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A/PROF MARK JENKINS



Contact Details

Organization: Population Health
Position: ASSOCIATE PROFESSOR IN EPIDEMIOLOGY (MEGA)
Email:
Homepage: www.epi.unimelb.edu.au
Work: 8344 0902
Fax: 03 9349 5815
Room: 207
Level: 02
Building: 723 Swanston St.
Campus: Parkville

Biography

Dr Jenkins is an epidemiologist who has over 10 years experience on the design, conduct, and analysis of studies examining the role of genetic and environmental causes of cancer. He is Co-Principal Investigator of NIH funded Colon Cancer Family Registry. He is the co-Chair of steering committee of the NIH funded international collaboration: the Colon Cancer Family Registry and is also a member of the Epidemiology Working Group of the Colon Cancer Family Registry. He has published over 90 peer reviewed articles, a large proportion of which are in genetic epidemiology of cancer, including colorectal cancer research. He has also published reviews articles and editorials on mismatch repair genes and colorectal cancer. He is an investigator on over 20 funded international and national research projects. He currently teaches, at postgraduate level, a course in Genetic Epidemiology and is coordinator of MPH student research projects. He has been a member of both national (NHMRC) and international review panels (NIH-EPIC) and contributes to peer review of national and international journals and funding bodies.

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
genetic epidemiology, cancer epidemiology breast cancer, colorecal cancer, asthma Australia

International Linkages

Country Establishment Collaboration
United States Columbia University Research
United States University of California - Irvine Research
United States National Institutes of Health Research
United States Southern California Research
United States Northern California Cancer Center Research
Canada Cancer Care Ontario Research
United States Fox Chase Cancer Center Research
Canada Huntsman Cancer Institute Research
United States Research Triangle Institute Research
United States Fred Hutchinson Cancer Research Center Research
United States Mayo Clinic Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 25-Mar-1988
Doctor of Philosophy University of Melbourne 10-Dec-1994

Memberships

Membership Type Membership Body Description Start Date End Date
Member International Society of Inherited Gastrointestinal Tumours Member 01-Jan-2005 31-Dec-2009
Member Cancer Epidemiology, Biomarkers & Prevention Editorial Board 01-Jan-2009

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship VicHealth Victorian Health Promotion Student Scholarship (3 years) 01-Jan-1990

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
RISK FACTORS, SCREENING, PROPHYLAXIS AND OUTCOMES IN INDIVIDUALS FROM BREAST CANCER FAMILIES: KCONFAB FOLLOW-UP STUDY Chief Investigator NHMRC Project Grants 01/01/2004
Risk factors for chronic respiratory diseases in middle age: 36-year follow up of the Tasmanian Asthma Study Chief Investigator NHMRC Project Grants 01/01/2004
MUTATIONS IN STEROID HORMONE METABOLISM GENES AND RISK OF BREAST CANCER Chief Investigator NATIONAL BREAST CANCER FOUNDATION Kathleen Cunningham Research Grant 01/01/2006
"Germline mutations in mismatch repair genes: prevalence, risk of cancer, and environmental modifiers of risk." Chief Investigator NHMRC Project Grants 01/01/2006
Genetic modifiers of environmental risk factors for longitudinal changes in asthma Chief Investigator L.E.W. CARTY CHARITABLE FUND Research Grants 01/05/2006
STUDIES INTO GYNAECOLOGICAL CANCERS ASSOCIATED WITH THE SYNDROME: HEREDITARY NONPOLYPOSIS COLON CANCER Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 27/11/2006
What are the breast cancer risks for an Australian women who carries a mutation in the BRCA1 or BRCA2 genes? Chief Investigator NHMRC Project Grants 01/01/2007
How can the risk of breast cancer be reduced in those with a strong family history of the disease? Chief Investigator NHMRC Project Grants 01/01/2007
Do different types of bowel cancer have different risk factors? Chief Investigator NHMRC Project Grants 01/01/2008
Identification and risk prediction of individuals at high risk of melanoma Principal Supervisor VIC CANCER AGENCY Early Career Seed Grant 15/09/2008
How do your genes affect your risk of melanoma, and what can you do about it? Chief Investigator NHMRC Project Grants 01/01/2009
CSIRO Flagship,Scholarship: FULL Principal Supervisor CSIRO FLAGSHIP COLLABORATIVE FUND Postgraduate Scholarships 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Eye injuries in rural Victoria


