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A/PROF ANN TURNLEY



Contact Details

Organization: Medicine, Dentistry and Health Sciences
Position: PRINCIPLE RESEARCH FELLOW
Email:
Homepage: http://www.cns.unimelb.edu.au/research/neuralregeneration/
Work: 83443981

Biography

Associate Professor Ann Turnley
Centre for Neuroscience, The University of Melbourne

Ann Turnley graduated from the University of Melbourne with a B.Sc. (Hons) in 1988 and a PhD, undertaken at the Walter & Eliza Hall Institute of Medical Research (WEHI), in 1992. She was awarded a Lucille P. Markey Charitable Trust Visiting Fellow Award (USA) to undertake a post-doctoral position at the Mount Sinai School of Medicine in New York. She returned to the WEHI in 1995 as an Australian Research Council Postdoctoral Fellow and then the Sir Colin and Lady MacKenzie Trust Fellow. A/Prof Turnley moved to the University of Melbourne in 2001 as the Roper Fellow, to head the Neural Regeneration Laboratory in the newly created Centre for Neuroscience. She is currently a National Health & Medical Research Council of Australia Senior Research Fellow, Associate Director of the Centre for Neuroscience and Secretary of the Australian Neuroscience Society. Her primary research interests revolve around understanding signaling mechanisms that may be exploited to promote repair of the nervous system. These include regulation of neural stem cell differentiation and migration and mechanisms that inhibit or promote axonal regeneration and astrocytic gliosis.

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
neural regeneration, neural stem cells, nerve regrowth, glial cell activation Australia

International Linkages

Country Establishment Collaboration
Japan Jichi Medical University Research
Sweden Gothenburg University Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) University of Melbourne 31-Dec-1988
Doctor of Philosophy University of Melbourne 12-Aug-1992

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Neuroscience Society Member 01-Jan-1990
Council Australian Neuroscience Society Secretary 01-Feb-2008
Member Society for Neuroscience (USA) Member 01-Jan-2003
Member International Society for Neurochemistry Member 01-Jan-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURAL REGENERATION Chief Investigator BHP COMMUNITY LTD -TRUSTEE FOR BHP COMMUNITY TRUST Research Grant 01/01/2002
NHMRC Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2005
SIGNALLING MECHANISMS REGULATING NEUROGENESIS AND NEURITE OUTGROWTH Chief Investigator NHMRC Project Grants 01/01/2005
Investigating the mechanisms and treatment of perinatal brain injury. Chief Investigator NHMRC Project Grants 01/01/2007
Effect of inflammation on neural stem cells Chief Investigator NHMRC Project Grants 01/01/2007
DEVELOPMENT OF EPHA4 PEPTIDE INHIBITORS FOR THE TREATMENT OF NEUROTRAUMA Chief Investigator TRANSPORT ACCIDENT COMMISSION Victorian Neurotrauma Initiative 07/05/2007
ROLE OF EPHA4 IN EAE Chief Investigator MULTIPLE SCLEROSIS RESEARCH AUSTRALIA Investigator Initiated Project Grants 01/01/2008
Factors affecting nerve repair in a model of Multiple Sclerosis Chief Investigator NHMRC Project Grants 01/01/2009
RESEARCH FELLOWSHIP - DR ANN TURNLEY Chief Investigator NHMRC Research Fellowship 29/10/2009
Development and regrowth of the nervous system-equipment request Chief Investigator EQUITY TRUSTEES Harold and Cora Brennen Benevolent Trust

Contracts

Title Role Funding Source Award Date
ROLE AND MECHANISMS OF IFN REGULATION OF ADULT NEURAL STEM CELL FUNCTION Chief Investigator NEUROSCIENCES VIC 01/06/2004
PRE-CLINICAL EVALUATION OF NV-06 AS NEURO-PROTECTIVE AGENT AGAINST CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY Chief Investigator MARSHALL EDWARDS PTY LTD 01/08/2005
EPHA4 BLOCKING IN SPINAL CORD INJURY (SCI) Chief Investigator UNIQUEST PTY LTD 01/06/2007
VEGF IN SPINAL CORD INJURY - CSL CONTRACT Chief Investigator CSL LIMITED 15/08/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Fibroblast growth factor-9 inhibits astrocyte differentiation of adult mouse neural progenitor cells.


    Year: 2009
    Journal: Journal of Neuroscience Research
    Volume: 87
    Issue: 10
    Page numbers: 2201-2210
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  • Cytokine-induced SOCS expression is inhibited by cAMP analogue: Impact on regeneration in injured retina
    Year: 2009
    Journal: Molecular and Cellular Neurosciences
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  • Growth hormone promotes proliferation of adult neurosphere cultures
    Year: 2009
    Journal: Growth Hormone & IGF Research
    Volume: 19
    Page numbers: 212-218
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  • Inhibition of neurosphere proliferation by IFNg but not IFNb is coupled to neuronal differentiation
    Year: 2009
    Journal: Journal of Neuroimmunology
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Publications in 2008

Journal Articles

  • Erythropoietin promotes axonal growth in a model of neuronal polarization.
    Year: 2008
    Journal: Molecular and Cellular Neurosciences
    Volume: 38
    Page numbers: 537-547
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  • Growth hormone signaling and hippocampal neurogenesis: insights from genetic models
    Year: 2008
    Journal: Hippocampus
    Volume: 18
    Page numbers: 1034-1050
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  • Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells
    Year: 2008
    Journal: Stem Cells
    Volume: 26
    Page numbers: 1146-1154
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  • Transgenic mice expressing the Peripherin-EGFP genomic reporter display intrinsic peripheral nervous system fluorescence.
    Year: 2008
    Journal: Transgenic Research
    Volume: 17
    Page numbers: 1103-1116
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/18709437?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
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  • Treadmill training after spinal cord injury improves motor recovery in mice.
    Year: 2008
    Journal: Journal of Neurotrauma
    Volume: 25
    Issue: 5
    Page numbers: 449-465
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  • c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain
    Year: 2008
    Journal: Stem Cells
    Volume: 26
    Page numbers: 173-181
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Publications in 2007

