009
Alzheimer's Disease and Metal Regulation Principal Supervisor NHMRC Scholarships 01/01/2009
The drug aprotinin may regulate iron in blood and cardiovascular tissue Chief Investigator NATIONAL HEART FOUNDATION Grants-in-Aid 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Glutathione precursor, N-Acetyl-Cysteine, Improves mismatch negativity in Schizophrenia patients


    Year: 2008
    Journal: Neuropsychopharmacology
    Volume: 33
    Page numbers: 2187-2199
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Glutathione: a novel treatment target in psychiatry
    Year: 2008
    Journal: Trends in Pharmacological Sciences
    Volume: 29
    Issue: 7
    Page numbers: 346-351
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Insights into Zn2+ homeostasis in neurons from experimental and modeling studies
    Year: 2008
    Journal: American Journal of Physiology - Cell Physiology
    Volume: 294
    Issue: 3
    Page numbers: 726-742
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Page numbers: 181-198
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • N-acetyl Cysteine as a Glutatione Precursor for Schizophrenia - A Double-Blind, Randomized, Placebo-Controlled Trial
    Year: 2008
    Journal: Biological Psychiatry
    Volume: 64
    Page numbers: 361-368
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • N-acetyl Cysteine for depressive symptoms in Bipolar Disorder - A Double-Blind, Randomized, Placebo-Controlled Trial
    Year: 2008
    Journal: Biological Psychiatry
    Volume: 64
    Page numbers: 468-475
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Sensitive, selective, and irreversible Inhibition of Cyclooxygenase-2 Activity by Copper
    Year: 2008
    Journal: ChemMedChem: chemistry enabling drug discovery
    Volume: 223-225
    Issue: 3
    Page numbers: 2
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Sequestration of Copper from beta-amyloid promotes selective lysis by Cyclen-Bybrid cleavage agents
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 46
    Page numbers: 31657-31664
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Therapeutics for Alzheimer's Disease Based on the Metal Hypothesis
    Year: 2008
    Journal: Neurotherapeutics
    Volume: 5
    Issue: 3
    Page numbers: 421-432
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2007

Book Chapters

  • Metal Ions and Alzheimer's disease
    Year: 2007
    Book: Interaction between neurons and glia in aging and disease
    Publisher: Springer(New York)
    Authors(s):
    Editors(s):
  • Metals, oxidative stress, and brain biology
    Year: 2007
    Book: Encyclopedia of Stress
    Publisher: Elsevier Science(Oxford)
    Authors(s):
    Editors(s):

Journal Articles

  • Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency


    Year: 2007
    Journal: Neuroscience
    Volume: 150
    Issue: 2
    Page numbers: 357-369
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
    Year: 2007
    Journal: Free Radical Biology and Medicine
    Volume: 42
    Issue: 10
    Page numbers: 1534-1542
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mechanisms of copper ion mediated Huntington's Disease progression.
    Year: 2007
    Journal: PLoS One
    Volume: March 2007
    Issue: 3
    Page numbers: e334
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mitochondria in aging and Alzheimer's disease
    Year: 2007
    Journal: Rejuvenation Research
    Volume: 10
    Page numbers: 349-357
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.
    Year: 2007
    Journal: PLoS One
    Volume: June 2007
    Issue: 6
    Page numbers: e536
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.
    Year: 2007
    Journal: FEBS Journal
    Volume: 274
    Page numbers: 3775-3783
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2006

Book Chapters

  • The Role of Metal Ions in Neurology. An Introduction
    Year: 2006
    Book: Metal Ions in Life Sciences: Neurodegenerative diseases and metal ions
    Publisher: Wiley - John Wiley & Sons(Chichester)
    Authors(s):
    Editors(s):

Journal Articles

  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Elevated cortical zinc in Alzheimer disease
    Year: 2006
    Journal: Neurology
    Volume: 67
    Issue: 1
    Page numbers: 69-75
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal homeostasis in Alzheimer's disease
    Year: 2006
    Journal: Expert Review of Neurotherapeutics
    Volume: 6
    Issue: 5
    Page numbers: 711-722
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metals and Alzheimer's disease
    Year: 2006
    Journal: Journal of Alzheimer's Disease
    Volume: 10
    Page numbers: 145-163
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Therapeutic treatments for Alzheimer's disease based on metal bioavailability
    Year: 2006
    Volume: 19
    Page numbers: 469-474
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2005

Book Chapters

  • Amyloid-beta metal interaction and metal chelation.
    Year: 2005
    Book: Alzheimer's disease: Cellular and molecular aspects of amyloid beta
    Publisher: Springer Verlag(New York)
    Authors(s):
  • Copper and zinc in Alzheimer's disease and amyotrophic lateral sclerosis.
    Year: 2005
    Book: Neurodegenerative diseases: Neurobiology, Pathogenesis and Therapeutics
    Publisher: Cambridge University Press(Cambridge)
    Authors(s):

