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A/PROF GRAHAM BALDWIN



Contact Details

Organization: Surgery - Austin Health and Northern Health
Position: PRINCIPAL RESEARCH FELLOW (NH&MRC)
Email:
Work: 9496 5592
Fax: 9458 1650
Room: 8.20
Level: 08
Building: Lance Townsend Building
Campus: Austin Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Growth factors and gastrointestinal cancer Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 12-Aug-1972
Doctor of Philosophy University of Melbourne 09-Aug-1975
Doctor of Science University of Melbourne 25-Aug-2005

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society of Biochemistry and Molecular Biology 01-Jan-1971
Member Gastroenterological Association of Australia 25-Jun-1993
Member National Association of Research Fellows 01-Jan-1994
Member American Gastroenterological Association 30-Aug-2007

Other Awards

Award Type Awarding Body Comments Date Awarded
David Syme Research Prize University of Melbourne 23-Dec-2003
Other (Award) Australian Society of Biochemistry and Molecular Biology GE Healthcare Biosciences Award 12-Apr-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
The biological activities of progastrin-derived peptides Chief Investigator NHMRC Research Fellowship 01/01/2002
The biological activity of metal ion-gastrin complexes Chief Investigator NATIONAL INSTITUTE OF HEALTH Research Project Grants 01/08/2002
The Mechanism of Action of Progastrins in Colorectal Cancer Chief Investigator NHMRC Project Grants 01/01/2003
PROGASTRIN DERIVED PEPTIDES: BIOLOGICAL ACTIVITIES AND FUNCTIONS IN THE GASTROINTESTINAL TRACT Chief Investigator NHMRC Project Grants 01/01/2005
Selective drug therapy in an experimental model of colorectal cancer liver metastases Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2005
THE BIOLOGY OF GASTRIN-FERRIC ION COMPLEXES Chief Investigator NHMRC Project Grants 01/01/2006
THE BIOLOGY OF GASTRIN-FERRIC ION COMPLEXES Chief Investigator NATIONAL INSTITUTE OF HEALTH Research Project Grants 05/04/2006
Biology of GRP precursors Chief Investigator NHMRC Project Grants 01/01/2007
RESEARCH FELLOWSHIP 2007 - BALDWIN Chief Investigator NHMRC Research Fellowship 01/01/2007
Physiology and pathology of novel forms of progastrin Chief Investigator NHMRC Project Grants 01/01/2008
ProGRP as a biomarker for prostate cancer Chief Investigator CANCER COUNCIL VICTORIA Grant in Aid 01/01/2008
Gastrin, Iron and Colorectal Cancer Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Journal Articles

  • Beta-Catenin/Tcf-4 inhibition after prograstrin targeting reduces growth and drives differentiation of intestinal tumors
    Year: 2007
    Journal: Gastroenterology
    Volume: 133
    Issue: 5
    Page numbers: 1554-1568
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  • c-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor
    Year: 2007
    Journal: Endocrinology
    Volume: 148
    Issue: 3
    Page numbers: 1330-1339
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  • cck receptors and cancer
    Year: 2007
    Journal: Current Topics in Medicinal Chemistry
    Volume: 7
    Issue: 12
    Page numbers: 1232-1238
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  • phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: biological implications
    Year: 2007
    Journal: Regulatory Peptides
    Volume: 143
    Page numbers: 1-14
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  • recombinant c-terminal fragments of the gastrin-releasing peptide precursor are bioactive
    Year: 2007
    Journal: Cancer Letters
    Volume: 254
    Page numbers: 87-93
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Publications in 2006

Book Chapters

  • Regulation of gastric acid secretion
    Year: 2006
    Book: Physiology of the Gastrointestinal Tract
    Publisher: Elsevier Science
    Authors(s):

