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Find an ExpertProfiling the University of Melbourne's Researchers

A/PROF EDOUARD NICE



Contact Details

Organization: Surgery - Royal Melbourne and Western Hospital
Position: Honorary (Principal Fellow)
Email:
Homepage: http://www.ludwig.edu.au/
Work: 9341 3135
Level: 06
Building: Med Research Building
Campus: Royal Melbourne Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Biosensors Australia
HPLC Australia
Proteomics Australia
EGFR Australia
Biomarkers Australia
Colon Cancer Australia

International Linkages

Country Establishment Collaboration
France Ecole Superieure de Biotechnologie de Strasbourg Technical Assistance/Training
Germany Ruprecht-Karls-Universitaet Heidelberg Technical Assistance/Training
Germany Hochschule Mannheim - University of Applied Sciences Technical Assistance/Training
Sweden Uppsala University Technical Assistance/Training
France CNRS Institut de Chimie des Substances Naturelles Research

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Probing membrane rafts using surface-selective multi-dimensional microscopy Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  •  Experimental Determination of Quantum Dot Size Distributions, Ligand Packing Densities, and Bioconjugation Using Analytical Unltracentrifugation.


    Year: 2008
    Journal: Nano Letters
    Volume: 8
    Issue: 9
    Page numbers: 2883-2890
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  • IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
    Year: 2008
    Journal: Blood
    Volume: 111
    Issue: 8
    Page numbers: 3978-3985
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  • Predominance of activated EGFR higher-order oliogmers on the cell surface.
    Year: 2008
    Journal: Growth Factors
    Volume: 26
    Issue: 6
    Page numbers: 316-324
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  • The PI(3,5)P2 and PI(4,5)P2 Interactomes
    Year: 2008
    Journal: Journal of Proteome Research
    Volume: 7
    Issue: 12
    Page numbers: 5295-5313
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Publications in 2007

Journal Articles

  • Evidence for a role of tumor-derived Laminin-511 in the metastatic progression of breast cancer.


    Year: 2007
    Journal: American Journal of Pathology
    Volume: 170
    Issue: 6
    Page numbers: 2135-2148
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  • Use of multidimensional separation protocols for the purification of trace components in complex biological samples for proteomic analysis


    Year: 2007
    Journal: Journal of Chromatography A
    Volume: 1168
    Issue: 2007
    Page numbers: 190-210
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  • A novel magnetic bead-based assay with high sensitvity and selectivity for analysis of telomerase in exfoliated cells from patients with bladder and colon cancer.
    Year: 2007
    Journal: Electrophoresis
    Volume: 28
    Issue: 23
    Page numbers: 4435-4446
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  • Influence of size, surface, cell line and kinetic properties on the specific binding of A33 anitgen-targeted multilayered paricles and capsules to colorectal cancer cells.
    Year: 2007
    Journal: ACS Nano
    Volume: 1
    Issue: 2
    Page numbers: 93-102
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  • Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
    Year: 2007
    Journal: FASEB Journal
    Volume: 21
    Issue: 2007
    Page numbers: 1088-1098
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  • Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naadimine A.
    Year: 2007
    Journal: Bioorganic and Medicinal Chemistry Letters
    Volume: 17
    Page numbers: 3741-3744
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Publications in 2006

Journal Articles

  • An automated peptide and protein thiazolidine coupling chemistry for biosensor immobilization giving a unique N-terminal orientation
    Year: 2006
    Journal: Analytical Biochemistry
    Volume: 348
    Issue: 2
    Page numbers: 315-317
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  • In situ phosphorylation of immobilzed receptors on biosensor surfaces: Application to E- cadherin/ß-catenin interactions.
    Year: 2006
    Journal: Analytical Biochemistry
    Volume: 357
    Issue: 2
    Page numbers: 277-288
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  • Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine Kinase
    Year: 2006
    Journal: Biochemical Pharmacology
    Volume: 71
    Issue: 2006
    Page numbers: 1422-1434
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  • Purification and characterization of a high specificity polyclonal antibody to the adnomatous polyposis coli tumour suppressor protein.
    Year: 2006
    Journal: Biomedical Chromatography
    Volume: 20
    Issue: 6-7
    Page numbers: 569-575
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  • Targeting and Uptake of Multilayered Particles to Colorectal Cancer Cells
    Year: 2006
    Journal: Advanced Materials
    Volume: 18
    Page numbers: 1998-2003
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  • The unfolded protein response transducer Ire1p contains a nuclear localisation sequence recognised by multiple beta importins
    Year: 2006
    Journal: Molecular Biology of the Cell
    Volume: 17
    Page numbers: 6309-5323
    Author(s):
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Publications in 2005