Journal Articles

  • Alzheimer disease β-amyloid activity mimics cholesterol oxidase
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Page numbers: 2556-2563
    Publisher: American Society of Clinical Investigation Inc(Michigan)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system.
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 50
    Page numbers: 41732-41743
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metals and amyloid-Β in Alzheimer's disease
    Year: 2005
    Journal: International Journal of Experimental Pathology
    Volume: 86
    Issue: 3
    Page numbers: 147-159
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 353-360
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 13355-13363
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment.
    Year: 2005
    Journal: Free Radical Biology and Medicine
    Volume: 38
    Issue: 2
    Page numbers: 258-261
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Model studies of cholesterol and ascorbate oxidation by copper complexes: Relevance to Alzheimer's disease beta-amyloid metallochemistry
    Year: 2005
    Journal: Journal of Inorganic Biochemistry
    Volume: 99
    Issue: 12
    Page numbers: 2403-2422
    Publisher: Elsevier Science(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Pilot study of the reducing effect of Amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5'Untranslated region
    Year: 2005
    Journal: Current Alzheimer Research
    Volume: 2
    Issue: 2
    Page numbers: 249-254
    Publisher: Bentham Science Publishers
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The neurobiology of zinc in health and disease.
    Year: 2005
    Journal: Nature Reviews Neuroscience
    Volume: 6
    Issue: 6
    Page numbers: 449-462
    Publisher: Nature Publishing Group(Houndmills)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2004

Journal Articles

  • Alzheimer's amyloid β-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide
    Year: 2004
    Journal: Neurobiology of Aging
    Volume: 25
    Page numbers: 563-568
    Publisher: Elsevier Science(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid Β-peptide by NMR
    Year: 2004
    Journal: Journal of Peptide Science
    Volume: 10
    Page numbers: 210-217
    Publisher: John Wiley & Sons(West Sussex)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Copper mediates dityrosine cross-linking of Alzheimer's amyloid-Β
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Page numbers: 560-568
    Publisher: American Chemical Society(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 8602-8607
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of Amyotrophic Lateral Sclerosis
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 7945-7950
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
    Publisher: Springer Verlag(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal-protein attenuating compounds (MPACs) for the treatment of Alzheimer's disease
    Year: 2004
    Journal: Drug Design Reviews Online
    Volume: 1
    Page numbers: 75-82
    Publisher: Bentham Science Publishers(Hilversum)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal-protein attenuating compounds and Alzheimer's disease
    Year: 2004
    Journal: Expert Opinion on Investigational Drugs
    Volume: 13
    Page numbers: 1585-1592
    Publisher: Ashley Publications(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mice transgenic for Alzheimer disease Β-amyloid develop lens cataracts that are rescued by antioxidant treatment
    Year: 2004
    Journal: Free Radical Biology and Medicine
    Volume: 38
    Page numbers: 258-261
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurodegenerative diseases and oxidative stress
    Year: 2004
    Journal: Nature Reviews Drug Discovery
    Volume: 3
    Page numbers: 205-214
    Publisher: Nature Publishing Group(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 3453-3459
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links Β-amyloid (AΒ) and generates AΒ-COX-2 hetero-oligomers that are increased in Alzheimer's disease
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 14673-14678
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Redox-active metals, oxidative stress, and Alzheimer's disease pathology
    Year: 2004
    Journal: Annals of The New York Academy of Sciences
    Volume: 1012
    Page numbers: 153-163
    Publisher: New York Academy of Sciences(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Serum copper: a biomarker for Alzheimer disease?
    Year: 2004
    Journal: Archives of Neurology
    Volume: 61
    Page numbers: 631-632
    Publisher: American Medical Association(Illinois)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1701-1703
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's AΒ peptides
    Year: 2004
    Journal: Journal of Inorganic Biochemistry
    Volume: 9
    Page numbers: 954-960
    Publisher: Elsevier Science(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Aβ metallobiology and the development of novel metal-compounds (MPACs) for Alzheimer's disease
    Year: 2003
    Journal: Current Medicinal Chemistry
    Volume: 3
    Issue: 4
    Page numbers: 309-315
    Publisher: Bentham Science Publishers(Hilversum)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Copper, β-amyloid, and Alzheimer's disease: tapping a sensitive connection
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 20
    Page numbers: 11193-11194
    Publisher: National Academy of Sciences(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Copper, zinc, and the metallobiology of Alzheimer disease
    Year: 2003
    Journal: Alzheimer Disease and Associated Disorders
    Volume: 17
    Issue: 3
    Page numbers: 147-150
    Publisher: Lippincott Williams & Wilkins
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Current status of metals as therapeutic targets in Alzheimer's disease
    Year: 2003
    Journal: Journal of the American Geriatrics Society
    Volume: 51
    Page numbers: 1143-1148
    Publisher: Blackwell Publishers(Massachusetts)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
    Year: 2003
    Journal: The Lancet
    Volume: 361
    Page numbers: 1258-1265
    Publisher: Lancet(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease
    Year: 2003
    Journal: Neuron
    Volume: 37
    Page numbers: 899-909
    Publisher: Cell Press(Massachusetts)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-β peptide with membrane lipid
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 5
    Page numbers: 2977-2982
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal-protein attenuation with Iodochlorhydroxyquin (Clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Year: 2003
    Journal: Archives of Neurology
    Volume: 60
    Page numbers: 1685-1691
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The medicinal metallochemistry of Alzheimer's disease
    Year: 2003
    Journal: Current Medicinal Chemistry
    Volume: 3
    Page numbers: 9-13
    Publisher: Bentham Science Publishers(Hilversum)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The metallobiology of Alzheimer's disease
    Year: 2003
    Journal: Trends in Neurosciences
    Volume: 26
    Issue: 4
    Page numbers: 207-214
    Publisher: Elsevier Science(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • To write a book, to plant a tree...
    Year: 2003
    Journal: Science
    Volume: 299
    Page numbers: 1318-1319
    Publisher: American Society for the Advancement of Science(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2002

