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DR JANETTA CULVENOR



Contact Details

Organization: Pathology
Position: SENIOR RESEARCH FELLOW
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/culvenor/
Work: 83443990
Fax: 83444004
Room: W703
Level: 07
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Neurodegenerative diseases, Parkinson's proteins, synuclein, kinases, presenilin protein complex Malaria, electron microscopy, biochemistry, cell biology Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) The Australian National University 31-Dec-1972
Doctor of Philosophy University of Melbourne 31-Dec-1991

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
"Gamma-secretase complex: molecular characterization, and moduation of enzymatic activity" Chief Investigator NHMRC Project Grants 01/01/2006
Cu/Zn superoxide dismutase aggregation and neurodegeneration in sporadic motor neuron disease Chief Investigator BETHLEHEM GRIFFITHS RESEARCH FOUNDATION Scholarships 01/01/2006
IDENTIFICATION OF A KEY AGGREGATING PROTEIN IN AGE-RELATED MACULAR DEGENERATION Chief Investigator BETHLEHEM GRIFFITHS RESEARCH FOUNDATION Medical Research Grants 01/01/2007
TARGET IDENTIFICATION OF THE MITOCHONDRIAL PARKINSON'S DISEASE PTEN-INDUCED KINASE 1 Chief Investigator MICHAEL J. FOX FOUNDATION FOR PARKINSON'S RESEARCH Rapid Response Innovation Awards 01/07/2007
DECIPHERING THE BIOCHEMICAL PROPERTIES OF PARKINSONS DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 Chief Investigator BRAIN FOUNDATION Specific Research Grants 01/09/2007
How active LRRK2 causes Parkinson's disease Chief Investigator NHMRC Project Grants 01/01/2009
How does inactivation of PINK1 cause Parkinson's disease? Chief Investigator NHMRC Project Grants 01/01/2009
Gamma-secretase and Alzheimer amyloid production Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Paradoxical condensation of copper with elevated β-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer's disease


    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 33
    Page numbers: 21899 - 907
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  • SLC30A3 Responds to Glucose- and Zinc Variations in β-Cells and Is Critical for Insulin Production and In Vivo Glucose-Metabolism During β-Cell Stress


    Year: 2009
    Journal: PLoS One
    Volume: 4
    Issue: 5
    Page numbers: e5684
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  • Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease
    Year: 2009
    Journal: Graefe's Archive for Clinical and Experimental Ophthalmology
    Volume: 247
    Issue: 9
    Page numbers: 1213-1221
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Publications in 2008

Journal Articles

  • α-Synuclein transgenic mice exhibit reduced anxiety-like behaviour
    Year: 2008
    Journal: Experimental Neurology
    Volume: 210
    Issue: 2
    Page numbers: 788-792
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  • Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)


    Year: 2008
    Journal: Journal of Neurochemistry
    Volume: 105
    Page numbers: 18-33
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  • Presenilin 1 Interacts with Acetylcholinesterase and Alters Its Enzymatic Activity and Glycosylation
    Year: 2008
    Journal: Molecular and Cellular Biology
    Volume: 28
    Issue: 9
    Page numbers: 2908-2919
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Publications in 2007

Journal Articles

  • A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease


    Year: 2007
    Journal: Neuroscience
    Volume: 147
    Issue: 4
    Page numbers: 1047-1058
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  • In vitro characterisation of Pittsburgh compound-B (PIB) binding to Lewy bodies
    Year: 2007
    Journal: Journal of Neuroscience
    Volume: 27
    Issue: 39
    Page numbers: 10365-10371
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  • Plasma alpha-synuclein is decreased in subjects with Parkinson's disease
    Year: 2007
    Journal: Experimental Neurology
    Volume: 204
    Issue: 2
    Page numbers: 583-588
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Publications in 2005

Journal Articles

  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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  • In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
    Year: 2005
    Journal: The FEBS Journal
    Volume: 272
    Issue: 21
    Page numbers: 5544-5557
    Publisher: Blackwell Publishers
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  • Transition-state analgoue gamma-secretase inhibitors stabilize a 900kDa presenilin/nicastrin complex
    Year: 2005
    Journal: Biochemistry
    Volume: 44
    Issue: 11
    Page numbers: 4332-4341
    Publisher: American Chemical Society(Washington DC)
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Publications in 2004

Journal Articles

  • Characterization of presenilin complexes from mouse and human brain using Blue Native gel eletrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
    Year: 2004
    Journal: European Journal of Biochemistry
    Volume: 271
    Page numbers: 375-383
    Publisher: Blackwell Science(Oxford)
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  • Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
    Year: 2004
    Journal: Molecular Brain Research
    Volume: 127
    Issue: 1-2
    Page numbers: 128-135
    Publisher: Elsevier Science(Amsterdam)
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  • Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Issue: 1
    Page numbers: 230-237
    Publisher: Blackwell Science(Oxford)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • α-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy
    Year: 2003
    Journal: Experimental Neurology
    Volume: 181
    Page numbers: 68-78
    Publisher: Academic Press(California)
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  • In vitro characterization of the presenilin-dependent γ-secretase complex using a novel affinity ligand
    Year: 2003
    Journal: Biochemistry
    Volume: 42
    Page numbers: 8133-8142
    Publisher: American Chemical Society(Washington DC)
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  • Selecting cells with different Alzheimer's disease γ-secretase activity using FACS: differential effect of presenilin exon 9 deletion on γ- and ε-cleavage
    Year: 2003
    Journal: European Journal of Biochemistry
    Volume: 270
    Page numbers: 495-506
    Publisher: Blackwell Science(Oxford)
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  • Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 39
    Page numbers: 37658-37663
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2002

Journal Articles

  • Alternative transcripts of presenilin-I associated with frontotemporal dementia
    Year: 2002
    Journal: NeuroReport
    Volume: 13
    Issue: 5
    Page numbers: 917-921
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Oligodendrocytes from neural stem cells express α-synuclein: increased numbers from presenilin I deficient mice
    Year: 2002
    Journal: NeuroReport
    Volume: 13
    Issue: 10
    Page numbers: 1-4
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Platelet α- and γ-synucleins in Parkinson's disease and normal control subjects
    Year: 2002
    Journal: Journal of Alzheimer's Disease
    Volume: 4
    Page numbers: 309-315
    Publisher: IOS Press(Amsterdam)
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Publications in 2001

Journal Articles

  • Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8359-8368
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  • Duck hepatitis B virus replication in primary bile duct epithelial cells
    Year: 2001
    Journal: Journal of Virology
    Volume: 75
    Page numbers: 7651-7661
    Publisher: American Society for Microbiology(Washington DC)
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  • The solubility of [alpha]-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
    Year: 2001
    Journal: Journal of Neurochemistry
    Volume: 76
    Page numbers: 87-96
    Publisher: Blackwell Science(Oxford)
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