Journal Articles

  • A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 26
    Page numbers: 1-25
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  • A simple method allowing DIC imaging in conjunction with confocal microscopy
    Year: 2005
    Journal: Journal of Microscopy - Oxford
    Volume: 217
    Issue: 3
    Page numbers: 265-274
    Publisher: Blackwell Science(Oxford)
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  • Enhanced Efficacy of Radioimmunotherapy with 90Y-CHX-A-DTPA-hu3S193 by Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling with EGFR Tyrosine Kinase Inhibitor AG1478
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Issue: 19 Suppl
    Page numbers: 7080 - 7086
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  • Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin and laminin
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 19
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  • Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG1478-mesylate, with albumin
    Year: 2005
    Journal: Analytical Biochemistry
    Volume: 342
    Issue: 2
    Page numbers: 292-299
    Publisher: Academic Press - Elsevier Science(San Diego)
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  • Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 34
    Page numbers: 30392-30399
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  • The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF)
    Year: 2005
    Journal: Growth Factors
    Volume: 23
    Issue: 2
    Page numbers: 97-110
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Publications in 2004

Journal Articles

  • Human antibody fragments specific for the epidermal growth factor receptor selected from larger non-immunized phage display libraries.


    Year: 2004
    Journal: Growth Factors
    Volume: 22
    Issue: 3
    Page numbers: 185-94
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  • CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 21
    Page numbers: 22387-22398
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 29
    Page numbers: 30375-30384
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Publications in 2003

Journal Articles

  • Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.


    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 26
    Page numbers: 15871-15876
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  • A binding motif for Siah ubiquitin ligase
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 6
    Page numbers: 3101-3106
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  • Strategies for the purification of laminin-10 for studies on colon cancer metastasis. Biomedical chromatography
    Year: 2003
    Journal: Journal of Chromatography B: Biomedical Sciences and Applications
    Volume: 2
    Issue: 3
    Page numbers: 201-211
    Publisher: Elsevier Science
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  • The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors
    Year: 2003
    Journal: Molecular Cell
    Volume: 11
    Issue: 2
    Page numbers: 495-505
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Publications in 2002

Journal Articles

  • A novel monoclonal antibody specific for the De2-7 EGFR that also recognises the EGFRexpressed in cells containing amplification of the EGFR gene.


    Year: 2002
    Journal: International Journal of Cancer
    Volume: 98
    Page numbers: 398-404
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  • Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
    Year: 2002
    Journal: Cell
    Volume: 110
    Issue: 6
    Page numbers: 763-773
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  • Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues
    Year: 2002
    Journal: Growth Factors
    Volume: 20
    Issue: 2
    Page numbers: 71-80
    Publisher: Harwood Academic Publishing GMBH(Reading)
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Publications in 2001

Journal Articles

  • Design of inhibitors of Ras-Raf interaction using a computational combinatorial algorithm.


    Year: 2001
    Journal: Protein Engineering
    Volume: 14
    Issue: 1
    Page numbers: 39-45
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  • Design of Ras-Raf interaction using a computational combinatorial algorithm
    Year: 2001
    Journal: Protein Engineering
    Volume: 14
    Page numbers: 39-45
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  • High-performace liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma
    Year: 2001
    Journal: Journal of Chromatography B: Biomedical Sciences and Applications
    Volume: 754
    Page numbers: 193-199
    Publisher: Elsevier Science
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  • High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.
    Year: 2001
    Journal: Journal of Chromatography B: Biomedical Sciences and Applications
    Volume: 754
    Page numbers: 193-199
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  • Identification of a Determinant of Epidermal Growth Factor Receptor Ligand-Binding Specificity Using a Truncated, High-Affinity Form of the Ectodomain
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8930-8939
    Publisher: American Chemical Society(Washington DC)
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  • Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C receptor VEGFR-3
    Year: 2001
    Journal: EMBO Journal
    Volume: 20
    Page numbers: 4762-4773
    Publisher: Oxford University Press(Oxford)
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  • Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins
    Year: 2001
    Journal: Experimental Cell Research
    Volume: 266
    Page numbers: 1-10
    Publisher: Academic Press(California)
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  • Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes.
    Year: 2001
    Journal: Journal of Peptide Research
    Volume: 58
    Page numbers: 204-212
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Synthesis, conformational studies and biological activity of N-alpha-mono-biotinylated rat relaxin
    Year: 2001
    Journal: Journal of Peptide Research
    Volume: 57
    Page numbers: 374-382
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Targeting properties of an anti-CD16/anti-CD30 biospecific antibody in an in vivo system
    Year: 2001
    Journal: Cancer Immunology, Immunotherapy
    Volume: 50
    Page numbers: 102-108
    Publisher: Springer Verlag(New York)
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  • The specificity of receptor binding by vascular endothelial growth factor-D is different in mouse and man
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 19166-19171
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes.
    Year: 2001
    Journal: Journal of Peptide Research
    Volume: 58
    Issue: 6
    Page numbers: 493-503
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Conference Publications/Papers

  • The use of a synthetic biotinylaged peptide probe for the isolation of adenoatous polyposis coli (APC) tumur suppressor protein complexes.
    Year: 2001
    Event name: 2nd International and 17th American Peptide Symposium.
    Conference Publication: Peptides. The Wave of the Future.
    Page numbers: 998-999
    Publisher: American Peptide Society(San Diego)
    Author(s):
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