PROF JAMES MCCLUSKEY

Contact Details

Organization:	Microbiology and Immunology
Position:	PROFESSOR
Email:
Homepage:	http://www.microbiol.unimelb.edu.au/research/groups/mccluskey
Work:	03 8344 5709
Room:	5.15
Level:	05
Building:	Microbiology Building
Campus:	Parkville

Biography

Current Appointment Professor and Head, Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, 3010 (tenured). Associate Dean Research, Faculty of Medicine Dentistry and Health Sciences (2006-current) Consultant Immunologist, Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, P.O. Box 354 South Melbourne, Victoria 3205. Member, Walter & Eliza Hall Medical Research Institute. Source of Current Salary: The University of Melbourne, Full time tenured appointment Previous Appointments 1977 Intern, Sir Charles Gairdner Hospital (S.C.G.H.) Perth, Western Australia. 1978 Senior Resident Medical Officer, S.C.G.H.Department of Pathology & Immunology, Monash Medical School, Monash University. 1990 Joint appointment as Director of Transplant Services, Red Cross Blood Transfusion Service, South Australia; Director of Cl 1979 Registrar Medicine/Gastroenterology, S.C.G.H. 1980 Registrar Renal/Diabetes/Endocrine/Neurology, S.C.G.H. 1981 Registrar Immunology/Rheumatology, Dept. Clinical Immunology, Royal Perth Hospital (R.P.H.) and S.C.G.H. 1982 Western Australian Arthritis and Rheumatism Foundation, Research Fellow and Clinical Associate in Clinical Immunology, Royal Perth Hospital and Q.E. II Medical Centre, Perth. 1983 January-April; Physician in Rheumatology, S.C.G.H. and Clinical Associate in Clinical Immunology, R.P.H., W.A. 1983 May 1983; Research Fellow, Laboratory of Immunology, NIAID, NIH, Bethesda, MD. 1984 Visiting Research Associate, Laboratory of Immunology, NIAID, NIH, Bethesda, MD. 1986 Arthritis Investigator, Laboratory of Immunology, NIAID, NIH, Bethesda Maryland. 1987 March - Senior Lecturer, Dept. Pathology & Immunology, Monash Medical School, Monash University. 1988 Senior Lecturer & Director of Clinical Immunology Laboratory, inical Immunology, Flinders Medical Centre and A/Professor in Clinical Immunology 1994 Professor (personal chair, 1994), Flinders University, South Australia. 1997 Professor of Microbiology & Immunology, The University of Melbourne & Consultant Immunologist, Australian Red Cross Blood Service, Victoria. 1998 Head of Department. 2003 Deputy Head of Department 2006- Head of Department and Associate Dean Research, Faculty of Medicine Dentistry and Health Sciences

Research Expertise and International Linkages

Research Expertise

Research Interest	Key Words	Country of Expertise
histocompatibility and immune response genetics	T cells, HLA molecules, Ag presentation, autoimmunity, Transplantation matching	Australia, United States of America

International Linkages

Country	Establishment	Collaboration
Germany	Hannover Medical School	Research, Technical Assistance/Training
United Kingdom	Institute for Animal Health	Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title	Institution	Date Awarded
Bachelor of Medical Science	The University of Western Australia	31-Dec-1974
Bachelor of Medicine & Bachelor of Surgery	The University of Western Australia	31-Dec-1976
Doctor of Medicine	The University of Western Australia	31-Dec-1989

Memberships

Membership Type	Membership Body	Description	Start Date
Member	American Association of Immunologists	Member	01-Aug-1989
Member	American Society for Histocompatibility and Immunogenetics	Member	06-Aug-2001
Member	European Foundation for Immunogenetics	Member	05-Aug-2002
Member	Australasian Society for Clinical Immunology and Allergy	Foundation Member	01-Feb-1988
Member	Australian Society for Immunology	Past President, member	04-Oct-1982
Senior Member	Australasian and South East Asian Tissue Typing Association	Past President, member	17-Aug-1982
Senior Member	International HLA and Immunogenetics Workshop Group	President	02-Dec-2005

Fellowships

Fellowship	Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP)	31-Dec-1983
Fellow of the Royal College of Pathologists, Australia (FRCPA)	31-Dec-1988