    Year: 2009
    Journal: Clinical and Experimental Ophthalmology
    Volume: 37
    Page numbers: 698-702
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  • Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis
    Year: 2009
    Journal: Familial Cancer
    Volume: 8
    Page numbers: 313-323
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  • Breast cancer risk is not increased in individuals with TWIST1 mutation confirmed Saethre-Chotzen syndrome: An Australian mulitcentre study
    Year: 2009
    Journal: Genes, Chromosomes & Cancer
    Volume: 48
    Page numbers: 533-538
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  • Germline MutY human homologue mutations and colorectal cancer: A multi-site case-control study
    Year: 2009
    Journal: Gastroenterology
    Volume: 136
    Page numbers: 1251-1260
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  • Relevance of the hygiene hypothesis to early vs. late onset allergic rhinitis
    Year: 2009
    Journal: Clinical and Experimental Allergy
    Volume: 39
    Page numbers: 370-378
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Publications in 2008

Journal Articles

  • The RAD51D E233G variant and breast cancer risk: population-based and clinic-based family studies of Australian women


    Year: 2008
    Journal: Breast Cancer Research and Treatment
    Volume: 112
    Issue: 1
    Page numbers: 35-39
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  • Association of a common AKAP9 variant with breast cancer risk: A collaborative analysis
    Year: 2008
    Journal: Journal of the National Cancer Institute
    Volume: 100
    Page numbers: 437-442
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  • Cancer Risk Management Practices of Noncarriers Within
    BRCA1/2 Mutation–Positive Families in the Kathleen
    Cuningham Foundation Consortium for Research Into
    Familial Breast Cancer
    Year: 2008
    Journal: Journal of Clinical Oncology
    Volume: 26
    Issue: 2
    Page numbers: 225-32
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  • Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype
    Year: 2008
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 17
    Issue: 7
    Page numbers: 1774-1780
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  • Is BRCA2 c.9079 G > A a predisposing variant for early onset breast cancer?
    Year: 2008
    Journal: Breast Cancer Research and Treatment
    Volume: 109
    Page numbers: 177-179
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  • Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
    Year: 2008
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 17
    Issue: 11
    Page numbers: 3208-3215
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  • Predictors of the use of complementary and alternative medicine (CAM) by women at high risk for breast cancer
    Year: 2008
    Journal: European Journal of Cancer
    Volume: 45
    Page numbers: 551-560
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  • Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies
    Year: 2008
    Journal: Breast Cancer Research and Treatment
    Volume: 109
    Page numbers: 91-99
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  • The clinical phenotype of Lynch Syndrome due to germ-line PMS2 mutations
    Year: 2008
    Journal: Gastroenterology
    Volume: 135
    Page numbers: 419-428
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Publications in 2007

Journal Articles

  • A Range of Simple Summary Genome-Wide Statistics for Detecting Genetic Linkage using High Density Marker Data


    Year: 2007
    Journal: Genetic Epidemiology
    Volume: 31
    Page numbers: 565-576
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  • Microsatellite instability markers for identifying early-onset colorectal cancers caused by germ-line mutations in DNA mismatch repair genes


    Year: 2007
    Journal: Clinical Cancer Research
    Volume: 13
    Issue: 10
    Page numbers: 2865-2869
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  • Pathology featues in Bethesda guidelines predict colorectal cancer microsatellite instability: A population-based study


    Year: 2007
    Journal: Gastroenterology
    Volume: 133
    Issue: 48
    Page numbers: 48-56
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  • Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry


    Year: 2007
    Journal: Cancer Research
    Volume: 67
    Issue: 23
    Page numbers: 11128-11132
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  • Accuracy of colorectal polyp self-reports: findings from the Colon Cancer Family Registry
    Year: 2007
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 16
    Issue: 9
    Page numbers: 1898-1901
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  • Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set
    Year: 2007
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 16
    Issue: 12
    Page numbers: 2557-2565
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  • Breast-feeding and atopic disease: A cohort study from childhood to middle age
    Year: 2007
    Journal: Journal of Allergy and Clinical Immunology
    Volume: 120
    Page numbers: 1051-1057
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  • Childhood adiposity predicts adult-onset current asthma in females: a 25-yr propsective study
    Year: 2007
    Journal: European Respiratory Journal
    Volume: 29
    Issue: 4
    Page numbers: 668-675
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  • Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: A longitudinal study
    Year: 2007
    Journal: Journal of Allergy and Clinical Immunology
    Volume: 120
    Page numbers: 863-869
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  • RAD51 135G→modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies
    Year: 2007
    Journal: American Journal of Human Genetics
    Volume: 81
    Page numbers: 1186-1200
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  • Serrated pathway colorectal cancer in the population: genetic consideration
    Year: 2007
    Journal: Gut
    Volume: 56
    Page numbers: 1453-1459
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  • Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years
    Year: 2007
    Journal: Breast Cancer Research and Treatment
    Volume: 10
    Page numbers: 9621-9629
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  • Validation study of the LAMBDA model for predicting the BRCA1 or BRCA2 mutation carrier status of North American Ashkenazi Jewish women
    Year: 2007
    Journal: Clinical Genetics
    Volume: 72
    Page numbers: 87-97
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Publications in 2006

