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PROF COLIN MASTERS



Contact Details

Organization: Medicine, Dentistry and Health Sciences
Position: Honorary (Laureate Professor)
Email:
Homepage: http://www.mhri.edu.au/
Work: 8344 1950
Fax: 9349 3235
Room: 330
Level: 03
Building: Alan Gilbert Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Neurodegenerative diseases Alzheimer's disease, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, etc... Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medical Science The University of Western Australia
Bachelor of Science The University of Western Australia
Doctor of Medicine The University of Western Australia

Memberships

Membership Type Membership Body Description Start Date End Date
Member Royal College of Physicians of London Member 10-Aug-2004

Fellowships

Fellowship Date Awarded
Fellow of the Royal College of Pathologists, Australia (FRCPA)

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
NATIONAL CREUTZFELDT-JAKOB DISEASE CASE REGISTRY Chief Investigator DO NOT USE (33041) - COMMONWEALTH DEPT OF HEALTH & AGEING Innovative Grants (DEPT OF HEALTH & AGEING) 01/07/2002
Neurogenomics & Neuroprotenomics Platform Chief Investigator NEUROSCIENCES VIC Research Project 01/03/2003
Identification & characterisation of genes involved in the copper regulation of the human Alzheimer's disease Amyloid-beta Precursor Protein(APP) gene Chief Investigator AUST RESEARCH COUNCIL Discovery Indigenous Researchers Development Scheme 01/01/2005
Role of metal ions and amyloid-beta in the pathology of Alzheimer's disease Chief Investigator WELLCOME TRUST International Research Fellowships 15/12/2005
A NATIONAL BIOMEDICAL ELECTRON PARAMAGNETIC RESONANCE AND MOLECULAR IMAGING CENTRE Chief Investigator MONASH UNIVERSITY Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2007
DEMENTIA COLLABORATIVE RESEARCH CENTRE 2 - UNIVERSITY OF MELBOURNE NODE Chief Investigator AUST NATIONAL UNIVERSITY Dementia Research Grants Program (NHMRC) 22/05/2007
Novel therpeutic approaches for Alzheimer's disease Chief Investigator NHMRC Project Grants 01/01/2008
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008

Contracts

Title Role Funding Source Award Date
SECOND AND THIRD RESEARCH FUNDING AND IP ASSIGNMENT AGREEMENT (PRANA) Chief Investigator PRANA BIOTECHNOLOGY LTD 01/12/2003
NSV_42_05_SAG21 (P2) : EXPRESSION PROFILING OF AD IMAGING TARGETS Chief Investigator NEUROSCIENCES VIC 02/12/2003
NSV_043_05_SAG22 (P3) : AMYLOID IMAGING WITH 18F-AB LIGAND AND PET Chief Investigator NEUROSCIENCES VIC 02/12/2003
Schering Imaging Chief Investigator PRANA BIOTECHNOLOGY LTD 02/12/2003
NSV_041_05_SAG20 (P1) : AMYLOID AB IMAGING LIGANDS : A HIGH THROUGHPUT SCREEN APPROACH - CHARACTERISATION OF AB BINDING COMPOUNDS Chief Investigator NEUROSCIENCES VIC 01/12/2005
THE AUSTRALIAN NATIONAL CREUTZFELDT-JAKOB DISEASE (CJD) REGISTRY Chief Investigator DEPT OF HEALTH & AGEING 01/02/2007
FRAMEWORK AGREEMENT- UOM, CSIRO AND PRANA BIOTECHNOLOGY Chief Investigator CSIRO,
PRANA BIOTECHNOLOGY LTD

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Formation of depamine-mediated α-synuclein-soluble oligomers requires methionine oxidation.


     


    Year: 2009
    Journal: Free Radical Biology and Medicine
    Volume: 46
    Page numbers: 1328-1337
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  • In vitro characterisation of BF227 binding to α-synuclein/Lewy bodies


    Year: 2009
    Journal: European Journal of Pharmacology
    Volume: 617
    Page numbers: 54-58
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  • Paradoxical condensation of copper with elevated β-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer's disease


