Contact Details
| Organization: | Medicine - St Vincent's Hospital, Medicine - St Vincent's Hospital, Bio21 Institute |
| Position: | ASSOCIATE PROFESSOR, PRINCIPAL RESEARCH FELLOW, Honorary (Principal Fellow) |
| Email: | |
| Homepage: | www.medstv.unimelb.edu.au |
| Work: | 9288 2592 |
| Fax: | 9288 2581 |
| Room: | 314 |
| Level: | 03 |
| Building: | Clinical Sciences Block |
| Campus: | St Vincents Hospital |
Research Expertise and International Linkages
Research Expertise
| Research Interest | Key Words | Country of Expertise |
|---|---|---|
| Cardiovascular disease | Australia | |
| Endocrinology | Diabetes, chronic kidney disease, heart failure, angiotensin, hypertension | Australia |
International Linkages
| Country | Establishment | Collaboration |
|---|---|---|
| Canada | St. Michael's Hospital | Research |
Qualifications, Honours, Fellowships and Other Awards
Qualifications
| Title | Institution | Date Awarded | Abbreviation |
|---|---|---|---|
| Bachelor of Medical Laboratory Science | Royal Melbourne Institute of Technology | 31-Dec-1994 | |
| Doctor of Philosophy | University of Melbourne | 31-Dec-1998 |
Memberships
| Membership Type | Membership Body | Description | Start Date | End Date |
|---|---|---|---|---|
| Member | American Diabetes Association | Member | 01-Jan-2001 | |
| Member | Australian and New Zealand Society of Nephrology | Member | 01-Jan-1998 | |
| Member | Australian Diabetes Society | Member | 01-Jan-1998 | |
| Member | ANZSN Scientific Programming Education Committee | Member | 01-Jan-2004 | |
| Member | Ausbiotechnology | Member | 01-Jan-2007 | |
| Member | Melbourne Bionetwork | Member | 01-Jan-2007 | |
| Member | Australian Inst of Company Directors | Member | 01-Jan-2007 | |
| Member | European diabetic Nephropathy Study Group | Invited Member | 01-Jan-2000 | |
| Member | International Society of Pathology | Invited Member | 01-Jan-2000 |
Other Awards
| Award Type | Awarding Body | Comments | Date Awarded |
|---|---|---|---|
| Other (Award) | High Blood Pressure Research Council | Travel Grant to Amsterdam, The Netherlands | 31-Dec-1998 |
| Other (Award) | International Society of Hypertension. | Travel Grant to Amsterdam, The Netherlands | 31-Dec-1998 |
| Other (Award) | Juvenile Diabetes Foundation of Australia | Travel Grant to Miami, USA | 31-Dec-1999 |
| Other (Award) | Juvenile Diabetes Foundation of Australia | Travel Grant to Lund, Sweden | 31-Dec-2000 |
| Other (Award) | ANZSN | Travel Grant to ANZSN DArwin | 31-Dec-2000 |
| Other (Award) | St Vincent's Hospital | Senior Investigator Award | 31-Dec-2002 |
| Scholarship | Universitas 21 Global | Scholarship to study Masters of Business Administration | 31-Dec-2004 |
| Other (Award) | TJ Neale Award for Nephrology Research | 04-Sep-2009 | |
| Scholarship | Mabel Kent Medical Faculty | Postgraduate Scholarship | 31-Dec-1996 |
| Other (Award) | International Society of Hypertension. | International Travel Grant to Glasgow, Scotland | 31-Dec-1996 |
| Other (Award) | National Heart Foundation | International Travel Grant to Glasgow, Scotland | 31-Dec-1996 |
| Scholarship | University of Melbourne | Shepherd M Lowe Scholarship for diabetes research | 31-Dec-1997 |
| Other (Award) | European Society of Diabetes | International Travel Grant to Helsinki, Finland | 31-Dec-1997 |
| Other (Award) | Servier Laboratories. | International Travel Grant to Helsinki, Finland and Copenhagen, Denmark | 31-Dec-1997 |
| Other (Award) | High Blood Pressure Research Council | Astra Young Investigator | 31-Dec-1995 |
Government Research Classifications
Research Fields, Courses and Discipline Classifications
- Cell Metabolism (BIOCHEMISTRY AND CELL BIOLOGY) (270102)
- Protein Targeting and Signal Transduction (BIOCHEMISTRY AND CELL BIOLOGY) (270103)
- Membrane Biology (BIOCHEMISTRY AND CELL BIOLOGY) (270104)
- Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) (BIOCHEMISTRY AND CELL BIOLOGY) (270105)
- Cell Development (incl. Cell Division and Apoptosis) (BIOCHEMISTRY AND CELL BIOLOGY) (270106)
- Enzymes (BIOCHEMISTRY AND CELL BIOLOGY) (270108)
- Gene Expression (GENETICS) (270201)