Journal Articles

  • Phenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell model.
    Year: 2007
    Journal: BMC Neuroscience
    Volume: 8
    Page numbers: 61
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  • Systemically delivered Erythropoietin transiently enhances adult hippocampal neurogenesis
    Year: 2007
    Journal: Journal of Neurochemistry
    Volume: 1021
    Page numbers: 1953-1965
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Publications in 2006

Journal Articles

  • Differential effects of SOGS2 on neuronal differentiation and morphology


    Year: 2006
    Journal: Brain Research
    Volume: 1067
    Page numbers: 138-145
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  • Eph tyrosine kinase receptor EphA4 is required for the topographic mapping of the corticospinal tract
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 42
    Page numbers: 15629-15634
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  • EphA4 Regulates Central Nervous system vascular formation
    Year: 2006
    Journal: Journal of Comparative Neurology
    Volume: 497
    Page numbers: 864-875
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  • Functional dentate gyrus neurogenesis in a rapid kindling seizure model
    Year: 2006
    Journal: European Journal of Neuroscience
    Volume: 24
    Page numbers: 3195-3203
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  • Roles of Eph receptors and ephrins in the normal and damaged adult CNS
    Year: 2006
    Journal: Brain Research Reviews
    Volume: 52
    Page numbers: 327-345
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Publications in 2005

Journal Articles

  • A brightness-area-product-based protocol for the quantitative assessment of antigen abundance in fluorescent immunohistochemistry
    Year: 2005
    Journal: Brain Research Protocols
    Volume: 15
    Issue: 1
    Page numbers: 21-29
    Publisher: Elsevier Science(Amsterdam)
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  • Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2
    Year: 2005
    Journal: Neuroscience
    Volume: 132
    Page numbers: 673-687
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Galanin in neuro(glio)genesis: expression of galanin and receptors by progenitor cells in vivo and in vitro and effects of galanin on neurosphere proliferation
    Year: 2005
    Journal: Neuropeptides
    Volume: 39
    Page numbers: 201-205
    Publisher: Churchill Livingstone(Edinburgh)
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  • Growth hormone and SOCS2 regulation of neuronal differentiation: possible role in mental function.
    Year: 2005
    Journal: Pediatric Endocrinology Reviews
    Volume: 2
    Issue: 3
    Page numbers: 366-371
    Publisher: YS Medical Media(Netanya)
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  • Role of SOCS2 in growth hormone actions
    Year: 2005
    Journal: Trends in Endocrinology and Metabolism
    Volume: 16
    Issue: No.2
    Page numbers: 53-58
    Publisher: Elsevier Science London(London)
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  • Seizures, not hippocampal neuronal death, provoke neurogenesis in a mouse rapid electrical amygdala kindling model of seizures
    Year: 2005
    Journal: Neuroscience
    Volume: 136
    Issue: 2005
    Page numbers: 405-415
    Publisher: Pergamon-Elsevier Science(Oxford)
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Publications in 2004

Journal Articles

  • Axonal regeneration and lack of astrocytic gliosis in EphA4-Deficient mice
    Year: 2004
    Journal: Journal of Neuroscience
    Volume: 24
    Issue: 45
    Page numbers: 10064-10073
    Publisher: Society of Neuroscience(Washington DC)
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  • Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness
    Year: 2004
    Journal: European Journal of Neuroscience
    Volume: 19
    Page numbers: 2069-2079
    Publisher: Blackwell Science(Oxford)
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  • Interferon-γ but not TNFα promotes neuronal differentiation and neurite outgrowth of murine adult neural stem cells.
    Year: 2004
    Journal: Experimental Neurology
    Volume: 187
    Issue: 2004
    Page numbers: 171-177
    Publisher: Academic Press(California)
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  • SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 16349-16355
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Suppressor of cytokine signalling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons
    Year: 2004
    Journal: European Journal of Neuroscience
    Volume: 20
    Issue: 2004
    Page numbers: 2260-2266
    Publisher: Blackwell Science(Oxford)
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Publications in 2002

Journal Articles

  • Failure of sensory neurons to express class I MHC is due to differential SOCS1 expression
    Year: 2002
    Journal: Journal of Neuroimmunology
    Volume: 123
    Page numbers: 35-40
    Publisher: Elsevier(Amsterdam)
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  • LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
    Year: 2002
    Journal: Nature Medicine
    Volume: 8
    Issue: 6
    Page numbers: 613-619
    Publisher: Nature America(New York)
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  • Suppressor of Cytokine signalling 2 regulates neuronal differentiation by inhibiting growth hormone signalling
    Year: 2002
    Journal: Nature Neuroscience
    Volume: 5
    Issue: 11
    Page numbers: 1155-1162
    Publisher: Nature America(Philadelphia)
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  • Tomacula in MAG-deficient mice
    Year: 2002
    Journal: Journal of the Peripheral Nervous System
    Volume: 7
    Page numbers: 181-189
    Publisher: Blackwell
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Publications in 2001

Journal Articles

  • SOCS1 regulates Interferon-gamma mediated sensory neuron survival.
    Year: 2001
    Journal: NeuroReport
    Volume: 12
    Page numbers: 1-3
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