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PROF PETER COWAN



Contact Details

Organization: Medicine - St Vincent's Hospital
Position: Honorary (Professorial Fellow)
Email:
Homepage: www.medstv.unimelb.edu.au
Work: 03 9288 3140
Fax: 03 9288 2581
Level: 01
Building: Healy Wing
Campus: St Vincents Hospital

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Institution not known
Doctor of Philosophy University of Melbourne

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
PRECLINICAL STUDIES IN XENOTRANSPLANTATION Chief Investigator NHMRC Project Grants 01/01/2006
ANTITHROMBOTIC EFFECT OF NTPDASE1/CD39 Chief Investigator NHMRC Project Grants 01/01/2006
INTRAVASCULAR COAGULOPATHY IN DISCORDANT XENOTRANSPLANTATION Chief Investigator NHMRC Project Grants 01/01/2007
WHICH TRANSGENIC PIG WILL BE USED FOR ISLET TRANSPLANTATION IN HUMANS? Chief Investigator NHMRC NHMRC/JDRF Special Program Grants in Type 1 Diabetes 01/01/2007
PROTECTING ISLET ALLOGRAFTS FROM INNATE AND COGNATE IMMUNITY Chief Investigator JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL Islet Transplation Program 01/06/2007
DEVELOPMENT OF RECOMBINANT RSOLCD39-PSGL AS A NOVEL THERAPEUTIC WITH ANTI-THROMBOTIC AND ANTI-INFLAMMATORY EFFECTS Chief Investigator NHMRC Development Grants 01/01/2008
CD39 expression prevents auto-immune destruction of beta cells Chief Investigator JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL Islet Transplation Program 01/08/2008
PRECLINICAL STUDIES IN XENOTRANSPLANATION Chief Investigator NHMRC Project Grants 01/01/2009
Genetic strategies to make cross-species organ transplantation work Principal Supervisor NHMRC Scholarships 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Glycosylation changes in hFUT1 transgenic mice increase TCR signaling
    and apoptosis resulting in thymocyte maturation arrest


    Year: 2008
    Journal: Molecular Immunology
    Volume: 45
    Issue: 8
    Page numbers: 2401-10
    Author(s):
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  • Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI


    Year: 2008
    Journal: American Journal of Transplantation
    Volume: 8
    Issue: 6
    Page numbers: 1101-12
    Author(s):
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  • Anti-Gal antibody-mediated skin graft
    rejection requires a threshold level of Gal
    expression
    Year: 2008
    Journal: Xenotransplantation
    Volume: 15
    Issue: 1
    Page numbers: 20-6
    Author(s):
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  • Enzymatic Properties of an Ecto-nucleoside Triphosphate
    Diphosphohydrolase from Legionella pneumophila
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 19
    Page numbers: 12909-18
    Author(s):
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  • Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 19
    Page numbers: 12909-12918
    Author(s):
    URL - restricted access Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence
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  • Gene-modified pigs
    Year: 2008
    Journal: Xenotransplantation
    Volume: 15
    Issue: 2
    Page numbers: 87-90
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  • Glycosylation changes in hFUT1 transgenic mice increase TCR signaling
    and apoptosis resulting in thymocyte maturation arrest
    Year: 2008
    Journal: Molecular Immunology
    Volume: 45
    Issue: 8
    Page numbers: 2401-10
    Author(s):
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  • Modification of kidney barrier function by the
    urokinase receptor
    Year: 2008
    Journal: Nature Medicine
    Volume: 14
    Issue: 1
    Page numbers: 35-63
    Author(s):
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  • Recombinant pig TFPI efficiently regulates
    human tissue factor pathways
    Year: 2008
    Journal: Xenotransplantation
    Volume: 15
    Issue: 3
    Page numbers: 191-197
    Author(s):
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  • The Impact of Purinergic Signaling on Renal
    Ischemia-Reperfusion Injury
    Year: 2008
    Journal: Transplantation
    Volume: 86
    Issue: 12
    Page numbers: 1707-12
    Author(s):
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  • The coagulation barrier in xenotransplantation: incompatibilities
    and strategies to overcome them
    Year: 2008
    Journal: Current Opinion in Organ Transplantation
    Volume: 13
    Issue: 2
    Page numbers: 178-183
    Author(s):
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Publications in 2007

