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A/PROF STEVEN COLLINS



Contact Details

Organization: Pathology
Position: PRINCIPAL RESEARCH FELLOW
Email:
Homepage: http://www.path.unimelb.edu.au/services/ancjdr/
Work: 8344 1945
Level: 03
Building: Alan Gilbert Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Prion diseases Australia

International Linkages

Country Establishment Collaboration
United Kingdom The University of Edinburgh Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medicine, Bachelor of Surgery University of Melbourne 04-Dec-1982
Doctor of Medicine University of Melbourne 11-Apr-1992

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Association of Neurologists Ordinary member 06-Jul-1993

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 17-Aug-1990

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize Australian Association of Neurologists 03-May-1990
Scholarship National Health and Medical Research Council post-graduate Medical Scholarship 01-Jan-1990
Scholarship FIDIA Visiting Trainee Scholarship 01-Jan-1992

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
practitioner fellowship Chief Investigator NHMRC Practitioner Fellowship 01/01/2006
Understanding human prion diseases. Chief Investigator NHMRC Project Grants 01/01/2007
BIOPHYSICAL PROPERTIES OF PEPTIDES REPRESENTING ENDOGENOUS PROCESSING OF HUMAN PRION PROTEIN Principal Supervisor BETHLEHEM GRIFFITHS RESEARCH FOUNDATION Medical Research Grants 01/01/2007
Early oxidative changes in live cells following infection with the neurodegenerative disease associated prion protein. Principal Supervisor BRAIN FOUNDATION Specific Research Grants 30/09/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • MRI lesion profiles in sporadic Creutzfeldt-Jakob disease


    Year: 2009
    Journal: Neurology
    Volume: 72
    Issue: 23
    Page numbers: 1994-2001
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  • The effects of prion protein expression on metal metabolism


    Year: 2009
    Journal: Molecular and Cellular Neurosciences
    Volume: 41
    Issue: 2
    Page numbers: 135 - 47
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  • 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease
    Year: 2009
    Journal: Journal of Neurology, Neurosurgery and Psychiatry
    Volume: 80
    Page numbers: 998-1001
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  • Association of the MELAS m.3243A>G mutation with myositis and the superiority of urine over muscle, blood and hair for mutation detection
    Year: 2009
    Journal: Journal of Clinical Neuroscience
    Volume: 16
    Issue: 9
    Page numbers: 1223-5
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  • Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response
    Year: 2009
    Journal: Journal of Cell Science
    Volume: 122
    Issue: 10
    Page numbers: 1518-1528
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  • Enhanced geographically-restricted surveillance simulates sporadic Creutzfeldt-Jakob disease clustering.
    Year: 2009
    Journal: Brain
    Volume: 132
    Page numbers: 493-501
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  • PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site
    Year: 2009
    Journal: Cell Research
    Volume: 19
    Page numbers: 1062-1078
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  • Therapeutic interventions ameliorating prion disease.
    Year: 2009
    Journal: Expert Review of Anti-infective Therapy
    Volume: 7
    Issue: 1
    Page numbers: 83-105
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Publications in 2008

Book Chapters

  • Analysis of Endogenous PrPC Processing in Neuronal and Non-neuronal Cell Lines
    Year: 2008
    Book: Prion Protein Protocols
    Publisher: Humana Press(New Jersey)
    Authors(s):
  • Molecular typing of PrPres in human sporadic CJD brain tissue
    Year: 2008
    Book: Prion Protein Protocols
    Publisher: Humana Press(New Jersey)
    Authors(s):

Journal Articles

  • Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 12
    Page numbers: 2793-2801
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  • Surveillance of Creutzfeldt-Jakob Disease in Australia: 2008


    Year: 2008
    Journal: Communicable Diseases Intelligence
    Volume: 32
    Issue: 2
    Page numbers: 232-236
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  • A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease
    Year: 2008
    Journal: Free Radical Biology and Medicine
    Volume: 45
    Issue: n/a
    Page numbers: 184-192
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Publications in 2007

Book Chapters

  • Chronic wasting disease.
    Year: 2007
    Book: McGraw-Hill 2007 Year Book of Science and Technology
    Publisher: McGraw-Hill Higher Education(Sydney)
    Authors(s):

Journal Articles

Publications in 2006

Journal Articles

  • CSF BACE1 activity is increased in CJD and Alzheimer disease versus other dementias.
    Year: 2006
    Journal: Neurology
    Volume: 67
    Page numbers: 710-712
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  • Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease
    Year: 2006
    Journal: Brain Research Bulletin
    Volume: 68
    Page numbers: 346-354
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  • Creutzfeldt-Jakob disease: Australian surveillance update to December 2005
    Year: 2006
    Journal: Communicable Diseases Intelligence
    Volume: 30
    Issue: 1
    Page numbers: 144-147
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  • Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease
    Year: 2006
    Journal: Brain
    Volume: 129
    Issue: 9
    Page numbers: 2278-2287
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  • Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002.
    Year: 2006
    Journal: BMC Public Health
    Volume: 6
    Page numbers: 278-287
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Conference Publications/Papers

  • Surveillance and prevention of vCJD and BSE: the Australian perspective.
    Year: 2006
    Event name: Addressing foodborne threats to health: policies, practices and global coordination.
    Conference Publication: Addressing foodborne threats to health: policies, practices and global coordination.
    Volume: 1
    Page numbers: 206-212.
    Publisher: The National Academies Press(Washington DC)
    Author(s):

Publications in 2005

Journal Articles

  • Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles
    Year: 2005
    Journal: Neurology
    Volume: 65
    Issue: 1
    Page numbers: 113-118
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Creutzfeldt-Jakob disease: Australian surveillance update to 31 December 2004
    Year: 2005
    Journal: Communicable Diseases Intelligence
    Volume: 29
    Issue: 3
    Page numbers: 269-271
    Publisher: Department of Health and Family Services
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  • Detection of prion epitopes on PrPc and PrPsc of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP
    Year: 2005
    Journal: Immunology and Cell Biology
    Volume: 83
    Issue: 6
    Page numbers: 632-637
    Publisher: Blackwell Science Asia(Carlton)
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  • Ethical considerations in presymptomatic testing for variant CJD
    Year: 2005
    Journal: Journal of Medical Ethics
    Volume: 31
    Page numbers: 625-630
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  • Extended period of asymptomatic prion disease after low dose inoculation: Assessment of detection methods and implcations for infection control
    Year: 2005
    Journal: Neurobiology of Disease
    Volume: 20
    Issue: 2
    Page numbers: 336-346
    Publisher: Academic Press(California)
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  • Genetic prion disease: the EUROCJD experience
    Year: 2005
    Journal: Human Genetics
    Volume: 118
    Page numbers: 166-174
    Publisher: Springer Verlag(New York)
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  • Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia and Canada
    Year: 2005
    Journal: Neurology
    Volume: 64
    Page numbers: 1586-1591
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Prion protein glycosylation
    Year: 2005
    Journal: Journal of Neurochemistry
    Volume: 93
    Issue: 4
    Page numbers: 793-801
    Publisher: Blackwell Science(Oxford)
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Publications in 2004

Book Chapters

  • Human prion diseases: cause, clinical and diagnostic aspects.
    Year: 2004
    Book: Prions. A challenge for science, medicine, and the public health system.
    Publisher: Karger AG(Basel)
    Authors(s):
  • Structural biology of prions.
    Year: 2004
    Book: Prions. A challenge for science, medicine, and the public health system.
    Publisher: Karger AG(Basel)
    Authors(s):

Journal Articles

  • Creutzfeldt-Jakob disease surveillance in Australia
    Year: 2004
    Journal: Communicable Diseases Intelligence
    Volume: 28
    Page numbers: 356-358
    Publisher: Department of Health and Family Services
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  • Diagnostic screening of mitochondrial DNA mutations in Australian adults 1990-2001
    Year: 2004
    Journal: Internal Medicine Journal
    Volume: 34
    Page numbers: 10-19
    Publisher: Blackwell Science Asia(Carlton)
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  • Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects
    Year: 2004
    Journal: Annals of Neurology
    Volume: 55
    Page numbers: 898-899
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  • Lyodura use and the risk of iatrogenic Creutzfeldt-Jakob disease in Australia
    Year: 2004
    Journal: Medical Journal of Australia
    Volume: 180
    Page numbers: 177-181
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Miyoshi myopathy - an unusual cause of calf pain and tightness
    Year: 2004
    Journal: Clinical Journal of Sport Medicine
    Volume: 14
    Page numbers: 45-47
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies
    Year: 2004
    Journal: Brain
    Volume: 127
    Page numbers: 2348-2359
    Publisher: Oxford University Press(Oxford)
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  • Transmissible spongiform encephalophaties
    Year: 2004
    Journal: The Lancet
    Volume: 363
    Page numbers: 51-61
    Publisher: Lancet(London)
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Publications in 2003