    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 33
    Page numbers: 21899 - 907
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  • 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease
    Year: 2009
    Journal: Journal of Neurology, Neurosurgery and Psychiatry
    Volume: 80
    Page numbers: 998-1001
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  • Alanine-2 Carbonyl is an Oxygen Ligand in Cu2+ Coordination of Alzheimer’s
    Disease Amyloid-β Peptide - Relevance to N-Terminally Truncated Forms
    Year: 2009
    Journal: Journal of the American Chemical Society
    Volume: 131
    Page numbers: 8760-8761
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    URL - restricted access http://pubs.acs.org/articlesonrequest/AOR-qQNcZvsq3Gkv6JnFnqy6
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  • Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease
    Year: 2009
    Journal: Graefe's Archive for Clinical and Experimental Ophthalmology
    Volume: 247
    Issue: 9
    Page numbers: 1213-1221
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  • Characterization of PiB binding to white matter in Alzheimer disease and other dementias
    Year: 2009
    Journal: Journal of Nuclear Medicine
    Volume: 50
    Issue: 2
    Page numbers: 198-204
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  • Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response
    Year: 2009
    Journal: Journal of Cell Science
    Volume: 122
    Issue: 10
    Page numbers: 1518-1528
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  • Enhanced geographically-restricted surveillance simulates sporadic Creutzfeldt-Jakob disease clustering.
    Year: 2009
    Journal: Brain
    Volume: 132
    Page numbers: 493-501
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  • Pleomorphic Copper Coordination by Alzheimer’s Disease Amyloid-β Peptide
    Year: 2009
    Journal: Journal of the American Chemical Society
    Volume: 131
    Issue: 3
    Page numbers: 1195-1207
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  • PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site
    Year: 2009
    Journal: Cell Research
    Volume: 19
    Page numbers: 1062-1078
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  • Regulation of Prion Gene Expression by Transcription Factors SP1 and Metal Transcription Factor-1
    Year: 2009
    Journal: Journal of Biological Chemistry
    Volume: 284
    Issue: 2
    Page numbers: 1291-1301
    Author(s):
    URL - restricted access http://www.jbc.org/cgi/content/abstract/284/2/1291
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  • Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Year: 2009
    Journal: Journal of Neurochemistry
    Volume: 108
    Page numbers: 1198-1207
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  • Therapeutic interventions ameliorating prion disease.
    Year: 2009
    Journal: Expert Review of Anti-infective Therapy
    Volume: 7
    Issue: 1
    Page numbers: 83-105
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Publications in 2008

Journal Articles

  • α-Synuclein transgenic mice exhibit reduced anxiety-like behaviour
    Year: 2008
    Journal: Experimental Neurology
    Volume: 210
    Issue: 2
    Page numbers: 788-792
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  • Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 9
    Page numbers: 1901-1917
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  • Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity


    Year: 2008
    Journal: Journal of Neuroscience
    Volume: 28
    Issue: 46
    Page numbers: 11950-11958
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  • Amyloid-β-Anti-Amyloid-β Complex Structure Reveals an Extended confirmation in the Immunodominant B-Cell Epitope


    Year: 2008
    Journal: Journal of Molecular Biology
    Volume: 377
    Issue: 1
    Page numbers: 181-192
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  • Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Aβ peptides associated with Alzheimer’s disease


    Year: 2008
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: n/a
    Issue: F64
    Page numbers: 438-441
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  • Dimeric structures of α-synuclein bind preferentially to lipid membranes


    Year: 2008
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1778
    Issue: 4
    Page numbers: 1112-1119
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  • Identification of the Alzheimer’s disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth


    Year: 2008
    Journal: Journal of Pathology
    Volume: 215
    Issue: 2008
    Page numbers: 155-163
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  • Inhibition of γ-secretase causes increased secretion of amyloid precursor C-terminal fragments in association with exosomes


    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Issue: 5
    Page numbers: 1469-1478
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  • Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Issue: 5
    Page numbers: 1469-1478
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    URL - restricted access http://www.fasebj.org/cgi/content/abstract/22/5/1469
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  • Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 12
    Page numbers: 2793-2801
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  • Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation


    Year: 2008
    Journal: Free Radical Biology and Medicine
    Volume: 44
    Issue: 1
    Page numbers: 44-55
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  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
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  • Surveillance of Creutzfeldt-Jakob Disease in Australia: 2008


