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PROF ASHLEY BUSH



Contact Details

Organization: Pathology
Position: Honorary (Professorial Fellow)
Email:
Work: 9389 2914
Fax: 9380 6182
Building: Medical Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Alzheimer's disease copper, metals, oxidative stress Australia

International Linkages

Country Establishment Collaboration
United States Massachusetts General Hospital Research, Teaching, Technical Assistance/Training
Chile Universidad de Concepcion Research, Technical Assistance/Training

Languages

Languages

Language Proficiency
English Speak, Read & Write

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Diploma in Psychological Medicine University of Melbourne 01-Jan-1988
Bachelor of Medicine University of Melbourne 01-Jan-1982
Ph.D. (Pathology) University of Melbourne 01-Jan-1993

Memberships

Membership Type Membership Body Description Start Date End Date
Member Royal Australian and New Zealand College of Psychiatrists Fellow 01-Jan-1989
Member American Academy for the Advancement of Science Member 01-Jan-1993
Member Society for Neuroscience Member 01-Jan-1993
Member American Medical Association Member 01-Jan-1995
Member The American Society for Biochemistry and Molecular Biology Member 01-Jan-2003

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australian and New Zealand College of Psychiatrists (FRANZCP)
Fellow of the Australian Academy of Technological Sciences and Engineering (FTSE) 01-Jan-2009

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Commonwealth Fund of New York 01-Jan-1992
Other (Award) The Royal Australian and New Zealand College of Psychiatry 01-Jan-1994
Other (Award) National Down Syndrome Society 01-Jan-1994
Scholarship Massachusetts General Hospital 01-Jan-1995
Prize American Academy of Neurology 01-Jan-2003
Other (Award) Australian Research Council 01-Jan-2004
Other (Award) Alzheimer's Association 01-Jan-2004
Medal Bethlehem Griffiths Research Foundation 01-Jan-2007
Other (Award) Paul B. Beeson 01-Jan-1998
Other (Award) Alzheimer's Association 01-Jan-2000

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Novel therapies for Alzheimer's disease based on A-beta - metal interactions Chief Investigator NHMRC Project Grants 01/01/2001
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
THE ROLE OF AMYLOID PROTEIN PRECURSOR IN MAMMALIAN COPPER TRANSPORT Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
APPLICATION OF COPPER-64 TO STUDIES ON ALZHEIMER'S DISEASE AND CHARACTERISATION OF NOVEL GENES AND PROTEINS INVOLVED IN COPPER HOMEOSTASIS Chief Investigator AINSE Awards 01/01/2007
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
PETER DOHERTY AUSTRALIAN BIOMEDICAL FELLOWSHIP - EXAMINATION OF THE INVOLVEMENT OF COPPER IN THE DEVELOPMENT AND PROGRESSION OF ALZHEIMER'S DISEASE Principal Supervisor NHMRC Training (Postdoctoral) Fellowships 01/01/2008
Amyloid precursor protein aids iron efflux from neurons Chief Investigator NHMRC Project Grants 01/01/2009
Neural Copper Homeostasis: the role of the Alzheimer Amyloid-beta Precursor Protein Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2009
APPLICATION OF COPPER-64 IN STUDIES OF THE ROLE OF COPPER IN ALZHEIMER'S DISEASE Chief Investigator AINSE Awards 01/01/2009
The drug aprotinin may regulate iron in blood and cardiovascular tissue Chief Investigator NATIONAL HEART FOUNDATION Grants-in-Aid 01/01/2009
Metals in Alzheimer's and Parkinson's diseases Chief Investigator NHMRC Research Fellowship 14/07/2010
DISEASES OF THE AGEING BRAIN Chief Investigator NHMRC Program Grants 01/01/2011
TRANSLATIONAL THERAPEUTICS AND DIAGNOSTICS FOR ALZHEIMER'S DISEASE Chief Investigator NHMRC Australia Fellowship 01/01/2011