Journal Articles

  • Circulating gastrin is increased in hemochromatosis
    Year: 2006
    Journal: FEBS Letters
    Volume: 580
    Page numbers: 6195-6198
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  • Gastrin-releasing peptide and cancer
    Year: 2006
    Journal: BBA - Reviews on Cancer
    Volume: 1766
    Issue: 12
    Page numbers: 23-41
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  • Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo.
    Year: 2006
    Journal: Regulatory Peptides
    Volume: 134
    Page numbers: 9-16
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  • Production, Secretion, and Biological Activity of the C-Terminal Flanking Peptide of Human Progastrin
    Year: 2006
    Journal: Gastroenterology
    Volume: 131
    Page numbers: 1463-1474
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  • Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP).
    Year: 2006
    Journal: Endocrinology
    Volume: 147
    Issue: 1
    Page numbers: 502-509
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Publications in 2005

Journal Articles

  • Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway.
    Year: 2005
    Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology
    Volume: 289
    Page numbers: 478-488
    Publisher: American Physiological Society(Maryland)
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  • Signalling junctions in the gut epithelium.
    Year: 2005
    Journal: Signal Transduction Knowledge Environment
    Volume: 277
    Page numbers: pe13
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Publications in 2004

Book Chapters

  • Gastrins, gastrin receptors, and colon cancer
    Year: 2004
    Book: Gastrin in the new millennium
    Publisher: Cure Foundation(Los Angeles)
    Authors(s):

Journal Articles

  • A novel effect of bismuth ions
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 4
    Page numbers: 2453-2460
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Biological activity and ferric ion binding of fragments of glycine-extended gastrin
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Issue: 37
    Page numbers: 11853-11861
    Publisher: American Chemical Society(Washington DC)
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  • Developmental expression and biological activity of gastrin-releasing peptide (GRP) and GRP receptors in the kidney
    Year: 2004
    Journal: American Journal of Physiology - Renal Physiology
    Volume: 287
    Page numbers: F578-F585
    Publisher: American Physiological Society(Maryland)
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  • Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins
    Year: 2004
    Journal: Journal of Endocrinology
    Volume: 181
    Page numbers: 315-325
    Publisher: Society of Endocrinology(Stokebristol)
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  • Gastrins, cholecystokinins and gastrointestinal cancer
    Year: 2004
    Journal: BBA - Reviews on Cancer
    Volume: 1704
    Page numbers: 1-10
    Publisher: Elsevier Science
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  • Identity and regulation of stored and secreted progastrin-derived peptides in sheep
    Year: 2004
    Journal: Endocrinology
    Volume: 145
    Issue: 11
    Page numbers: 5129-5140
    Publisher: Endocrine Society(Maryland)
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  • PPARΑ agonists stimulate progastrin production in human colorectal carcinoma cells
    Year: 2004
    Journal: Regulatory Peptides
    Volume: 120
    Page numbers: 243-251
    Publisher: Elsevier Science(Amsterdam)
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  • Properties of the complex between recombinant human progastrin and ferric ions
    Year: 2004
    Journal: The Protein Journal
    Volume: 23
    Issue: 1
    Page numbers: 65-70
    Publisher: Kluwer Academic/Plenum Publishers
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  • Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor
    Year: 2004
    Journal: Biochemical Pharmacology
    Volume: 68
    Page numbers: 2129-2142
    Publisher: Pergamon-Elsevier Science(Oxford)
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Publications in 2003

Journal Articles

  • Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells
    Year: 2003
    Journal: Journal of Cell Science
    Volume: 116
    Page numbers: 1187-1197
    Publisher: Company of Biologists(Cambridge)
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Publications in 2002

Journal Articles

  • Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 48602-48609
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Metabolism of recombinant progastrin in sheep
    Year: 2002
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 283
    Page numbers: E449-E456
    Publisher: American Physiological Society(Maryland)
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  • Preparation of biologically active recombinant human progastrin1-80
    Year: 2002
    Journal: Journal of Protein Chemistry
    Volume: 21
    Issue: 7
    Page numbers: 465-471
    Publisher: Kluwer Academic/Plenum Publishers(New York)
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Publications in 2001

Journal Articles

  • Binding sites for progastrin-derived peptides in colonic crypts
    Year: 2001
    Journal: Journal of Gastroenterology & Hepatology
    Volume: 16
    Page numbers: 169-175
    Publisher: Blackwell Science Asia(Carlton)
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