Other Awards

Award Type	Awarding Body	Comments	Date Awarded
Medal	American Society for Histocompatibility and Immunogenetics	Rose Payne Medal for Distinguished cContributions to the field of Histocompatibility and Immunogenetics	12-Oct-2007
Prize	University of Western Australia	Dr. F. Simpson Prize for top student in 1st year Dental Science	10-Nov-1969
Prize	University of Western Australia	Convocation Prize for top student in 2nd year Dental Science	09-Nov-1970
Prize	Australian Rheumatology Society	Parr Prize for Excellence in Rheumatology Research, awarded jointly with Professor Tom Gordon, Flinders University of South Australia	06-Aug-1995
Medal	Royal Australasian College of Physicians	Priscilla Kincaid Smith Oration	06-Aug-2000
Medal	American Society for Histocompatibility and Immunogenetics (ASHI)	Rose Payne Award and Medal for distinguished scientific contributions to the field of histocompatibility and immunogenetics	12-Oct-2007
Scholarship	University of Western Australia	W.A. and M.G. Saw Medical Research Fellowship	01-Jan-1983
Other (Award)	American Arthritis Foundation	American Arthritis Investigator Award	04-Aug-1986

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title	Role	Funding Source	Scheme	Award Date
Antigen presentation, recognition and the immune response	Chief Investigator	NHMRC	Program Grants	01/01/2002
Defining the molecular basis of T cell allorecognition	Chief Investigator	ROCHE ORGAN TRANSPLANTATION RESEARCH FOUNDATION	Research Grant - Letter of Intent	01/04/2002
Role of AIRE in Autoimmunity and the influence of HLA DR3-DQ2 Haplotype	Principal Supervisor	NHMRC	Medical & Dental Postgraduate Scholarships	01/01/2003
CONDITIONS OF AWARD FOR THE NATIONAL RESEARCH CENTRES IN HIV, HEPATITIS AND SEXUALLY TRANSMITTED INFECTIONS	Chief Investigator	DEPT OF HEALTH & AGEING	Commonwealth AIDS Research Grants	01/01/2004
THE STRUCTURAL AND FUNCTIONAL BASIS OF TUMOUR RECOGNITION BY NKT CELLS	Chief Investigator	CANCER COUNCIL VICTORIA	Grants-in-Aid	01/01/2006
2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE)	Chief Investigator	NHMRC	Program Grants	01/01/2007
Understanding the structural basis of T cell allorecognition	Chief Investigator	ROCHE ORGAN TRANSPLANTATION RESEARCH FOUNDATION	Research Grant - Letter of Intent	01/01/2007
MASS SPECTROMETRY FACILITY FOR THE QUANTITATION AND ANALYSIS OF POST-TRANSLATIONALLY MODIFIED PEPTIDES	Chief Investigator	AUST RESEARCH COUNCIL	Linkage Infrastructure (Equipment and Facilities)	01/01/2008
The basis of immune-mediated drug reactions	Chief Investigator	NHMRC	Project Grants	01/01/2009
Multi-photon imaging for infection, immunity, and self recognition	Chief Investigator	AUST RESEARCH COUNCIL	Linkage Infrastructure (Equipment and Facilities)	01/01/2009
Biorad ProteOn XPR36 Surface Plasmon Resonance system	Chief Investigator	PERPETUAL TRUSTEES AUST LTD	Clive & Vera Ramaciotti Establishment Grant	01/01/2009
AUSTRALIAN CENTRE FOR HEPATITIS AND HIV VIROLOGY RESEARCH (ACH2)	Chief Investigator	DEPT OF HEALTH & AGEING	Commonwealth AIDS Research Grants	01/05/2009

Contracts

Title	Role	Funding Source	Award Date
BIOACTIVITY ASSESSMENT OF NEXVAX2 IN A RELEVANT IN VIVO MOUSE MODEL: CANDIDATE PEPTIDE VACCINES WILL BE TESTED FOR THEIR ABILITY TO MODULATE ANTO-GLIADIN T CELL RESPONSES	Chief Investigator	NEXPEP PTY LTD	30/10/2007

Additional Grant and Contract Information

MHMRC Program grant 2007-2011

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

TCD8 response in diverse outcomes of recurrent exposure to Hepatitis C virus.