    Year: 2008
    Journal: Communicable Diseases Intelligence
    Volume: 32
    Issue: 2
    Page numbers: 232-236
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  • A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease
    Year: 2008
    Journal: Free Radical Biology and Medicine
    Volume: 45
    Issue: n/a
    Page numbers: 184-192
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  • Amyloid load in parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emissin tomography
    Year: 2008
    Journal: Journal of Neurology, Neurosurgery and Psychiatry
    Volume: 79
    Issue: 13
    Page numbers: 1331-1338
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  • Appearance modeling of 11 C PiB PET images: characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
    Year: 2008
    Journal: Neuroimage
    Volume: 43
    Page numbers: 430-439
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  • Cu2+ Binding Modes of Recombinant α-Synuclein – Insights from EPR Spectroscopy
    Year: 2008
    Journal: Journal of the American Chemical Society
    Volume: 130
    Issue: 24
    Page numbers: 7766-7773
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  • Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein
    Year: 2008
    Journal: Biochemistry
    Volume: 47
    Issue: 5
    Page numbers: 1425-1434
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  • Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
    Year: 2008
    Journal: Lancet Neurology
    Volume: 7
    Page numbers: 129-135
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  • Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Page numbers: 181-198
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  • Mechanisms of aβ mediated neurodegeneration in Alzheimer's disease
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 2
    Page numbers: 181-198
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  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
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  • Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer’s Disease Amyloid-β Peptide
    Year: 2008
    Journal: Biophysical Journal
    Volume: 94
    Page numbers: 2752-2766
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  • The ART of Loss: Aβ Imaging in the Evaluation of Alzheimer’s Disease and other Dementias
    Year: 2008
    Journal: Molecular Neurobiology: a review journal
    Volume: 38
    Issue: 1
    Page numbers: 1-15
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Publications in 2007

Books

  • Therapeutic strategies in dementia
    Year: 2007
    Publisher: Clinical Publishing(Oxford)
    Authors(s):

Journal Articles

  •  Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • β-amyloid and memory in nondemented individuals: Evidence for preclinical Alzheimer's disease


    Year: 2007
    Journal: Brain
    Volume: 130
    Issue: 11
    Page numbers: 1-8
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  • A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease


    Year: 2007
    Journal: Neuroscience
    Volume: 147
    Issue: 4
    Page numbers: 1047-1058
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  • Family clustering of viliuisk encephalomyelitis in traditional and new geographic regions


    Year: 2007
    Journal: Emerging Infectious Diseases
    Volume: 13
    Issue: 9
    Page numbers: 1321-1326
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  • Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism



    Year: 2007
    Journal: The Lancet Neurology
    Volume: 7
    Issue: 2
    Page numbers: 129-135
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  • Packaging of prions into exosomes is associated with a novel pathway of PrP processing.


    Year: 2007
    Journal: Journal of Pathology
    Volume: 211
    Issue: 5
    Page numbers: 582-590
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  • A primer of amyloid nomenclature
    Year: 2007
    Journal: Amyloid - The Journal of Protein Folding Disorders
    Volume: 14
    Issue: 3
    Page numbers: 179-183
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  • Cholesterol and Clioquinol modulation of Ab(1-42) interaction with phospholipid bilayers and metals
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 3135-3144
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  • Creutzfeldt-Jakob disease: Australian surveillance update to March 2007
    Year: 2007
    Journal: Communicable Diseases Intelligence
    Volume: 31
    Issue: 2
    Page numbers: 194-197
    Author(s):
    URL - open access http://www.health.gov.au/internet/wcms/publishing.nsf/Content/cda-cdi3102-pdf-cnt.htm/$FILE/cdi3102d.pdf
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  • Decline in verbal memory in non-demented older adults.
    Year: 2007
    Journal: Journal of Clinical and Experimental Neuropsychology
    Volume: 29
    Page numbers: 706-718
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  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
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  • Enzymatic detergent treatment protocol that reduces protease-resistant prion protein load and infectivity from surgical-steel monofilaments contaminated with a human-derived prion strain
    Year: 2007
    Journal: Journal of General Virology
    Volume: 88
    Issue: 10
    Page numbers: 2905-2914
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  • Impaired Peripheral Endothelial Microvascular Responsiveness in Alzheimer's Disease
    Year: 2007
    Journal: Journal of Alzheimer's Disease
    Volume: 11
    Issue: 1
    Page numbers: 25-32
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  • In vitro characterisation of Pittsburgh compound-B (PIB) binding to Lewy bodies
    Year: 2007
    Journal: Journal of Neuroscience
    Volume: 27
    Issue: 39
    Page numbers: 10365-10371
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  • Membrane interactions and the effect of metal ions on the amyloidogenic fragment Ab(25-35) in comparison to Ab(1-42).
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 2400-2408
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  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.
    Year: 2007
    Journal: PLoS One
    Volume: June 2007
    Issue: 6
    Page numbers: e536
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  • Novel prion protein gene mutation presenting with subacute PSP-like syndrome
    Year: 2007
    Journal: Neurology
    Volume: 68
    Page numbers: 868-870
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  • Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
    Year: 2007
    Journal: Journal of Molecular Biology
    Volume: 367
    Issue: 1
    Page numbers: 148-161
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    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/17239395?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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  • Visual Assessment Versus Quantitative Assessment of 11C-PIB PET and 18F-FDG PET for Detection of Alzheimer's Disease
    Year: 2007
    Journal: Journal of Nuclear Medicine
    Volume: 48
    Issue: 4
    Page numbers: 547-52
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Publications in 2006