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2011

Journal Articles

  • Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study


    Year: 2011
    Journal: Dementia and Geriatric Cognitive Disorders
    Volume: 31
    Issue: 3
    Page numbers: 173-178
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  • Copper promotes the trafficking of the Amyloid Precursor Protein
    Year: 2011
    Journal: Journal of Biological Chemistry
    Volume: 286
    Issue: 10
    Page numbers: 8252-8262
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  • Dimensions of improvement in a clinical trial of N-acetyl cysteine for bipolar disorder
    Year: 2011
    Journal: Acta Neuropsychiatrica
    Volume: 23
    Issue: 2
    Page numbers: 87-88
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  • Effects of anticholingergic drugs on cognitive function in older Australians: results from the AIBL study
    Year: 2011
    Journal: Dementia and Geriatric Cognitive Disorders
    Volume: 31
    Issue: 3
    Page numbers: 173-178
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  • Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study
    Year: 2011
    Journal: Journal of Alzheimer's Disease
    Volume: 27
    Issue: 4
    Page numbers: 909-922
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  • Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease
    Year: 2011
    Journal: PLoS One
    Volume: 6
    Issue: 3
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  • N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial
    Year: 2011
    Journal: Journal of Affective Disorders
    Volume: 129
    Issue: 1-3
    Page numbers: 317-320
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  • N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and D-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder
    Year: 2011
    Journal: Neuroscience Letters
    Volume: 499
    Issue: 3
    Page numbers: 149-153
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  • Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging
    Year: 2011
    Journal: Neurology
    Volume: 76
    Issue: 12
    Page numbers: 1091-1098
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  • Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity
    Year: 2011
    Journal: Journal of Biological Chemistry
    Volume: 286
    Issue: 11
    Page numbers: 9776-9786
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  • The Alzheimer's therapeutic PBT2 promotes amylolid-B degredation and GSK3 phorphorylation via a  metal chaperone activity
    Year: 2011
    Journal: Journal of Neurochemistry
    Volume: 119
    Issue: 1
    Page numbers: 220-230
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  • The Neurophysiology and Pathology of Brain Zinc
    Year: 2011
    Journal: Journal of Neuroscience
    Volume: 31
    Issue: 45
    Page numbers: 16076-16085
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Publications in 2010

Journal Articles

  • Biological metals and Alzheimer's disease: Implications for therpeutics and diagnostics


    Year: 2010
    Journal: Progress in Neurobiology
    Volume: 29
    Issue: 1
    Page numbers: 1-18
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  • Serum Zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability


    Year: 2010
    Journal: Biometals
    Volume: 23
    Page numbers: 173-179
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  • Altered microglial copper homeostasis in a mouse model of Alzheimer's disease
    Year: 2010
    Journal: Journal of Neurochemistry
    Volume: 114
    Issue: 6
    Page numbers: 1630-1638
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  • Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?
    Year: 2010
    Journal: Journal of Neuroscience
    Volume: 30
    Issue: 5
    Page numbers: 1631-1636
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  • Copper in the brain and Alzheimer's disease
    Year: 2010
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 15
    Issue: 1
    Page numbers: 61-76
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  • Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans
    Year: 2010
    Journal: Cell Metabolism
    Volume: 12
    Issue: 3
    Page numbers: 260-272
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  • Monomerized Cu,Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding
    Year: 2010
    Journal: Free Radical Biology and Medicine
    Volume: 48
    Issue: 7
    Page numbers: 945-952
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  • PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses
    Year: 2010
    Journal: Journal of Alzheimer's Disease
    Volume: 20
    Issue: 2
    Page numbers: 509-516
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  • Plasma Amyloid-β as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging
    Year: 2010
    Journal: Journal of Alzheimer's Disease
    Volume: 20
    Issue: 4
    Page numbers: 1233-1242
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  • Plasma amyloid-beta as a biomarker in Alzheimer's disease:the AIBL study of aging
    Year: 2010
    Journal: Journal of Alzheimer's Disease
    Volume: 20
    Issue: 4
    Page numbers: 1233-1242
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  • Tau protein: Relevance to Parkinson's disease
    Year: 2010
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 42
    Issue: 11
    Page numbers: 1775-1778
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  • Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain
    Year: 2010
    Journal: Metallomics: integrated biometal science
    Volume: 2
    Issue: 11
    Page numbers: 745-753
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Publications in 2009

Journal Articles

  • ß-amyloid as a molecular therapeutic target in Alzheimer's disease
    Year: 2009
    Journal: Drugs of Today
    Volume: 45
    Issue: 4
    Page numbers: 293-304
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  • A role for glutathione in the pathophysiology of bipolar disorder and schizoprenia? Animal models and relevance to clinical practice
    Year: 2009
    Journal: Current Medicinal Chemistry
    Volume: 16
    Page numbers: 2965-2976
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  • Chronic Exposure to High Levels of Zinc or Copper has little Effect on Brain Metal Homeostasis or Aβ Accumulation in Transgenic APP-C100 Mice