Journal Articles

  • A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila
    Year: 2007
    Journal: Cellular Microbiology
    Volume: 9
    Issue: 8
    Page numbers: 1922-35
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  • Blockade of the passive cell death pathway does not prevent tolerance induction to islet grafts
    Year: 2007
    Journal: Transplantation
    Volume: 83
    Issue: 5
    Page numbers: 653-5
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  • Building on the GalKO platform
    Year: 2007
    Journal: Transplantation
    Volume: 84
    Issue: 1
    Page numbers: 10-11
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  • Coagulation and the xenograft endothelium
    Year: 2007
    Journal: Xenotransplantation
    Volume: 14
    Issue: 1
    Page numbers: 7-12
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  • Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets
    Year: 2007
    Journal: Xenotransplantation
    Volume: 14
    Issue: 2
    Page numbers: 119-25
    Author(s):
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  • Molecular regulation of xenoreactivity
    Year: 2007
    Journal: Current Opinion in Organ Transplantation
    Volume: 12
    Page numbers: 30-36
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  • Production of homozygous α-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer
    Year: 2007
    Journal: Xenotransplantation
    Volume: 14
    Issue: 4
    Page numbers: 339-44
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  • Reply to 'Critics slam Russian trial to test pig pancreas for diabetes'
    Year: 2007
    Journal: Nature Medicine
    Volume: 13
    Issue: 6
    Page numbers: 662-3
    Author(s):
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  • Response to valdes-gonzalez "clinical trial of islet xenotransplantation in mexico"
    Year: 2007
    Journal: Xenotransplantation
    Volume: 14
    Issue: 1
    Page numbers: 90-91
    Author(s):
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  • Salutary roles of CD39 in transplantation
    Year: 2007
    Journal: Transplantation Reviews
    Volume: 21
    Page numbers: 54-63
    Author(s):
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Publications in 2006

Journal Articles

  • Cardiac and skin Xenograft survival in different recipient mouse strains
    Year: 2006
    Journal: Transplantation
    Volume: 82
    Issue: 10
    Page numbers: 1362-9
    Author(s):
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  • Intravascular thrombosis in discordant xenotransplantation
    Year: 2006
    Journal: Transplantation
    Volume: 82
    Issue: 9
    Page numbers: 1119-23
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  • The transgenic expression of human CD39 on murine islets inhibits clotting of human blood
    Year: 2006
    Journal: Transplantation
    Volume: 82
    Issue: 3
    Page numbers: 428-432
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  • Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter
    Year: 2006
    Journal: Xenotransplantation
    Volume: 13
    Issue: 6
    Page numbers: 514-21
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Publications in 2005

Journal Articles

  • Human Factor H-Related Protein 5 Has Cofactor Activity, Inhibits C3 Convertase Activity, Binds Heparin and C-Reactive Protein, and Associates with Lipoprotein
    Year: 2005
    Journal: Journal of Immunology
    Volume: 174
    Page numbers: 6250-6256
    Author(s):
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  • Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets from Oxidative Injury and Improves Islet Graft Function
    Year: 2005
    Journal: Diabetes
    Volume: 54
    Page numbers: 2109-2116
    Publisher: American Diabetes Association(Virginia)
    Author(s):
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  • Prevention of hyperacute rejection in a model of orthoptopic liver xenotransplantation from pig to baboon using polytransgenic pig livers (CD55, CD59, and H-transferase)
    Year: 2005
    Journal: Transplantation Proceedings
    Volume: 37
    Page numbers: 4103-4106
    Publisher: Elsevier Science(New York)
    Author(s):
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  • Transgenic expression of human complement regulators reduces skeletal muscle ischaemia/reperfusion injury in mice
    Year: 2005
    Journal: Clinical Science
    Volume: 108
    Page numbers: 47-53
    Publisher: Portland Press(London)
    Author(s):
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Publications in 2004

