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Find an ExpertProfiling the University of Melbourne's Researchers

PROF STEPHEN KENT



Contact Details

Organization: Microbiology and Immunology
Position: PRINCIPAL RESEARCH FELLOW 1
Email:
Homepage: www.microbiol.unimelb.edu.au/people/kent
Work: +61 3 8344 9939
Fax: +61 3 8344 3846
Room: 2.03
Level: 02
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Immune escape. We are studying how immune pressures result in immune escape variants and the impact this has on the fitness of the virus Australia, United States of America, Indonesia
Nanoparticle vaccines. We are investigating these vaccines which have the potential for controlled release of important HIV vaccine antigens Australia, United States of America, Indonesia
Combined Influenza-AIDS vaccines Australia, United States of America, Indonesia
CD4 T cell subsets: what really counts in preventing HIV disease? Australia, Indonesia, United States of America
Utility of anti-envelope T cell immunity Australia, United States of America, Indonesia
Immune therapy. We have shown that reinfusing autologous cells coated with overlapping peptide (termed OPAL) can induce high levels of T cell immunity Australia, United States of America, Indonesia
Antibody dependent cellular cytotoxicity - a neglected anti-HIV immune response Australia, United States of America, Indonesia
How fast do anti-HIV T cells kill infected cells - differences in killing kinetics across HIV vaccines Australia, United States of America, Indonesia
HIV vaccines to induce broadly neutralising antibodies Australia, United States of America, Indonesia

International Linkages

Country Establishment Collaboration
United States National Institutes of Health Exchange, Research
United States University of Wisconsin Exchange, Research, Technical Assistance/Training
United States Johns Hopkins University Research
Indonesia Bogor Agricultural University Exchange, Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medicine & Bachelor of Surgery Monash University 31-Dec-1985
Doctor of Medicine Monash University 31-Dec-1996

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 31-Dec-1993

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
DNA AND AVIPOX VACCINES FOR HIV Chief Investigator NHMRC Medical & Dental Postgraduate Scholarships 01/01/2002
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2003
HIV Infection: Immunobiology and Vaccine design Chief Investigator NHMRC Program Grants 01/01/2004
OPAL immunotherapy for AIDS Chief Investigator NHMRC Development Grants 01/01/2005
IMMUNE RESPONSES TARGETING ENFUVITIDE SENSITIVE AND RESISTANT VIRUSES Chief Investigator ROCHE PRODUCTS PTY LTD FUZEON Inititatives - National Discoveries Awards - 27/09/2006
THERAPEUTIC VACCINES TO PROTECT AGAINST DRUG RESISTANT HIV Chief Investigator GLAXOSMITHKLINE AUSTRALIA GSK Post Graduate Support Grant 01/12/2006
Establishment of the HIV reservoir during acute infection Chief Investigator THE AMERICAN FOUNDATION FOR AIDS RESEARCH (AMFAR) Targeted RFP: Optimizing the Treatment of HIV Infection 01/07/2007
NHMRC Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2008
THE DYNAMICS OF LATENCY IN CHRONIC VIRAL INFECTION Chief Investigator UNIVERSITY OF NSW Discovery Projects (AUST RESEARCH COUNCIL) 01/01/2009
HIV & HCV VACCINES AND IMMUNOPATHOGENESIS - SUPPORT FUNDING Chief Investigator UNIVERSITY OF NSW Research Support (UNIVERSITY OF NEW SOUTH WALES - DO NOT USE (636)) 01/01/2009
Royal Australasian College of Physicians Fellowship Principal Supervisor ROYAL AUST COLLEGE OF PHYSICIANS Fellowships and Scholarships (General Award) 01/01/2009
ESCAPE AND REVERSION OF CRITICAL IMMUNE RESPONSES: INSIGHTS INTO EFFECTIVE IMMUNITY TO HIV Chief Investigator UNIVERSITY OF MELBOURNE Melbourne Research Grants Scheme
VACCINE FOR HIV USING NOVEL MUSCOSAL VECTOR AND ADJUVANT Chief Investigator GATES FOUNDATION Grand Challenges Explorations

Contracts

Title Role Funding Source Award Date
SAFETY STUDIES OF OPAL VACCINE TECHNOLOGY Chief Investigator OPAL PTY LTD 01/01/2006
EFFICACY STUDIES OF OPAL VACCINE TECHNOLOGY Chief Investigator OPAL PTY LTD 30/01/2006
OPAL IMMUNOTHERAPY: COMPARING DELIVERY OF PEPTIDE VACCINES BY WHOLE BLOOD VS PBMC IN MACAQUES Chief Investigator MASSACHUSETTS GENERAL HOSPITAL 13/11/2007
WHOLE INACTIVATED SIV PULSED BLOOD STUDY IN MONKEYS Chief Investigator OPAL PTY LTD 23/06/2008
LICENSE AGREEMENT - OPAL IMMUNOTHERAPY: COMPARING DELIVERY OF PEPTIDE VACCINES BY WHOLE BLOOD VS PBMC IN MACAQUES Chief Investigator OPAL PTY LTD

