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A/PROF GEOFF SHAW



Contact Details

Organization: Zoology
Position: ASSOCIATE PROFESSOR AND READER
Email:
Homepage: http://www.zoology.unimelb.edu.au/aboutus/staff/index.php?135,4
Work: 8344 6267
Fax: 8344 7909
Room: 359
Level: 03
Building: Zoology Building
Campus: Parkville

Biography

I graduated from the University of Tasmania with a major in Mathematics, and first class honours in Zoology. After teaching biology and mathematics at year 11-12 for 4 terms, I decided to undertake further research training. I completed a PhD at Murdoch University under the supervision of Dr Marilyn Renfree, investigating the control of pregnancy in tammar wallabies. I undertook postdoctoral research on the effects of growth factors on sheep reproduction at the University of Queensland before returning to work on marsupials as a National Research fellow and later a Sir Colin McKenzie Research Fellow in Comparative Anatomy, in the Department of Anatomy at Monash University. I took up a lectureship at the University of Melbourne in 1991 and was promoted to my current position in 2001.

My research centres on mammalian reproductive physiology and development. I have studied a diverse range or species including humans, but the central focus is on marsupials. Major projects at present investigate sexual determination and differentiation, genomic imprinting, the physiology and endocrinology of birth, the uterine, hormonal and metabolic control of embryonic diapause, embryo culture, the application of artificial reproductive technologies to endangered species and comparative aspects of lactation. I am also involved in the functional analysis if genetic information derived from the ARC Centre for Kangaroo Genomics. Marsupials have enormous potential as research models to contrast with data from humans and mice, and my research highlights and leverages this potential.

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Reproduction and Development Marsupial, sexual determination, differentiation, reproductive endocrinology, embryogenesis Australia

International Linkages

Country Establishment Collaboration
United States The University of Texas Southwestern Medical Center Research
United States The University of Texas M. D. Anderson Cancer Center Research
Japan Tokyo Medical and Dental University Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Tasmania
Grad Dip Murdoch University
Doctor of Philosophy Murdoch University
Bachelor of Science with Honours University of Tasmania

Memberships

Membership Type Membership Body Description Start Date End Date
Unspecified Australian Society for Reproductive Biology Member 01-Jan-1979
Unspecified Australian Mammal Society Member 01-Jan-1979 01-Jan-2004
Member Editorial Board, Journal of Endocrinology Member of the Editorial board of the Journal of Endocrinology 01-Sep-2002

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Marsupial germ cells and genes Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2002
Novel mechanisms for virilisation Chief Investigator NHMRC Project Grants 01/01/2002
Re-uniting marsupials & eutherians by embryonic micromanipulation Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2003
Gonadal Sex Reversal Chief Investigator NHMRC Project Grants 01/01/2003
Extrinsic control of mammalian germ cell delineation Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
Ovarian development Chief Investigator NHMRC Project Grants 01/01/2007
Causes of hypospadias Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Early onset of ghrelin production in a marsupial
    Year: 2009
    Journal: Molecular and Cellular Endocrinology
    Volume: 299
    Issue: 2
    Page numbers: 266-273
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Publications in 2008

