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A/PROF AMANDA FOSANG



Contact Details

Organization: Paediatrics Royal Children's Hospital
Position: PRINCIPAL RESEARCH FELLOW
Email:

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Understanding the complex cell-matrix interactions that lead to arthritis Arthritis, cartilage, proteinases, aggrecan Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 21-Apr-1982
Doctor of Philosophy Monash University 23-Apr-1986

Memberships

Membership Type Membership Body Description Start Date End Date
Member Matrix Biology Society of Australia and New Zealand Secretary 01-Jan-1995 31-Dec-2001
Member Orthopaedic Research Society (USA) Member 01-Jan-1990
Member National Association of Research Fellows Member 01-Jan-1994

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Cartilage destruction in arthritis: mechanism of aggrecanase and matrix metalloproteinase action in vivo and in vitro Chief Investigator NHMRC Project Grants 01/01/2001
Cartilage destruction in arthritis: mechanism of aggrecanase and matrix metalloproteinase action in vivo and in vitro Chief Investigator NHMRC Research Fellowship 01/01/2001
THE ROLE OF AGGRECANASE AND MATRIX METALLOPROTEINASES IN CART Chief Investigator PFIZER AUST PTY LTD Cardio Vascular Lipid Research Grants 05/03/2004
Cartilage destruction in joint disease: studies with ADAMTS-4 and ADAMTS-5 deficient mice Chief Investigator NHMRC Project Grants 01/01/2005
How important is collagen destruction in arthritis? A study with collagenase-resistant knockin mice Chief Investigator NHMRC Project Grants 01/01/2006
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2006
Regulation of ADAMTS-5 activity by keratan sulphate Chief Investigator NHMRC Project Grants 01/01/2007
Understanding skeletal development Chief Investigator NHMRC Project Grants 01/01/2008
A bioactive aggrecan fragment Chief Investigator NHMRC Project Grants 01/01/2010

Contracts

Title Role Funding Source Award Date
ANALYSIS OF KERATAN SULPHATE-DEFICIENT MICE Chief Investigator ASTRAZENECA UK 01/01/2006
IN VIVO ANALYSIS OF COLLAGENASE-RESISTANT AND COLLAGENASE / AGGRECANASE-RESISTANT MICE Chief Investigator PFIZER AUST PTY LTD 26/10/2007
ACUTE AND SURGICAL MODELS OF ARTHRITIS IN ADAMTS-4 AND ADAMTS-5 DEFICIENT MICE Chief Investigator ASTRAZENECA UK 27/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Publications in 2008

Journal Articles

Reports

  • Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage
    Year: 2008
    Customer: 4
    Report No:: 8
    Publisher: The International Society of Musculoskeletal and Neuronal Interactions
    Authors:

Publications in 2007

Journal Articles

  • Induction of Increased cAMP Levels in Articular Chondrocytes Blocks Matrix Metalloproteinase-Mediated Cartilage Degradation, but Not Aggrecanase-Mediated Cartilage Degradation


    Year: 2007
    Journal: Arthritis and Rheumatism
    Volume: 56
    Issue: 5
    Page numbers: 1549-1558
    Author(s):
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  • ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulphate-rich region of aggrecan.
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 12
    Page numbers: 8632-8640
    Author(s):
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  • Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
    Year: 2007
    Journal: Journal of Clinical Investigation
    Volume: 117
    Issue: 6
    Page numbers: 1627-1363
    Author(s):
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  • Changes in versican and chondroitin sulfate proteoglycans during structural development of the lung
    Year: 2007
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 293
    Page numbers: R784-R792
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  • Distinguishing Aggrecan Loss from Aggrecan Proteolysis in ADAMTS-4 and ADAMTS-5 Single and Double Deficient Mice
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 52
    Page numbers: 37420-37428
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  • MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays
    Year: 2007
    Journal: Osteoarthritis and Cartilage
    Volume: 15
    Issue: 2
    Page numbers: 212-221
    Author(s):
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Conference Publications/Papers

