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DR QIAO-XIN LI



Contact Details

Organization: Pathology
Position: SENIOR RESEARCH OFFICER
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs
Work: 45878
Fax: 44004
Room: 539
Level: 05
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Neurodegenerative diseases Alzheimer's disease, Parkinson's disease, motor neuron disease Australia

International Linkages

Country Establishment Collaboration
Singapore National University of Singapore Exchange, Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Zhongshan University 31-Jan-1982
Doctor of Philosophy The University of Texas 15-Aug-1989

Memberships

Membership Type Membership Body Description Start Date End Date
Member Society for Neuroscience Member 01-Jan-1997
Member Alzheimer's Australia Vic member 01-Jan-1995

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship Ciba Foundation 12-Jul-1995

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Investigatin a diagnostic marker for Parkinson's disease-alpha-synuclein and/or associated protein DJ-1 parkin? Chief Investigator BRAIN FOUNDATION Parkinson's Disease Research Grant 01/01/2005
Cu/Zn superoxide dismutase aggregation and neurodegeneration in sporadic motor neuron disease Chief Investigator BETHLEHEM GRIFFITHS RESEARCH FOUNDATION Scholarships 01/01/2006
A SERIAL ANALYSIS OF GENE EXPRESSION (SAGE) PROFILE OF THE TG2576 MOUSE MODEL OF ALZHEIMER'S DISEASE Principal Supervisor ALZHEIMER'S AUST RESEARCH LTD Rosemary Foundation Travel Grant 03/10/2006
THE USE OF CU-ATSM TREATMENT TO IDENTIFY CELLULAR MECHANISMS OF MOTOR NEURON DEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS. Chief Investigator MOTOR NEURONE DISEASE INST OF AUST Grants-in-Aid 07/11/2007
Developing new blood test for Alzheimer's disease based on beta-secretase activity Chief Investigator ANZ CHARITABLE TRUSTS Judith Jane Mason & Harold Stannett Williams Memorial Foundation 29/09/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Paradoxical condensation of copper with elevated β-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer's disease


    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 33
    Page numbers: 21899 - 907
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  • Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease
    Year: 2009
    Journal: Graefe's Archive for Clinical and Experimental Ophthalmology
    Volume: 247
    Issue: 9
    Page numbers: 1213-1221
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  • Characterization of PiB binding to white matter in Alzheimer disease and other dementias
    Year: 2009
    Journal: Journal of Nuclear Medicine
    Volume: 50
    Issue: 2
    Page numbers: 198-204
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  • Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 2
    Page numbers: 381-386
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  • Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Year: 2009
    Journal: Journal of Neurochemistry
    Volume: 108
    Page numbers: 1198-1207
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Publications in 2008

Journal Articles

  • α-Synuclein transgenic mice exhibit reduced anxiety-like behaviour
    Year: 2008
    Journal: Experimental Neurology
    Volume: 210
    Issue: 2
    Page numbers: 788-792
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  • Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 9
    Page numbers: 1901-1917
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  • Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms


    Year: 2008
    Journal: Biochemical Journal
    Volume: 412
    Page numbers: 141-152
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  • Rapid Restoration of Cognition in Alzheimer’s Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
    Year: 2008
    Journal: Neuron
    Volume: 59
    Issue: 1
    Page numbers: 43-55
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  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
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  • The β-amyloid protein of Alzheimer’s disease increases neuronal CRMP-2 phosphorylation by Rho-GTP mechanism
    Year: 2008
    Journal: Brain
    Volume: 131
    Page numbers: 90-108
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Publications in 2007

Journal Articles

  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
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  • In vitro characterisation of Pittsburgh compound-B (PIB) binding to Lewy bodies
    Year: 2007
    Journal: Journal of Neuroscience
    Volume: 27
    Issue: 39
    Page numbers: 10365-10371
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  • Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
    Year: 2007
    Journal: Free Radical Biology and Medicine
    Volume: 42
    Issue: 10
    Page numbers: 1534-1542
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  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.
    Year: 2007
    Journal: PLoS One
    Volume: June 2007
    Issue: 6
    Page numbers: e536
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  • Plasma alpha-synuclein is decreased in subjects with Parkinson's disease
    Year: 2007
    Journal: Experimental Neurology
    Volume: 204
    Issue: 2
    Page numbers: 583-588
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Publications in 2006

