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A/PROF PAUL GOOLEY



Contact Details

Organization: Biochemistry and Molecular Biology
Position: DEPUTY HEAD
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_gooley.htm
Work: (03) 8344 2273
Fax: (03) 9348 1421
Room: 123
Level: 01
Building: Bio21 Incubator Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Nuclear Magnetic Resonance Specroscopy Protein Structure and Function Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of New South Wales
Doctor of Philosophy University of New South Wales

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian and New Zealand Society for Magnetic Resonance No data 01-Feb-1996
Member Australian Socciety for Biochemistry and Molecular Biology no data 01-Feb-1996

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Enhancing the cardioprotective effect of diadenosine tetraphosphate: designing inhibitors against Ap4A hydrolase Chief Investigator NHMRC Project Grants 01/01/2003
The activation of lipoprotein lipase by apolipoprotein C-II Chief Investigator NHMRC Project Grants 01/01/2003
Apolipoproteins and Amyloid formation in Atheroma Chief Investigator NHMRC Project Grants 01/01/2005
Evolution, structure and function of key components in a molecular machine Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
Membrane protein structure and interaction facility Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2006
Relaxin Family Peptide Receptors Chief Investigator NHMRC Project Grants 01/01/2007
Investigating the subunit interactions of a molecular protein import machine Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
Structural investigations of the mitochondrial protein import receptor complex Chief Investigator AINSE Awards 01/01/2008
MELBOURNE BIOMOLECULAR NMR NETWORK Chief Investigator MONASH UNIVERSITY,
UNIVERSITY OF MELBOURNE
Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2009
Functional analysis of relaxin and INSL3 receptors Chief Investigator NHMRC Project Grants 01/01/2010
Metabolomics of Chronic Fatigue Syndrome Chief Investigator ANZ CHARITABLE TRUSTS Judith Jane Mason & Harold Stannett Williams Memorial Foundation 01/01/2011
Explaining the differences in affinity and of carbohydrate binding of the glycogen-sensing enzyme, AMPK Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2011
ADVANCED CHARACTERISATION OF MATERIALS BY NUCLEAR MAGNETIC RESONANCE Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2011
A 700 MHZ NMR SPECTROMETER FOR THE MELBOURNE BIOMOLECULAR NMR NETWORK: A HIGH THROUGHPUT RESOURCE Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2012
Using protein dynamics to identify novel pathways of activation of the diabetes enzyme target AMPK Chief Investigator THE CASS FOUNDATION LTD Science & Medicine Grants

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2011

Journal Articles

  • A Dynamic Pharmacophore Drives the Interaction between Psalmotoxin-1 and the Putative Drug Target Acid-sensing Ion Channel 1a.
    Year: 2011
    Journal: Molecular Pharmacology
    Volume: 80
    Issue: 5
    Page numbers: 796-808
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  • A Structural Model for Apolipoprotein C-II Amyloid Fibrils: Experimental Characterization and Molecular Dynamics Simulations
    Year: 2011
    Journal: Journal of Molecular Biology
    Volume: 405
    Issue: 5
    Page numbers: 1246-1266
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  • Automated NMR relaxation dispersion data analysis using NESSY
    Year: 2011
    Journal: BMC Bioinformatics
    Volume: 12
    Issue: 421
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  • Macromolecular NMR spectroscopy for the non-spectroscopist.
    Year: 2011
    Journal: FEBS Journal
    Volume: 278
    Issue: 5
    Page numbers: 687-703
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  • Macromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination.
    Year: 2011
    Journal: FEBS Journal
    Volume: 278
    Issue: 5
    Page numbers: 704-715
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  • Recognition of Mitochondrial Targeting Sequences by the Import Receptors Tom20 and Tom22
    Year: 2011
    Journal: Journal of Molecular Biology
    Volume: 405
    Issue: 3
    Page numbers: 804-818
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  • relaxGUI: a new software for fast and simple NMR relaxation data analysis and calculation of ps-ns and μs motion of proteins.
    Year: 2011
    Journal: Journal of Biomolecular NMR
    Volume: 50
    Page numbers: 147-155
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Publications in 2010

Journal Articles

  • A sample preparation protocol for 1H nuclear magnetic resonance studies of water-soluble metabolites in blood and urine
    Year: 2010
    Journal: Analytical Biochemistry
    Volume: 398
    Page numbers: 263-265
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  • AMPK beta subunits display isoform specific affinities for carbohydrates
    Year: 2010
    Journal: FEBS Letters
    Volume: 584
    Issue: 15
    Page numbers: 3499-3503
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  • Membrane protein SMP-1 is required for normal flagellum function in Leishmania.
    Year: 2010
    Journal: Journal of Cell Science
    Volume: 123
    Issue: Pt 4
    Page numbers: 544-554
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  • Membrane receptors: Structure and function of the Relaxin Family Peptide Receptors
    Year: 2010
    Journal: Molecular and Cellular Endocrinology
    Volume: 320
    Page numbers: 1-15
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  • Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.
    Year: 2010
    Journal: Journal of Molecular Biology
    Volume: 399
    Issue: 3
    Page numbers: 358-366
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Publications in 2009