  • ADAMTS-5 activity in synovial fibroblasts is different to chondrocytes
    Year: 2007
    Event name: Orthopaedic Research Society Conference 2007
    Conference Publication: Trans. Orthp.Res. Soc.
    Volume: 32
    Page numbers: 576
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Aggrecan catabolism in mice lacking both ADAMTS-4 and ADAMTS-5 activities: evidence for another aggrecanase in cartilage
    Year: 2007
    Event name: Orthopaedic Research Society Conference 2007
    Conference Publication: Trans Orth Res Soc 2007
    Volume: 32
    Page numbers: 82
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Characterisation of a knock-in mouse with type 11collagen resistant to collagenase
    Year: 2007
    Event name: Orthopaedic Research Society Conference 2007
    Conference Publication: Trans. Orthp.Res. Soc.
    Volume: 32
    Page numbers: 172
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Lypsosomal exocytosis in hypertrophic chondrocytes
    Year: 2007
    Event name: Orthopaedic Research Society 2007 conference
    Conference Publication: Trans Orth Res Soc 2007
    Volume: 32
    Page numbers: 0593
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
    URL - open access http://www.springerlink.com/content/0ut3523718707484/

Publications in 2006

Journal Articles

  • ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures


    Year: 2006
    Journal: Osteoarthritis and Cartilage
    Volume: 14
    Issue: 4
    Page numbers: 392-402
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  • The Accumulation of Intracellular ITEGE and DIPEN Neoepitopes in Bovine Articular Chondrocytes Is Mediated by CD44 Internalization of Hyaluronan
    Year: 2006
    Journal: Arthritis and Rheumatism
    Volume: 54
    Issue: 2
    Page numbers: 443-454
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Conference Publications/Papers

  • Murine epiphyseal chondrocytes exhibit spontaneous ADAMTS-5 mediated aggreanolysis
    Year: 2006
    Event name: Orthopaedic Research Society Conference 2006
    Conference Publication: Trans Orth Res Soc 2006
    Volume: 31
    Issue: 1
    Page numbers: 465
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):

Publications in 2005

Journal Articles

  • ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo
    Year: 2005
    Journal: Arthritis and Rheumatism
    Volume: 52
    Issue: 5
    Page numbers: 1461-1472
    Author(s):
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  • ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    Year: 2005
    Journal: Nature
    Volume: 434
    Issue: 7033
    Page numbers: 648-652
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  • Aggrecan knock-in mice are resistant to proteolysis by MMP or ADAMTS enzymes in the interglobular domain.
    Year: 2005
    Journal: Scandinavian Journal of Rheumatology
    Volume: 34
    Page numbers: 13-15
    Author(s):
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  • Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development
    Year: 2005
    Journal: Molecular and Cellular Biology
    Volume: 25
    Issue: 8
    Page numbers: 3388-3399
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  • N-Linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 25
    Page numbers: 23615-23621
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  • Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan
    Year: 2005
    Journal: FEBS Letters
    Volume: 579
    Issue: 22
    Page numbers: 5019-5023
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  • Reduction of arthritis severity in protease-activated receptor-deficient mice
    Year: 2005
    Journal: Arthritis and Rheumatism
    Volume: 52
    Page numbers: 1325-1332
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  • The role of hepatocyte growth factor in the humoral regulation of inguinal hernia closure
    Year: 2005
    Journal: Journal of Pediatric Surgery
    Volume: 40
    Issue: 12
    Page numbers: 1865-1868
    Author(s):
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Conference Publications/Papers

  • ADAMTS-5 is the major aggrecanase in cartilage: In vitro studies with ADAMTS-4 and ADAMTS-5 deficient mice
    Year: 2005
    Event name: Orthopaedic Research Society Conference 2006
    Conference Publication: Trans Orth Res Soc 2005
    Volume: 30
    Page numbers: 206
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Generation of mice with aggrecan resistant to aggrecanase cleavage in IGD
    Year: 2005
    Event name: Orthopaedic Research Society Conference 2005
    Conference Publication: Trans Orth Res Soc 2005
    Volume: 30
    Page numbers: 357
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):