Book Chapters

  • Alzheimer's Disease
    Year: 2006
    Book: Platelets
    Publisher: Academic Press - Elsevier Science(San Diego)
    Authors(s):
  • Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aβ amyloid of Alzheimer's disease
    Year: 2006
    Book: Alzheimer: 100 years and beyond
    Publisher: Springer Verlag(Heidelberg)
    Authors(s):
    Editors(s):
  • The Melbourne Aging Study
    Year: 2006
    Book: Mild Cognitive Impairment: International Perspectives
    Publisher: Taylor & Francis Ltd(New York)
    Authors(s):
    Editors(s):

Journal Articles

  • Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons


    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 98
    Page numbers: 1278-1289
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  • Inhibition of γ-secretase as a therapeutic intervention for Alzheimer's disease


    Year: 2006
    Journal: CNS Drugs
    Volume: 20
    Issue: 5
    Page numbers: 351-372
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  • Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Aβ amyloid pathway
    Year: 2006
    Journal: Brain
    Volume: 129
    Page numbers: 2823-2839
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  • Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 356
    Page numbers: 759-770
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  • C-terminal truncation and Parkinson's disease-associated mutations down regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
    Year: 2006
    Journal: Human Molecular Genetics
    Volume: 15
    Issue: 21
    Page numbers: 3251-3262
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  • CSF BACE1 activity is increased in CJD and Alzheimer disease versus other dementias.
    Year: 2006
    Journal: Neurology
    Volume: 67
    Page numbers: 710-712
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  • Copper-dependent inhibition of cytochrome c oxidase by Aβ1-42 requires reduced methionine at residue 35 of the Aβ peptide
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 99
    Page numbers: 226-236
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  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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  • Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease
    Year: 2006
    Journal: Brain Research Bulletin
    Volume: 68
    Page numbers: 346-354
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  • Creutzfeldt-Jakob disease: Australian surveillance update to December 2005
    Year: 2006
    Journal: Communicable Diseases Intelligence
    Volume: 30
    Issue: 1
    Page numbers: 144-147
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  • Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease.
    Year: 2006
    Journal: Neurobiology of Aging
    Volume: 27
    Page numbers: 614-623
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Delineating common molecular mechanisms in Alzheimer's and prion diseases
    Year: 2006
    Journal: Trends in Biochemical Sciences
    Volume: 31
    Issue: 8
    Page numbers: 465-472
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  • Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease
    Year: 2006
    Journal: Brain
    Volume: 129
    Issue: 9
    Page numbers: 2278-2287
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  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
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  • Linker histone H1 binds to disease associated amyloid-like fibrils
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 361
    Page numbers: 493-505
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  • Mild memory impairment in healthy older adults is distinct from normal aging
    Year: 2006
    Journal: Brain and Cognition
    Volume: 60
    Page numbers: 146-155
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  • Molecular Dissection of the Interaction Between APP and Its Neuronal Trafficking Receptor SorLA/LR11
    Year: 2006
    Journal: Biochemistry
    Volume: 45
    Page numbers: 2618-2628
    Author(s):
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  • Molecular mechanisms for Alzheimer ’s disease: implications for neuroimaging and therapeutics
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 97
    Page numbers: 1700-1725
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  • Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in amyotrophic lateral sclerosis mouse models
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 153-165
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  • Pathways to the discovery of the Aβ amyloid of Alzheimer's disease
    Year: 2006
    Journal: Journal of Alzheimer's Disease
    Volume: 9
    Page numbers: 155-161
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  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
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  • The beta amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane.
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 96
    Page numbers: 53-64
    Author(s):
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Publications in 2005