Journal Articles

  • BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Year: 2006
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 15
    Issue: 10
    Page numbers: 1863-1870
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  • Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource


    Year: 2006
    Journal: Breast Cancer Research
    Volume: 8
    Page numbers: R12
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  • Chromosome 2q24.2 is lost in sporadic but not in BRCA1-associated ovarian carcinomas


    Year: 2006
    Journal: Pathology
    Volume: 38
    Issue: 2
    Page numbers: 145-151
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  • Genetic and histopathologic evaluation of BRCA1 and BRCA2 DNA sequence variants of unknown clinical significance


    Year: 2006
    Journal: Cancer Research
    Volume: 66
    Issue: 4
    Page numbers: 2019-2027
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  • Is childhood immunisation associated with atopic disease from age 7 to 32 years?


    Year: 2006
    Journal: Thorax
    Volume: 62
    Page numbers: 270-275
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  • Measures of familial aggregation depend on definition of family history: meta-analysis for colorectal cancer


    Year: 2006
    Journal: Journal of Clinical Epidemiology
    Volume: 59
    Page numbers: 114-124
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  • Cancer risks for mismatch repair gene mutation carriers: a population-based early onset case-family study.
    Year: 2006
    Journal: Clinical Gastroenterology and Hepatology
    Volume: 4
    Page numbers: 489-498
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  • Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling
    Year: 2006
    Journal: Genes, Chromosomes & Cancer
    Volume: 45
    Page numbers: 1169-1181
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  • Evaluation of models to predict BRCA germline mutations
    Year: 2006
    Journal: British Journal of Cancer
    Volume: 95
    Page numbers: 914-920
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  • Genetic, functional and histopathological evaluation of two C-terminal BRCA1 missense variants
    Year: 2006
    Journal: Journal of Medical Genetics
    Volume: 43
    Issue: 1
    Page numbers: 74-83
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  • Histopathological features of breast cancer in carriers of  ATM gene variants
    Year: 2006
    Journal: Histopathology
    Volume: 49
    Page numbers: 523-532
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  • IN REPLY: Is it time to abandon microsatellite instability as a pre-screen for selecting families for mutation testing for mismatch repair genes?
    Year: 2006
    Journal: Journal of Clinical Oncology
    Volume: 24
    Issue: 12
    Page numbers: 1962-1963
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  • Large genomic alterations in hMSH2 and hMLH1 in early-onset colorectal cancer: identification of a large complex de novo hMLH1 alteration
    Year: 2006
    Journal: Clinical Genetics
    Volume: 70
    Page numbers: 250-252
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  • Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years
    Year: 2006
    Journal: European Journal of Cancer
    Volume: 42
    Page numbers: 1357-1361
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  • Morphology of breast cancer as a means of triage of patients for BRCA1 genetic testing
    Year: 2006
    Journal: American Journal of Surgical Pathology
    Volume: 30
    Issue: 11
    Page numbers: 1357-1366
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  • No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Year: 2006
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 15
    Issue: 8
    Page numbers: 1565-1567
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  • Parity and decreased use of oral contraceptives as predictors of asthma in young women
    Year: 2006
    Journal: Clinical and Experimental Allergy
    Volume: 36
    Page numbers: 609-613
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  • Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T>G and c.1066-6T>G (IVS10-6T>G) from the Breast Cancer Family Registry
    Year: 2006
    Journal: Human Mutation
    Volume: 27
    Issue: 11
    Page numbers: 1122-1128
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  • Rationale for, and approach to, studying modifiers of risk in persons with a genetic predisposition to colorectal cancer
    Year: 2006
    Journal: Current Colorectal cancer Reports
    Volume: 2
    Page numbers: 173-178
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  • Risk of colorectal cancer in monoallelic and biallelic carriers of MYH mutations: a population-based case-family study
    Year: 2006
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 15
    Issue: 2
    Page numbers: 312-314
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  • Risk-reducing surgery, screening and chemoprevention practices of BRCA1 and BRCA2 mutation carriers: a prospecitve cohort study
    Year: 2006
    Journal: Clinical Genetics
    Volume: 70
    Page numbers: 198-206
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  • The Colorectal Cancer Family Registry: An international resource for studying the genetic and molecular epidemiology of colorectal cancer
    Year: 2006
    Journal: Gastrointestinal Cancer Update
    Volume: 46
    Page numbers: 14-20
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  • Tracing 8,600 participants 36 years after recruitment at age seven for the Tasmanian Asthma Study
    Year: 2006
    Journal: Australian and New Zealand Journal of Public Health
    Volume: 30
    Issue: 2
    Page numbers: 105-110
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  • Who remembers whether they had asthma as children?
    Year: 2006
    Journal: Journal of Asthma (New York)
    Volume: 43
    Page numbers: 727-730
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Publications in 2005