    Year: 2009
    Journal: Cellular & Molecular Neurobiology
    Volume: 29
    Issue: 5
    Page numbers: 757-767
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  • Effects of N-acetylcysteine on substance use in bipolar disorder: A randomised placebo-controlled clinical trial
    Year: 2009
    Journal: Acta Neuropsychiatrica
    Volume: 21
    Page numbers: 285-291
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  • Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice
    Year: 2009
    Journal: Behavioural Brain Research
    Volume: 198
    Page numbers: 258-262
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  • Intracellular amyloid formation in muscle cells of Aß-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
    Year: 2009
    Journal: Molecular Neurodegeneration
    Volume: 4
    Issue: 1
    Article number: 2
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  • Paradoxical condensation of copper with elevated β-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer's disease

    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 33
    Page numbers: 21899 - 907
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  • Pharmacotherapeutic targets in Alzheimer's disease
    Year: 2009
    Journal: Journal of Cellular and Molecular Medicine
    Volume: 13
    Issue: 1
    Page numbers: 61-86
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    URL - open access http://www3.interscience.wiley.com.ezp.lib.unimelb.edu.au/cgi-bin/fulltext/121521873/PDFSTART
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  • Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models
    Year: 2009
    Journal: Metallomics: integrated biometal science
    Volume: 1
    Issue: 1
    Page numbers: 53-58
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  • SLC30A3 Responds to Glucose- and Zinc Variations in β-Cells and Is Critical for Insulin Production and In Vivo Glucose-Metabolism During β-Cell Stress

    Year: 2009
    Journal: PLoS One
    Volume: 4
    Issue: 5
    Article number: e5684
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  • Targeting the progression of Parkinson's disease
    Year: 2009
    Journal: Current Neuropharmacology
    Volume: 7
    Page numbers: 9-36
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  • The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
    Year: 2009
    Journal: International Psychogeriatrics
    Volume: 21
    Issue: 4
    Page numbers: 672-687
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  • The Caernorhabditis elegans Abeta1-42 model of Alzheimer's disease predominantly expresses Abeta3-42

    Year: 2009
    Journal: Biological Chemistry
    Volume: 284
    Issue: 34
    Page numbers: 22697-22702
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  • Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid

    Year: 2009
    Journal: Neurobiology of Aging
    Volume: 30
    Page numbers: 1069-1077
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Publications in 2008

Journal Articles

  • Glutathione precursor, N-Acetyl-Cysteine, Improves mismatch negativity in Schizophrenia patients

    Year: 2008
    Journal: Neuropsychopharmacology
    Page numbers: 2187-2199
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  • Glutathione: a novel treatment target in psychiatry
    Year: 2008
    Journal: Trends in Pharmacological Sciences
    Volume: 29
    Issue: 7
    Page numbers: 346-351
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  • Insights into Zn2+ homeostasis in neurons from experimental and modeling studies
    Year: 2008
    Journal: American Journal of Physiology - Cell Physiology
    Volume: 294
    Issue: 3
    Page numbers: C726-C742
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  • N-acetyl Cysteine as a Glutatione Precursor for Schizophrenia - A Double-Blind, Randomized, Placebo-Controlled Trial
    Year: 2008
    Journal: Biological Psychiatry
    Volume: 64
    Page numbers: 361-368
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  • N-acetyl Cysteine for depressive symptoms in Bipolar Disorder - A Double-Blind, Randomized, Placebo-Controlled Trial
    Year: 2008
    Journal: Biological Psychiatry
    Volume: 64
    Page numbers: 468-475
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  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease

    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
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  • Sensitive, selective, and irreversible Inhibition of Cyclooxygenase-2 Activity by Copper
    Year: 2008
    Journal: ChemMedChem
    Volume: 3
    Issue: 2
    Page numbers: 223-225
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  • Sequestration of Copper from beta-amyloid promotes selective lysis by Cyclen-Bybrid cleavage agents
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 46
    Page numbers: 31657-31664
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  • Therapeutics for Alzheimer's Disease Based on the Metal Hypothesis
    Year: 2008
    Journal: Neurotherapeutics
    Volume: 5
    Issue: 3
    Page numbers: 421-432
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Publications in 2007