- Animal Physiology - Systems (PHYSIOLOGY) (270603)
- Humoral Immunology and Immunochemistry (IMMUNOLOGY) (320203)
- Medical Biochemistry: Carbohydrates (MEDICAL BIOCHEMISTRY AND CLINICAL CHEMISTRY) (320302)
- Medical Biochemistry: Proteins and Peptides (MEDICAL BIOCHEMISTRY AND CLINICAL CHEMISTRY) (320305)
- Basic Pharmacology (PHARMACOLOGY AND PHARMACEUTICAL SCIENCES) (320502)
- Clinical Pharmacology and Therapeutics (PHARMACOLOGY AND PHARMACEUTICAL SCIENCES) (320503)
- Cell Physiology (MEDICAL PHYSIOLOGY) (320602)
- Systems Physiology (MEDICAL PHYSIOLOGY) (320603)
- Dermatology (CLINICAL SCIENCES) (321002)
- Cardiology (incl. Cardiovascular Diseases) (CLINICAL SCIENCES) (321003)
- Endocrinology (CLINICAL SCIENCES) (321004)
- Intensive Care (CLINICAL SCIENCES) (321009)
- Nephrology and Urology (CLINICAL SCIENCES) (321012)
- Opthalmology and Vision Science (CLINICAL SCIENCES) (321016)
Socio-Economic Objective Classifications
- Treatments (e.g. chemicals, anntibiotics) (HUMAN PHARMACEUTICAL PRODUCTS) (670403)
- Endocrine organs and diseases (incl. Diabetes) (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730105)
- Cardiovascular system and diseases (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730106)
- Hearing, vision, speech and their disorders (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730111)
- Urogenital system and disorders (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730115)
- Organs, diseases & abnormal conditions not elsewhere classified (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730118)
- Preventive medicine (PUBLIC HEALTH) (730213)
Grants and Contracts
Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.
Grants
| Title | Role | Funding Source | Scheme | Award Date |
|---|---|---|---|---|
| Novel strategies for the early identification, prevention and treatment of the microvascular complications of diabetes | Chief Investigator | NHMRC | NHMRC/JDRF Special Program Grants in Type 1 Diabetes | 01/01/2002 |
| Novel therapies to inhibit the progression of diabetic nephropathy: applications of molecular and cellular pathology | Chief Investigator | JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL | Regular Research Grants | 01/07/2002 |
| Mitogen activated protein kinase (MAPK) and the progression of diabetic nephropathy | Chief Investigator | DIABETES AUST RESEARCH TRUST | Research Grants | 01/12/2005 |
| MECHANISMS OF KIDNEY FIBROSIS IN DIABETIC NEPHROPATHY | Chief Investigator | UNIVERSITY OF SYDNEY | Project Grants (NHMRC) | 01/01/2006 |
| Renal effects of the combination of atorvastatin and quinapril in experimental diabetic nephropathy | Principal Supervisor | AUST KIDNEY FOUNDATION | Summer Vacation Scholarships | 01/01/2006 |
| Combination therapy with PKC-Bata and ACE inhibition may offer superior renal protection | Principal Supervisor | AUST KIDNEY FOUNDATION | Summer Vacation Scholarships | 01/01/2006 |
| Erythropoietin: A novel therapy for diabetic nephropathy, cardiomyopathy and retinopathy | Chief Investigator | ELI LILLY AUST PTY LTD | Endocrinology Research Grant Programme | 31/01/2006 |
| THE ROLE OF UROTENSIN II INHIBITION IN EXPERIMENTAL PROGRESSIVE DIABETIC NEPHROPATHY | Chief Investigator | DIABETES AUST RESEARCH TRUST | Research Grants | 01/01/2007 |
| CCL2 DNA vaccination to prevent diabetic cardiac fibrosis | Chief Investigator | DIABETES AUST RESEARCH TRUST | Research Grants | 14/11/2007 |
| Diabetic drug thiazolidinediones attenuate thioredoxin-interacting protein via kruppel-like factors dependent pathways in diabetic nephropathy | Chief Investigator | DIABETES AUST RESEARCH TRUST | Research Grants | 14/11/2007 |
| BIOMEDICAL - DIABETIC KIDNEY DISEASE: POTENTIAL FOR CELL-BASED THERAPY | Principal Supervisor | NHMRC | Scholarships | 01/01/2008 |
| Mitochondrial oxidative stress and diabetic complications | Chief Investigator | JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL | Innovative Grants | 01/03/2008 |
| Novel approach to Inhibit RAGE and protect from diabetic nephropathy | Chief Investigator | JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL | Innovative Grants | 01/09/2008 |