Journal Articles

  • A protein-truncating mutation in CYP17A1 in three sisters with early-onset breast cancer
    Year: 2005
    Journal: Human Mutation
    Volume: 26
    Issue: 4
    Page numbers: 298-302
    Publisher: Wiley-Liss(New York)
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  • CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study
    Year: 2005
    Journal: Breast Cancer Research
    Volume: 7
    Issue: 4
    Page numbers: R513-R521
    Publisher: Publications Current Science(London)
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  • Evidence of BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer
    Year: 2005
    Journal: Clinical Gastroenterology and Hepatology
    Volume: 3
    Page numbers: 254-263
    Publisher: WB Saunders Co
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  • Isolated loss of PMS2 expression in colorectal cancers: Frequency, patient age, and familial aggregation
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Issue: 18
    Page numbers: 6466-6471
    Publisher: American Association for Cancer Research(Alabama)
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  • Molecular characterization and cancer risk associated with BRCA1 and BRCA2 splice site variants identified with multiple-case breast cancer families
    Year: 2005
    Journal: Human Mutation
    Volume: 26
    Issue: 5
    Page numbers: 495
    Publisher: Wiley-Liss(New York)
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  • Two ATM variants and breast cancer risk
    Year: 2005
    Journal: Human Mutation
    Volume: 25
    Page numbers: 6
    Publisher: Wiley-Liss(New York)
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  • Use of molecular tumour characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer
    Year: 2005
    Journal: Journal of Clinical Oncology
    Volume: 23
    Issue: 27
    Page numbers: 6524-6532
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Publications in 2004

Journal Articles

  • Prognosis of premenopausal breast cancer and childbirth prior to diagnosis
    Year: 2004
    Journal: Journal of Clinical Oncology
    Volume: 22
    Issue: 4
    Page numbers: 699-705
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Publications in 2003

Journal Articles

  • A specific GFP expression assay, penetrance estimate, and histological assessment for a putative splice site mutation in BRCA1
    Year: 2003
    Journal: Human Mutation
    Volume: 22
    Page numbers: 86-91
    Publisher: Wiley-Liss(New York)
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  • Average age-specific cumulative risk of breast cancer according to type and site of germline mutations in BRCA1 and BRCA2 estimated from multiple-case breast cancer families attending Australian family cancer clinics
    Year: 2003
    Journal: Human Genetics
    Volume: 112
    Page numbers: 542-551
    Publisher: Springer Verlag(New York)
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  • Contributions of ATM mutations to familial breast and ovarian cancer
    Year: 2003
    Journal: Cancer Research
    Volume: 63
    Page numbers: 3325-3333
    Publisher: American Association for Cancer Research(Alabama)
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  • Strong familial risks associated with early-onset breast cancer are only partly BRCA1 and BRCA2 related
    Year: 2003
    Journal: Journal of the National Cancer Institute
    Volume: 95
    Issue: 6
    Page numbers: 448-457
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Publications in 2002

Journal Articles

  • A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community
    Year: 2002
    Journal: Vaccine
    Volume: 20
    Page numbers: 1831-1836
    Publisher: Elsevier Science(Oxford)
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  • After hMSH2 and hMLH1 - what next? Analysis of three-generational, population-based, early-onset colorectal cancer families
    Year: 2002
    Journal: International Journal of Cancer
    Volume: 102
    Page numbers: 166-171
    Publisher: Wiley-Liss(New York)
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  • Dominant Negative ATM Mutations in Breast Cancer Families
    Year: 2002
    Journal: Journal of the National Cancer Institute
    Volume: 94
    Issue: 3
    Page numbers: 205-215
    Publisher: National Cancer Institute(Maryland)
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