Book Chapters

  • Metal Ions and Alzheimer's disease
    Year: 2007
    Book: Interaction between neurons and glia in aging and disease
    Publisher: Springer(New York)
    Authors(s):
    Editors(s):
  • Metals, oxidative stress, and brain biology
    Year: 2007
    Book: Encyclopedia of Stress
    Publisher: Elsevier Science(Oxford)
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Journal Articles

  • Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency
    Year: 2007
    Journal: Neuroscience
    Volume: 150
    Issue: 2
    Page numbers: 357-369
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  • Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
    Year: 2007
    Journal: Free Radical Biology and Medicine
    Volume: 42
    Issue: 10
    Page numbers: 1534-1542
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  • Mechanisms of copper ion mediated Huntington's Disease progression.
    Year: 2007
    Journal: PLoS One
    Volume: 2
    Issue: 3
    Article number: e334
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  • Mitochondria in aging and Alzheimer's disease
    Year: 2007
    Journal: Rejuvenation Research
    Volume: 10
    Page numbers: 349-357
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  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.
    Year: 2007
    Journal: PLoS One
    Volume: 2
    Issue: 6
    Article number: e536
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  • The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.
    Year: 2007
    Journal: FEBS Journal
    Volume: 274
    Page numbers: 3775-3783
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Publications in 2006

Book Chapters

  • The Role of Metal Ions in Neurology. An Introduction
    Year: 2006
    Book: Metal Ions in Life Sciences: Neurodegenerative diseases and metal ions
    Publisher: Wiley - John Wiley & Sons(Chichester)
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Journal Articles

  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Elevated cortical zinc in Alzheimer disease
    Year: 2006
    Journal: Neurology
    Volume: 67
    Issue: 1
    Page numbers: 69-75
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  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
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  • Metal homeostasis in Alzheimer's disease
    Year: 2006
    Journal: Expert Review of Neurotherapeutics
    Volume: 6
    Issue: 5
    Page numbers: 711-722
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  • Metals and Alzheimer's disease
    Year: 2006
    Journal: Journal of Alzheimer's Disease
    Volume: 10
    Page numbers: 145-163
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  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
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  • Therapeutic treatments for Alzheimer's disease based on metal bioavailability
    Year: 2006
    Volume: 19
    Page numbers: 469-474
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Publications in 2005

Book Chapters

  • Amyloid-beta metal interaction and metal chelation.
    Year: 2005
    Book: Alzheimer's disease: Cellular and molecular aspects of amyloid beta
    Publisher: Springer Verlag(New York)
    Authors(s):
  • Copper and zinc in Alzheimer's disease and amyotrophic lateral sclerosis.
    Year: 2005
    Book: Neurodegenerative diseases: Neurobiology, Pathogenesis and Therapeutics
    Publisher: Cambridge University Press(Cambridge)
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Journal Articles

  • Alzheimer disease β-amyloid activity mimics cholesterol oxidase
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Page numbers: 2556-2563
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system.
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 50
    Page numbers: 41732-41743
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Metals and amyloid-Β in Alzheimer's disease
    Year: 2005
    Journal: International Journal of Experimental Pathology
    Volume: 86
    Issue: 3
    Page numbers: 147-159
    Publisher: Blackwell Science(Oxford)
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  • Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 353-360
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  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 13355-13363
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  • Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment.
    Year: 2005
    Journal: Free Radical Biology and Medicine
    Volume: 38
    Issue: 2
    Page numbers: 258-261
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  • Model studies of cholesterol and ascorbate oxidation by copper complexes: Relevance to Alzheimer's disease beta-amyloid metallochemistry
    Year: 2005
    Journal: Journal of Inorganic Biochemistry
    Volume: 99
    Issue: 12
    Page numbers: 2403-2422
    Publisher: Elsevier Science(New York)
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  • Pilot study of the reducing effect of Amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5'Untranslated region
    Year: 2005
    Journal: Current Alzheimer Research
    Volume: 2
    Issue: 2
    Page numbers: 249-254
    Publisher: Bentham Science Publishers
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  • The neurobiology of zinc in health and disease.
    Year: 2005
    Journal: Nature Reviews Neuroscience
    Volume: 6
    Issue: 6
    Page numbers: 449-462
    Publisher: Nature Publishing Group(Houndmills)
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Publications in 2004