Book Chapters

  • Neuropathology of Alzheimer's disease
    Year: 2005
    Book: Dementia
    Publisher: Hodder Headline(London)
    Authors(s):
  • Role of AΒ amyloid in the pathogenesis of Alzheimer's disease
    Year: 2005
    Book: Dementia
    Publisher: Hodder Headline(London)
    Authors(s):
  • The neuropathology of Alzheimer's disease in the year 2005
    Year: 2005
    Book: Neurodegenerative diseases: neurobiology, pathologenesis and therapeutics
    Publisher: Cambridge University Press(Cambridge)
    Authors(s):

Journal Articles

  • Imaginem oblivionis: the prospects of neuroimaging for early detection of Alzheimer's disease
    Year: 2005
    Journal: Journal of Clinical Neuroscience
    Volume: 12
    Issue: 3
    Page numbers: 221-230
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
    Author(s):
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  • Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles
    Year: 2005
    Journal: Neurology
    Volume: 65
    Issue: 1
    Page numbers: 113-118
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 3
    Page numbers: 672-679
    Publisher: Society of Neuroscience(Washington DC)
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  • Creutzfeldt-Jakob disease: Australian surveillance update to 31 December 2004
    Year: 2005
    Journal: Communicable Diseases Intelligence
    Volume: 29
    Issue: 3
    Page numbers: 269-271
    Publisher: Department of Health and Family Services
    Author(s):
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  • Crystallisation and preliminary crystallographic studies of the copper binding domain of the amyloid recursor protein of Alzheimer's disease
    Year: 2005
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: F61
    Page numbers: 93-95
    Publisher: Blackwell Publishers(Oxford)
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  • Detection of prion epitopes on PrPc and PrPsc of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP
    Year: 2005
    Journal: Immunology and Cell Biology
    Volume: 83
    Issue: 6
    Page numbers: 632-637
    Publisher: Blackwell Science Asia(Carlton)
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  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
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  • Ethical considerations in presymptomatic testing for variant CJD
    Year: 2005
    Journal: Journal of Medical Ethics
    Volume: 31
    Page numbers: 625-630
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  • Extended period of asymptomatic prion disease after low dose inoculation: Assessment of detection methods and implcations for infection control
    Year: 2005
    Journal: Neurobiology of Disease
    Volume: 20
    Issue: 2
    Page numbers: 336-346
    Publisher: Academic Press(California)
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  • Homo- and heterodimerization of APP family members promotes intercellular adhesion
    Year: 2005
    Journal: EMBO Journal
    Volume: 24
    Issue: 20
    Page numbers: 3624-3634
    Publisher: Oxford University Press(Oxford)
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  • In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
    Year: 2005
    Journal: The FEBS Journal
    Volume: 272
    Issue: 21
    Page numbers: 5544-5557
    Publisher: Blackwell Publishers
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  • Metals and amyloid-Β in Alzheimer's disease
    Year: 2005
    Journal: International Journal of Experimental Pathology
    Volume: 86
    Issue: 3
    Page numbers: 147-159
    Publisher: Blackwell Science(Oxford)
    Author(s):
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  • Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 353-360
    Author(s):
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  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 13355-13363
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Neuronal sorting protein-related sorLA/LR11 regulates processing of the amyloid precursor protein
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 38
    Page numbers: 13461-13466
    Publisher: National Academy of Sciences(Washington DC)
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  • Prion protein glycosylation
    Year: 2005
    Journal: Journal of Neurochemistry
    Volume: 93
    Issue: 4
    Page numbers: 793-801
    Publisher: Blackwell Science(Oxford)
    Author(s):
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  • Rare genetically defined causes of dementia
    Year: 2005
    Journal: International Psychogeriatrics
    Volume: 17
    Page numbers: s149-s194
    Publisher: Springer(New York)
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  • The amyloid precursor protein (APP) of Alzheimer disease and its paralog APLP2 modulate the Cu/Zn-NO catalyzed degradation of glypican-1 heparan sulfate in vivo
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 14
    Page numbers: 13913-13920
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The preparation of 123/125I-clioquinol for the study of AΒ protein in Alzheimer's disease
    Year: 2005
    Journal: Journal of Labelled Compounds & Radiopharmaceuticals
    Volume: 48
    Page numbers: 473-484
    Publisher: John Wiley & Sons(West Sussex)
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  • Transition-state analgoue gamma-secretase inhibitors stabilize a 900kDa presenilin/nicastrin complex
    Year: 2005
    Journal: Biochemistry
    Volume: 44
    Issue: 11
    Page numbers: 4332-4341
    Publisher: American Chemical Society(Washington DC)
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Publications in 2004

