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A/PROF GRAHAM BALDWIN



Contact Details

Organization: Surgery - Austin Health and Northern Health
Position: PRINCIPAL RESEARCH FELLOW (NH&MRC)
Email:
Work: 9496 5592
Fax: 9458 1650
Room: 8.20
Level: 08
Building: Lance Townsend Building
Campus: Austin Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Growth factors and gastrointestinal cancer Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 12-Aug-1972
Doctor of Philosophy University of Melbourne 09-Aug-1975
Doctor of Science University of Melbourne 25-Aug-2005

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society of Biochemistry and Molecular Biology Member 01-Jan-1971
Member Gastroenterological Association of Australia Member, Research Committee 25-Jun-1993
Member National Association of Research Fellows Member 01-Jan-1994
Member American Gastroenterological Association Member 30-Aug-2007

Other Awards

Award Type Awarding Body Comments Date Awarded
David Syme Research Prize University of Melbourne 23-Dec-2003
Other (Award) Australian Society of Biochemistry and Molecular Biology GE Healthcare Biosciences Award 12-Apr-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
The biological activities of progastrin-derived peptides Chief Investigator NHMRC Research Fellowship 01/01/2002
The biological activity of metal ion-gastrin complexes Chief Investigator NATIONAL INSTITUTE OF HEALTH Research Project Grants 01/08/2002
The Mechanism of Action of Progastrins in Colorectal Cancer Chief Investigator NHMRC Project Grants 01/01/2003
PROGASTRIN DERIVED PEPTIDES: BIOLOGICAL ACTIVITIES AND FUNCTIONS IN THE GASTROINTESTINAL TRACT Chief Investigator NHMRC Project Grants 01/01/2005
Selective drug therapy in an experimental model of colorectal cancer liver metastases Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2005
THE BIOLOGY OF GASTRIN-FERRIC ION COMPLEXES Chief Investigator NHMRC Project Grants 01/01/2006
THE BIOLOGY OF GASTRIN-FERRIC ION COMPLEXES Chief Investigator NATIONAL INSTITUTE OF HEALTH Research Project Grants 05/04/2006
Biology of GRP precursors Chief Investigator NHMRC Project Grants 01/01/2007
RESEARCH FELLOWSHIP 2007 - BALDWIN Chief Investigator NHMRC Research Fellowship 01/01/2007
Physiology and pathology of novel forms of progastrin Chief Investigator NHMRC Project Grants 01/01/2008
ProGRP as a biomarker for prostate cancer Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2008
Gastrin, Iron and Colorectal Cancer Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth
    Year: 2009
    Journal: Biochimica et Biophysica Acta - Molecular Cell Research
    Volume: 1793
    Issue: 3
    Page numbers: 477-488
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  • Peptide processing and biology in human disease
    Year: 2009
    Journal: Current Opinion in Endocrinology, Diabetes and Obesity
    Volume: 16
    Page numbers: 79-85
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Publications in 2008

Book Chapters

  • Gastrin-releasing peptide
    Year: 2008
    Book: Encyclopedia of Cancer
    Publisher: Springer Verlag(London)
    Authors(s):

Journal Articles

  • Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by gastrins


    Year: 2008
    Journal: Cellular Signaling
    Volume: 20
    Page numbers: 83-93
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  • Gastrin is not required for liver regeneration
    Year: 2008
    Journal: ANZ Journal of Surgery
    Volume: 78
    Page numbers: 68-71
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  • Interrelationships between circulating gastrin and iron status in mice and humans
    Year: 2008
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 295
    Page numbers: 855-861
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  • PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins
    Year: 2008
    Journal: Biochimica et Biophysica Acta - Molecular Cell Research
    Volume: 1783
    Page numbers: 1943-1954
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  • Preparation and properties of recombinant rat and human procholecystokinin57-95
    Year: 2008
    Journal: The Protein Journal
    Volume: 27
    Page numbers: 186-191
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  • Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Page numbers: 2018-2022
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  • Tyrosine modification enhances metal ion binding
    Year: 2008
    Journal: Biochemical Journal
    Volume: 416
    Page numbers: 77-84
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Publications in 2007