Publications in 2004

Journal Articles

  • Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
    Year: 2004
    Journal: Development
    Volume: 131
    Page numbers: 5883-5895
    Author(s):
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  • Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep.
    Year: 2004
    Journal: The Journal of Physiology
    Volume: 554
    Issue: 2
    Page numbers: 505-517
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Conference Publications/Papers

  • ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in vivo or in vitro
    Year: 2004
    Event name: Orthopaedic Research Society Conference 2004
    Conference Publication: Trans Orth Res Soc 2004
    Volume: 29
    Page numbers: 608
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Degradative mechanisms in mouse articular cartliage:  Use of in vitro models to analyse proteolysis and loss of aggrecan and link protein
    Year: 2004
    Event name: Orthopaedic Research Society AGM
    Conference Publication: Trans Orthop res Soc
    Volume: 28
    Page numbers: 699
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Expression and characterisation of recombinant keratan sulphate-containing G1-G2
    Year: 2004
    Event name: Orthopaedic Research Society Conference 2004
    Conference Publication: Trans Orth Res Soc 2004
    Volume: 29
    Page numbers: 572
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Generation of mice with aggrecan resistant to cleavage at the major MMP-site
    Year: 2004
    Event name: orthopaedic Research Society Conference 2004
    Conference Publication: Trans Orth Res Soc 2004
    Volume: 29
    Page numbers: 107
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):

Publications in 2003

Journal Articles

  • Neoepitopes as biomarkers of cartilage catabolism.
    Year: 2003
    Journal: Inflammation Research
    Volume: 52
    Issue: 7
    Page numbers: 277-282
    Author(s):
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Publications in 2002

Journal Articles

  • ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 18
    Page numbers: 16059-16066
    Author(s):
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  • Matrix metalloproteinases are active following guanidine hydrochloride extraction of cartilage: generation of DIPEN neopitope dialysis
    Year: 2002
    Journal: Matrix Biology
    Volume: 21
    Page numbers: 425-428
    Author(s):
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  • The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinasw-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases
    Year: 2002
    Journal: Biochemical Journal
    Volume: 364
    Page numbers: 181-190
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Conference Publications/Papers

  • ADAMTS4 (aggrecanase-1) cleaves at both the aggrecanase site (glu373-ala374) and the matrix metalloproteinase site (asn34-phe342) in the aggrecan interglobular domain
    Year: 2002
    Event name: Orthopaedic Research Society
    Conference Publication: Trans Orthop Res Soc
    Volume: 27
    Page numbers: 438
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Extracellular hyalurornan binding is necessary for the intercellualr accumulation of ITEGE epitope in bovine articlur chondrocytes
    Year: 2002
    Event name: Orthopaedic Research Society - 48th Annual Meeting
    Conference Publication: Trans Orthop Res Soc
    Volume: 27
    Page numbers: 413
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • Keratan sulphate in the aggrecan interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on aggrecan
    Year: 2002
    Event name: Orthopaedic Research Society
    Conference Publication: Trans Orthop Res Soc
    Volume: 29
    Page numbers: 232
    Publisher: Orthopaedic Research Society(Dallas)
    Author(s):
  • The collagen-binding fragment of fibtonectin induces MMP-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases
    Year: 2002
    Event name: Orthopaedic Research Society 48th Annual Meeting
    Conference Publication: Trans Orthop Res Soc
    Volume: 27
    Page numbers: 156
    Publisher: Orthoptic Association of Australia
    Author(s):

Publications in 2001

Journal Articles

  • Antibodies to MMP-cleaved aggrecan
    Year: 2001
    Journal: Methods in Molecular Biology
    Volume: 151
    Page numbers: 425-449
    Author(s):
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  • Immunolocalization of Matrix Metalloproteinases in Partial-Thickness Defects in Pig Articular Cartilage
    Year: 2001
    Journal: Journal of Bone and Joint Surgery: American Volume
    Volume: 83A
    Issue: 6
    Page numbers: 826-838
    Author(s):
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  • To clot or not to clot
    Year: 2001
    Journal: Nature
    Volume: 413
    Page numbers: 475-476
    Author(s):
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