Journal Articles

  • Alzheimer's amyloid β-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide
    Year: 2004
    Journal: Neurobiology of Aging
    Volume: 25
    Page numbers: 563-568
    Publisher: Elsevier Science(New York)
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  • Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid Β-peptide by NMR
    Year: 2004
    Journal: Journal of Peptide Science
    Volume: 10
    Page numbers: 210-217
    Publisher: John Wiley & Sons(West Sussex)
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  • Copper mediates dityrosine cross-linking of Alzheimer's amyloid-Β
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Page numbers: 560-568
    Publisher: American Chemical Society(Washington DC)
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  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
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  • Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 8602-8607
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of Amyotrophic Lateral Sclerosis
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 7945-7950
    Publisher: Society of Neuroscience(Washington DC)
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  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
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  • Metal-protein attenuating compounds (MPACs) for the treatment of Alzheimer's disease
    Year: 2004
    Journal: Drug Design Reviews Online
    Volume: 1
    Page numbers: 75-82
    Publisher: Bentham Science Publishers(Hilversum)
    Author(s):
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  • Metal-protein attenuating compounds and Alzheimer's disease
    Year: 2004
    Journal: Expert Opinion on Investigational Drugs
    Volume: 13
    Page numbers: 1585-1592
    Publisher: Ashley Publications(London)
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  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Neurodegenerative diseases and oxidative stress
    Year: 2004
    Journal: Nature Reviews Drug Discovery
    Volume: 3
    Page numbers: 205-214
    Publisher: Nature Publishing Group(London)
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  • Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 3453-3459
    Publisher: Society of Neuroscience(Washington DC)
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  • Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links Β-amyloid (AΒ) and generates AΒ-COX-2 hetero-oligomers that are increased in Alzheimer's disease
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 14673-14678
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Redox-active metals, oxidative stress, and Alzheimer's disease pathology
    Year: 2004
    Journal: Annals of The New York Academy of Sciences
    Volume: 1012
    Page numbers: 153-163
    Publisher: New York Academy of Sciences(New York)
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  • Serum copper: a biomarker for Alzheimer disease?
    Year: 2004
    Journal: Archives of Neurology
    Volume: 61
    Page numbers: 631-632
    Publisher: American Medical Association(Illinois)
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  • The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1701-1703
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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  • Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's AΒ peptides
    Year: 2004
    Journal: Journal of Inorganic Biochemistry
    Volume: 9
    Page numbers: 954-960
    Publisher: Elsevier Science(New York)
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  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Aβ metallobiology and the development of novel metal-compounds (MPACs) for Alzheimer's disease
    Year: 2003
    Journal: Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents
    Volume: 3
    Issue: 4
    Page numbers: 309-315
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  • Copper, β-amyloid, and Alzheimer's disease: tapping a sensitive connection
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 20
    Page numbers: 11193-11194
    Publisher: National Academy of Sciences(Washington DC)
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  • Copper, zinc, and the metallobiology of Alzheimer disease
    Year: 2003
    Journal: Alzheimer Disease and Associated Disorders
    Volume: 17
    Issue: 3
    Page numbers: 147-150
    Publisher: Lippincott Williams & Wilkins
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  • Current status of metals as therapeutic targets in Alzheimer's disease
    Year: 2003
    Journal: Journal of the American Geriatrics Society
    Volume: 51
    Page numbers: 1143-1148
    Publisher: Blackwell Publishers(Massachusetts)
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  • Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
    Year: 2003
    Journal: The Lancet
    Volume: 361
    Page numbers: 1258-1265
    Publisher: Lancet(London)
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  • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease
    Year: 2003
    Journal: Neuron
    Volume: 37
    Page numbers: 899-909
    Publisher: Cell Press(Massachusetts)
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  • Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-β peptide with membrane lipid
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 5
    Page numbers: 2977-2982
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Metal-protein attenuation with Iodochlorhydroxyquin (Clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Year: 2003
    Journal: Archives of Neurology
    Volume: 60
    Page numbers: 1685-1691
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  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
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  • The medicinal metallochemistry of Alzheimer's disease
    Year: 2003
    Journal: Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents
    Volume: 3
    Page numbers: 9-13
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  • The metallobiology of Alzheimer's disease
    Year: 2003
    Journal: Trends in Neurosciences
    Volume: 26
    Issue: 4
    Page numbers: 207-214
    Publisher: Elsevier Science(London)
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  • To write a book, to plant a tree...
    Year: 2003
    Journal: Science
    Volume: 299
    Page numbers: 1318-1319
    Publisher: American Society for the Advancement of Science(Washington DC)
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Publications in 2002

