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A/PROF DAVID HOWELLS



Contact Details

Organization: Medicine - Austin Health and Northern Health
Position: PRINCIPAL RESEARCH FELLOW (NH&MRC)
Email:
Work: 9496 3789
Fax: 9457 5485
Room: 7.23
Level: 07
Building: Lance Townsend Building
Campus: Austin Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Neuroscience Neuroregeneration, neuroprotection, immune response, stroke, spinal cord, parkinsons disease Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Philosophy University of London

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEW DOPAMINERGIC NEURONS IN THE PARKINSON'S DISEASE STRIATUM: ESTABLISHMENT OF PHENOTYPE, FUNCTION AND ORIGIN Chief Investigator NHMRC Research Fellowship 01/01/2001
Characterisation of the ischaemic penumbra in a rat model of stroke Chief Investigator NHMRC Medical & Dental Postgraduate Scholarships 01/01/2003
Translational research in stroke Chief Investigator NHMRC Program Grants 01/01/2003
TRAUMATIC INJURY TO BRAIN & SPINAL CORD: SECONDARY INJURY, DEVELOPMENT & EVALUATION OF NEW TREATMENTS Chief Investigator TRANSPORT ACCIDENT COMMISSION Victorian Neurotrauma Initiative 01/09/2006
2007 PROGRAM GRANT - (IMPROVING STROKE OUTCOMES: NEW TARGETS AND THERAPIES) Chief Investigator NHMRC Program Grants 01/01/2007
RESEARCH FELLOWSHIP 2007 - HOWELLS Chief Investigator NHMRC Research Fellowship 01/01/2007
REGENERATION OF THE CORTICOSPINAL TRACT IN THE INJURED SPINAL CORD Chief Investigator TRANSPORT ACCIDENT COMMISSION Victorian Neurotrauma Initiative 01/01/2007
AMELIORATION OF MACROPHAGE CYTOTOXICITY AFTER SPINAL CORD INJURY: IMPACT ON SECONDARY INJURY AND AXONAL REGENERATION Chief Investigator TRANSPORT ACCIDENT COMMISSION Victorian Neurotrauma Initiative 01/05/2007
BIOMEDICAL - CAN THE EMBRYONIC RAT SPINAL CORD INFLUENCE REGROWTH AFTER ADULT SPINAL CORD INJURY? Principal Supervisor NHMRC Scholarships 01/01/2008
RESEARCH FELLOWSHIP - SRF B Chief Investigator NHMRC Research Fellowship 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis


    Year: 2009
    Journal: BMC Neuroscience
    Volume: 10
    Issue: 120
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  • Characterisation of the timing of binding of the hypoxia tracer FMISO after stroke
    Year: 2009
    Journal: Brain Research
    Volume: 1288
    Page numbers: 135-142
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  • Good laboratory practice:  preventing introduction of bias at the bench
    Year: 2009
    Journal: International Journal of Stroke
    Volume: 4
    Issue: 1
    Page numbers: 3-5
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  • Scope of preclinical testing versus quality control within experiments
    Year: 2009
    Journal: Stroke
    Volume: 40
    Issue: 7
    Page numbers: e497
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  • Update of the stroke therapy academic industry roundtable preclinical recommendations
    Year: 2009
    Journal: Stroke
    Volume: 40
    Issue: 6
    Page numbers: 2244-2250
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Publications in 2008

Journal Articles

  • Comparison of inflammation in the brain and spinal cord following mechanical injury


     


    Year: 2008
    Journal: Journal of Neurotrauma
    Volume: 25
    Issue: 10
    Page numbers: 1217-1225
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  • Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality


    Year: 2008
    Journal: Stroke
    Volume: 39
    Page numbers: 2824-2829
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  • Stimulation of axonal sprouting by trophic factors immobilized within the wound core


    Year: 2008
    Journal: Brain Research
    Volume: 1209
    Page numbers: 49-56
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Publications in 2007

Book Chapters

  • Imaging the Penumbra: Positron Emission Tomography Fluoromisonidazole


    Year: 2007
    Book: The Ischemic Penumbra
    Publisher: Informa Healthcare
    Authors(s):
    Editors(s):

Journal Articles

  • How can we improve the pre-clinical development of drugs for stroke?


