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Find an ExpertProfiling the University of Melbourne's Researchers

DR ROBERT CHERNY



Contact Details

Organization: Pathology
Position: Honorary (Principal Fellow)
Email:
Homepage: http://www.mhri.edu.au
Work: 9388 1633
Building: No Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Alzheimer's Disease Australia

International Linkages

Country Establishment Collaboration
United States Massachusetts General Hospital Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 31-Dec-1980
Doctor of Philosophy Monash University 31-Dec-1990

Memberships

Membership Type Membership Body Description Start Date End Date
Unspecified The Society for Neuroscience (USA) member 01-Sep-2006
Unspecified Australian Society for Neuroscience member 01-Sep-2006

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Novel therapies for Alzheimer's disease based on A-beta - metal interactions Chief Investigator NHMRC Project Grants 01/01/2001
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
Identifying the toxic principle in Alzheimer's disease/ Purification and characterisation of toxic amyloid beta species in Alzheimer's disease Chief Investigator AUST ROTARY HEALTH RESEARCH FUND Mental Illness Research Ian Scott Fellowship 01/01/2004
Developing a novel therapy for Parkinson's Disease Chief Investigator NHMRC Project Grants 01/01/2008
Neural Copper Homeostasis: the role of the Alzheimer Amyloid-beta Precursor Protein Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Paradoxical condensation of copper with elevated β-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer's disease


    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 33
    Page numbers: 21899 - 907
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  • Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Year: 2009
    Journal: Journal of Neurochemistry
    Volume: 108
    Page numbers: 1198-1207
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Publications in 2008

Journal Articles

  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
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  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
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Publications in 2007

Book Chapters

  • Metals, oxidative stress, and brain biology
    Year: 2007
    Book: Encyclopedia of Stress
    Publisher: Elsevier Science(Oxford)
    Authors(s):
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Journal Articles

  • Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.


    Year: 2007
    Journal: Neurobiology of Aging
    Volume: 28
    Issue: 6
    Page numbers: 907-913
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  • Abeta produced as a fusion to maltose binding protein can be readily purified and stably associates with copper and zinc.
    Year: 2007
    Journal: Protein and Peptide Letters
    Volume: 14
    Issue: 1
    Page numbers: 83-86
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  • Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.
    Year: 2007
    Journal: Brain Research
    Volume: 1140
    Page numbers: 188-194
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  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
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  • Mechanisms of copper ion mediated Huntington's Disease progression.
    Year: 2007
    Journal: PLoS One
    Volume: March 2007
    Issue: 3
    Page numbers: e334
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  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.
    Year: 2007
    Journal: PLoS One
    Volume: June 2007
    Issue: 6
    Page numbers: e536
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Publications in 2006

Journal Articles

  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Dimerisation of N-acetyl-L-tyrosine ethyl ester and Abeta peptides via formation of dityrosine
    Year: 2006
    Journal: Free Radical Research
    Volume: 40(1)
    Page numbers: 1-9
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  • Elevated cortical zinc in Alzheimer disease
    Year: 2006
    Journal: Neurology
    Volume: 67
    Issue: 1
    Page numbers: 69-75
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  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
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  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
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Publications in 2005

Journal Articles

  • Alzheimer disease β-amyloid activity mimics cholesterol oxidase
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Page numbers: 2556-2563
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 3
    Page numbers: 672-679
    Publisher: Society of Neuroscience(Washington DC)
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  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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  • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system.
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 50
    Page numbers: 41732-41743
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 353-360
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Publications in 2004

Journal Articles

  • Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid Β-peptide by NMR
    Year: 2004
    Journal: Journal of Peptide Science
    Volume: 10
    Page numbers: 210-217
    Publisher: John Wiley & Sons(West Sussex)
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  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 8602-8607
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of Amyotrophic Lateral Sclerosis
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 7945-7950
    Publisher: Society of Neuroscience(Washington DC)
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  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
    Publisher: Springer Verlag(New York)
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  • Metal-protein attenuating compounds (MPACs) for the treatment of Alzheimer's disease
    Year: 2004
    Journal: Drug Design Reviews Online
    Volume: 1
    Page numbers: 75-82
    Publisher: Bentham Science Publishers(Hilversum)
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  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 3453-3459
    Publisher: Society of Neuroscience(Washington DC)
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  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
    Year: 2003
    Journal: The Lancet
    Volume: 361
    Page numbers: 1258-1265
    Publisher: Lancet(London)
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  • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease
    Year: 2003
    Journal: Neuron
    Volume: 37
    Page numbers: 899-909
    Publisher: Cell Press(Massachusetts)
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  • Metal-protein attenuation with Iodochlorhydroxyquin (Clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Year: 2003
    Journal: Archives of Neurology
    Volume: 60
    Page numbers: 1685-1691
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  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The medicinal metallochemistry of Alzheimer's disease
    Year: 2003
    Journal: Current Medicinal Chemistry
    Volume: 3
    Page numbers: 9-13
    Publisher: Bentham Science Publishers(Hilversum)
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Publications in 2002

Journal Articles

  • Metalloenzyme-like activity of Alzheimer's disease β-amyloid
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 40302-40308
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 47
    Page numbers: 44670-44676
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2001

Journal Articles

  • Alzheimer's Disease Amyloid-[beta] Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 23
    Page numbers: 20466-20473
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
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  • Treatment with a copper-zinc chelator markedly and rapidly inhibits [beta]-amyloid accumulation in Alzheimer's disease transgenic mice
    Year: 2001
    Journal: Neuron
    Volume: 30
    Page numbers: 665-676
    Publisher: Cell Press(Massachusetts)
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