Year:	2009
Journal:	Immunology and Cell Biology
Volume:	87
Page numbers:	464-472
Author(s):
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Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

Year:	2009
Journal:	Immunity
Volume:	30
Issue:	6
Page numbers:	777-88
Author(s):
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Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 Vβ7 Semi-invariant NKT T Cell Receptors

Year:	2009
Journal:	Immunity
Volume:	31
Issue:	1
Page numbers:	47-59
Author(s):
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Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Year:	2009
Journal:	Journal of Experimental Medicine
Volume:	206
Issue:	1
Page numbers:	209-219
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19139173
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Resistance to Celiac Disease in Humanized HLA-DR3-DQ2-Transgenic Mice Expressing Specific Anti-Gliadin CD4+ T cells

Year:	2009
Journal:	Journal of Immunology
Volume:	182
Issue:	12
Page numbers:	7440-7450
Author(s):
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T Cell Receptor CDR2β and CDR3β Loops Collaborate Functionally to Shape the iNKT Cell Repertoire

Year:	2009
Journal:	Immunity
Volume:	31
Issue:	1
Page numbers:	60-71
Author(s):
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The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length

Year:	2009
Journal:	Molecular Immunology
Volume:	46
Page numbers:	1911-1917
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19157553
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The shaping of T cell receptor recognition by self-tolerance

Year:	2009
Journal:	Immunity
Volume:	30
Issue:	2
Page numbers:	193-203
Author(s):
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Publications in 2008

Book Chapters

Major Histocompatibility Complex (MHC) Molecules: Structure, Function, and Genetics

Year:	2008
Book:	Fundamental Immunology
Publisher:	Lippincott Williams & Wilkins(Philadelphia)
Authors(s):

Journal Articles

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR

Year:	2008
Journal:	Journal of Experimental Medicine
Volume:	205
Issue:	4
Page numbers:	939-49
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18378792
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Dressing for the occasion: APCs make antigens presentable

Year:	2008
Journal:	Current Opinion in Immunology
Volume:	20
Page numbers:	49-51
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18249104
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Fiber-modified recombinant adenoviral constructs encoding hepatitis C virus proteins induce potent HCV-specific T cell response

Year:	2008
Journal:	Clinical Immunology
Volume:	128
Page numbers:	329-339
Author(s):
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Human Leukocyte Antigen Class I-Restricted Activation of CD8⁺ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

Year:	2008
Journal:	Immunity
Volume:	28
Page numbers:	822-832
Author(s):
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Immunodominance Hierarchies and Gender Bias in Direct T _CD8-Cell Alloreactivity

Year:	2008
Journal:	American Journal of Transplantation
Volume:	8
Page numbers:	121-132
Author(s):
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Impact of clonal competition for peptide-MHC complexes on the CD8⁺ T-cell repertoire selection in a persistent viral infection

Year:	2008
Journal:	Blood
Volume:	111
Issue:	8
Page numbers:	4283-4292
Author(s):
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T cell allorecognition and MHC restriction-A case of Jekyll and Hyde?

Year:	2008
Journal:	Molecular Immunology
Volume:	45
Page numbers:	583-598
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17869342
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T-cell allorecognition: a case of mistaken identity or deja vu?

Year:	2008
Journal:	Trends in Immunology (formerly Immunology Today)
Volume:	29
Issue:	5
Page numbers:	220-226
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18378495
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T-cell receptor bias and immunity

Year:	2008
Journal:	Current Opinion in Immunology
Volume:	20
Page numbers:	119-25
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/pubmed/18207719?dopt=Citation
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T-cells behaving badly: structural insights into alloreactivity and autoimmunity

Year:	2008
Journal:	Current Opinion in Immunology
Volume:	20
Page numbers:	575-580
Author(s):
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The fidelity, occasional promiscuity, and versatility of T cell receptor recognition

Year:	2008
Journal:	Immunity
Volume:	28
Page numbers:	304-14
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18342005
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Publications in 2007

Journal Articles

A Structural and Immunological Basis for the Role of Human Leukocyte Antigen DQ8 in Celiac Disease

Year:	2007
Journal:	Immunity
Volume:	27
Page numbers:	23-34
Author(s):
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A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Year:	2007
Journal:	Nature Immunology
Volume:	8
Page numbers:	268-276
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17259989
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CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.