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Book Chapters

  • Prime-boost strategies in DNA vaccines
    Year: 2006
    Book: Methods in Molecular Medicine, Vol. 127: DNA vaccines: methods and protocols
    Publisher: Humana Press(New Jersey)
    Authors(s):
    Editors(s):

Journal Articles

  • A randomized, placebo-controlled phase 1 trail of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1
    Year: 2006
    Journal: AIDS
    Volume: 20
    Issue: 2
    Page numbers: 294-297
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  • CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ Memory CD4+ T cells
    Year: 2006
    Journal: Journal of Virology
    Volume: 80
    Issue: 20
    Page numbers: 10151-10161
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  • Characteristics of effective immune control of simian/human immunodeficiency virus in pigtail macaques
    Year: 2006
    Journal: AIDS Research and Human Retroviruses
    Volume: 22
    Issue: 1
    Page numbers: 27-32
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  • Comparative evaluation of simian, simian-human, and human immunodeficiency virus infections in the pigtail macaque (Macaca nemestrina) model
    Year: 2006
    Journal: AIDS Research and Human Retroviruses
    Volume: 22
    Issue: 6
    Page numbers: 580-588
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  • Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines. Implications for future trials
    Year: 2006
    Journal: Human Vaccines
    Volume: 2
    Issue: 3
    Page numbers: 134-136
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  • Fitness constraints on immune escape from HIV: Implications of envelope as a target for both HIV-specific T cells and antibody
    Year: 2006
    Journal: Current HIV Research
    Volume: 4
    Issue: 2
    Page numbers: 191-197
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  • Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials
    Year: 2006
    Journal: Vaccine
    Volume: 24
    Issue: 9
    Page numbers: 1378-1388
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  • MHC class I allele frequencies in pigtail macaques of diverse origin
    Year: 2006
    Journal: Immunogenetics
    Volume: 58
    Issue: 12
    Page numbers: 995-1001
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Publications in 2005

Journal Articles

  • Enhanced Cellular Immunity in Macaques following a Novel Peptide Immunotherapy
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 6
    Page numbers: 3748-3757
    Publisher: American Society for Microbiology(Washington DC)
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  • Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 2
    Page numbers: 684-695
    Publisher: American Society for Microbiology(Washington DC)
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  • Comparison of Whole Gene and Whole Virus Scrambled Antigen Approaches for DNA Prime and Fowlpox Virus Boost HIV Type 1 Vaccine Regimens in Macaques
    Year: 2005
    Journal: AIDS Research and Human Retroviruses
    Volume: 21
    Issue: 4
    Page numbers: 292-300
    Publisher: Mary Ann Leibert Publishers(New Rochelle, NY)
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  • Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use
    Year: 2005
    Journal: Vaccine
    Volume: 23
    Issue: 38
    Page numbers: 4647-4657
    Publisher: Elsevier Science(Oxford)
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  • Genetic influences on HIV infection: implications for vaccine development
    Year: 2005
    Journal: Sexual Health
    Volume: 2
    Issue: 2
    Page numbers: 53-62
    Publisher: CSIRO Publications
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  • Granulocyte contamination dramatically inhibits spot formation in AIDS virus-specific ELISpot assays: Analysis and strategies to ameliorate
    Year: 2005
    Journal: Journal of Immunological Methods
    Volume: 297
    Issue: 1-2
    Page numbers: 177-186
    Publisher: Elsevier Science(Amsterdam)
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  • Induction of T-Cell Immunity to Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 12
    Page numbers: 7728-7737
    Publisher: American Society for Microbiology(Washington DC)
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  • Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3
    Year: 2005
    Journal: Vaccine
    Volume: 23
    Issue: 42
    Page numbers: 5009-5021
    Publisher: Elsevier Science(Oxford)
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  • Phenotypic and kinetic analysis of effective simian-human immunodeficiency virus-specific T cell responses in DNA- and fowlpox virus-vaccinated macaques
    Year: 2005
    Journal: Virology
    Volume: 337
    Issue: 2
    Page numbers: 222-234
    Publisher: Academic Press(California)
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  • Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 9
    Page numbers: 5721-5731
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  • Reduced Hepatitis B Virus (HBV)-Specific CD4+ T-Cell Responses in Human Immunodeficiency Virus Type 1-HBV-Coinfected Individuals Receiving HBV-Active Antiretroviral Therapy
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 5
    Page numbers: 3038-3051
    Publisher: American Society for Microbiology(Washington DC)
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  • Reversion of immune escape HIV variants upon transmission: insights into effective viral immunity
    Year: 2005
    Journal: Trends in Microbiology
    Volume: 13
    Issue: 6
    Page numbers: 243-246
    Publisher: Elsevier Science London(London)
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  • Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques
    Year: 2005
    Journal: Vaccine
    Volume: 23
    Issue: 16
    Page numbers: 1949-1956
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  • The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion
    Year: 2005
    Journal: Journal of Medical Primatology
    Volume: 34
    Issue: 5-6
    Page numbers: 282-293
    Publisher: Munksgaard International Publishers(Copenhagen)
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Publications in 2004

