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PROF SHAUN BRENNECKE



Contact Details

Organization: Obstetrics and Gynaecology Royal Women's Hospital/Mercy
Position: CHAIR OF OBSTETRICS & GYNAECOLOGY
Email:
Homepage: www.obsgyn.unimelb.edu.au
Work: 8345 3700
Fax: 8345 3702
Level: 07
Building: No Building
Campus: Royal Womens Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Maternal-fetal medicine. Human pregnancy. Pre-eclampsia. Preterm labour. Fetal welfare. Fetal growth restriction. Miscarriage. Perinatal mortality and morbidity. Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Arts Adelaide University
Bachelor of Medical Science Adelaide University
Doctor of Philosophy University of Oxford
Bachelor of Medicine & Bachelor of Surgery Adelaide University

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (FRANZCOG)

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
IDENTIFICATION OF PRE-ECLAMPSIA SUSCEPTIBILITY GENES Chief Investigator SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH Research Project Grants (NATIONAL INSTITUTE OF HEALTH) 09/09/2006
STEM CELLS IN A HUMAN PREGNANCY DISORDER Chief Investigator NHMRC Project Grants 01/01/2008
UNDERSTANDING THE MOLECULAR MECHANISM OF FETAL GROWTH RESTRICTION; A PREGNANCY DISORDER THAT PREVENTS A HEALTHY START TO LIFE Chief Investigator MINISTER ELLISON TRUSTEES Minter Ellison Marian and EH Flack Trust (MINTER ELLISON LAWYERS)

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study)
    Year: 2009
    Journal: European Journal of Human Genetics
    Volume: 17
    Page numbers: 250-257
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  • Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia
    Year: 2009
    Journal: Molecular Human Reproduction
    Volume: 15
    Issue: 3
    Page numbers: 195-204
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  • The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations
    Year: 2009
    Journal: Human Genetics
    Volume: 126
    Page numbers: 655-666
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Publications in 2008

Journal Articles

  • GAPDH, 18S rRNA and YWHAZ are suitable endogenous reference genes for relative gene expression studies in placental tissues from human idiopathic fetal growth restriction
    Year: 2008
    Journal: Placenta
    Volume: 29
    Page numbers: 798-801
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  • Calreticulin in human pregnancy and pre-eclampsia
    Year: 2008
    Journal: Molecular Human Reproduction
    Volume: 14
    Issue: 5
    Page numbers: 309-315
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  • Genetic association of preeclampsia to the inflammatory response gene SEPS1
    Year: 2008
    Journal: American Journal of Obstetrics and Gynecology
    Volume: 198
    Page numbers: 336.e1-e5
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  • Homeodomain protein HLX is expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta
    Year: 2008
    Journal: Reproduction, Fertility and Development
    Volume: 20
    Page numbers: 357-367
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  • Novel homeobox genes are differentially expressed in placental microvascular endothelial cells compared with macrovascular cells
    Year: 2008
    Journal: Placenta
    Volume: 29
    Page numbers: 624-630
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  • The prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian antenatal population
    Year: 2008
    Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
    Volume: 48
    Page numbers: 536-541
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Publications in 2007

Journal Articles

  • Homeobox gene HLX1 is a regulator of colony stimulating factor-1 dependent trophoblast cell proliferation
    Year: 2007
    Journal: Placenta
    Volume: 28
    Page numbers: 991-998
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  • Homeobox genes are differentially expressed in macrovascular human umbilical vein endothelial cells and microvascular placental endothelial cells
    Year: 2007
    Journal: Placenta
    Volume: 28
    Page numbers: 219-223
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  • Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach
    Year: 2007
    Journal: Molecular Human Reproduction
    Volume: 13
    Issue: 1
    Page numbers: 61-67
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  • The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction
    Year: 2007
    Journal: FASEB Journal
    Volume: 21
    Issue: November (13)
    Page numbers: 3592-3605
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Publications in 2006

Journal Articles

  • Expression of adrenomedullin mRNA is altered with gestation and labour in human placenta and fetal membranes


    Year: 2006
    Journal: Clinical Science
    Volume: 110
    Page numbers: 337-342
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  • Objective prioritization of positional candidate genes at a quantitative trait locus for pre-elcampsia on 2q22