Year:	2007
Journal:	Nature
Volume:	448
Issue:	7149
Page numbers:	44-49
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Germline-encoded recognition of diverse glycolipids by natural killer T cells

Year:	2007
Journal:	Nature Immunology
Volume:	8
Issue:	10
Page numbers:	1105-1113
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/pubmed/17828267?dopt=Citation
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How a Home-Grown T Cell Receptor Interacts with a Foreign Landscape

Year:	2007
Journal:	Cell
Volume:	129
Page numbers:	19-20
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17418777
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Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

Year:	2007
Journal:	AIDS
Volume:	21
Page numbers:	1233-1244
Author(s):
URL - open access	http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17545699
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More than one reason to rethink the use of peptides in vaccine design

Year:	2007
Journal:	Nature Reviews Drug Discovery
Volume:	6
Issue:	5
Page numbers:	404-14
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17473845
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Structural Insight into Natural Killer T Cell Receptor Recognition of CD1d

Year:	2007
Journal:	Advances in Experimental Medicine and Biology
Volume:	598
Page numbers:	20-34
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Structural Studies on HLA-G: Implications for Ligand and Receptor

Year:	2007
Journal:	Human Immunology
Volume:	68
Issue:	4
Page numbers:	220-226
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17400055
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T Cell Epitopes of the La/SSB Autoantigen in Humanized Transgenic Mice Expressing the HLA Class II Haplotype DRB1*0301/DQB1*0201

Year:	2007
Journal:	Arthritis and Rheumatism
Volume:	56
Issue:	10
Page numbers:	3387-3398
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17907193
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The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV

Year:	2007
Journal:	European Journal of Immunology
Volume:	37
Issue:	4
Page numbers:	946-953
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17357107
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The production and crystallization of the human leucocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease

Year:	2007
Journal:	Acta Crystallographica Section F - Structural Biology and Crystallization Communications
Volume:	63
Page numbers:	1021-1025
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/pubmed/18084083?dopt=Citation
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Publications in 2006

Book Chapters

Tolerance and Immunity to the Ro/La RNP Complex

Year:	2006
Book:	Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease
Publisher:	Wiley-VCH(Berlin)
Authors(s):
Editors(s):

Journal Articles

Alloreactivity between Disparate Cognate and Allogeneic pMHC-I Complexes Is the Result of Highly Focused, Peptide-dependent Structural Mimicry

Year:	2006
Journal:	Journal of Biological Chemistry
Volume:	45
Page numbers:	34324-34332
Author(s):
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A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition

Year:	2006
Journal:	Journal of Experimental Medicine
Volume:	203
Issue:	3
Page numbers:	661-673
Author(s):
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A structural perspective on MHC class Ib molecules in adaptive immunity

Year:	2006
Journal:	Trends in Immunology (formerly Immunology Today)
Volume:	27
Issue:	9
Page numbers:	413-420
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Disparate thermodynamics governing T cell receptor–MHC-I interactions implicate extrinsic factors in guiding MHC restriction

Year:	2006
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	103
Issue:	17
Page numbers:	6641-6646
Author(s):
URL - restricted access	http://www.pnas.org/cgi/content/full/103/17/6641
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Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate.

Year:	2006
Journal:	Bone Marrow Transplantation
Volume:	37
Page numbers:	773-779
Author(s):
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Have we cut ourselves too short in mapping CTL epitopes

Year:	2006
Journal:	Trends in Immunology (formerly Immunology Today)
Volume:	27
Issue:	1
Page numbers:	11-16
Author(s):
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Humanized transgenic miceexpressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restrictied T-cell responses

Year:	2006
Journal:	Tissue Antigens
Volume:	68
Issue:	3
Page numbers:	210-219
Author(s):
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Immunodominance and Immunodomination: Critical Factors in Developing Effective CD8⁺ T-Cell-Based Cancer Vaccines

