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PROF JOEL BORNSTEIN



Contact Details

Organization: Physiology
Position: PROFESSOR
Email:
Homepage: http://www.physiology.unimelb.edu.au/lab-enl/enl.asp
Work: 83445850
Fax: 83445818
Room: N617
Level: 06
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
relationship between intestinal movements and secretion cholera, diarrhoea, digestion Australia, Sweden
neurogastroenterology enteric nervous system, intestinal behaviour Australia
synaptic transmission neuropeptides, serotonin, acetylcholine, ATP, enteric neurons Australia
computer simulation of neural circuits modelling, enteric neuroscience, neural networks Australia, Sweden

International Linkages

Country Establishment Collaboration
United Kingdom King's College London Research
Sweden Goteborg University Research, Technical Assistance/Training
United States Columbia University Research, Technical Assistance/Training
United States Purdue University Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Honours Monash University 04-Dec-1972
Doctor of Philosophy Monash University 28-Oct-1976

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Neuroscience Society Ordinary 01-Feb-1980
Member American Association for the Advancement of Science Ordinary 30-Sep-1976
Member American Gastroenterological Association Ordinary 30-Nov-2000
Member International Society for Autonomic Neuroscience Executive member 29-Nov-1996

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Neural mechanisms mediating hypersecretion and motility patterns induced by enterotoxins Chief Investigator NHMRC Project Grants 01/01/2003
Mechanisms regulating nutrient induced motor patterns in the isolated small intestine Chief Investigator NHMRC Project Grants 01/01/2004
Neural coordination of intestinal motility and mucosal secretion of water and salt - role in toxin induced diarrhoea Chief Investigator NHMRC Project Grants 01/01/2006
The role of serotonin in intestinal movement Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2006
Mechanisms that propel gut contents prior to the development of adult systems Chief Investigator NHMRC Project Grants 01/01/2007
Electrical activity in early enteric neuron development Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
How nutrients and other gut contents produce the gut movements essential to the digestion of food and excretion of waste Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Neurochemical and morphological phenotypes of vagal afferent neurons innervating the adult mouse jejunum
    Year: 2009
    Journal: Neurogastroenterology and Motility
    Volume: 21
    Issue: 9
    Page numbers: 994-1001
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Publications in 2008

Journal Articles

  • Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon
    Year: 2008
    Journal: Neuroscience
    Volume: 156
    Issue: 2
    Page numbers: 334-343
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  • Disturbances of colonic motility in mouse models of Hirschsprung's disease
    Year: 2008
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 294
    Issue: 4
    Page numbers: G996-G1008
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  • Insights into mechanisms of intestinal segmentation in guinea pigs: a combined computational modeling and in vitro study
    Year: 2008
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 295
    Page numbers: G534-G541
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  • Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo
    Year: 2008
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 294
    Page numbers: G165-G173
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  • Purinergic mechanisms in the control of gastrointestinal motility
    Year: 2008
    Journal: Purinergic Signalling
    Volume: 4
    Issue: 3
    Page numbers: 197-212
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  • Synaptic transmission from the submucosal plexus to the myenteric plexus in Guinea-pig ileum
    Year: 2008
    Journal: Neurogastroenterology and Motility
    Volume: 20
    Issue: 10
    Page numbers: 1165-1173
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  • Targets of myenteric interneurons in the guinea-pig small intestine
    Year: 2008
    Journal: Neurogastroenterology and Motility
    Volume: 20
    Issue: 5
    Page numbers: 566-575
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Publications in 2007

Journal Articles

  • Development of colonic motility in the neonatal mouse - studies using spatiotemporal maps
    Year: 2007
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 292
    Page numbers: G930-G938
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  • Elevated motility-related transmucosal potential difference in the upper small intestine in the irritable bowel syndrome
    Year: 2007
    Journal: Neurogastroenterology and Motility
    Volume: 19
    Issue: 10
    Page numbers: 812-820
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  • Local inhibitory reflexes excited by mucosal application of nutrient amino acids in guinea pig jejunum
    Year: 2007
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 292
    Page numbers: G1660-G1670
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  • Mapping 5-HT inputs to enteric neurons of the guinea-pig small intestine
    Year: 2007
    Journal: Neuroscience
    Volume: 145
    Page numbers: 556-567
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  • Mechanisms underlying nutrient-induced segmentation in isolated guinea pig small intestine
    Year: 2007
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 294
    Issue: 4
    Page numbers: G1162-G1172
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  • Synaptic transmission at functionally identified synapses in the enteric nervous system: Roles for both ionotropic and metabotropic receptors
    Year: 2007
    Journal: Current Neuropharmacology
    Volume: 1-17
    Issue: 5
    Page numbers: 1
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Publications in 2006

