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DR SOF ANDRIKOPOULOS



Contact Details

Organization: Medicine - Austin Health and Northern Health
Position: RD WRIGHT FELLOW
Email:
Work: 9496 2403
Fax: 9497 4554
Building: No Building
Campus: Repatriation Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Diabetes Insulin secretion, islet beta cell dysfunction, animal models, glucose toxicity, lipotoxicity Australia, United States of America

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 31-Dec-1990
Doctor of Philosophy University of Melbourne 31-Dec-1996

Memberships

Membership Type Membership Body Description Start Date End Date
Member European Association for the Study of Diabetes Full Member 01-Jan-1993
Member American Diabetes Association Full Member 01-Jan-1996
Member Australian Diabetes Society Full Member 01-Jan-1990

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Investigating insulin secretory dysfunciton in Type 2 diabetes Chief Investigator NHMRC Clinical Career Development Award 01/01/2003
The consequences of islet beta fructose-1,6-bisphosphatase overexpression on insulin secretory function Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2005
Identification and characterisation of a gene causing insulin hypersecretion in a mouse model of diabetes susceptibility Chief Investigator NHMRC Project Grants 01/01/2006
INVESTIGATION OF THE FUNCTION OF SEL S A NOVEL SELENOPROTEIN Chief Investigator CHEMGENEX PHARMACEUTICALS LIMITED,
AUST RESEARCH COUNCIL
Linkage Projects (AUST RESEARCH COUNCIL) 01/01/2006
Study of the Mechanisms of Obesity, and insulin resistance in transgenic rats overexpressing PEPCK Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
INVESTIGATION OF THE IMPORTANCE OF FIRST-PHASE INSULIN SECRETION ON GLUCOSE TOLERANCE AND INSULIN RESISTANCE Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
IMPROVEMENT IN HEPATIC INSULIN SENSITIVITY IN LIVER SPECIFIC SOCS KNOCKOUT MICE Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
Insulin secretion in beta-cell FBPase mice Chief Investigator NHMRC Project Grants 01/01/2007
GENETIC ANALYSIS OF REDUCED INSULIN SECRETION IN DIABETES SUSCEPTIBLE MICE Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2007
INVESTIGATING THE ROLE OF FRUCTOSE-1, 6-BISPHOSPHATASE IN HEPATIC GLUCOSE PRODUCTION AND FOOD INTAKE REGULATION Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2007
The cause and consequences of reduced insulin secretion in the NZO mouse Chief Investigator NHMRC Project Grants 01/01/2008
INVESITGATION OF THE ROLE OF NEPRILYSIN IN INSULIN SECRETION AND PANCREATIC BETA-CELL DYSFUNCTION Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2008
B-CELL MASS AND FUNCTION IN TYPE 1 DIABETES MELLITUS AND ISLET TRANSPLANTATION Chief Investigator GARVAN INSTITUTE OF MEDICAL RESEARCH Program Grants (NHMRC) 01/01/2008
The role of a liver enzyme in controlling body weight Chief Investigator NHMRC Project Grants 01/01/2009
Investigating the novel roles of HERP in Type 2 Diabetes Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2009
Why too much insulin secretion is bad for diabetes Chief Investigator NHMRC Career Development Awards 01/01/2009
Investigation of the impact of a muscle glucose storage defect on glucose metabolism and exercise capacity Chief Investigator ANZ CHARITABLE TRUSTS Medical Research and Technology Grants 01/01/2009
A Novel Role of Herp in Type 2 Diabetes Chief Investigator THE CASS FOUNDATION LTD Science & Medicine Grants 01/01/2009

Contracts

Title Role Funding Source Award Date
TO DETERMINE THE EFFECT OF DICARBA AOD9604 ON BODY WEIGHT REGULATION IN THE NZO MOUSE Chief Investigator POLYCHIP PHARMACEUTICALS PTY LTD 24/10/2006
STARPHARMA CONSULTANCY - DENDRIMER CONJUGATED INSULIN PROJECT Chief Investigator STARPHARMA PTY LTD 01/12/2007
DENDRIMER CONJUGATED INSULIN DOSE EFFECTIVENESS STUDY Chief Investigator STARPHARMA PTY LTD 01/03/2008
STARPHARMA CONSULTANCY - ORAL EFFECTIVENESS OF DENDRIMER CONJUGATED INSULIN Chief Investigator STARPHARMA PTY LTD 22/04/2008
STARPHARMA CONSULTANCY - DENDRIMER CONJUGATED INSULIN DOSE EFFECTIVENESS STUDY - PART 2 Chief Investigator STARPHARMA PTY LTD 24/04/2008
STARPHARMA CONSULTANCY - 5-HOUR STUDY OF DENDRIMER CONJUGATED INSULIN Chief Investigator STARPHARMA PTY LTD 25/06/2008
AUS BIO LTD CONSULTANCY - MD960 EVALUATION Chief Investigator AUS BIO LIMITED 28/07/2008
PHOSPHAGENIC CONSULTANCY - CREAM INSULIN EFFECT IN DIABETES Chief Investigator PHOSPHAGENIC LTD 29/07/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Use of a temporary "solubilizing" peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation


    Year: 2009
    Journal: Bioconjugate Chemistry
    Volume: 20
    Page numbers: 1390-1396
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  • Position statement of the Australian Diabetes Society:  individualisation of glycated haemoglobin targets for adults with diabetes mellitus
    Year: 2009
    Journal: Medical Journal of Australia
    Volume: 191
    Issue: 6
    Page numbers: 339-344
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  • Reactive oxygen species enhance insulin sensitivity
    Year: 2009
    Journal: Cell Metabolism
    Volume: 10
    Issue: 4
    Page numbers: 260-272
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Publications in 2008