Year:	2006
Journal:	Cancer Research
Volume:	95
Issue:	2006
Page numbers:	203-247
Author(s):
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Immunological aspects of pregnancy

Year:	2006
Journal:	Clinics in Dermatology
Volume:	24
Issue:	2
Page numbers:	84-7
Author(s):
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Neo-epitopes are required for immunogenicity of the La/SS-B nuclear antigen in the context of late apoptotic cells

Year:	2006
Journal:	Clinical and Experimental Immunology
Volume:	143
Issue:	2
Page numbers:	237-248
Author(s):
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Specificty on a knife-edge: the αβ T cell receptor

Year:	2006
Journal:	Current Opinion in Structural Biology
Volume:	16
Issue:	6
Page numbers:	787-795
Author(s):
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Structural basis for a major histocompatability complex class 1b-restricted T cell response

Year:	2006
Journal:	Nature Immunology
Volume:	7
Issue:	3
Page numbers:	256-264
Author(s):
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Structural determinants of T-cell receptor bias in immunity

Year:	2006
Journal:	Nature Reviews Immunology
Volume:	6
Page numbers:	883-894
Author(s):
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TCRα Genes Direct MHC Restriction in the Potent Human T Cell Response to a Class I-bound Viral Epitope

Year:	2006
Journal:	Journal of Immunology
Volume:	177
Page numbers:	6804-6814
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The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt.

Year:	2006
Journal:	Acta Crystallographica Section F - Structural Biology and Crystallization Communications
Volume:	62
Issue:	1
Page numbers:	70-73
Author(s):
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Publications in 2005

Journal Articles

Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection¹

Year:	2005
Journal:	Journal of Immunology
Volume:	174
Issue:	9
Page numbers:	5593-5601
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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CD1d antigen presentation: treats for NKT cells

Year:	2005
Journal:	Nature Immunology
Volume:	6
Issue:	8
Page numbers:	754-756
Publisher:	Nature America(New York)
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CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection¹

Year:	2005
Journal:	Journal of Immunology
Volume:	175
Issue:	6
Page numbers:	3826-3834
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface

Year:	2005
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	102
Issue:	9
Page numbers:	3360-3365
Publisher:	National Academy of Sciences(Washington DC)
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High Resolution Structures of Highly Bulged Viral Epitopes Bound to Major Histocompatibility Complex Class I. Implications for T-cell Receptor Engagement and T-cell Immunodominance

Year:	2005
Journal:	Journal of Biological Chemistry
Volume:	280
Issue:	25
Page numbers:	23900-23909
Publisher:	American Society for Biochemistry and Molecular Biology(Maryland)
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Induction of T-Cell Immunity to Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1

Year:	2005
Journal:	Journal of Virology
Volume:	79
Issue:	12
Page numbers:	7728-7737
Publisher:	American Society for Microbiology(Washington DC)
Author(s):
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Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8⁺ T cell populations

Year:	2005
Journal:	Nature Immunology
Volume:	6
Issue:	4
Page numbers:	382-389
Author(s):
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Qualitative and Quantitative Differences in Peptides Bound to HLA-B27 in the Presence of Mouse versus Human Tapasin Define a Role for Tapasin as a Size-Dependent Peptide Editor¹

Year:	2005
Journal:	Journal of Immunology
Volume:	174
Issue:	12
Page numbers:	7833-7844
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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Structural studies on the alphabeta T-cell receptor

Year:	2005
Journal:	IUBMB Life
Volume:	57
Issue:	8
Page numbers:	575-582
Publisher:	Taylor & Francis Ltd(Pennsylvania)
Author(s):
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T Cell Determinants Incorporating B-Amino Acid Residues Are Protease Resistant and Remain Immunogenic In Vivo

Year:	2005
Journal:	Journal of Immunology
Volume:	175
Page numbers:	3810-3818
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Year:	2005
Journal:	Nature Immunology
Volume:	6
Issue:	11
Page numbers:	1114-1122
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The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Year:	2005
Journal:	Nature Immunology
Volume:	6
Issue:	2
Page numbers:	171-180
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The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Year:	2005
Journal:	Journal of Experimental Medicine
Volume:	202
Issue:	9
Page numbers:	1249-1260
Publisher:	Rockefeller University Press(New York)
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Conference Publications/Papers