Journal Articles

  • Allogenic sensitization is more effective than xenogenic sensitization in eliciting Gal-mediated skin graft rejection
    Year: 2004
    Journal: Transplantation
    Volume: 77
    Page numbers: 751-753
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Altered immune system glycosylation causes colitis in α1,2-fucosyltransferase transgenic mice
    Year: 2004
    Journal: Inflammatory Bowel Diseases
    Volume: 10
    Issue: 5
    Page numbers: 546-556
    Publisher: Lippincott Williams & Wilkins
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  • Characterization of pig intercellular adhesion molecule-2 and its interaction with human LFA-1
    Year: 2004
    Journal: American Journal of Transplantation
    Volume: 4
    Page numbers: 515-525
    Publisher: Blackwell Munksgaard(Copenhagen)
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  • Enhanced expression of glutathione peroxidase protects islet β cells from hypoxia-reoxygenation
    Year: 2004
    Journal: Xenotransplantation
    Volume: 11
    Page numbers: 53-59
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  • Fate of αGal +/+ pancreatic islet grafts after transplantation into αGal knockout mice
    Year: 2004
    Journal: Xenotransplantation
    Volume: 11
    Page numbers: 323-331
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  • Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
    Year: 2004
    Journal: Journal of Clinical Investigation
    Volume: 113
    Issue: 10
    Page numbers: 1440-1446
    Publisher: American Society of Clinical Investigation Inc(Michigan)
    Author(s):
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Publications in 2003

Journal Articles

  • Galactose-α1,3-galactose knockout mouse: a surrogate recipient
    Year: 2003
    Journal: Current Opinion in Organ Transplantation
    Volume: 8
    Issue: 1
    Page numbers: 70-75
    Publisher: Lippincott Williams & Wilkins(Baltimore)
    Author(s):
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  • Targeting gene expression to endothelium in transgenic animals: a comparison of the human ICAM-2, PECAM-1 and endoglin promoters
    Year: 2003
    Journal: Xenotransplantation
    Volume: 10
    Issue: 3
    Page numbers: 223-231
    Author(s):
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Publications in 2002

Journal Articles

  • Gal mismatch alone causes skin graft rejection in mice
    Year: 2002
    Journal: Transplantation
    Volume: 74
    Issue: 5
    Page numbers: 637-645
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
    Author(s):
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  • Leukocyte recruitment in xenotransplantation
    Year: 2002
    Journal: Current Opinion in Organ Transplantation
    Volume: 7
    Issue: 5
    Page numbers: 85-91
    Publisher: Lippincott Williams & Wilkins(Baltimore)
    Author(s):
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  • Location and structure of the human FHR-5 gene
    Year: 2002
    Journal: Genetica
    Volume: 114
    Issue: 2
    Page numbers: 157-161
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
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  • Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation
    Year: 2002
    Journal: American Journal of Transplantation
    Volume: 2
    Issue: 6
    Page numbers: 520-525
    Publisher: Blackwell Munksgaard(Copenhagen)
    Author(s):
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  • Transgenic perspectives in xenotransplantation, 2001
    Year: 2002
    Journal: Xenotransplantation
    Volume: 9
    Issue: 5
    Page numbers: 305-308
    Publisher: Munksgaard International Publishers(Oxford)
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  • Xenotransplantation: past achievements and future promise
    Year: 2002
    Journal: Heart, Lung and Circulation
    Volume: 11
    Issue: 1
    Page numbers: 32-41
    Publisher: Blackwell Science Asia
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Publications in 2001

Journal Articles

  • Alternative Approaches to Reducing Gal Expression in Pig Organs.
    Year: 2001
    Journal: Graft
    Publisher: Sage Publications(California)
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  • Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice.
    Year: 2001
    Journal: Transplant Immunology
    Volume: 9
    Page numbers: 51-56
    Publisher: Elsevier Science
    Author(s):
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  • Deleting the Gal Epitope from the Donor Pig.
    Year: 2001
    Journal: Graft
    Publisher: Sage Publications(California)
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  • Effect of DNA concentration on transgenesis rates in mice and pigs.
    Year: 2001
    Journal: Transgenic Research
    Volume: 10
    Page numbers: 523-531
    Publisher: Kluwer Academic Publishers
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  • Human Factor H-Related Protein 5 (FHR-5). A new complement-associated protein.
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 9
    Page numbers: 6747-6754
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
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  • Preventing Acute Vascular Rejection.
    Year: 2001
    Journal: Graft
    Publisher: Sage Publications(California)
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  • Vascular gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters.
    Year: 2001
    Journal: Gene Therapy
    Volume: 8
    Page numbers: 897-904
    Publisher: Nature Publishing Group(Basingstroke)
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