Journal Articles

  • Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion


    Year: 2008
    Journal: Diabetes
    Volume: 57
    Issue: 2007
    Page numbers: 1887-1895
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  • Identification of the Alzheimer’s disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth


    Year: 2008
    Journal: Journal of Pathology
    Volume: 215
    Issue: 2008
    Page numbers: 155-163
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  • Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver


     


     


    Year: 2008
    Volume: 295
    Page numbers: E1132-E1141
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  • Evaluating the glucose tolerance test in mice
    Year: 2008
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 295
    Page numbers: E1323-E1332
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  • Insulin may have a role to play in protecting beta cells from deterioration in diabetes. Reply to Del Parigi A [letter]
    Year: 2008
    Journal: Diabetologia
    Volume: 51
    Issue: 2008
    Page numbers: 1341-1342
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  • Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin
    Year: 2008
    Journal: Diabetologia
    Volume: 51
    Issue: 2008
    Page numbers: 540-545
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Publications in 2007

Journal Articles

  • Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity


    Year: 2007
    Journal: Diabetes Obesity & Metabolism
    Volume: 5
    Issue: 6
    Page numbers: 840-852
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  • In vivo quantification of fat content in mice using the Hologic QDR 4500A densitometer
    Year: 2007
    Journal: Obesity Research & Clinical Practice
    Volume: 1
    Page numbers: 69-77
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  • Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes
    Year: 2007
    Journal: Diabetologia
    Volume: 50
    Issue: 2007
    Page numbers: 2476-2485
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Publications in 2006

Journal Articles

  • Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis
    Year: 2006
    Journal: Endocrinology
    Volume: 147
    Issue: 2006
    Page numbers: 2764-2772
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  • The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets
    Year: 2006
    Journal: Diabetologia
    Volume: 49
    Issue: 2006
    Page numbers: 1254-1263
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  • Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Year: 2006
    Journal: Cell Metabolism
    Volume: 4
    Issue: 6
    Page numbers: 465-74
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Publications in 2005

Journal Articles

  • Socs 1 deficiency enhances hepatic insulin signaling
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 31516-31521
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet
    Year: 2005
    Journal: Journal of Endocrinology
    Volume: 187
    Page numbers: 45-53
    Publisher: Society of Endocrinology(Stokebristol)
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  • High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction
    Year: 2005
    Journal: Journal of Molecular Endocrinology
    Volume: 35
    Page numbers: 39-48
    Publisher: Society for Endocrinology(Stokebristol)
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  • Investigational agents that protect pancreatic islet Β-cells from failure
    Year: 2005
    Journal: Expert Opinion on Investigational Drugs
    Volume: 14
    Issue: 10
    Page numbers: 1241-1250
    Publisher: Ashley Publications(London)
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Publications in 2004

Journal Articles

  • Elevated SNAP-25 is associated with fatty acid-induced impairment of mouse islet function
    Year: 2004
    Journal: Biochemical and Biophysical Research Communications
    Volume: 317
    Page numbers: 472-477
    Publisher: Academic Press(California)
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  • Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide
    Year: 2004
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 286
    Page numbers: E418-E424
    Publisher: American Physiological Society(Maryland)
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  • Improved islet morphology after blockade of the renin-agiotensin system in the ZDF rat
    Year: 2004
    Journal: Diabetes
    Volume: 53
    Page numbers: 989-997
    Publisher: American Diabetes Association(Virginia)
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  • Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2, and 129T2) in response to a high-fat diet
    Year: 2004
    Journal: Journal of Nutrition
    Volume: 134
    Page numbers: 3264-3269
    Publisher: American Institute of Nutrition(Maryland)
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  • Molecular mechanisms of increased glucose production: Identifying potential therapeutic targets
    Year: 2004
    Journal: Journal of Investigative Medicine
    Volume: 52
    Page numbers: 389-393
    Publisher: BC Decker Inc(Ontario)
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Publications in 2003

Journal Articles

  • Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation
    Year: 2003
    Journal: Biochemical and Biophysical Research Communications
    Volume: 302
    Page numbers: 837-840
    Publisher: Academic Press(California)
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  • Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney
    Year: 2003
    Journal: Diabetologia
    Volume: 123
    Page numbers: 456-789
    Publisher: Springer Verlag(New York)
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  • Threshold effects of glucose transporter-4 (GLUT-4) deficiency on cardiac glucose uptake and development of hypertrophy
    Year: 2003
    Journal: Journal of Molecular Endocrinology
    Volume: 31
    Page numbers: 449-459
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Publications in 2002

Journal Articles

  • Comparison of insulin secretory function in two mouse models with different susceptibility to beta cell failure
    Year: 2002
    Journal: Endocrinology
    Volume: 143
    Page numbers: 2085-2092
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  • Effects of free fatty acids on insulin secretion in obesity
    Year: 2002
    Journal: Obesity Reviews
    Volume: 3
    Page numbers: 103-112
    Publisher: Blackwell Science
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  • The hexosamine biosynthesis pathway regulates insulin secretion via protein glycoylation in mouse islets
    Year: 2002
    Journal: Archives of Biochemistry and Biophysics
    Volume: 405
    Page numbers: 275-279
    Publisher: Academic Press(California)
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Publications in 2001

Book Chapters

  • The New Zealand obese mouse: A polygenic model of type 2 diabetes
    Year: 2001
    Book: Animal Models of Diabetes A Primer
    Publisher: Harwood Academic Publishers(Amsterdam)
    Authors(s):

Journal Articles

  • Mechanism of fat-induced hepatic glucoeogenesis: effect of metformin
    Year: 2001
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 281
    Page numbers: E275-E282
    Publisher: American Physiological Society(Maryland)
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