Journal Articles

  • Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
    Year: 2004
    Journal: Journal of Virology
    Volume: 79
    Issue: 2
    Page numbers: 684-695
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  • Efficacy of DNA and Fowlpox Virus Priming/Boosting Vaccines for Simian/Human Immunodeficiency Virus
    Year: 2004
    Journal: Journal of Virology
    Volume: 78
    Issue: 24
    Page numbers: 13819-13828
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  • Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFNγ or IL-12
    Year: 2004
    Journal: Vaccine
    Volume: Volume 23
    Issue: 2
    Page numbers: 188-197
    Publisher: Elsevier Science(Oxford)
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  • Vaccines and Vaccine Strategies Against HIV
    Year: 2004
    Journal: Current Drug Targets
    Volume: 5
    Issue: 1
    Page numbers: 71-88
    Publisher: Bentham Science Publishers(Hilversum)
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Publications in 2003

Journal Articles

  • Decreased neurotropism of nefLong Terminal Repeat (nef/LTR)-deleted simian immunodeficiency virus
    Year: 2003
    Journal: Journal of NeuroVirology
    Volume: 9
    Issue: 4
    Page numbers: 442-451
    Publisher: Taylor & Francis Ltd
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Publications in 2002

Journal Articles

  • Chimeric Human Papilloma Virus-Simian/Human Immunodeficiency Virus Virus-like-Particle Vaccines: Immunogenicity and Protective Efficacy in Macaques
    Year: 2002
    Journal: Virology
    Volume: 301
    Page numbers: 176-187
    Publisher: Academic Press(California)
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  • Evidence of Recombination between 3' and 5' LTRs in Macaques Inoculated with SIV DNA
    Year: 2002
    Journal: AIDS Research and Human Retroviruses
    Volume: 18
    Issue: 3
    Page numbers: 227-230
    Publisher: Mary Ann Leibert Publishers(New Rochelle, NY)
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  • Knowledge and commitment for action: the 14th International AIDS Conference, Barcelona, July 2002
    Year: 2002
    Journal: Medical Journal of Australia
    Volume: 177
    Page numbers: 587-589
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Vaccines for HIV in the developing world
    Year: 2002
    Journal: Internal Medicine Journal
    Volume: 32
    Page numbers: 136-137
    Publisher: Blackwell Science Asia(Carlton)
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Publications in 2001

Journal Articles

  • Attenuated and Wild-Type HIV-1 Infections and Long Terminal Repeat-Mediated Gene Expression from Plasmids Delivered by Gene Gun to Human Skin ex Vivo and Macaques in vivo
    Year: 2001
    Journal: Virology
    Volume: 287
    Page numbers: 71-78
    Publisher: Academic Press(California)
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  • Determining the immune mechanisms of protection from AIDS: correlates of immunity and the development of syngeneic macaques
    Year: 2001
    Journal: Immunological Reviews
    Volume: 183
    Page numbers: 94-108
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Simian immunodeficiency virus infections in vervet monkeys (Clorocebus aethiops) at an Australian zoo
    Year: 2001
    Journal: Australian Veterinary Journal
    Volume: 79
    Issue: 6
    Page numbers: 406-408
    Publisher: Australian Veterinary Association(Brunswick)
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  • Vaccination with Attenuated Simian Immunodeficiency Virus by DNA Inoculation
    Year: 2001
    Journal: Journal of Virology
    Volume: 75
    Issue: 23
    Page numbers: 11930-11934
    Publisher: American Society for Microbiology(Washington DC)
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  • Vaccines to prevent HIV and AIDS
    Year: 2001
    Journal: Microbiology Australia
    Volume: 22
    Issue: 1 March 2001
    Page numbers: 12-15
    Publisher: Cambridge Media(West Leederville)
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