Journal Articles

  • In vitro culture of peri-gastrulation embryos of a macropodid marsupial
    Year: 2008
    Journal: Journal of Anatomy
    Volume: 212
    Page numbers: 180-191
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  • Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians
    Year: 2008
    Journal: Nature Genetics
    Volume: 40
    Page numbers: 971-976
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  • Evolution of the DKN1C/KCNQOT1 imprinted domain
    Year: 2008
    Journal: BMC Evolutionary Biology
    Volume: 8
    Page numbers: 163
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  • Exon 3 of the growth hormone receptor (GH-R) is specific to eutherian mammals
    Year: 2008
    Journal: Molecular and Cellular Endocrinology
    Volume: 296
    Issue: 1-2
    Page numbers: 64-68
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  • Expression and protein localisation of IGF2 in the marsupial placenta
    Year: 2008
    Journal: BMC Developmental Biology
    Volume: 8
    Issue: 17
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  • Genomic imprinting in marsupial placentation
    Year: 2008
    Journal: Reproduction
    Volume: 136
    Page numbers: 523-531
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  • Long-term efficacy of levonorgestrel implants for fertility control of eastern grey kangaroos (Macropus giganteus)
    Year: 2008
    Journal: Wildlife Research
    Volume: 35
    Page numbers: 520-524
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  • Physical map of two tammar wallaby chromosomes: A strategy for mapping in non-model mammals
    Year: 2008
    Journal: Chromosome Research
    Volume: 16
    Issue: 8
    Page numbers: 1159-1175
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  • The evolution of the DLK1-DIO3 imprinted domain in mammals
    Year: 2008
    Journal: PLoS Biology
    Volume: 6
    Issue: 6
    Page numbers: 1292-1305
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  • The functional development of Leydig cells in a marsupial
    Year: 2008
    Journal: Journal of Anatomy
    Volume: 212
    Page numbers: 55-66
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  • The vomeronasal organ of the tammar wallaby
    Year: 2008
    Journal: Journal of Anatomy
    Volume: 213
    Page numbers: 93-105
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Publications in 2007

Journal Articles

  • Effects of levonorgestrel on ovulation and oestrous behaviour in the female tammar wallaby
    Year: 2007
    Journal: Reproduction, Fertility and Development
    Volume: 19
    Page numbers: 335-340
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  • Insulin is imprinted in the placenta of the marsupial, Macropus eugenii
    Year: 2007
    Journal: Developmental Biology
    Volume: 309
    Page numbers: 317-328
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  • Marsupial WT1 Has a Novel Isoform and Is Expressed in Both Somatic and Germ Cells in the Developing Ovary and Testis
    Year: 2007
    Journal: Sexual Development
    Volume: 1
    Page numbers: 169-180
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  • Perturbed growth and development in marsupial young after reciprocal cross-fostering between species
    Year: 2007
    Journal: Reproduction, Fertility and Development
    Volume: 19
    Page numbers: 976-983
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  • Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting
    Year: 2007
    Journal: PLoS Genetics
    Volume: 3
    Issue: 4
    Page numbers: 0531-0537
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Publications in 2006

Book Chapters

  • Reproduction
    Year: 2006
    Book: Marsupials
    Publisher: Cambridge University Press
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Journal Articles

  • Differential expression of WNT4 in testicular and ovarian development in a marsupial
    Year: 2006
    Journal: BMC Developmental Biology
    Volume: 6
    Page numbers: 44
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  • Growth and histology of ovarian follicles after cold storage in the tammar wallaby
    Year: 2006
    Journal: Reproduction, Fertility and Development
    Volume: 18
    Page numbers: 677-688
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  • Hormonal control of birth behavior in the Tasmanian devil Sarcophilus harrisii
    Year: 2006
    Journal: Hormones and Behavior
    Volume: 50
    Page numbers: 417-423
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  • Parturition and perfect prematurity: birth in marsupials
    Year: 2006
    Journal: Australian Journal of Zoology
    Volume: 54
    Page numbers: 139-149
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  • Role of the alternate pathway of dihydrotestosterone formation in virilization of the Wolffian ducts of the tammar wallaby, Macropus eugenii
    Year: 2006
    Journal: Endocrinology
    Volume: 147
    Issue: 5
    Page numbers: 2368-2373
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  • Sexual development of a model marsupial male
    Year: 2006
    Journal: Australian Journal of Zoology
    Volume: 54
    Page numbers: 151-158
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Publications in 2005