Journal Articles

  • Discovery of Inhibitors of Lupin Diadenosine 5′,5′′′-p1,p4- Tetraphosphate Hydrolase by Virtual Screening
    Year: 2009
    Journal: Biochemistry
    Volume: 48
    Issue: 32
    Page numbers: 7614-20
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  • Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome
    Year: 2009
    Journal: In Vivo: international journal of experimental and clinical pathophysiology and drug research
    Volume: 23
    Issue: 4
    Page numbers: 621-628
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  • Structure and Function of Human Apolipoprotein
    Year: 2009
    Journal: Current Topics in Biochemical Research
    Volume: 2009
    Issue: 11
    Page numbers: 61-74
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

Publications in 2005

Journal Articles

  • 1H, 13C and 15N Resonance Assignments of the Cytosolic Domain of Tom20 from Arabidopsis thaliana
    Year: 2005
    Journal: Journal of Biomolecular NMR
    Volume: 33
    Page numbers: 198-198
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • 1H, 13C and 15N resonance assignments of the 17kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP
    Year: 2005
    Journal: Journal of Biomolecular NMR
    Volume: 31
    Issue: 2
    Page numbers: 181-182
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • A statistical approach to the interpretation of molecular dynamics simulations of calmodulin equilibrium dynamics.
    Year: 2005
    Journal: Protein Science
    Volume: 14
    Page numbers: 2955-2963
    Publisher: Cold Spring Harbour Laboratory Press(New York)
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  • Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20
    Year: 2005
    Journal: Journal of Molecular Biology
    Volume: 347
    Page numbers: 81-93
    Publisher: Academic Press(London)
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  • The human LGR7 Low-Density Lipoprotein Class A Module Requires Calcium for Structure
    Year: 2005
    Journal: Annals of The New York Academy of Sciences
    Volume: 1041
    Page numbers: 27-34
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  • Validating the use of database potentials in protein structure determination by NMR.
    Year: 2005
    Journal: FEBS Letters
    Volume: 579
    Issue: 25
    Page numbers: 5542-5548
    Publisher: Elsevier Science(Amsterdam)
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Publications in 2004

Journal Articles

  • Structure and substrate binding mechanism of human AP(4)A hydrolase
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 9
    Page numbers: 8471-8481
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  • The structure and interactions of human apolipoprotein C-II dodecyl phosphocholine
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Page numbers: 8084-8093
    Publisher: American Chemical Society(Washington DC)
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Publications in 2003

Journal Articles

  • Dynamics of Ca2+ -saturated calmodulin D129N mutant studied by multiple molecular dynamics simulations
    Year: 2003
    Journal: Protein Science
    Volume: 12
    Page numbers: 2215-2229
    Publisher: Cold Spring Harbour Laboratory Press(New York)
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  • Multiple heparin binding domains of respiratory syncytial virus G mediate binding to mammalian cells
    Year: 2003
    Journal: Archives of Virology
    Volume: 148
    Page numbers: 1987-2003
    Publisher: Springer-Verlag Wein(Vienna)
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  • The use of model selection in the model-free analysis of protein dynamics
    Year: 2003
    Journal: Journal of Biomolecular NMR
    Volume: 25
    Page numbers: 25-39
    Publisher: Kluwer Academic Publishers(Dordrecht)
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Publications in 2002

Journal Articles

  • Human vascular endothelial growth factor B: Characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies
    Year: 2002
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 29
    Issue: 11
    Page numbers: 1024-1029
    Publisher: Blackwell Science Asia(Carlton)
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  • Letter to the editor: backbone resonance assignment of the 2H, 13C, 15N labelled 32kDa central domain of Escherichia coli TyrR
    Year: 2002
    Journal: Journal of Biomolecular NMR
    Volume: 22
    Page numbers: 381-382
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase
    Year: 2002
    Journal: Protein Science
    Volume: 11
    Page numbers: 2041-2047
    Publisher: Cold Spring Harbour Laboratory Press(New York)
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  • The Structure of Ap4A Hydrolase Complexed with ATP-MgFx Reveals the Basis of Substrate Binding
    Year: 2002
    Journal: Structure
    Volume: 10
    Page numbers: 205-213
    Publisher: Cell Press(Cambridge)
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Publications in 2001

Journal Articles

  • Characterization of active-site residues in diadenosine tetraphosphate hydrolase from Lupinus angustifolius
    Year: 2001
    Journal: Biochemical Journal
    Volume: 357
    Page numbers: 399-405
    Publisher: Portland Press(London)
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  • Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases.
    Year: 2001
    Journal: Acta Crystallographica Section D - Biological Crystallography
    Volume: 57
    Page numbers: 459-461
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • NMR Structure of Human Apolipoprotein C-11 in the Presence of Sodium Dodecyl Sulfate
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Issue: 18
    Page numbers: 5414-5421
    Publisher: American Chemical Society(Washington DC)
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  • The interaction of human apolipoprotein C-1 with sub-micellar phospholipid
    Year: 2001
    Journal: European Journal of Biochemistry
    Volume: 268
    Page numbers: 2838-2846
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