Journal Articles

  • Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons
    Year: 2006
    Journal: Autonomic Neuroscience - Basic & Clinical
    Volume: 124
    Page numbers: 26-30
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  • Effects of cholera toxin on the potential difference and motor responses induced by distension in the rat proximal small intestine in vivo
    Year: 2006
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 290
    Page numbers: G948-G958
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  • Intrinsic sensory neurons of mouse gut - toward a detailed knowledge of enteric neural circuitry across species. Focus on "Characterization of myenteric sensory neurons in the mouse small intestine"
    Year: 2006
    Journal: Journal of Neurophysiology
    Volume: 96
    Page numbers: 973-974
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  • Serotonergic receptors in therapeutic approaches to gastrointestinal disorders
    Year: 2006
    Journal: Current Opinion in Pharmacology
    Volume: 547-552
    Issue: 6
    Page numbers: 6
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Publications in 2005

Journal Articles

  • Recurrent networks of submucous neurons controlling intestinal secretion: a modeling study
    Year: 2005
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 288
    Issue: 5
    Page numbers: G887-G896
    Publisher: American Physiological Society(Maryland)
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  • Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum and reduced by the 5-hydroxytrytamine7 receptor antagonist SB 269970
    Year: 2005
    Journal: Neuroscience
    Volume: 134
    Issue: 3
    Page numbers: 975-986
    Publisher: Pergamon-Elsevier Science(Oxford)
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Publications in 2004

Journal Articles

  • ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    Year: 2004
    Journal: The Journal of Physiology
    Volume: 556
    Page numbers: 571-584
    Publisher: Cambrige University Press(New York)
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  • Computational model of the migrating motor complex of the small intestine
    Year: 2004
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 286
    Page numbers: G564-G572
    Publisher: American Physiological Society(Maryland)
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  • Enteric motor and interneuronal circuits controlling motility
    Year: 2004
    Journal: Neurogastroenterology and Motility
    Volume: 16
    Page numbers: 34-38
    Publisher: Blackwell Science(Oxford)
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  • Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input
    Year: 2004
    Journal: Neuroscience
    Volume: 126
    Page numbers: 137-147
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum
    Year: 2004
    Journal: The Journal of Physiology
    Volume: 556
    Page numbers: 557-569
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  • Synaptic transmission in simple motility reflex pathways excited by distension in guinea pig distal colon
    Year: 2004
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 287
    Page numbers: G1017-G1027
    Publisher: American Physiological Society(Maryland)
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  • The enteric nervous system is not essential for the propulsion of gut contents in fetal mice
    Year: 2004
    Journal: Gut
    Volume: 53
    Page numbers: 1546-1547
    Publisher: British Medical Journal Publishing Group(London)
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Publications in 2003

Journal Articles

  • Cholinergic transmission to colonic circular muscle of children with slow-transit constipation is unimpaired, but transmission via NK2 receptors is lacking
    Year: 2003
    Journal: Neurogastroenterology and Motility
    Volume: 15
    Page numbers: 669-678
    Publisher: Blackwell Science(Oxford)
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  • Inhibitory cotransmission or after-hyperpolarizing potentials can regulate firing in recurrent networks with excitatory metabotropic transmission
    Year: 2003
    Journal: Neuroscience
    Volume: 120
    Issue: 2
    Page numbers: 333-352
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Nicotinic transmission at functionally distinct synapses in descending reflex pathways of the rat colon
    Year: 2003
    Journal: Neurogastroenterology and Motility
    Volume: 15
    Issue: 2
    Page numbers: 161-171
    Publisher: Blackwell Science(Oxford)
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Publications in 2002

Book Chapters

  • Enteric reflexes that influence motility
    Year: 2002
    Book: Innervation of the Gastrointestinal Tract
    Publisher: Taylor & Francis Ltd(London)
    Authors(s):

Journal Articles

  • ATP and 5-HT are the principal neurotransmitters in the descending excitatory reflex pathway of the guinea-pig ileum
    Year: 2002
    Journal: Neurogastroenterology and Motility
    Volume: 14
    Page numbers: 255-264
    Publisher: Blackwell Science(Oxford)
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  • ATP as a Putative Sensory Mediator: Activation of intrinsic sensory neurons of the Myenteric Plexus via P2X Receptors
    Year: 2002
    Journal: Journal of Neuroscience
    Volume: 22
    Issue: 12
    Page numbers: 4767-4775
    Publisher: Society of Neuroscience(Washington DC)
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  • Slow excitatory synaptic potentials evoked by distension in myenteric descending interneurones of guinea-pig ileum
    Year: 2002
    Journal: The Journal of Physiology
    Volume: 539
    Issue: 2
    Page numbers: 589-602
    Publisher: Cambrige University Press(New York)
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Publications in 2001

Journal Articles

  • Alzheimer's disease and A[beta] toxicity: from top to bottom
    Year: 2001
    Journal: Nature Reviews Neuroscience
    Volume: 2
    Page numbers: 595-598
    Publisher: Nature Publishing Group(Houndmills)
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  • Role of a2-adrenoceptors in the sympathetic inhibition of motility reflexes of guinea-pig ileum
    Year: 2001
    Journal: The Journal of Physiology
    Volume: 534
    Page numbers: 465-478
    Publisher: Cambrige University Press(New York)
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