Journal Articles

  • Birth of pouch young after artificial insemination in the tammar wallaby Macropus eugenii
    Year: 2005
    Journal: Biology of Reproduction
    Volume: 72
    Page numbers: 451-459
    Publisher: Society for the Study of Reproduction(Wisconsin)
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  • Changes in semen quality and morphology of the reproductive tract of the male tammar wallaby parallel seasonal breeding activity in the female
    Year: 2005
    Journal: Reproduction
    Volume: 130
    Page numbers: 367-378
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Cross-fostering in Macropus eugenii leads to increased weight but not accelerated gastrointestinal maturation
    Year: 2005
    Journal: Journal of Experimental Zoology
    Volume: 303A
    Page numbers: 331-344
    Publisher: John Wiley & Sons
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  • Genomic imprinting of IGF2, p57KIP2 and PEG1/MEST in a marsupial, the tammar wallaby
    Year: 2005
    Journal: Mechanisms of Development
    Volume: 122
    Page numbers: 213-222
    Publisher: Elsevier Science(Amsterdam)
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  • Long-term effects of deslorelin implants on reproduction in the female tammar wallaby (Macropus eugenii)
    Year: 2005
    Journal: Reproduction
    Volume: 129
    Page numbers: 361-369
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Mating sequence, dominance and paternity success in captive male tammar wallabies
    Year: 2005
    Journal: Reproduction
    Volume: 130
    Issue: 3
    Page numbers: 367-378
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Ontogeny and pathway of formation of 5α-androstane-3α, 17β-diol in the testes of the immature brushtail possum Trichosurus vulpecula
    Year: 2005
    Journal: Reproduction, Fertility and Development
    Volume: 17
    Issue: 6
    Page numbers: 603-609
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Publications in 2004

Journal Articles

  • Effects of a gonadotropin-releasing hormone agonist implant on reproduction in a male marsupial, Macropus eugenii
    Year: 2004
    Journal: Biology of Reproduction
    Volume: 70
    Issue: 6
    Page numbers: 1836-1842
    Publisher: Society for the Study of Reproduction(Wisconsin)
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  • Intra-cytoplasmic sperm injection in a marsupial
    Year: 2004
    Journal: Reproduction
    Volume: 128
    Page numbers: 595-605
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Marsupial anti-Müllerian hormone gene structure, regulatory elements, and expression
    Year: 2004
    Journal: Biology of Reproduction
    Volume: 70
    Page numbers: 160-167
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  • Penile development is initiated in the tammar wallaby pouch young during the period when 5alpha-androstane-3alpha, 17beta-diol is secreted by the testes
    Year: 2004
    Journal: Endocrinology
    Volume: 145
    Page numbers: 3346-3352
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Publications in 2003

Journal Articles

  • 5α-androstane-3α, 17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane-3α, 17α-diol-20-one as a key intermediate
    Year: 2003
    Journal: Endocrinology
    Volume: 144
    Issue: 2
    Page numbers: 575-580
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  • Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii)
    Year: 2003
    Journal: Biology of Reproduction
    Volume: 68
    Issue: 3
    Page numbers: 929-936
    Publisher: Society for the Study of Reproduction(Wisconsin)
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  • Unsolved problems in male physiology: Studies in a marsupial
    Year: 2003
    Journal: Molecular and Cellular Endocrinology
    Volume: 211
    Page numbers: 33-36
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Publications in 2002