    Year: 2006
    Journal: Molecular Human Reproduction
    Volume: 12
    Issue: 8
    Page numbers: 505-512
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  • A cost-effectiveness analysis of the intrapartum fetal pulse oximetry multicentre randomised controlled trial (the FOREMOST trial)
    Year: 2006
    Journal: BJOG
    Volume: 113
    Page numbers: 1080-1087
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  • Clinicians' evaluations of fetal oximetry sensor placement in a multicentre randomised trial (the FOREMOST trial)
    Year: 2006
    Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
    Volume: 46
    Page numbers: 234-239
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  • Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population
    Year: 2006
    Journal: Human Biology
    Volume: 78
    Issue: 4
    Page numbers: 403-412
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  • Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction
    Year: 2006
    Journal: Molecular Human Reproduction
    Volume: 12
    Issue: 12
    Page numbers: 763-769
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  • Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction
    Year: 2006
    Journal: Molecular Human Reproduction
    Volume: 12
    Issue: 5
    Page numbers: 335-340
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  • Homeobox gene HLX1 expression is decreased in idopathic human fetal growth restriction
    Year: 2006
    Journal: American Journal of Pathology
    Volume: 168
    Issue: 2
    Page numbers: 511-518
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  • Increased adrenomedullin protein content and mRNA expression in human fetal membranes but not placental tissue in pre-eclampsia
    Year: 2006
    Journal: Molecular Human Reproduction
    Volume: 12
    Issue: 3
    Page numbers: 181-186
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  • Maternal identity change as a consequence of antenatal hospitalization
    Year: 2006
    Journal: Health Care for Women International
    Volume: 27
    Page numbers: 762-776
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  • The -56T HLA-G promoter polymorphism is not associated with pre-eclampsia/eclampsia in Australian and New Zealand women
    Year: 2006
    Journal: Hypertension in Pregnancy
    Volume: 25
    Page numbers: 63-71
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  • The effect of intrapartum fetal pulse oximetry, in the presence of a nonreassuring fetal heart rate pattern, on operative delivery rates: A multicenter, randomized, controlled trial (the FOREMOST trial)
    Year: 2006
    Journal: American Journal of Obstetrics and Gynecology
    Volume: 194
    Issue: 3
    Page numbers: 606e1-606e16
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  • Women's evaluation of their experience in a multicenter randomized controlled trial of intrapartum fetal pulse oximetry (The FOREMOST Trial)
    Year: 2006
    Journal: Birth - Issues in Perinatal Care
    Volume: 33
    Issue: 2 June
    Page numbers: 101-109
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Publications in 2005

Journal Articles

  • 5β-dihydroprogesterone and steroid 5β-reductase decrease in association with human parturition at term
    Year: 2005
    Journal: Molecular Human Reproduction
    Volume: 11
    Issue: 7
    Page numbers: 495-501
    Publisher: Oxford University Press(Oxford)
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  • An emerging role for comprehensive proteome analysis in human pregnancy research
    Year: 2005
    Journal: Reproduction
    Volume: 129
    Page numbers: 685-696
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Detection of CAG repeats in pre-eclampsia/eclampsia using the repeat expansion detection method
    Year: 2005
    Journal: Molecular Human Reproduction
    Volume: 11
    Issue: 7
    Page numbers: 481-487
    Publisher: Oxford University Press(Oxford)
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  • Fetal growth restriction is associated with increased apoptosis in the chorionic trophoblast cells of human fetal membranes
    Year: 2005
    Journal: Placenta
    Volume: 26
    Page numbers: 329-338
    Publisher: WB Saunders Co(London)
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  • Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia
    Year: 2005
    Journal: Journal of Reproductive Immunology
    Volume: 68(1-2)
    Issue: Dec
    Page numbers: 105-120
    Publisher: Elsevier Science Ireland(Coclare)
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Publications in 2004

Journal Articles

Publications in 2003

Journal Articles

  • Cost-effectiveness and patient satisfaction with pregnancy day care for hypertensive disorders of pregnancy
    Year: 2003
    Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
    Volume: 43
    Page numbers: 207-212
    Publisher: Australian and New Zealand Journal of Obstetrics and Gynaecology(East Melbourne)
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  • Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes
    Year: 2003
    Journal: Journal of Perinatal Medicine
    Volume: 31
    Page numbers: 475-483
    Publisher: Walter de Gruyter(New York)
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  • Is there an increased role for general practice in making women more aware of folate supplementation to prevent neural tube defects?
    Year: 2003
    Journal: Australian Family Physician
    Volume: 32
    Issue: 7
    Page numbers: 568-569
    Publisher: Royal Australian College of General Practitioners
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  • Labour-associated changes in adrenomedullin content in human placenta and fetal membranes
    Year: 2003
    Journal: Clinical Science
    Volume: 105
    Page numbers: 419-423
    Publisher: Portland Press(London)
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Publications in 2002

