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DR HELEN MACLEAN



Contact Details

Organization: Medicine - Austin Health and Northern Health
Position: R D WRIGHT FELLOW
Email:
Homepage: http://www.austinmedicine.unimelb.edu.au/research/mol-endo/androgens-muscle.html
Work: 03-9496 5794
Fax: 03-9457 5485
Room: 7.5
Level: 07
Building: Lance Townsend Building
Campus: Austin Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
androgen action in skeletal muscle physiology, skeletal muscle, hypertrophy, muscle wasting Australia
steroid hormone action & androgen receptor function androgens, testosterone, dihydrotestosterone, androgen receptor Australia
genetically modified mouse models in molecular endocrinology androgen receptor, skeletal muscle, genetically modified mouse models, knockout, transgenic, androgens, testosterone Australia
obesity & adipose tissue biology fat, obesity, metabolic syndrome, type 2 diabetes, metabolism Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Honours) University of Melbourne 31-Dec-1988
Doctor of Philosophy University of Melbourne 08-Apr-1998

Memberships

Membership Type Membership Body Description Start Date End Date
Member Endocrine Society of Australia Chair, Program Organising Committee, Annual Scientific Meeting (2007-2009) 01-Jan-1990
Member The Endocrine Society (USA) Member 01-Jun-1996
Member Women in Endocrinology Member 01-Jun-2001
Member Scientific Advisory Board, Teeleostin Pty Ltd Scientific Advisory Board 01-Aug-2008
Member Australian Society for Medical Research member 01-Feb-2003

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship NHMRC Dora Lush Biomedical Scholarship 17-Feb-1992
Other (Award) Austin Health AustHos Travelling Fellowship 19-Oct-2005
Other (Award) American Society for Bone & Mineral Research Young Investigator Award 26-Sep-2001
Other (Award) The Endocrine Society (USA) Travel Award 20-Jun-2001
Prize Premier of Victoria Premier's Award for Medical Research (Commendation) 12-Jun-1996
Other (Award) Endocrine Society of Australia Sandoz Junior Award 18-Sep-1991
Prize University of Melbourne Dwight's Prize in Genetics 18-Dec-1987

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
The mechanisms of anabolic androgen actions in skeletal muscles Chief Investigator NHMRC R Douglas Wright Awards 01/01/2005
The molecular mechanisms of anabolic androgen actions in skeletal muscle Chief Investigator NHMRC Project Grants 01/01/2005
Control of fat mass by male sex hormones Chief Investigator NHMRC Project Grants 01/01/2007
Non-classical androgen actions Chief Investigator NHMRC Project Grants 01/01/2008
mechanism mediating anabolic actions of androgens in skeletal muscle Chief Investigator SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION Medical Research Grants 19/06/2008
INVESTIGATING NON-CLASSICAL SIGNALLING PATHWAYS OF THE ANDROGEN RECEPTOR Chief Investigator THE ENDOCRINE SOCIETY OF AUSTRALIA Researcher Higher Degree Scholarship 25/02/2009
TARGET GENES OF ANDROGENS IN SKELETAL MUSCLE Chief Investigator SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION Medical Research Grants 15/07/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Unraveling androgen action in muscle: genetic tools probing cellular mechanisms


    Year: 2009
    Journal: Endocrinology
    Volume: 150
    Issue: 8
    Page numbers: 3437-3439
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Publications in 2008