Journal Articles

  • Beta-Catenin/Tcf-4 inhibition after prograstrin targeting reduces growth and drives differentiation of intestinal tumors
    Year: 2007
    Journal: Gastroenterology
    Volume: 133
    Issue: 5
    Page numbers: 1554-1568
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  • c-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor
    Year: 2007
    Journal: Endocrinology
    Volume: 148
    Issue: 3
    Page numbers: 1330-1339
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  • cck receptors and cancer
    Year: 2007
    Journal: Current Topics in Medicinal Chemistry
    Volume: 7
    Issue: 12
    Page numbers: 1232-1238
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  • phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: biological implications
    Year: 2007
    Journal: Regulatory Peptides
    Volume: 143
    Page numbers: 1-14
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  • recombinant c-terminal fragments of the gastrin-releasing peptide precursor are bioactive
    Year: 2007
    Journal: Cancer Letters
    Volume: 254
    Page numbers: 87-93
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Publications in 2006

Book Chapters

  • Regulation of gastric acid secretion
    Year: 2006
    Book: Physiology of the Gastrointestinal Tract
    Publisher: Elsevier Science
    Authors(s):

Journal Articles

  • Circulating gastrin is increased in hemochromatosis
    Year: 2006
    Journal: FEBS Letters
    Volume: 580
    Page numbers: 6195-6198
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  • Gastrin-releasing peptide and cancer
    Year: 2006
    Journal: BBA - Reviews on Cancer
    Volume: 1766
    Issue: 12
    Page numbers: 23-41
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  • Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo.
    Year: 2006
    Journal: Regulatory Peptides
    Volume: 134
    Page numbers: 9-16
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  • Production, Secretion, and Biological Activity of the C-Terminal Flanking Peptide of Human Progastrin
    Year: 2006
    Journal: Gastroenterology
    Volume: 131
    Page numbers: 1463-1474
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  • Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP).
    Year: 2006
    Journal: Endocrinology
    Volume: 147
    Issue: 1
    Page numbers: 502-509
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Publications in 2005

Journal Articles

  • Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway.
    Year: 2005
    Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology
    Volume: 289
    Page numbers: 478-488
    Publisher: American Physiological Society(Maryland)
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  • Signalling junctions in the gut epithelium.
    Year: 2005
    Journal: Signal Transduction Knowledge Environment
    Volume: 277
    Page numbers: pe13
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Publications in 2004

Book Chapters

  • Gastrins, gastrin receptors, and colon cancer
    Year: 2004
    Book: Gastrin in the new millennium
    Publisher: Cure Foundation(Los Angeles)
    Authors(s):

Journal Articles

  • A novel effect of bismuth ions
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 4
    Page numbers: 2453-2460
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Biological activity and ferric ion binding of fragments of glycine-extended gastrin
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Issue: 37
    Page numbers: 11853-11861
    Publisher: American Chemical Society(Washington DC)
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  • Developmental expression and biological activity of gastrin-releasing peptide (GRP) and GRP receptors in the kidney
    Year: 2004
    Journal: American Journal of Physiology: Renal Physiology
    Volume: 287
    Page numbers: F578-F585
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  • Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins
    Year: 2004
    Journal: Journal of Endocrinology
    Volume: 181
    Page numbers: 315-325
    Publisher: Society of Endocrinology(Stokebristol)
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  • Gastrins, cholecystokinins and gastrointestinal cancer
    Year: 2004
    Journal: BBA - Reviews on Cancer
    Volume: 1704
    Page numbers: 1-10
    Publisher: Elsevier Science
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  • Identity and regulation of stored and secreted progastrin-derived peptides in sheep
    Year: 2004
    Journal: Endocrinology
    Volume: 145
    Issue: 11
    Page numbers: 5129-5140
    Publisher: Endocrine Society(Maryland)
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  • PPARΑ agonists stimulate progastrin production in human colorectal carcinoma cells
    Year: 2004
    Journal: Regulatory Peptides
    Volume: 120
    Page numbers: 243-251
    Publisher: Elsevier Science(Amsterdam)
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  • Properties of the complex between recombinant human progastrin and ferric ions
    Year: 2004
    Journal: The Protein Journal
    Volume: 23
    Issue: 1
    Page numbers: 65-70
    Publisher: Kluwer Academic/Plenum Publishers
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  • Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor
    Year: 2004
    Journal: Biochemical Pharmacology
    Volume: 68
    Page numbers: 2129-2142
    Publisher: Pergamon-Elsevier Science(Oxford)
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Publications in 2003