Journal Articles

  • Antenatal and intrapartum antecedents of cerebral palsy: a case-control study
    Year: 2002
    Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
    Volume: 42
    Issue: 2
    Page numbers: 138-146
    Publisher: Australian and New Zealand Journal of Obstetrics and Gynaecology(East Melbourne)
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  • Letter to the Editor: Maternal antecedents to cerebral palsy in preterm infants
    Year: 2002
    Journal: Developmental Medicine and Child Neurology
    Volume: 44
    Page numbers: 498-498
    Publisher: Cambridge University Press(New York)
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  • The effect of hospitalisation on ambulatory blood pressure in pregnancy
    Year: 2002
    Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
    Volume: 42
    Issue: 5
    Page numbers: 490 - 493
    Publisher: Australian and New Zealand Journal of Obstetrics and Gynaecology(East Melbourne)
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  • Thrombomodulin Ala455Val dimorphism is not associated with pre-eclampsia in Australian and New Zealand Women
    Year: 2002
    Journal: Gynecologic and Obstetric Investigation
    Volume: 54
    Page numbers: 43-45
    Publisher: Karger(Basel)
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  • Update on intrapartum fetal pulse oximetry
    Year: 2002
    Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
    Volume: 42
    Issue: 2
    Page numbers: 119
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Publications in 2001

Journal Articles

  • A simple high-pressure liquid chromatography cotinine assay: validation of smoking status in pregnant women
    Year: 2001
    Journal: Annals of Clinical Biochemistry
    Volume: 38
    Page numbers: 333-338
    Publisher: The Royal Society of Medicine Press(London)
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  • An Australian twin study of the genetic basis of preeclampsia and eclampsia
    Year: 2001
    Journal: American Journal of Obstetrics and Gynecology
    Volume: 184
    Issue: 3
    Page numbers: 374-381
    Publisher: Mosby(Missouri)
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  • Blood pressure in late pregnancy and work outside the home
    Year: 2001
    Journal: Obstetrics and Gynecology
    Volume: 97
    Issue: 3
    Page numbers: 361-365
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  • C677T Methylenetetrahydrofolate reductase polymorphism is not a risk factor for pre-eclampsia/eclampsia among Australian women
    Year: 2001
    Journal: Human Heredity
    Volume: 51
    Page numbers: 20-22
    Publisher: Karger(Basel)
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  • Elevated interleukin-8 concentrations in cervical secretions are associated with preterm labour
    Year: 2001
    Journal: Gynecologic and Obstetric Investigation
    Volume: 51
    Page numbers: 165-168
    Publisher: Karger(Basel)
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  • Listeriosis: an unusual presentation of an uncommon condition
    Year: 2001
    Journal: Journal of Obstetrics and Gynaecology
    Volume: 21
    Issue: 5
    Page numbers: 536-537
    Publisher: Carfax Publishing(New Jersey)
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  • Placental glucose transport and utilisation is altered at term in insulin-treated, gestational-diabetic patients
    Year: 2001
    Journal: Diabetologia
    Volume: 44
    Page numbers: 1133-1139
    Publisher: Springer Verlag(New York)
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  • Team midwife care: maternal and infant outcomes
    Year: 2001
    Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
    Volume: 41
    Issue: 3
    Page numbers: 257-264
    Publisher: Australian and New Zealand Journal of Obstetrics and Gynaecology(East Melbourne)
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Conference Publications/Papers

  • Pre-term labour is associated with increased adrenomedullin concentration in human fetal membranes but not in placenta
    Year: 2001
    Event name: 53rd Annual Congress of Japan Society of Obstetrics and Gynecology
    Conference Publication: Frontiers in Obstetrics and Gynecology
    Volume: 2001
    Page numbers: 147-152
    Publisher: Monduzzi Editore(Bologna)
    Author(s):
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