Journal Articles

  • Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats


    Year: 2008
    Journal: Bone
    Volume: 42
    Issue: 2008
    Page numbers: 1164-1174
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  • A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice
    Year: 2008
    Journal: Physiological Genomics
    Volume: 33
    Issue: 2008
    Page numbers: 133-137
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  • Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia inMice
    Year: 2008
    Journal: Journal of Bone & Mineral Research
    Volume: 23
    Issue: 8
    Page numbers: 1182-1193
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  • Generation and analysis of an androgen-responsive myoblast cell line indicates that androgens regulate myotube protein accretion
    Year: 2008
    Journal: Journal of Endocrinological Investigation
    Volume: 31
    Page numbers: 910-918
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  • Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice
    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Page numbers: 2676-89
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  • Intermittent Fugu parathyroid hormone 1 (1-34) is an ababolic bone agent in young male rats and osteopenic ovariectomized rats
    Year: 2008
    Journal: Bone
    Volume: 42
    Issue: 6
    Page numbers: 1164-74
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  • Oestradiol-induced spermatogenesis requires a functional androgen receptor
    Year: 2008
    Journal: Reproduction, Fertility and Development
    Volume: 20
    Page numbers: 861-870
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Publications in 2006

Journal Articles

  • Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice
    Year: 2006
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 291
    Issue: 2006
    Page numbers: E506-E516
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  • Current and future approaches using genetically modified mice in endocrine research
    Year: 2006
    Journal: American Journal of Physiology - Endocrinology and Metabolism
    Volume: 291
    Issue: 2006
    Page numbers: E429-E438
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  • Double-Strand DNA Break Repair With Repllication Slippage on Two Strands: A Novel Mechanism of Deletion Formation
    Year: 2006
    Journal: Human Mutation
    Volume: 27
    Issue: 2006
    Page numbers: 483-489
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Publications in 2005

Journal Articles

  • Age-dependent differences in androgen binding affinity in a family with spinal and bulbar muscular atrophy
    Year: 2005
    Journal: Neurological Research
    Volume: 27
    Issue: 5
    Page numbers: 548-551
    Publisher: Maney Publishing(Leeds)
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  • Androgen regulation of satellite cell function
    Year: 2005
    Journal: Journal of Endocrinology
    Volume: 186
    Page numbers: 21-31
    Publisher: Society of Endocrinology(Stokebristol)
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  • Localization of indian hedgehog and PTH/PTHrP receptor expression in relation to chondrocyte proliferation during mouse bone development
    Year: 2005
    Journal: Development Growth & Differentiation
    Volume: 47
    Page numbers: 59-63
    Publisher: Blackwell Publishers(Oxford)
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Publications in 2004

Journal Articles

  • Application of differential display in the identification of androgen-regulated genes
    Year: 2004
    Journal: Endocrine Research
    Volume: 30
    Issue: 1
    Page numbers: 69-82
    Publisher: Marcel Dekker(New York)
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  • Expression of Stral3 during mouse endochondral bone development
    Year: 2004
    Journal: Gene Expression Patterns
    Volume: 4
    Page numbers: 633-636
    Publisher: Elsevier Science
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  • Genetically modified animal models as tools for studying bone and mineral metabolism
    Year: 2004
    Journal: Journal of Bone & Mineral Research
    Volume: 19
    Issue: 6
    Page numbers: 882-892
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  • Increased frequency of long androgen receptor CAG repeats in male breast cancers
    Year: 2004
    Journal: Breast Cancer Research and Treatment
    Volume: 88
    Page numbers: 239-246
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Novel androgen receptor gene mutations in Australian patients with complete androgen insensitivity syndrome
    Year: 2004
    Journal: Human Mutation
    Volume: 23
    Issue: 3
    Page numbers: 287-292
    Publisher: Wiley-Liss(New York)
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  • The cyclin-dependent kinase inhibitor p57Kip2 mediates proliferative actions of PTHrP in chondrocytes
    Year: 2004
    Journal: Journal of Clinical Investigation
    Volume: 113
    Issue: 9
    Page numbers: 1334-1343
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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Publications in 2003

Journal Articles

  • Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development
    Year: 2003
    Journal: Developmental Biology
    Volume: 262
    Page numbers: 51-63
    Publisher: Academic Press(California)
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Publications in 2002

Journal Articles

  • p107 and p130 Coordinately Regulate Proliferation, Cbfa1 Expression, and Hypertrophic Differentiation during Endochondral Bone Development
    Year: 2002
    Journal: Developmental Biology
    Volume: 247
    Issue: 2002
    Page numbers: 271-285
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