University home page

Find an ExpertProfiling the University of Melbourne's Researchers

DR ROBERT ALAN CHERNY



Contact Details

Organization: Pathology
Position: Honorary (Principal Fellow)
Email:
Homepage: http://www.mhri.edu.au
Work: 9388 1633
Building: No Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Alzheimer's Disease Australia

International Linkages

Country Establishment Collaboration
United States Massachusetts General Hospital Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 31-Dec-1980
Doctor of Philosophy Monash University 31-Dec-1990

Memberships

Membership Type Membership Body Description Start Date End Date
Unspecified The Society for Neuroscience (USA) 01-Sep-2006
Unspecified Australian Society for Neuroscience 01-Sep-2006

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Novel therapies for Alzheimer's disease based on A-beta - metal interactions Chief Investigator NHMRC Project Grants 01/01/2001
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
Identifying the toxic principle in Alzheimer's disease/ Purification and characterisation of toxic amyloid beta species in Alzheimer's disease Chief Investigator AUST ROTARY HEALTH RESEARCH FUND Mental Illness Research Ian Scott Fellowship 01/01/2004
Developing a novel therapy for Parkinson's Disease Chief Investigator NHMRC Project Grants 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Book Chapters

  • Metals, oxidative stress, and brain biology
    Year: 2007
    Book: Encyclopedia of Stress
    Publisher: Elsevier Science(Oxford)
    Authors(s):
    Editors(s):

Journal Articles

  • Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.


    Year: 2007
    Journal: Neurobiology of Aging
    Volume: 28
    Issue: 6
    Page numbers: 907-913
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Abeta produced as a fusion to maltose binding protein can be readily purified and stably associates with copper and zinc.
    Year: 2007
    Journal: Protein and Peptide Letters
    Volume: 14
    Issue: 1
    Page numbers: 83-86
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.
    Year: 2007
    Journal: Brain Research
    Volume: 1140
    Page numbers: 188-194
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mechanisms of copper ion mediated Huntington's Disease progression.
    Year: 2007
    Journal: PLoS One
    Volume: March 2007
    Issue: 3
    Page numbers: e334
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.
    Year: 2007
    Journal: PLoS One
    Volume: June 2007
    Issue: 6
    Page numbers: e536
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2006

Journal Articles

  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Dimerisation of N-acetyl-L-tyrosine ethyl ester and Abeta peptides via formation of dityrosine
    Year: 2006
    Journal: Free Radical Research
    Volume: 40(1)
    Page numbers: 1-9
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Elevated cortical zinc in Alzheimer disease
    Year: 2006
    Journal: Neurology
    Volume: 67
    Issue: 1
    Page numbers: 69-75
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2005

Journal Articles

  • Alzheimer disease β-amyloid activity mimics cholesterol oxidase
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Page numbers: 2556-2563
    Publisher: American Society of Clinical Investigation Inc(Michigan)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 3
    Page numbers: 672-679
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system.
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 50
    Page numbers: 41732-41743
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 353-360
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2004

Journal Articles

  • Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid Β-peptide by NMR
    Year: 2004
    Journal: Journal of Peptide Science
    Volume: 10
    Page numbers: 210-217
    Publisher: John Wiley & Sons(West Sussex)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 8602-8607
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of Amyotrophic Lateral Sclerosis
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 7945-7950
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
    Publisher: Springer Verlag(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal-protein attenuating compounds (MPACs) for the treatment of Alzheimer's disease
    Year: 2004
    Journal: Drug Design Reviews Online
    Volume: 1
    Page numbers: 75-82
    Publisher: Bentham Science Publishers(Hilversum)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Page numbers: 3453-3459
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.