The Structural and Functional Importance of Deamidation of the Dominant Gliadin Epitope in HLA-DQ8 Associated Celiac Disease

Year:	2005
Event name:	35th ASI - 14th IHIWS
Conference Publication:	Tissue Antigens
Volume:	66
Issue:	5
Page numbers:	443-443
Publisher:	Blackwell Publishing
Author(s):

A Super-Bulged Epitope and Single Amino Acid Polymorphism Identify Critical Features for T Cell Recognition

Year:	2005
Event name:	35th ASI - 14th IHIWS
Conference Publication:	Tissue Antigens
Volume:	66
Issue:	5
Page numbers:	571-571
Publisher:	Blackwell Publishing
Author(s):

Gluten-immunity Resembling Coeliac Disease in HLA Transgenic Mice

Year:	2005
Event name:	35th ASI - 14th IHIWS
Conference Publication:	Tissue Antigens
Volume:	66
Issue:	5
Page numbers:	393-394
Publisher:	Blackwell Publishing
Author(s):

Human-like Recognition of a Dominant Coeliac Disease Epitope by Murine CD4+ T Cells from HLA DR3-DQ2 Transgenic Animals

Year:	2005
Event name:	35th ASI - 14th IHIWS
Conference Publication:	Tissue Antigens
Volume:	66
Issue:	5
Page numbers:	375-376
Publisher:	Blackwell Publishing
Author(s):

Recognition of the Non-Classical MHC Class I Molecule, HLA-E, by the Adaptive Immune System

Year:	2005
Event name:	35th ASI - 14th IHIWS
Conference Publication:	Tissue Antigens
Volume:	66
Issue:	5
Page numbers:	443-443
Publisher:	Blackwell Publishing
Author(s):

The Clinical Impact in Haematopoietic Stem Cell Transplant Patients of Polymorphic Genes which Influence the Action of Methotrexate

Year:	2005
Event name:	35th ASI - 14th IHIWS
Conference Publication:	Tissue Antigens
Volume:	66
Issue:	5
Page numbers:	500-500
Publisher:	Blackwell Publishing
Author(s):

Publications in 2004

Journal Articles

Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAB OKT3

Year:	2004
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	101
Issue:	20
Page numbers:	7675-7680
Publisher:	National Academy of Sciences(Washington DC)
Author(s):
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Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Year:	2004
Journal:	Journal of Biological Chemistry
Volume:	279
Issue:	22
Page numbers:	23438-23446
Publisher:	American Society for Biochemistry and Molecular Biology(Maryland)
Author(s):
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Immunodominant CD4⁺ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant

Year:	2004
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	101
Issue:	25
Page numbers:	9363-9368
Publisher:	National Academy of Sciences(Washington DC)
Author(s):
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Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Year:	2004
Journal:	Journal of Experimental Medicine
Volume:	200
Page numbers:	13-24
Author(s):
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Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Year:	2004
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	101
Issue:	12
Page numbers:	4180-4185
Publisher:	National Academy of Sciences(Washington DC)
Author(s):
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TAP genes and immunity

Year:	2004
Journal:	Current Opinion in Immunology
Volume:	16
Issue:	5
Page numbers:	651-659
Publisher:	Current Biology(London)
Author(s):
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The Structure of H-2K^b and K^bm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance^1,2

Year:	2004
Journal:	Journal of Immunology
Volume:	173
Page numbers:	402-409
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Year:	2004
Journal:	Acta Crystallographica Section D - Biological Crystallography
Volume:	D60
Page numbers:	1425-1428
Publisher:	Munksgaard International Publishers(Copenhagen)
Author(s):
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Publications in 2003

Book Chapters

The Major Histocompatibility Complex and its Encoded Proteins

Year:	2003
Book:	Funamental Immunology
Publisher:	Lippincott Williams & Wilkins(New York)
Authors(s):

Journal Articles

A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition

Year:	2003
Journal:	Journal of Experimental Medicine
Volume:	198
Issue:	5
Page numbers:	679-691
Author(s):
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A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