Book Chapters

  • Copper, zinc and Alzheimer's disease
    Year: 2002
    Book: Diet-brain connections: impact on memory, mood, aging and disease
    Publisher: Kluwer Academic Publishers(Norwell)
    Authors(s):

Journal Articles

  • Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region
    Year: 2002
    Journal: Journal of Molecular Neuroscience
    Volume: 19
    Page numbers: 77-82
    Publisher: Humana Press
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 45518-45528
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Brain zinc: physiology and pathophysiology
    Year: 2002
    Journal: Biometals
    Volume: 14
    Page numbers: 353-366
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?
    Year: 2002
    Journal: Nature Neuroscience
    Volume: 5
    Issue: 10
    Page numbers: 919
    Publisher: Nature America(Philadelphia)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal complexing agents as therapies for Alzheimer's disease
    Year: 2002
    Journal: Neurobiology of Aging
    Volume: 23
    Page numbers: 1031-1038
    Publisher: Elsevier Science(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metalloenzyme-like activity of Alzheimer's disease β-amyloid
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 40302-40308
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 47
    Page numbers: 44670-44676
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Response: '...and C is for Clioquinol' - the A[beta]Cs of Alzheimer's disease
    Year: 2002
    Journal: Trends in Neurosciences
    Volume: 25
    Issue: 3
    Page numbers: 123-124
    Publisher: Elsevier Science(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The galvanization of beta-amyloid in Alzheimer's disease
    Year: 2002
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 99
    Issue: 11
    Page numbers: 7317-7319
    Publisher: National Academy of Sciences(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2001

Book Chapters

  • Neuroinflammatory responses in the Alzheimer's disease brain promote the oxidative post-translational modifiction of amyloid deposits
    Year: 2001
    Book: Alzheimer's disease: advances in etiology, pathogenesis and therapeutics
    Publisher: John Wiley & Sons(West Sussex)
    Authors(s):
  • Parallels between the redox properties and toxicity of A[beta] in Alzheimer's disease and mutant Cu/Zn-SOD in Familial Amyotropic Lateral Sclerosis
    Year: 2001
    Book: Alzheimer's disease: advances in etiology, pathogenesis and therapeutics
    Publisher: John Wiley & Sons(West Sussex)
    Authors(s):

Journal Articles

  • Alzheimer's Disease Amyloid-[beta] Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 23
    Page numbers: 20466-20473
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Clinoquinol's return: cautions from Japan
    Year: 2001
    Journal: Science
    Volume: 292
    Page numbers: 2251-2252
    Publisher: American Society for the Advancement of Science(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Computerised cognitive assessment of concussed Australian Rules footballers
    Year: 2001
    Journal: British Journal of Sports Medicine
    Volume: 35
    Page numbers: 354-360
    Publisher: British Medical Journal Publishing Group(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways
    Year: 2001
    Journal: Journal of Neurochemistry
    Volume: 76
    Page numbers: 1509-1520
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Redox-active iron mediates amyloid-beta toxicity
    Year: 2001
    Journal: Free Radical Biology and Medicine
    Volume: 30
    Issue: 4
    Page numbers: 447-450
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Synaptically released zinc: physiological functions and pathological effects
    Year: 2001
    Journal: Biometals
    Volume: 14
    Issue: 3-4
    Page numbers: 353-366
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Therapeutic targets in the biology of Alzheimer's disease
    Year: 2001
    Journal: Current Opinion in Psychiatry
    Volume: 14
    Page numbers: 341-348
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Treatment with a copper-zinc chelator markedly and rapidly inhibits [beta]-amyloid accumulation in Alzheimer's disease transgenic mice
    Year: 2001
    Journal: Neuron
    Volume: 30
    Page numbers: 665-676
    Publisher: Cell Press(Massachusetts)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
top of page