Journal Articles

  • Administration of 5α-Androstane-3α, 17β-diol to female tammar wallaby pouch young causes development of a mature prostate and male urethra
    Year: 2002
    Journal: Endocrinology
    Volume: 143
    Issue: 7
    Page numbers: 2643-2651
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  • Androgen physiology: unsolved problems at the millennium
    Year: 2002
    Journal: Molecular and Cellular Endocrinology
    Volume: 198
    Page numbers: 1-5
    Publisher: Elsevier Science Ireland(Coclare)
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  • Effect of an anti-androgen on testicular descent and inguinal closure in a marsupial, the tammar wallaby (Macropus eugenii)
    Year: 2002
    Journal: Reproduction
    Volume: 124
    Issue: 6
    Page numbers: 865-874
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Effects of oestrogen treatment on testicular descent, inguinal closure and prostatic development in a male marsupial, Macropus eugenii
    Year: 2002
    Journal: Reproduction
    Volume: 124
    Page numbers: 73-83
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Fertility control in the eastern grey kangaroo using levonorgestrel implants
    Year: 2002
    Journal: Journal of Wildlife Management
    Volume: 66
    Issue: 2
    Page numbers: 470-477
    Publisher: Wildlife Society(Bethesda)
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  • Influence of donor age on development of gonadal tissue from pouch young of the tammar wallaby, Macropus eugenii, after cryopreservation and xenografting into mice
    Year: 2002
    Journal: Reproduction
    Volume: 123
    Page numbers: 143-153
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  • Long-term fertility control in the kangaroo and the wallaby using levonorgestrel implants
    Year: 2002
    Journal: Reproduction
    Volume: 60
    Page numbers: 71-80
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • SOX9 has both conserved and novel roles in marsupial sexual differentiation
    Year: 2002
    Journal: Genesis
    Volume: 33
    Page numbers: 131-139
    Publisher: Wiley-Liss(New York)
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  • Structure and expression of the follicle-stimulating hormone receptor gene in a marsupial, Macropus eugenii
    Year: 2002
    Journal: Molecular Reproduction and Development
    Volume: 63
    Page numbers: 24-31
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  • The development of the gubernaculum and inguinal closure in the marsupial Macropus eugenii
    Year: 2002
    Journal: Journal of Anatomy
    Volume: 201
    Page numbers: 239-256
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  • The marsupial model for male phenotypic development
    Year: 2002
    Journal: Trends in Endocrinology and Metabolism
    Volume: 13
    Issue: 2
    Page numbers: 78-83
    Publisher: Elsevier Science London(London)
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Conference Publications/Papers

  • The hormonal control of sexual development
    Year: 2002
    Event name: Novartis Foundation Symposium
    Conference Publication: The genetics and biology of sex determination
    Volume: 244
    Page numbers: 136-156
    Publisher: Wiley - John Wiley & Sons(Chichester)
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Publications in 2001

Journal Articles

  • Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial
    Year: 2001
    Journal: Gene
    Volume: 277
    Page numbers: 209-219
    Publisher: Elsevier Science(Amsterdam)
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  • Differential regulation of contractility and nitric oxide sensitivity in gravid and nongravid myometrium during late pregnancy in a marsupial
    Year: 2001
    Journal: Endocrinology
    Volume: 142
    Issue: 6
    Page numbers: 2244-2251
    Publisher: Endocrine Society(Maryland)
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  • Estrogen-Induced Gonadal Sex Reversal in the Tammar Wallaby
    Year: 2001
    Journal: Biology of Reproduction
    Volume: 65
    Page numbers: 613-621
    Publisher: Society for the Study of Reproduction(Wisconsin)
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  • Fetal control of parturition in marsupials
    Year: 2001
    Journal: Reproduction, Fertility and Development
    Volume: 13
    Page numbers: 653-659
    Publisher: CSIRO Publications(Collingwood)
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  • Germ cells, gonads and sex reversal in marsupials
    Year: 2001
    Journal: International Journal of Developmental Biology
    Volume: 45
    Page numbers: 557-567
    Publisher: UBC Press(Bilbao)
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  • Sex down under: the differentiation of sexual dimorphisms during marsupial development
    Year: 2001
    Journal: Reproduction, Fertility and Development
    Volume: 13
    Page numbers: 679-690
    Publisher: CSIRO Publications(Collingwood)
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  • The influence of estrogen on the developing male marsupial
    Year: 2001
    Journal: Reproduction, Fertility and Development
    Volume: 13
    Page numbers: 231-240
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  • Virilization of the urogenital sinus of the tammar wallaby is not unique to 5alpha-androstane-3alpha, 17beta-diol
    Year: 2001
    Journal: Molecular and Cellular Endocrinology
    Volume: 181
    Page numbers: 111-115
    Publisher: Elsevier Science Ireland(Coclare)
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