| FT011, directly targeting myocardial fibrosis will improve heart function in experimental model of diabetic cardiomyopathy | Chief Investigator | DIABETES AUST RESEARCH TRUST | Research Grants | 01/01/2009 |
| NHMRC Research Fellowship 2009 - KELLY | Chief Investigator | NHMRC | Research Fellowship | 01/01/2009 |
| DEVELOPMENT OF NEW ANTI-FIBROTIC DRUGS FOR PREVENTION OF DIABETIC NEPHROPATHY | Chief Investigator | NHMRC | Development Grants | 01/01/2009 |
Contracts
| Title | Role | Funding Source | Award Date |
|---|---|---|---|
| IF SURAMIN ADMINISTERED INTRAVITREALLY TO REN-2 DIABETIC RATES CAN REDUCE DIABETIC RETINOPATHY | Chief Investigator | RADICAL BIOTECHNOLOGY PTY LTD | 07/10/2007 |
| THE ROLE OF ALISKIREN IN A RAT MODEL OF IGA NEPHROPATHY | Chief Investigator | NOVARTIS PHARMA AG | 01/05/2008 |
| TRANILAST MEDICINAL CHEMISTRY | Chief Investigator | FIBROTECH THERAPEUTICS PTY LTD | 01/04/2009 |
| TESTING FIBROTECH COMPOUNDS IN THE DIABETIC REN-2 RAT MODEL OF NEPHROPATHY | Chief Investigator | FIBROTECH THERAPEUTICS PTY LTD | 01/04/2009 |
Additional Grant and Contract Information
2002• Novel therapeutic interventions for the treatment of diabetic nephropathy: Application of Molecular and Cellular pathology, JDRF Career Development Award, CI Darren Kelly, $650,000 (2002-2007).
• Effect of PPAR-gamma agonists in experimental diabetic nephropathy. Lilly Endocrinology Research Grant R Langham, DJ Kelly and RE Gilbert, $23,000 (2002).
2003
• Mechanisms of Renal Enlargement: The role of EGF receptor tyrosine kinase in early diabetic nephropathy. Diabetes Australia Research Trust, CI Darren Kelly, $39,100 (2004).
• The role of stems cells in the mesentery, CI Darren Kelly, St Vincent’s hospital Research grant, $3000.
• Effect of combined atorvastatin and quinapril in experimental diabetic nephropathy. Australian Kidney Foundation Medical Research Seeding Grant. R Langham, DJ Kelly and RE Gilbert $15,000 (2003).
• Effect of combined atorvastatin and quinapril in experimental diabetic nephropathy. Pfizer Cardiovascular Lipid Research Grant. R Langham, DJ Kelly and RE Gilbert $47,000 (2003)
2004
• The role of growth factor inhibition in the diabetic Ren-2 rat. CI Richard Gilbert and Darren Kelly, GlaxoSmith Kline $197,000
• The role of ALK-5 (TGF-ß blockade) in chronic renal disease. CI Richard Gilbert and Darren Kelly, Glaxo Smith Kline, $160,000
• The role of renin inhibition in the diabetic Ren-2 rat kidney. CI Darren Kelly, Richard Gilbert, Novartis $185,000 USD.
• Analysis of RNA quantity and quality using the Agilent Bioanalyser. University of Melbourne Faculty of Medicine Equipment Grant, R Langham, R Gow, D Kelly, RE Gilbert. $39,000 (2004)
2005
• The role of MAPK in the progression of diabetic nephropathy. CI Darren Kelly, St Vincent’s health, $5,000.
• Renal effects of the combination of quinapril and atorvastatin in experimental diabetic nephropathy. Kidney Health Australia Summer Scholarship, CI Darren Kelly, $1,200.
• Combination therapy with an RAS blocker and PKC blocker may offer superior renal protection. Kidney Health Australia Summer Scholarship, CI Darren Kelly, $1,200.
• Combination therapies and Diabetic Nephropathy, JDRF Summer scholarship, CI Darren Kelly, $3000.
• Erthyropoietin: A novel therapy for diabetic nephropathy, cardiomyopathy and retinopathy. CI Jennifer Wilkinson-Berka, Daren Kelly, Eli Lilly, $30,000.
• Faculty of Medicine, University of Melbourne Equipment Grant to purchase a echocardiography machine for rodents, CI Richard Gilbert, Kim Connelly, Darren Kelly, David Prior, $175,000.
2006
• Co-chief Investigator with Assoc Prof Robyn Langham. The role of MAPK inhibition and Diabetic nephropathy (Jacquot Bequest), $65,000.
• The role of urotensin II and diabetic nephropathy, CI Darren Kelly,DART, $42,500.
• Investigation of the PKCß inhibitor, ruboxistaurin in diastolic heart failure in experimental diabetes, CI Darren Kelly, Eli Lilly, $30,000
• Faculty of Medicine Equipment Grant. Purchase an Aperio Image Analysis system, CI Darren Kelly, $125,000.
Publications
Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.