Book Chapters

  • Copper, zinc and Alzheimer's disease
    Year: 2002
    Book: Diet-brain connections: impact on memory, mood, aging and disease
    Publisher: Kluwer Academic Publishers(Norwell)
    Authors(s):

Journal Articles

  • Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region
    Year: 2002
    Journal: Journal of Molecular Neuroscience
    Volume: 19
    Page numbers: 77-82
    Publisher: Humana Press
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  • An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 45518-45528
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Brain zinc: physiology and pathophysiology
    Year: 2002
    Journal: Biometals
    Volume: 14
    Page numbers: 353-366
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  • Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?
    Year: 2002
    Journal: Nature Neuroscience
    Volume: 5
    Issue: 10
    Page numbers: 919-919
    Publisher: Nature America(Philadelphia)
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  • Metal complexing agents as therapies for Alzheimer's disease
    Year: 2002
    Journal: Neurobiology of Aging
    Volume: 23
    Page numbers: 1031-1038
    Publisher: Elsevier Science(New York)
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  • Metalloenzyme-like activity of Alzheimer's disease β-amyloid - Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 43
    Page numbers: 40302-40308
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  • Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 47
    Page numbers: 44670-44676
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Response: '...and C is for Clioquinol' - the A[beta]Cs of Alzheimer's disease
    Year: 2002
    Journal: Trends in Neurosciences
    Volume: 25
    Issue: 3
    Page numbers: 123-124
    Publisher: Elsevier Science(London)
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  • The galvanization of beta-amyloid in Alzheimer's disease
    Year: 2002
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 99
    Issue: 11
    Page numbers: 7317-7319
    Publisher: National Academy of Sciences(Washington DC)
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Publications in 2001

Book Chapters

  • Neuroinflammatory responses in the Alzheimer's disease brain promote the oxidative post-translational modifiction of amyloid deposits
    Year: 2001
    Book: Alzheimer's disease: advances in etiology, pathogenesis and therapeutics
    Publisher: John Wiley & Sons(West Sussex)
    Authors(s):
  • Parallels between the redox properties and toxicity of A[beta] in Alzheimer's disease and mutant Cu/Zn-SOD in Familial Amyotropic Lateral Sclerosis
    Year: 2001
    Book: Alzheimer's disease: advances in etiology, pathogenesis and therapeutics
    Publisher: John Wiley & Sons(West Sussex)
    Authors(s):

Journal Articles

  • Alzheimer's Disease Amyloid-[beta] Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 23
    Page numbers: 20466-20473
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Clinoquinol's return: cautions from Japan
    Year: 2001
    Journal: Science
    Volume: 292
    Page numbers: 2251-2252
    Publisher: American Society for the Advancement of Science(Washington DC)
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  • Computerised cognitive assessment of concussed Australian Rules footballers
    Year: 2001
    Journal: British Journal of Sports Medicine
    Volume: 35
    Page numbers: 354-360
    Publisher: British Medical Journal Publishing Group(London)
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  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
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  • Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways
    Year: 2001
    Journal: Journal of Neurochemistry
    Volume: 76
    Page numbers: 1509-1520
    Publisher: Blackwell Science(Oxford)
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  • Redox-active iron mediates amyloid-beta toxicity
    Year: 2001
    Journal: Free Radical Biology and Medicine
    Volume: 30
    Issue: 4
    Page numbers: 447-450
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Synaptically released zinc: physiological functions and pathological effects
    Year: 2001
    Journal: Biometals
    Volume: 14
    Issue: 3-4
    Page numbers: 353-366
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
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  • Therapeutic targets in the biology of Alzheimer's disease
    Year: 2001
    Journal: Current Opinion in Psychiatry
    Volume: 14
    Page numbers: 341-348
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Treatment with a copper-zinc chelator markedly and rapidly inhibits [beta]-amyloid accumulation in Alzheimer's disease transgenic mice
    Year: 2001
    Journal: Neuron
    Volume: 30
    Page numbers: 665-676
    Publisher: Cell Press(Massachusetts)
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