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A/PROF DAVID ASHLEY



Contact Details

Organization: Surgery - Royal Melbourne and Western Hospital, Paediatrics Royal Children's Hospital
Position: Honorary (Senior Fellow), Honorary (Principal Fellow)
Email:

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University
Bachelor of Medicine Monash University
Doctor of Philosophy Institution not known

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP)

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize Monash University Harriet Prize in Internal Medicine 01-Jan-1986

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
A novel approach to immune reconstitution and dendritic cell vaccination after intensive chemotherapy in neuroblastoma Chief Investigator NHMRC Practitioner Fellowship 01/01/2001

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
    Year: 2008
    Journal: British Journal of Cancer
    Volume: 99
    Issue: 2
    Page numbers: 294-304
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  • Intramedullary spinal cord tumors: Patterns of care in Victoria from 1998-2000.


     


    Year: 2008
    Journal: Asia-Pacific Journal of Clinical Oncology
    Volume: 4
    Issue: 2
    Page numbers: 77-80
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  • Multi-Institution Prospective Trial of Reduced-Dose Craniospinal Irradiation (23.4 GY) Followed by Conformal Posterior Fossa (36 GY) and Primary Site Irradiation (55.8 GY) and Dose-Intensive Chemotherapy for Average-Risk Medulloblastoma.


    Year: 2008
    Journal: International Journal of Radiation: Oncology - Biology - Physics
    Volume: 70
    Issue: 3
    Page numbers: 782-787
    Author(s):
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  • Amifostine Protects against Cisplatin-Induced Ototoxicity in Children with Average -Risk Medulloblastoma.
    Year: 2008
    Journal: Journal of Clinical Oncology
    Volume: 26
    Issue: 22
    Page numbers: 3749-3755
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  • Brain stem gliomas: Patterns of care in Victoria from1998-2000.
    Year: 2008
    Journal: Journal of Clinical Neuroscience
    Volume: 15
    Issue: 3
    Page numbers: 237-240
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  • Co-stimulation molecule expression and subset distribution of blood dendritic cells in normal children and newly diagnosed pediatric leukemia and lymphoma patients.
    Year: 2008
    Journal: Experimental Hematology
    Volume: 36
    Issue: 12
    Page numbers: 1691-1703
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  • Rhabdoid tumour: a malignancy of early childhod with variable primary site, histology and clinical behaviour.
    Year: 2008
    Journal: Pathology
    Volume: 40
    Page numbers: 664-670
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/18985520
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  • The use of chemotherapy in patients with gliomas.  Patterns of care in Victoria 1998-2000.
    Year: 2008
    Journal: Journal of Clinical Neuroscience
    Volume: 15
    Issue: 4
    Page numbers: 398-401
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Conference Publications/Papers

  • Insights into epigenetics of atypical rhabdoid tumors-the potential for treatment wiht histone deacetylase inhibitors
    Year: 2008
    Event name: Society of Neuro-oncology conference
    Conference Publication: Neuro-oncology
    Volume: 10
    Issue: 3
    Page numbers: 372
    Publisher: Duke University Press
    Author(s):

Publications in 2007

Journal Articles

  • Adverse hypersensitivity reactions to Mesna as adjunctive therapy for cyclophosphamide.


    Year: 2007
    Journal: Pediatric Blood & Cancer
    Volume: 49
    Issue: 3
    Page numbers: 341-343
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  • Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs


    Year: 2007
    Journal: Cell Death & Differentiation
    Volume: 14
    Page numbers: 348-357
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  • Multiple Factors Contribute to Neuropsychological Outcome in Children With Posterior Fossa Tumors
    Year: 2007
    Journal: Developmental Neuropsychology
    Volume: 32
    Issue: 2
    Page numbers: 729-748
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  • Pediatric Brain Tumor Patients: Their Parents'  Perceptions of the Hospital Experience
    Year: 2007
    Journal: Journal of Pediatric Oncology Nursing
    Volume: 24
    Issue: 2
    Page numbers: 95-105
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  • Pediatric Brain Tumour Patients: Their Parents’ Perceptions of the Hospital Experience