Book Chapters

  • Vaccines Against Alzheimer's Disease
    Year: 2004
    Book: New Generation Vaccines
    Publisher: Dekker - Marcel Dekker(New York)
    Authors(s):

Journal Articles

  • APP intracellular domain is increased and soluble AΒ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease
    Year: 2004
    Journal: Neurobiology of Disease
    Volume: 16
    Page numbers: 124-132
    Publisher: Academic Press(California)
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  • Brain Βamyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1
    Year: 2004
    Journal: Neurochemical Research
    Volume: 29
    Page numbers: 2281-2286
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  • Characterization of presenilin complexes from mouse and human brain using Blue Native gel eletrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
    Year: 2004
    Journal: European Journal of Biochemistry
    Volume: 271
    Page numbers: 375-383
    Publisher: Blackwell Science(Oxford)
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  • Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid Β-peptide by NMR
    Year: 2004
    Journal: Journal of Peptide Science
    Volume: 10
    Page numbers: 210-217
    Publisher: John Wiley & Sons(West Sussex)
    Author(s):
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  • Creutzfeldt-Jakob disease surveillance in Australia
    Year: 2004
    Journal: Communicable Diseases Intelligence
    Volume: 28
    Page numbers: 356-358
    Publisher: Department of Health and Family Services
    Author(s):
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  • Effects of rhodiola on Alzheimer pathology and open field activity in APP-C100 transgenic mice
    Year: 2004
    Journal: Chinese Journal of Gerontology
    Volume: 24
    Page numbers: 530-533
    Publisher: Editorial Department of Chinese Journal of Gerontology(Beijing)
    Author(s):
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  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
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  • Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
    Year: 2004
    Journal: Molecular Brain Research
    Volume: 127
    Issue: 1-2
    Page numbers: 128-135
    Publisher: Elsevier Science(Amsterdam)
    Author(s):
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  • Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cullular copper levels in primary mouse cortical neurons and embryonic fibroblasts
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Page numbers: 423-428
    Publisher: Blackwell Science(Oxford)
    Author(s):
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  • Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects
    Year: 2004
    Journal: Annals of Neurology
    Volume: 55
    Page numbers: 898-899
    Author(s):
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  • Interaction of the molecular chaperone ΑB-crystallin with Α-synuclein: effects on amyloid fibril formation and chaperone activity
    Year: 2004
    Journal: Journal of Molecular Biology
    Volume: 340
    Page numbers: 1167-1183
    Publisher: Academic Press(London)
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  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
    Publisher: Springer Verlag(New York)
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  • Lyodura use and the risk of iatrogenic Creutzfeldt-Jakob disease in Australia
    Year: 2004
    Journal: Medical Journal of Australia
    Volume: 180
    Page numbers: 177-181
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Metal-protein attenuating compounds (MPACs) for the treatment of Alzheimer's disease
    Year: 2004
    Journal: Drug Design Reviews Online
    Volume: 1
    Page numbers: 75-82
    Publisher: Bentham Science Publishers(Hilversum)
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  • Metal-protein attenuating compounds and Alzheimer's disease
    Year: 2004
    Journal: Expert Opinion on Investigational Drugs
    Volume: 13
    Page numbers: 1585-1592
    Publisher: Ashley Publications(London)
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  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Neurodegenerative diseases and oxidative stress
    Year: 2004
    Journal: Nature Reviews Drug Discovery
    Volume: 3
    Page numbers: 205-214
    Publisher: Nature Publishing Group(London)
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  • Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Issue: 1
    Page numbers: 230-237
    Publisher: Blackwell Science(Oxford)
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  • Subtle memory decline over 12 months in mild cognitive impairment
    Year: 2004
    Journal: Dementia and Geriatric Cognitive Disorders
    Volume: 18
    Issue: 2004
    Page numbers: 342-348
    Publisher: S Karger AG(Basel)
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  • The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-link cleavages
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 18146-18156
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
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