Year:	2003
Journal:	Immunity
Volume:	18
Page numbers:	1-20
Author(s):
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Atopy, respiratory function and HLA-DR in Aboriginal Australians

Year:	2003
Journal:	Human Molecular Genetics
Volume:	12
Issue:	6
Page numbers:	625-630
Publisher:	Oxford University Press(Oxford)
Author(s):
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Biology and functions of human leukocyte antigen-G in health and sickness*

Year:	2003
Journal:	Tissue Antigens
Volume:	62
Page numbers:	273-284
Publisher:	Munksgaard International Publishers(Copenhagen)
Author(s):
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Human T-cells recognise N-terminally Fmoc-modified peptide

Year:	2003
Journal:	Vaccine
Volume:	21
Page numbers:	3638-3646
Publisher:	Elsevier Science(Oxford)
Author(s):
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Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

Year:	2003
Journal:	Tissue Antigens
Volume:	62
Page numbers:	408-417
Publisher:	Munksgaard International Publishers(Copenhagen)
Author(s):
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Tolerance through Indifference: Autoreactive B Cells to the Nuclear Antigen La Show No Evidence of Tolerance in a Transgenic Model¹

Year:	2003
Journal:	Journal of Immunology
Volume:	171
Page numbers:	5890-5900
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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Publications in 2002

Book Chapters

Nomenclature and serology of HLA class I and class II alleles (Unit A1.V)

Year:	2002
Book:	Current Protocols in Immunology
Publisher:	John Wiley & Sons(New York)
Authors(s):

Journal Articles

A 320-Kilobase Artificial Chromosome Encoding the Human HLA DR3-DQ2 MHC Haplotype Confers HLA Restriction in Transgenic Mice¹

Year:	2002
Journal:	Journal of Immunology
Volume:	168
Page numbers:	3050-3056
Author(s):
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Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex

Year:	2002
Journal:	FEBS Letters
Volume:	527
Page numbers:	27-32
Publisher:	Elsevier Science(Amsterdam)
Author(s):
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Optimization of the MHC Class I Peptide Cargo Is Dependent on Tapasin

Year:	2002
Journal:	Immunity
Volume:	16
Page numbers:	509-520
Publisher:	Cell Press(Massachusetts)
Author(s):
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Restricted Specificity of Intermolecular Spreading to Endogenous La (SS-B) and 60 kDa Ro (SS-A) in Experimental Autoimmunity

Year:	2002
Journal:	Scandinavian Journal of Immunology
Volume:	56
Page numbers:	168-173
Publisher:	Blackwell Publishers(Oxford)
Author(s):
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The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance

Year:	2002
Journal:	Structure
Volume:	10
Page numbers:	1521-1532
Publisher:	Cell Press(Cambridge)
Author(s):
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The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization¹

Year:	2002
Journal:	Journal of Immunology
Volume:	169
Page numbers:	5153-5160
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.

Year:	2002
Journal:	Acta Crystallographica Section D - Biological Crystallography
Volume:	58
Page numbers:	2131-2134
Author(s):
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Publications in 2001

Journal Articles

Clinical Relevance of the Minor Histocompatibility Antigen HA-1 in Allogeneic Bone Marrow Transplantation Between HLA Identical Siblings

Year:	2001
Journal:	Transplantation Proceedings
Volume:	33
Page numbers:	1760-1761
Publisher:	Elsevier Science(New York)
Author(s):
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Cognate T cells Help Is Sufficient to Trigger Anti-Nuclear Autoantibodies in Naive Mice

Year:	2001
Journal:	Journal of Immunology
Volume:	166
Issue:	9
Page numbers:	5826-5834
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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Genomic diversity of natural killer cell receptor genes in three populations

Year:	2001
Journal:	Tissue Antigens
Volume:	57
Page numbers:	358-362
Publisher:	Munksgaard International Publishers(Copenhagen)
Author(s):
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Quantitative and Qualitative Influences of Tapasin on the Class I Peptide Repertoire

Year:	2001
Journal:	Journal of Immunology
Volume:	166
Page numbers:	1016-1027
Author(s):
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PROF JAMES MCCLUSKEY

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