    Year: 2007
    Journal: Journal of Pediatric Oncology Nursing
    Volume: 24
    Issue: 2
    Page numbers: 95-105
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  • Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma
    Year: 2007
    Journal: Pharmacogenetics
    Volume: 17
    Issue: 9
    Page numbers: 709-717
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  • Temozolomide in pediatric low-grade glioma.
    Year: 2007
    Journal: Pediatric Blood & Cancer
    Volume: 49
    Issue: 6
    Page numbers: 808-811
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Publications in 2006

Journal Articles

  • Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.


    Year: 2006
    Journal: Journal of Clinical Oncology
    Volume: 24
    Issue: 12
    Page numbers: 1924-31
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  • Caspase-8 Levels Correlate With the Expression of Signal Transducer and Activator or Transcription 1 in High-Grade But Not Lower Grade Neuroblastoma
    Year: 2006
    Journal: Cancer
    Volume: 107
    Issue: 4
    Page numbers: 824-831
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  • Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1homologue CED-4, but can interact with EGL-1
    Year: 2006
    Journal: Journal of Cell Science
    Volume: 119
    Page numbers: 2572-2582
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  • Intelligence and adaptive function in children diagnosed with brain tumour during infancy
    Year: 2006
    Journal: Neuro-Oncology
    Volume: 80
    Page numbers: 295-303
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  • Phase II study of two-weekly temozolomide in patients with high-grade gliomas.
    Year: 2006
    Journal: Journal of Clinical Neuroscience
    Volume: 13
    Issue: 1
    Page numbers: 18-22
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  • Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-call rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Year: 2006
    Journal: Lancet Oncology
    Volume: 7
    Page numbers: 813-20
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Publications in 2005

Journal Articles

  • Caspase 8 is absent or low in many ex vivi gliomas.
    Year: 2005
    Journal: Cancer
    Volume: 104
    Issue: 1487-1496
    Page numbers: 7
    Publisher: John Wiley & Sons(New York)
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  • Caspase-8 is absent or low in many ex vivo gliomas
    Year: 2005
    Journal: Cancer
    Volume: 104
    Issue: 7
    Page numbers: 1487-1496
    Publisher: John Wiley & Sons(New York)
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  • Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma.
    Year: 2005
    Journal: Journal of Clinical Oncology
    Volume: 23
    Issue: 24
    Page numbers: 5511-5519
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  • Results of a Phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children with stage 4 neuroblastoma
    Year: 2005
    Journal: Cancer
    Volume: 103
    Issue: 6
    Page numbers: 1280-1291
    Publisher: John Wiley & Sons(New York)
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Publications in 2004

Journal Articles

  • White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumour.


    Year: 2004
    Journal: Journal of Clinical Oncology
    Volume: 22
    Issue: 22
    Page numbers: 4551-60
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  • Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis.
    Year: 2004
    Journal: Molecular Carcinogenesis
    Volume: 39
    Issue: 3
    Page numbers: 173-182
    Publisher: John Wiley & Sons(New York)
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  • Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Year: 2004
    Journal: Journal of Clinical Oncology
    Volume: 22
    Issue: 6
    Page numbers: 984-993
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  • Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer
    Year: 2004
    Journal: Neuro-Oncology
    Volume: 6
    Issue: 3
    Page numbers: 236-246
    Publisher: Carden Jennings Publishing(Virginia)
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  • Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supretentorial primitive neuroectodermal tumor
    Year: 2004
    Journal: Journal of Clinical Oncology
    Volume: 22
    Issue: 16
    Page numbers: 3357-3365
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Supratentorial tanycytic ependymoma.
    Year: 2004
    Journal: Journal of Clinical Neuroscience
    Volume: 11
    Issue: 8
    Page numbers: 928-30
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Publications in 2003

Journal Articles

  • Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression


    Year: 2003
    Journal: Cancer
    Volume: 2
    Issue: 397-405
    Page numbers: 98
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  • General anaesthesia or conscious sedation for painful procedures in childhood cancer: the family's perspective
    Year: 2003
    Journal: Archives of Disease in Childhood
    Volume: 88
    Page numbers: 253-257
    Publisher: BMJ Publishing Group(London)
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  • Health-related quality of life of children with acute lymphoblastic leukaemia: comparisons and correlations between parent and clinician reports.
    Year: 2003
    Journal: International Journal of Cancer
    Volume: 103
    Issue: 4
    Page numbers: 514-518
    Publisher: Wiley-Liss(New York)
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  • Letter to the editor - Randomized study of low-dose involved-field radiation
    Year: 2003
    Journal: Journal of Clinical Oncology
    Volume: 21
    Issue: 6
    Page numbers: 1192-1192
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Randomized comparison of low-dose involved-field.
    Year: 2003
    Journal: Journal of Clinical Oncology
    Volume: 21
    Page numbers: 1192
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Publications in 2002

Journal Articles

  • Change in serum procalcitonin (ΔPCT) predicts the clinical outcome of children admitted with febrile neutropenia
    Year: 2002
    Journal: British Journal of Haematology
    Volume: 118
    Page numbers: 1197-1198
    Publisher: Blackwell Science(Oxford)
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  • Expression and mutation analysis of the Wilms tumor 1 gene in human neural tumours
    Year: 2002
    Journal: International Journal of Cancer
    Volume: 97
    Page numbers: 713-715
    Publisher: Wiley-Liss(New York)
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  • General anaesthesia or conscious sedation for painful procedures in childhood cancer: the family's perspective
    Year: 2002
    Journal: Archives of Disease in Childhood
    Volume: 87
    Page numbers: 0-4
    Publisher: BMJ Publishing Group(London)
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  • Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy
    Year: 2002
    Journal: British Journal of Haematology
    Volume: 119
    Page numbers: 204-211
    Publisher: Blackwell Science(Oxford)
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  • Phase II study of carboplatin in children with progressive low-grade gliomas
    Year: 2002
    Journal: Journal of Clinical Oncology
    Volume: 20
    Issue: 13
    Page numbers: 2951-2958
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Temozolomide-induced flare in high-grade gliomas: a new clinical entity
    Year: 2002
    Journal: Internal Medicine Journal
    Volume: 32
    Page numbers: 346-348
    Publisher: Blackwell Science Asia(Carlton)
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  • Treatment of high risk or recurrent meningiomas with hydroxyurea
    Year: 2002
    Journal: Journal of Clinical Neuroscience
    Volume: 9
    Issue: 2
    Page numbers: 156-158
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
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Publications in 2001

Journal Articles

  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells
    Year: 2001
    Journal: Oncogene
    Volume: 20
    Page numbers: 5789-5798
    Publisher: Nature Publishing Group(Basingstroke)
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  • Carboplatin chemotherapy for progressive intramedullary spinal cord low-grade gliomas in children: Three case studies and a review of the literature
    Year: 2001
    Journal: Neuro-Oncology
    Volume: 3
    Issue: 4
    Page numbers: 251-257
    Publisher: Carden Jennings Publishing(Virginia)
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  • Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction
    Year: 2001
    Journal: Neuro-Oncology
    Volume: 3
    Issue: 4
    Page numbers: 229-240
    Publisher: Carden Jennings Publishing(Virginia)
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  • Expression of GAGE Genes in Neuroblastoma by Reverse Transcription - Polymerase Chain Reaction
    Year: 2001
    Journal: Cancer Research Therapy and Control
    Volume: 11
    Page numbers: 197-203
    Publisher: Harwood Academic Publishers
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  • Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial PNET after craniospinal radiotherapy: Results of a collaborative study
    Year: 2001
    Journal: Journal of Clinical Oncology
    Volume: 19
    Issue: 10
    Page numbers: 2696-2704
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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