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PROF ASHLEY IAN BUSH



Contact Details

Organization: Pathology
Position: Honorary (Professorial Fellow)
Email:
Homepage: www.mhri.edu.au/
Work: 9389 2914
Fax: 9380 6182
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Alzheimer's disease copper, metals, oxidative stress Australia

International Linkages

Country Establishment Collaboration
United States Massachusetts General Hospital Research, Teaching, Technical Assistance/Training

Languages

Languages

Language Proficiency
English Speak, Read & Write

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Diploma in Psychological Medicine University of Melbourne 01-Jan-1988
Bachelor of Medicine University of Melbourne 01-Jan-1982
Ph.D. (Pathology) University of Melbourne 01-Jan-1993

Memberships

Membership Type Membership Body Description Start Date End Date
Member Royal Australian and New Zealand College of Psychiatrists 01-Jan-1989
Member American Academy for the Advancement of Science 01-Jan-1993
Member Society for Neuroscience 01-Jan-1993
Member American Medical Association 01-Jan-1995
Member The American Society for Biochemistry and Molecular Biology 01-Jan-2003

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australian and New Zealand College of Psychiatrists (FRANZCP)

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Commonwealth Fund of New York 01-Jan-1992
Other (Award) The Royal Australian and New Zealand College of Psychiatry 01-Jan-1994
Other (Award) National Down Syndrome Society 01-Jan-1994
Scholarship Massachusetts General Hospital 01-Jan-1995
Other (Award) Paul B. Beeson 01-Jan-1998
Other (Award) Alzheimer's Association 01-Jan-2000
Prize American Academy of Neurology 01-Jan-2003
Other (Award) Australian Research Council 01-Jan-2004
Other (Award) Alzheimer's Association 01-Jan-2004
Medal Bethlehem Griffiths Research Foundation 01-Jan-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Novel therapies for Alzheimer's disease based on A-beta - metal interactions Chief Investigator NHMRC Project Grants 01/01/2001
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
THE ROLE OF AMYLOID PROTEIN PRECURSOR IN MAMMALIAN COPPER TRANSPORT Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
APPLICATION OF COPPER-64 TO STUDIES ON ALZHEIMER'S DISEASE AND CHARACTERISATION OF NOVEL GENES AND PROTEINS INVOLVED IN COPPER HOMEOSTASIS Chief Investigator AINSE Awards 01/01/2007
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
PETER DOHERTY AUSTRALIAN BIOMEDICAL FELLOWSHIP - EXAMINATION OF THE INVOLVEMENT OF COPPER IN THE DEVELOPMENT AND PROGRESSION OF ALZHEIMER'S DISEASE Principal Supervisor NHMRC Training (Postdoctoral) Fellowships 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Book Chapters

  • Metal Ions and Alzheimer's disease
    Year: 2007
    Book: Interaction between neurons and glia in aging and disease
    Publisher: Springer(New York)
    Authors(s):
    Editors(s):
  • Metals, oxidative stress, and brain biology
    Year: 2007
    Book: Encyclopedia of Stress
    Publisher: Elsevier Science(Oxford)
    Authors(s):
    Editors(s):

Journal Articles

  • Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency


    Year: 2007
    Journal: Neuroscience
    Volume: 150
    Issue: 2
    Page numbers: 357-369
    Author(s):
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  • Glutathione precursor, N-Acetyl-Cysteine, Improves mismatch egativity in Schizophrenia patients


    Year: 2007
    Journal: Neuropsychopharmacology
    Volume: n/a
    Page numbers: 1-13
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  • Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
    Year: 2007
    Journal: Free Radical Biology and Medicine
    Volume: 42
    Issue: 10
    Page numbers: 1534-1542
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  • Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease
    Year: 2007
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: In press
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  • Mechanisms of copper ion mediated Huntington's Disease progression.
    Year: 2007
    Journal: PLoS One
    Volume: March 2007
    Issue: 3
    Page numbers: e334
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  • Mitochondria in aging and Alzheimer's disease
    Year: 2007
    Journal: Rejuvenation Research
    Volume: 10
    Page numbers: 349-357
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  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.
    Year: 2007
    Journal: PLoS One
    Volume: June 2007
    Issue: 6
    Page numbers: e536
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  • The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.
    Year: 2007
    Journal: FEBS Journal
    Volume: 274
    Page numbers: 3775-3783
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Publications in 2006

Book Chapters

  • The Role of Metal Ions in Neurology. An Introduction
    Year: 2006
    Book: Metal Ions in Life Sciences: Neurodegenerative diseases and metal ions
    Publisher: Wiley - John Wiley & Sons(Chichester)
    Authors(s):
    Editors(s):

Journal Articles

  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Elevated cortical zinc in Alzheimer disease
    Year: 2006
    Journal: Neurology
    Volume: 67
    Issue: 1
    Page numbers: 69-75
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  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
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  • Metal homeostasis in Alzheimer's disease
    Year: 2006
    Journal: Expert Review of Neurotherapeutics
    Volume: 6
    Issue: 5
    Page numbers: 711-722
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  • Metals and Alzheimer's disease
    Year: 2006
    Journal: Journal of Alzheimer's Disease
    Volume: 10
    Page numbers: 145-163
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  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
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  • Therapeutic treatments for Alzheimer's disease based on metal bioavailability
    Year: 2006
    Volume: 19
    Page numbers: 469-474
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Publications in 2005

Book Chapters

  • Amyloid-beta metal interaction and metal chelation.
    Year: 2005
    Book: Alzheimer's disease: Cellular and molecular aspects of amyloid beta
    Publisher: Springer Verlag(New York)
    Authors(s):
  • Copper and zinc in Alzheimer's disease and amyotrophic lateral sclerosis.
    Year: 2005
    Book: Neurodegenerative diseases: Neurobiology, Pathogenesis and Therapeutics
    Publisher: Cambridge University Press(Cambridge)
    Authors(s):

Journal Articles

  • Alzheimer disease β-amyloid activity mimics cholesterol oxidase
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Page numbers: 2556-2563
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system.
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 50
    Page numbers: 41732-41743
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Metals and amyloid-Β in Alzheimer's disease
    Year: 2005
    Journal: International Journal of Experimental Pathology
    Volume: 86
    Issue: 3
    Page numbers: 147-159
    Publisher: Blackwell Science(Oxford)
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  • Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 353-360
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  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity