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DR GENEVIEVE EVIN



Contact Details

Organization: Pathology
Position: SENIOR RESEARCH OFFICER
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/evin/
Work: 8344-4205
Fax: 8344-4004
Room: W541
Level: 05
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Proteases implicated in Alzheimer and other neurodegenerative diseases Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Science University of Nancy I 31-Dec-1978
Master of Science University of Nancy I 31-Dec-1977

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
"Gamma-secretase complex: molecular characterization, and moduation of enzymatic activity" Chief Investigator NHMRC Project Grants 01/01/2006
DESIGNING AND TESTING NOVEL PRECURSORS FOR ALZHEIMERS DISEASE BASED ON BACE1 INHIBITION Chief Investigator ANZ CHARITABLE TRUSTS Wicking Trust 24/09/2007
Developing new blood test for Alzheimer's disease based on beta-secretase activity Chief Investigator ANZ CHARITABLE TRUSTS Judith Jane Mason & Harold Stannett Williams Memorial Foundation 29/09/2008
Gamma-secretase and Alzheimer amyloid production Chief Investigator NHMRC Project Grants 01/01/2009
REGULATION OF AMYLOID-BETA PRODUCTION BY GLYCOSPHINGOLIPID SYNTHESIS INHIBITION Chief Investigator UNIVERSITY OF NSW Project Grants (NHMRC)

Contracts

Title Role Funding Source Award Date
COLLABORATION AGREEMENT Chief Investigator THE MENTAL HEALTH RESEARCH INST,
WALTER & ELIZA HALL INST		 10/02/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Paradoxical condensation of copper with elevated β-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer's disease


    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 33
    Page numbers: 21899 - 907
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Publications in 2008

Journal Articles

  • Presenilin 1 Interacts with Acetylcholinesterase and Alters Its Enzymatic Activity and Glycosylation
    Year: 2008
    Journal: Molecular and Cellular Biology
    Volume: 28
    Issue: 9
    Page numbers: 2908-2919
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Publications in 2006

Journal Articles

  • Inhibition of γ-secretase as a therapeutic intervention for Alzheimer's disease


    Year: 2006
    Journal: CNS Drugs
    Volume: 20
    Issue: 5
    Page numbers: 351-372
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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Publications in 2005

Journal Articles

  • In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
    Year: 2005
    Journal: The FEBS Journal
    Volume: 272
    Issue: 21
    Page numbers: 5544-5557
    Publisher: Blackwell Publishers
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  • Transition-state analgoue gamma-secretase inhibitors stabilize a 900kDa presenilin/nicastrin complex
    Year: 2005
    Journal: Biochemistry
    Volume: 44
    Issue: 11
    Page numbers: 4332-4341
    Publisher: American Chemical Society(Washington DC)
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Publications in 2004

Journal Articles

  • APP intracellular domain is increased and soluble AΒ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease
    Year: 2004
    Journal: Neurobiology of Disease
    Volume: 16
    Page numbers: 124-132
    Publisher: Academic Press(California)
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  • Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 50
    Page numbers: 52535-52542
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Characterization of presenilin complexes from mouse and human brain using Blue Native gel eletrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
    Year: 2004
    Journal: European Journal of Biochemistry
    Volume: 271
    Page numbers: 375-383
    Publisher: Blackwell Science(Oxford)
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  • Effects of rhodiola on Alzheimer pathology and open field activity in APP-C100 transgenic mice
    Year: 2004
    Journal: Chinese Journal of Gerontology
    Volume: 24
    Page numbers: 530-533
    Publisher: Editorial Department of Chinese Journal of Gerontology(Beijing)
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  • Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
    Year: 2004
    Journal: Molecular Brain Research
    Volume: 127
    Issue: 1-2
    Page numbers: 128-135
    Publisher: Elsevier Science(Amsterdam)
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  • Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects
    Year: 2004
    Journal: Annals of Neurology
    Volume: 55
    Page numbers: 898-899
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  • Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Issue: 1
    Page numbers: 230-237
    Publisher: Blackwell Science(Oxford)
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  • The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-link cleavages
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 18146-18156
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets
    Year: 2003
    Journal: Journal of Neuroscience Research
    Volume: 74
    Page numbers: 386-392
    Publisher: Wiley-Liss(New York)
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  • Selecting cells with different Alzheimer's disease γ-secretase activity using FACS: differential effect of presenilin exon 9 deletion on γ- and ε-cleavage
    Year: 2003
    Journal: European Journal of Biochemistry
    Volume: 270
    Page numbers: 495-506
    Publisher: Blackwell Science(Oxford)
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Publications in 2002

Journal Articles

  • A novel ε-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with notch processing
    Year: 2002
    Journal: Biochemistry
    Volume: 41
    Page numbers: 2825-2835
    Publisher: American Chemical Society(Washington DC)
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  • Alternative transcripts of presenilin-I associated with frontotemporal dementia
    Year: 2002
    Journal: NeuroReport
    Volume: 13
    Issue: 5
    Page numbers: 917-921
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Biogenesis and metabolism of Alzheimer's disease Aβ amyloid peptides
    Year: 2002
    Journal: Peptides
    Volume: 23
    Page numbers: 1285-1297
    Publisher: Elsevier(New York)
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  • Carboxyl-terminal fragments of the amyloid precursor protein in Alzheimer's disease brain: detection of [gamma]-secretase products
    Year: 2002
    Journal: Brain Aging International Journal
    Volume: 2
    Issue: 3
    Page numbers: 61-66
    Publisher: Eonia Publishing(Bucharest)
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  • Increased expression of the amyloid precursor β-secretase in Alzheimer's disease
    Year: 2002
    Journal: Annals of Neurology
    Volume: 51
    Page numbers: 783-786
    Publisher: Wiley-Liss(New York)
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Publications in 2001

Journal Articles

  • Altered expression of Apolipoprotein E, Amyoid Precursor Protein and Presenilin-1 is associated with Chronic Reactive Gliosis in rat cortical tissue
    Year: 2001
    Journal: Neuroscience
    Volume: 106
    Page numbers: 557-569
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8359-8368
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  • Pharmacological knock-down of the Presenilin 1 heterodimer by a novel [gamma]-secretase inhibitor
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 48
    Page numbers: 45394-45402
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from [gamma]-secretase
    Year: 2001
    Journal: European Journal of Biochemistry
    Volume: 268
    Page numbers: 5329-5336
    Publisher: Blackwell Science(Oxford)
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