    Year: 2007
    Journal: Trends in Neurosciences
    Volume: 30
    Issue: 9
    Page numbers: 433-439
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  • Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis


    Year: 2007
    Journal: Brain
    Volume: 130
    Issue: 2007
    Page numbers: 3063 - 3074
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  • Isolating cells from non-sperm cellular mixtures using the PALM® microlaser micro dissection system


    Year: 2007
    Journal: Forensic Science International
    Volume: 10
    Issue: 2007
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Publications in 2006

Journal Articles

  • 1,026 experimental treatments in acute stroke
    Year: 2006
    Journal: Annals of Neurology
    Volume: 59(3)
    Issue: 2006
    Page numbers: 467-477
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  • Characterization of Fluoromisonidazole Binding in Stroke
    Year: 2006
    Journal: Stroke
    Volume: 37
    Issue: 2006
    Page numbers: 1862-1867
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  • F-18 labelled N,N-bis-haloethylamino-phenylsulfoxides - a new class of compounds for the imaging of hypoxic tissue
    Year: 2006
    Journal: Journal of Labelled Compounds & Radiopharmaceuticals
    Volume: 49
    Issue: 2006
    Page numbers: 1089-1103
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  • Inflammation following stroke
    Year: 2006
    Journal: Journal of Clinical Neuroscience
    Volume: 13
    Issue: 2006
    Page numbers: 1-8
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  • Laser microdissection and pressure catapulting with PALM® to assist typing of target DNA in dirt samples
    Year: 2006
    Journal: International Congress Series
    Volume: 1288
    Issue: 2006
    Page numbers: 559-561
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  • Modification of the method of thread manufacture improves stroke induction rate and reduces motality afer thread-occlusion of the middle cerebral artery in young or aged rats
    Year: 2006
    Journal: Journal of Neuroscience
    Volume: 155
    Issue: 2006
    Page numbers: 285-290
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  • Striatal Dopaminergic Neurons Are Lost with Parkinson's Disease Progression
    Year: 2006
    Journal: Movement Disorders
    Volume: 21
    Issue: 12
    Page numbers: 2208-2211
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Publications in 2005

Journal Articles

  • Dopaminergic Innervation of the Human Striatum in Parkinson's Disease
    Year: 2005
    Journal: Movement Disorders
    Volume: 20
    Issue: 7
    Page numbers: 810-818
    Publisher: Wiley-Liss(New York)
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  • Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons
    Year: 2005
    Journal: Experimental Neurology
    Volume: 192
    Page numbers: 226-234
    Publisher: Academic Press(California)
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  • Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke
    Year: 2005
    Journal: Journal of Pineal Research
    Volume: 38
    Page numbers: 35-41
    Publisher: Blackwell Publishers(Oxford)
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  • Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke
    Year: 2005
    Journal: Journal of Cerebral Blood Flow and Metabolism
    Volume: 25
    Page numbers: 713-721
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury
    Year: 2005
    Journal: Stroke
    Volume: 36
    Page numbers: 1241-1246
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Publications in 2004

Journal Articles

  • Imaging the Ischemic Penumbra with 18F-Fluoromisonidazole in a Rat Model of Ischemic Stroke
    Year: 2004
    Journal: Stroke
    Volume: 35
    Issue: 2004
    Page numbers: 975-980
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  • Pooling of animal experimental data reveals influence of study design and publication bias
    Year: 2004
    Journal: Stroke
    Volume: 35
    Page numbers: 1203-1208
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • The resistance to ischemia of white and gray matter after stroke
    Year: 2004
    Journal: Annals of Neurology
    Volume: 56
    Page numbers: 695-701
    Publisher: Wiley-Liss(New York)
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Publications in 2003

Journal Articles

  • CNS regeneration: clinical possibility or basic science fantasy?
    Year: 2003
    Journal: Journal of Clinical Neuroscience
    Volume: 10
    Issue: 5
    Page numbers: 523-534
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
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  • Can the time window for administration of thrombolytics in stroke be increased?
    Year: 2003
    Journal: CNS Drugs
    Volume: 17
    Issue: 14
    Page numbers: 995-1011
    Publisher: Adis International(Bayauckland)
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  • Stem Cells: do they replace or stimulate?
    Year: 2003
    Journal: Stroke
    Volume: 34
    Page numbers: 2082-2083
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Stem cell therapies: a tale of caution
    Year: 2003
    Journal: Medical Journal of Australia
    Volume: 179
    Page numbers: 164-166
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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Publications in 2002

Journal Articles

  • Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge


    Year: 2002
    Journal: Molecular and Cellular Neurosciences
    Volume: 21
    Issue: 2002
    Page numbers: 436-453
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  • Periwound dopaminergic sprouting is dependent on numbers of wound macrophages
    Year: 2002
    Journal: European Journal of Neuroscience
    Volume: 15
    Page numbers: 826-832
    Publisher: Blackwell Science(Oxford)
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  • Salvaging the ischaemic penumbra: more than just reperfusion?
    Year: 2002
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 29
    Page numbers: 1-10
    Publisher: Blackwell Science Asia(Carlton)
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Publications in 2001

Journal Articles

  • New dopaminergic neurons in Parkinson's disease striatum
    Year: 2001
    Journal: Focus on Parkinson's disease
    Volume: 13
    Issue: 2
    Page numbers: 48-49
    Publisher: Australian Academic Press(Bowen Hills)
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