Book Chapters

  • Alzheimer's Disease
    Year: 2006
    Book: Platelets
    Publisher: Academic Press - Elsevier Science(San Diego)
    Authors(s):

Journal Articles

  • Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons


    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 98
    Page numbers: 1278-1289
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  • Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease.
    Year: 2006
    Journal: Neurobiology of Aging
    Volume: 27
    Page numbers: 614-623
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
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  • Linker histone H1 binds to disease associated amyloid-like fibrils
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 361
    Page numbers: 493-505
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  • Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in amyotrophic lateral sclerosis mouse models
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 153-165
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Publications in 2005

Journal Articles

  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 3
    Page numbers: 672-679
    Publisher: Society of Neuroscience(Washington DC)
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  • Metals and amyloid-Β in Alzheimer's disease
    Year: 2005
    Journal: International Journal of Experimental Pathology
    Volume: 86
    Issue: 3
    Page numbers: 147-159
    Publisher: Blackwell Science(Oxford)
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Publications in 2004

Journal Articles

  • APP intracellular domain is increased and soluble AΒ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease
    Year: 2004
    Journal: Neurobiology of Disease
    Volume: 16
    Page numbers: 124-132
    Publisher: Academic Press(California)
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  • Brain Βamyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1
    Year: 2004
    Journal: Neurochemical Research
    Volume: 29
    Page numbers: 2281-2286
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  • Effects of rhodiola on Alzheimer pathology and open field activity in APP-C100 transgenic mice
    Year: 2004
    Journal: Chinese Journal of Gerontology
    Volume: 24
    Page numbers: 530-533
    Publisher: Editorial Department of Chinese Journal of Gerontology(Beijing)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • α-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy
    Year: 2003
    Journal: Experimental Neurology
    Volume: 181
    Page numbers: 68-78
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  • Metal-protein attenuation with Iodochlorhydroxyquin (Clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Year: 2003
    Journal: Archives of Neurology
    Volume: 60
    Page numbers: 1685-1691
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  • Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets
    Year: 2003
    Journal: Journal of Neuroscience Research
    Volume: 74
    Page numbers: 386-392
    Publisher: Wiley-Liss(New York)
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Publications in 2002

Book Chapters

  • Alzheimer's disease
    Year: 2002
    Book: Platelets
    Publisher: Academic Press(California)
    Authors(s):

Journal Articles

  • Alterations in vascular reactivity in single- and double-transgenic mice coexpressing human APP-C100 and mutant SOD1 genes
    Year: 2002
    Journal: Chinese Medical Journal
    Volume: 115
    Page numbers: 696-701
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  • Alzheimer's disease Aβ peptides are secreted by fresh and transformed human lymphocytes
    Year: 2002
    Journal: Alzheimer's Reports
    Volume: 5
    Issue: 2
    Page numbers: 29-40
    Publisher: Cardiff University, School of Biosciences
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  • Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzeimer's disease amyloid AB protein
    Year: 2002
    Journal: Journal of Alzheimer's Disease
    Volume: 4
    Page numbers: 467-478
    Publisher: IOS Press(Amsterdam)
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  • Oligodendrocytes from neural stem cells express α-synuclein: increased numbers from presenilin I deficient mice
    Year: 2002
    Journal: NeuroReport
    Volume: 13
    Issue: 10
    Page numbers: 1-4
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  • Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 47
    Page numbers: 44670-44676
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Platelet α- and γ-synucleins in Parkinson's disease and normal control subjects
    Year: 2002
    Journal: Journal of Alzheimer's Disease
    Volume: 4
    Page numbers: 309-315
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Publications in 2001

Journal Articles

  • The solubility of [alpha]-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
    Year: 2001
    Journal: Journal of Neurochemistry
    Volume: 76
    Page numbers: 87-96
    Publisher: Blackwell Science(Oxford)
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