Journal Articles

  • Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation
    Year: 2003
    Journal: Brain Research
    Volume: 966
    Page numbers: 231-244
    Publisher: Elsevier Science(Amsterdam)
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  • Novel prion protein insert mutation associated with prolonged neurodegenerative illness
    Year: 2003
    Journal: Neurology
    Volume: 60
    Page numbers: 1620-1624
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Organ distribution of prion proteins in variant Creutzfeldt-Jakob disease
    Year: 2003
    Journal: The Lancet Infectious Diseases
    Volume: 3
    Page numbers: 214-222
    Publisher: The Lancet Publishing Group(London)
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  • Variant Creutzfeldt-Jakob disease and the potential for its accidental transmission following surgery with contaminated instruments: the risk of transmission in Australia
    Year: 2003
    Journal: Folia Neuropathologica
    Volume: 41
    Page numbers: 1-10
    Publisher: Polish Association of Neuropathologists
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Publications in 2002

Journal Articles

  • Apparently sporadic CJD and covert health-care transmissions
    Year: 2002
    Journal: The Lancet Neurology
    Volume: 1
    Page numbers: 470-471
    Publisher: The Lancet Publishing Group
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  • Creutzfeldt-Jakob disease cluster in an Australian rural city
    Year: 2002
    Journal: Annals of Neurology
    Volume: 52
    Page numbers: 115-118
    Publisher: Wiley-Liss(New York)
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  • Creutzfeldt-Jakob disease in Australia 1970-1999
    Year: 2002
    Journal: Neurology
    Volume: 59
    Page numbers: 1365-1371
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Meningoencephalomyelitis with vasculitis due to varicella zoster virus: a case report and review of the literature
    Year: 2002
    Journal: Pathology
    Volume: 34
    Page numbers: 88-93
    Publisher: Carfax Publishing(Basingstroke)
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  • Prions in skeletal muscle
    Year: 2002
    Journal: Australian Veterinary Journal
    Volume: 80
    Issue: 8
    Page numbers: 484-485
    Publisher: Australian Veterinary Association(Brunswick)
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  • Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model
    Year: 2002
    Journal: Annals of Neurology
    Volume: 52
    Page numbers: 503-506
    Publisher: Wiley-Liss(New York)
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  • Variant Creutzfeldt-Jakob disease: where are we?
    Year: 2002
    Journal: Microbiology Australia
    Volume: May
    Page numbers: 31-32
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Publications in 2001

Book Chapters

  • Human prion diseases: cause, clinical and diagnostic aspects
    Year: 2001
    Book: Prions. A challenge for science, medicine and public health system
    Publisher: S Karger AG(Basel)
    Authors(s):
  • Structural biology of prions
    Year: 2001
    Book: Prions. A challenge for science, medicine and public health system
    Publisher: S Karger AG(Basel)
    Authors(s):

Journal Articles

  • 'Mad cows' and variant Creutzfeldt-Jakob Disease (vCJD)
    Year: 2001
    Journal: Microbiology Australia
    Volume: July
    Page numbers: 20-21
    Publisher: Cambridge Media(West Leederville)
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  • Classical and variant Creutzfeldt-Jakob diseases and their potential impact on the practice of clinical dentistry in Australia
    Year: 2001
    Journal: Australian Dental Journal
    Volume: 46
    Issue: 4
    Page numbers: 251-257
    Publisher: Australian Dental Association(Sydney)
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  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
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  • Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies
    Year: 2001
    Journal: Journal of Clinical Neuroscience
    Volume: 8
    Issue: 5
    Page numbers: 387-397
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
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  • Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126
    Year: 2001
    Journal: Journal of Neuroscience Research
    Volume: 65
    Page numbers: 565-572
    Publisher: Wiley-Liss(New York)
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  • Muscle pain and cramps
    Year: 2001
    Journal: Medicine Today
    Volume: 1 June 2001
    Page numbers: 20-31
    Publisher: Medicine Today
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  • Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons
    Year: 2001
    Journal: Neurobiology of Disease
    Volume: 8
    Page numbers: 299-316
    Publisher: Academic Press(California)
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  • Transmissible spongiform encephalopathies in Australia
    Year: 2001
    Journal: Communicable Diseases Intelligence
    Volume: 25
    Page numbers: 248-253
    Publisher: Department of Health and Family Services
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