Journal Articles

  • Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells
    Year: 2003
    Journal: Journal of Cell Science
    Volume: 116
    Page numbers: 1187-1197
    Publisher: Company of Biologists(Cambridge)
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Publications in 2002

Journal Articles

  • Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 48602-48609
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Metabolism of recombinant progastrin in sheep
    Year: 2002
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 283
    Page numbers: E449-E456
    Publisher: American Physiological Society(Maryland)
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  • Preparation of biologically active recombinant human progastrin1-80
    Year: 2002
    Journal: Journal of Protein Chemistry
    Volume: 21
    Issue: 7
    Page numbers: 465-471
    Publisher: Kluwer Academic/Plenum Publishers(New York)
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Publications in 2001

Journal Articles

  • Binding sites for progastrin-derived peptides in colonic crypts
    Year: 2001
    Journal: Journal of Gastroenterology and Hepatology
    Volume: 16
    Page numbers: 169-175
    Publisher: Blackwell Science Asia(Carlton)
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  • Biologically active recombinant human progastrin 6-80 contains a tightly bound calcium ion
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 11
    Page numbers: 7791-7796
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  • Biologically active recombinant human progastrin6-80 contains a tightly bound calcium ion
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 11
    Page numbers: 7791-7796
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Biology and pathology of non-amidated gastrins
    Year: 2001
    Journal: Scandinavian Journal of Clinical and Laboratory Investigation
    Volume: 61
    Issue: Suppl 234
    Page numbers: 123-128
    Publisher: Taylor & Francis Ltd(Oslo)
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  • HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line
    Year: 2001
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 280
    Page numbers: G910-G921
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  • Identification of a 70-kDa gastrin-binding protein on DLD-1 human colorectal carcinoma cells
    Year: 2001
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 33
    Page numbers: 1071-1079
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Inhibition of the preferential binding of actin to the N-terminal hydratase domain of the 78-kDa gastrin-binding protein by non-steroidal anti-inflammatory drugs and gastrin receptor antagonists
    Year: 2001
    Journal: Biochemical Pharmacology
    Volume: 61
    Page numbers: 1129-1136
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric epithelial cells
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 44
    Page numbers: 40402-40410
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Mutation of lysine residues of the 78-kDa gastrin-binding protein reduces gastrin binding
    Year: 2001
    Journal: Journal of Protein Chemistry
    Volume: 20
    Issue: 5
    Page numbers: 345-351
    Publisher: Kluwer Academic/Plenum Publishers(New York)
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  • Regulatory peptides: what do they regulate?
    Year: 2001
    Journal: Trends in Endocrinology and Metabolism
    Volume: 12
    Page numbers: 46-47
    Publisher: Elsevier Science London(London)
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  • Selective, high-affinity binding of ferric ions by glycine-extended gastrin17
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Issue: 36
    Page numbers: 10741-10746
    Publisher: American Chemical Society(Washington DC)
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  • Short term infusion of glycine-extended gastrin17 stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa.
    Year: 2001
    Journal: International Journal of Cancer
    Volume: 94
    Page numbers: 307-313
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  • Short term infusion of glycine-extended gastrin17 stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa
    Year: 2001
    Journal: International Journal of Cancer
    Volume: 94
    Page numbers: 307-313
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  • Short term infusion of glycine-extended gastrin17 stimulates both proliferation and formation of aberrant cyrpt foci in rat colonic mucosa
    Year: 2001
    Journal: International Journal of Cancer
    Volume: 94
    Page numbers: 307-313
    Publisher: Wiley-Liss(New York)
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